Abstract: The present invention relates to a method of detecting a target antibody, particularly a target autoantibody, in a sample, using a small molecule fluorophore-labelled target antigen, or a functional fragment, functional variant or functional derivative thereof that specifically binds to the target antibody. Detection is typically carried out using immunodiffusion or immunoelectrophoresis. The invention also relates to methods of diagnosing disease, particularly autoimmune disease, using small molecule fluorophore labelled target antigens and autoantigens. Small molecule fluorophore labelled target antigens, including autoantigens, are also disclosed, as are uses such.

Abstract: Text messages over some period of time are collected. Topic identifiers, such as hashtags, are extracted from the text messages. The text messages associated with each topic identifier are processed to identify which topic identifiers are associated with group chats based on information associated with the text messages such as the times when the text messages were generated and whether the text messages identify user accounts. The topic identifiers that are determined to be associated with the group chats are incorporated into applications that allow users to search for group chats, and to view text messages from past group chats.

Abstract: In preferred embodiments, the present invention provides methods of treatment and pharmaceutical compositions for the suppression, alleviation and prevention of the often chronic, severe and debilitating pain that can accompany inflammatory diseases and neuropathic insults, pain that is often unresponsive to conventional analgesic treatment. The preferred embodiments of the present invention further relate to methods of treatment and pharmaceutical compositions using benzodiazepine derivatives that provide suppression, alleviation and prevention of neuropathic pain, migraine-related pain and inflammatory pain with reduced sedative and ataxic side effects.

Abstract: An apparatus, system and method for inhibiting electronic article surveillance, EAS, system alarming are provided. A receiver is configured to receive captured identification data after a transaction. A processor is configured to determine whether the captured identification data is associated with the transaction. The processor is further configured to determine whether to inhibit EAS system alarming based at least in part on the determination whether the captured identification data is associated with the transaction. The determination whether to inhibit EAS system alarming is made without regard to whether an active EAS tag is detected. A transmitter configured to transmit an authorization message. The authorization message indicates whether to inhibit EAS system alarming.

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.

Abstract: The application relates to a process for producing a coating by thermal spraying, in particular by plasma spraying, in which a component, in particular a cylinder liner, is internally coated with an alloy, wherein a plasma nozzle, to which a plasma gas and a transporting gas are fed, rotates about a wire and is movable along a longitudinal axis of the bore, such that the bore is coated as seen from the inside all around and in the axial direction of the bore. What is proposed is a variable gas stream or a variable flow rate of the transporting gas and/or of the plasma gas, it being possible for the flow rate to be set over the axial length (x) of the bore to be coated.

Abstract: Production of recombinant Tumor Necrosis Factor Receptor fused to the Fc region of an antibody (TNFRII-Fc fragment fusion protein) in a glycoengineered yeast strain that is capable of producing sialylated N-glycans and O-glycans is described. Compositions of TNFRII-Fc fragment fusion protein comprising dystroglycan type O-glycans and sialylated N- and O-glycans with only terminal N-acetylneuraminic acid (NANA) residues in an ?2,6-linkage are provided. In particular aspects, methods are provided for modulating the in vivo pharmacokinetics of the TNFRII-Fc fragment fusion protein by altering the O-glycan structure on the molecule.

Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.

Abstract: A financial institution can provide financial services to a plurality of remote devices, such as personal computers, personal data assistants, screen phones, automatic teller machines, external service providers, and internally to staff terminals and individual branches. By separating the components of the system into independent components, the system and method can be developed and tested on a component level rather than the entire system level, thereby reducing the development and maintenance cycle time. The system and method operate in sessions and can employ a dialog component for gathering information from a customer, a rule broker component for providing answers to the various legal and regulatory rules in a particular country, a language man component for selecting appropriate language, a transaction executor component for performing transactions, and a presentation manager component for formatting outputs to the customer.

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.

Abstract: A method for determining the laundry load size according to one embodiment of the invention in an automatic clothes washer comprising supplying water to a reference water level to define a first amount of water, supplying water from the reference water level to a second water level above the reference water level and sufficient to submerge the laundry load to define a second amount of water, and determining a load size for the laundry load based on the second amount of water such that errors associated with the first amount of water are not considered in the load size determination based on the second amount of water.

Abstract: A computer mouse designed to reduce the symptoms of and/or prevent Carpel Tunnel Syndrome.

Abstract: The invention relates to an apparatus and a method for imaging the vascular structure and vascular blood flow of an organ or tissue and, in particular, relates to a selective wavelength epi-illumination endoscopic imaging apparatus to image vascular tissues and real time capillary blood flow in vivo. The invention also relates to determining the blood oxygen content of the organ or tissue.

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.

Abstract: A method for determining the laundry load size according to one embodiment of the invention in an automatic clothes washer comprising supplying water to a reference water level to define a first amount of water, supplying water from the reference water level to a second water level above the reference water level and sufficient to submerge the laundry load to define a second amount of water, and determining a load size for the laundry load based on the second amount of water such that errors associated with the first amount of water are not considered in the load size determination based on the second amount of water.

Abstract: The present invention relates to a method of detecting a target antibody, particularly a target autoantibody, in a sample, using a small molecule fluorophore-labelled target antigen, or a functional fragment, functional variant or functional derivative thereof that specifically binds to the target antibody. Detection is typically carried out using immunodiffusion or immunoelectrophoresis. The invention also relates to methods of diagnosing disease, particularly autoimmune disease, using small molecule fluorophore labelled target antigens and autoantigens. Small molecule fluorophore labelled target antigens, including autoantigens, are also disclosed, as are uses such.

Abstract: A security sensor system comprises one or more laser detection and ranging (LADAR) sensors configured for accumulation of three-dimensional image data. In one embodiment, the one or more LADAR sensors each comprise a LADAR device, such as a MEMS device, configured to transmit a plurality of laser pulses, and a microprocessor operatively coupled to the LADAR device. One or more data storage devices is operatively coupled to the microprocessor and configured to store the three-dimensional image data, as well as predetermined protected area boundary and fixed object definitions. A GPS receiver can be operatively coupled to the microprocessor and a GPS antenna. The microprocessor is configured to perform a LADAR image analysis that compares the three-dimensional image data with the protected area boundary and fixed object definitions to identify one or more potential intruders.

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.

Abstract: A method for determining the laundry load size according to one embodiment of the invention in an automatic clothes washer comprising supplying water to a reference water level to define a first amount of water, supplying water from the reference water level to a second water level above the reference water level and sufficient to submerge the laundry load to define a second amount of water, and determining a load size for the laundry load based on the second amount of water such that errors associated with the first amount of water are not considered in the load size determination based on the second amount of water.

Abstract: A method is described for producing protein compositions having reduced amounts of O-linked glycosylation. The method includes producing the protein in cells cultured in the presence of an inhibitor of Pmt-mediated O-linked glycosylation and/or in the presence of one or more ?-1,2-mannosidases.