Abstract: A method for manufacturing a silicon hydrogel gel contact lens having a hydrophilic surface is provided, whereby a hydrophilic biomedical material such as, HEMA, GMA, GMMA, NVP, MAA, MMA, PVA, PU, HA, collagen, chitosan, polydextrose, etc. is combined with a surface of a soft silicone gel or a silicone hydrogel material to form a sandwiched structure of a body of a contact lens. With this method, the surface of the soft silicone gel or the silicone hydrogel material can be completely coated with the hydrophilic biomedical material, so that a hydrophobic silicone dry spot on the surface resulting from a hydrophobic silicone component in the soft silicone gel or silicone hydrogel material is completely coated. Thus, a contact lens having a completely hydrophilic surface and a high oxygen-permeability is formed, which can be more comfortably worn for a longer time.

Abstract: A dynamo system comprises a flywheel mounted on a shaft intermediate its ends. A circular track in the dynamo system includes an inward groove structure to keep the ends of the shaft tracked inside while the flywheel rotating and spinning, the shaft's ends is dangling inside the circular track so that the shaft's ends will move freely along the circular course of the circular track while the flywheel rotates and spins.

Abstract: The present invention provides an addressable multi-channel peristaltic pump. According to the invention, this pump design allows for selection and operation of one or more pump heads on a drive shaft, while locking other non-selected pump heads in a stationary position. It is possible to operate the multi-channel pump using a limited number of motors, preferably two motors: a selector motor and a dispense motor. Thus, the pump provides for pumping or dispensing of one or more fluids without the need for multiple pumps. Likewise, compared with typical single motor multi-channel systems, where all pump heads on the drive shaft must rotate at the same time, the present invention provides for selective dispensing of one or more fluids. The pumps of the present invention are suitable for any multiple fluid transfer application, including in automated multi-channel reagent dispensing systems, such as nucleic acid purification systems.

Abstract: A roller assembly for a frameless sliding glass door has a bracket, a roller and at least one fastening device. The bracket is attached to the frameless sliding glass door and a track and has at least one elongated hole, an adjustment hole and a set screw. The at least one elongated hole is formed through the bracket near the lower end. The adjustment hole is formed through the lower edge of the bracket and communicates with the elongated hole in the lower end of the bracket. The set screw is threaded and corresponds with the adjustment hole. The roller is rotatable connected to the rear surface of the bracket in the upper end and mounted on the track. The fastening device is connected to the bracket and the frameless sliding glass door through the elongated hole and the corresponding through hole.

Abstract: The present invention provides an automated system for purification of a substance of interest. The system generally comprises an instrument for moving fluids through the system, a reagent pack for storing fluids, and a purification cartridge. The cartridge comprises two filtration units for binding substances based on different physical properties. The cartridge also comprises rotary valves for control of movement of fluids on the cartridge. In preferred embodiments, the system is useful for purifying RNA from blood samples.

Abstract: A transdermal drug delivery system includes a drug source, an adhesive for applying the system to a skin surface, a penetration enhancer for enhancing penetration of the drug into the skin surface, an energy source and a contact for conveying energy from said energy source through said adhesive and the penetrating enhancer.

Abstract: A composition comprising from about 0.001% to about 0.4% cyclosporin A, a surfactant, and an oil having a specific gravity from 0.8 to 0.95 is disclosed herein.

Abstract: Lacrimal canalicular inserts include a polymeric component and a therapeutic component. The therapeutic component is released from the inserts for extended periods of time, such as for more than about 2 weeks after placement in a lacrimal canaliculus of an individual. The polymeric component may include one or more non-biodegradable polymers, one or more biodegradable polymers, or combinations thereof. The therapeutic component may include one or more therapeutic agents. Therapeutically effective amounts of the therapeutic component are released from the insert and provide sustained drug delivery to the eye and/or the nasolacrimal system of the individual.

Abstract: A composition is disclosed herein comprising from about 0.001% to about 0.

Abstract: Methods of treating an eye of a human or animal include administering to an eye of a human or animal a composition in the form of an emulsion including water, a hydrophobic component and a cyclosporin component in a therapeutically effective amount of less than 0.1% by weight of the composition. The weight ratio of the cyclosporin component to the hydrophobic component is less than 0.8.

Abstract: Prednisolone acetate compositions, and methods, eye drops, and medicaments related thereto, are disclosed herein.

Abstract: Triamcinolone compositions, and methods of using such compositions, useful for injection into the vitreous of human eyes or into a joint are provided. Such compositions can include triamcinolone particles present in a therapeutically effective amount, a viscosity inducing component, and an aqueous carrier component. The compositions have viscosities of at least about 10 cps or about 100 cps at a shear rate of 0.1/second. In a preferred embodiment, the viscosity is in the range of from about 80,000 cps to about 300,000 cps. In a most preferred embodiment, the viscosity is in the range of from about 140,000 cps to about 280,000 cps t a shear rate of 0.1/second at 25° C. The compositions advantageously suspend the triamcinolone particles for prolonged periods of time.

Abstract: Compositions and methods useful for at least assisting in visualizing vitreous bodies of eyes of humans or animals are provided. Such compositions include a contrast component and a carrier component and are substantially free of any therapeutic agent effective to have pharmacological activity in an eye in which the composition is placed. Methods of using such compositions as visualization devices are also provided.

Abstract: An apparatus having a fabric and method of forming thereof. The fabric's load bearing surface for supporting a load, comprising: at least one layer(s) (Ln) wherein n=0, ?1, ?2, . . . ?i, wherein n=0 represents the at least one layer(s) (Ln) of the load bearing surface that contacts the load. An n=?1, ?2, . . . ?i, represents successive underlying at least one layer(s) (Ln) of the load bearing surface. An n=?i, represents a bottom underlying at least one layer(s) (Ln). The fabric consists essentially of a polyurethane fiber and a fiber that is chemically different from the polyurethane fiber, and wherein the fabric has been stretched to the point just before encountering the Young's Modulus. The method comprising: cutting the fabric to a predetermined pattern; and stretching the fabric to the point just before encountering the Young's Modulus.

Abstract: A composition comprising a therapeutically effective amount of cyclosporin A, a blend of oils having a specific gravity of from 0.90 to 1.07, and a surfactant is disclosed herein.

Abstract: A direct conversion satellite tuner is fully integrated on a common substrate. The integrated tuner receives an RF signal having a plurality of channels and down-converts a selected channel directly to baseband for further processing. The integrated tuner includes on-chip local oscillator generation, tunable baseband filters, and DC Offset cancellation. The integrated tuner can be implemented in a completely differential I/Q configuration for improved electrical performance. The entire direct conversion satellite tuner can be fabricated on a single semiconductor substrate using standard CMOS processing, with minimal off-chip components. The tuner configuration described herein is not limited to processing TV signals, and can be utilized to down-convert other RF signals to an IF frequency or baseband.

Abstract: A liquid comprising a therapeutically effective concentration of a cyclosporin and a vitamin E tocopherol polyethylene glycol succinate, wherein said liquid is an emulsion. is disclosed herein. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.

Abstract: An integrated receiver with channel selection and image rejection substantially implemented on a single CMOS integrated circuit is described. A receiver front end provides programable attenuation and a programable gain low noise amplifier. Frequency conversion circuitry advantageously uses LC filters integrated onto the substrate in conjunction with image reject mixers to provide sufficient image frequency rejection. Filter tuning and inductor Q compensation over temperature are performed on chip. The filters utilize multi track spiral inductors. The filters are tuned using local oscillators to tune a substitute filter, and frequency scaling during filter component values to those of the filter being tuned. In conjunction with filtering, frequency planning provides additional image rejection. The advantageous choice of local oscillator signal generation methods on chip is by PLL out of band local oscillation and by direct synthesis for in band local oscillator.

Abstract: Biocompatible intraocular implants include a steroid and an auxiliary agent, where the auxiliary agent is present in an amount sufficient to lessen the severity of at least one side effect compared to the use of an otherwise identical implant lacking said auxiliary agent. The steroid and the auxiliary agent may be present on the same intraocular implant or on different implants. The steroid and auxiliary agent may be associated with a biodegradable polymer matrix, such as a matrix of a two biodegradable polymers. Or, the steroid may be associated with a polymeric coating having one or more openings effective to permit the steroid to be released into an external environment. The implants containing the steroid and an auxiliary agent may be placed in an eye to treat one or more ocular conditions while reducing the side effects otherwise accompanying steroid use.

Abstract: A composition is described herein comprising cyclosporin A, polysorbate 80, a polyoxyethylene stearate, and an oil; wherein the composition is an emulsion which is ophthalmically acceptable. Methods of treating diseases or conditions using said compositions, and medicaments related thereto, are also disclosed herein.