Abstract: A method of planning a coverage path to cover an area. The method includes a computing arrangement iteratively receiving, generating and displaying. The computing arrangement is configured to receive a range acceptable user-inputs. The receiving includes receiving user-input within the range of acceptable user-inputs. The generating includes generating a feasible coverage path based on the user-input. The displaying includes displaying at least some detail of the feasible coverage path.

Abstract: A handheld vacuum cleaner includes a pistol grip which is positioned generally transverse to a longitudinal axis of the vacuum cleaner that runs from a front end to a rear end thereof. It also includes an air inlet positioned forward of the pistol grip, and a vacuum motor configured to draw dirty air into a dirt separator of the vacuum cleaner through the air inlet and exhaust clean air from the vacuum cleaner through an air outlet. The handheld vacuum cleaner further includes an electronic visual display which faces generally rearwards. The handheld vacuum cleaner may be part of a stick vacuum cleaner.

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for determining a predicted structure of a protein that is specified by an amino acid sequence. In one aspect, a method comprises: obtaining a multiple sequence alignment for the protein; determining, from the multiple sequence alignment and for each pair of amino acids in the amino acid sequence of the protein, a respective initial embedding of the pair of amino acids; processing the initial embeddings of the pairs of amino acids using a pair embedding neural network comprising a plurality of self-attention neural network layers to generate a final embedding of each pair of amino acids; and determining the predicted structure of the protein based on the final embedding of each pair of amino acids.

Abstract: This application relates to methods and apparatus for temperature monitoring for integrated circuits, and in particular to temperature monitoring using a locked-loop circuits, e.g. FLLs, PLLs or DLLs. According to embodiments a locked-loop circuit (200, 600) includes a controlled signal timing module (201, 601), wherein the timing properties of an output signal (SOUT, SFB) are dependent on a value of a control signal and on temperature. A controller (201, 601) compares a feedback signal (SFB) output from the timing module to a reference signal (SREF) and generates a control signal (SC) to maintain a desired timing relationship. A temperature monitor (202) monitors temperature based on the value of the control signal. For FLLs and PLLs the signal timing module may be a controlled oscillator (201).

Abstract: A drug delivery device (100) for administering a low dose of a medicament includes a housing (111) and a drug reservoir (101) disposed in the housing (111). A needle (135) is connected to the drug reservoir (101). A pressure applying member (113) is movably connected to the housing (111) and is movable between first and second positions. The pressure applying member (113) does not apply pressure to the drug reservoir (101) in the first position and applies pressure to the drug reservoir (101) in the second position to dispense medicament stored in the drug reservoir (101). A method of administering a low dose of insulin to simulate a first-phase insulin response of a pancreas is also disclosed.

Abstract: The invention relates to a microarray structure that may include a substrate material layer, a continuous three-dimensional (3D) surface layer on the substrate material layer that is capable of functionalisation for use as an array, and an inert material. The structure may include accurately defined and functionalisable isolated areas which are millimeter to nanometer in size. The functionalisable areas may be part of the continuous 3D surface layer and may be isolated by the inert material but interconnected within the structure by the continuous 3D surface layer.

Abstract: A needle changing device for use on a medication delivery device includes an engagement element that is configured to engage the medication delivery device and pierce a septum of the medication delivery device, a needle holder connected to the engagement element, the needle holder having a needle changing septum having a reservoir, the reservoir being in continuous fluid communication with the engagement element, and a plurality of needles configured to pierce the needle changing septum, wherein when the needle holder is in a first position, the plurality of needles are disengaged from the reservoir of the needle changing septum, and when the needle holder is in a second position, one of the plurality of needles enters into fluid communication with the reservoir of the needle changing septum and is partially exposed outside the needle changing device for medicament delivery.

Abstract: A filter system having a filter media retainer seal includes: at least one underdrain block having a top wall, a bottom wall, and a pair of side walls extending between the top wall and the bottom wall; a filter media retainer mounted onto the top wall of the at least one underdrain block; and at least one rib positioned between the underdrain block and the filter media retainer. The at least one rib forms a seal between the underdrain block and the filter media retainer, and prevents filter media from entering the underdrain block. The at least one rib can be monolithically formed to the at least one underdrain block. Alternatively, the at least one rib is monolithically formed to the filter media retainer. The rib is crushable and/or it bites into a surface on the adjoining part to reduce or eliminate the need for a separate sealant.

Abstract: Vial dosing systems and methods are disclosed. A vial dosing device includes a connecting body coupleable to a vial, a cannulated plunger having a proximal end coupled to the connecting body, a dose chamber adapted to slidably receive a distal end of the cannulated plunger and to expel medicament through a distal end of the dose chamber, and a plunger tip check valve coupled to the cannulated plunger and adapted for fluid flow from the cannulated plunger through the plunger tip check valve into the dose chamber.

Abstract: The invention relates to a microarray structure including a substrate material layer, a continuous three-dimensional (3D) surface layer on the substrate material layer that is capable of functionalisation for use as an array, and an inert material wherein the structure includes accurately defined and functionalisable isolated areas which are millimeter to nanometer in size. The functionalised areas are part of the continuous 3D surface layer and are isolated by the inert material and are interconnected within the structure by the continuous 3D surface layer.