Abstract: Described herein are ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands, pharmaceutical compositions, and methods of use of such ligands and compositions in treatment of anxiety disorders, epilepsy and schizophrenia with reduced sedative and ataxic side effects. In embodiments, such as ?3 or ?2 or ?2/?3 GABAergic receptor subtype selective ligands lack ester linkages and may be thus relatively insensitive to hydrolysis by esterases.

Abstract: Systems and methods for detecting a security tag. The methods comprise: detecting motion of the security tag while in use to protect an article from unauthorized removal from a protected area; and emitting a first waveform from a radiating device of the security tag in response to the motion's detection. The first waveform is detectable by an Electronic Article Surveillance (“EAS”) monitoring system. The radiating device comprises a device other than an EAS element, a Radio Frequency Identification (“RFID”) device and a Near Field Communication (“NFC”) enabled device.

Abstract: An impact absorbing structure comprises a unitary material formed as a stretch-dominated hollow cell structure and a helmet comprising such a structure as an inner impact resistant liner.

Abstract: A foot orthotic having a body adapted to support a foot of a user is disclosed. The foot orthotic has a stiffness adjusting member (6) adapted to be mounted to the body to adjust the stiffness of the orthotic. Protrusions on the body enable the stiffness adjusting member (6) to be mounted to the body.

Abstract: Drilling apparatus and method, the apparatus comprising: a first robot (10); a first member (30) (e.g. a pressure foot) and a drilling tool (38) both coupled to the first robot (10); a second robot (12); and a second member (52) coupled to the second robot (12); wherein the apparatus is arranged to press the members (30, 52) against opposite sides of a part to be drilled (2, 100) (e.g. an aircraft panel) so as to hold the part (2, 100) and prevent deflection of at least a portion of the part (2, 100); and the first member (30) and the drilling tool (38) are arranged such that the drilling tool (38) may drill into the portion of the part (2, 100) of which deflection is opposed from the side of the part (2, 100) pressed against by the first member (30). The robots (10, 12) may be robotic arms.

Abstract: Drilling apparatus and method, the apparatus comprising: a first robot (10); a first member (30) (e.g. a pressure foot) and a drilling tool (38) both coupled to the first robot (10); a second robot (12); and a second member (52) coupled to the second robot (12); wherein the apparatus is arranged to press the members (30, 52) against opposite sides of a part to be drilled (2, 100) (e.g. an aircraft panel) so as to hold the part (2, 100) and prevent deflection of at least a portion of the part (2, 100); and the first member (30) and the drilling tool (38) are arranged such that the drilling tool (38) may drill into the portion of the part (2, 100) of which deflection is opposed from the side of the part (2, 100) pressed against by the first member (30). The robots (10, 12) may be robotic arms.

Abstract: Disclosed is a method and apparatus for machining a workpiece (2). The method comprises: specifying a path along which a cutting tool (6) is to be moved during machining of the workpiece (2), the path comprising a plurality of segments (26); defining, for each segment (26), an entry point and an entry path (32) from a point remote from the workpiece (2) to that entry point; moving a first cutting tool (6) along the tool path from a first point to a second point and machining the workpiece (2); after the first cutting tool (6) has been moved to the second point, moving the first cutting tool (6) to a point remote from the workpiece (2); moving a second cutting tool (18) along the entry path (32) of the segment (26) that contains the second point, and then from the entry point to the second point.

Abstract: Disclosed is a method and apparatus for machining a workpiece (2). The method comprises specifying a path along which a cutting tool (6) is moved during machining the workpiece (2), the path comprising segments (26); defining, for each segment (26), an exit point on that segment (26); defining, for each segment (26), an exit path (38) from the exit point of that segment (26) to a point remote from the workpiece (2); performing a machining process including moving the cutting tool (6) along the tool path and machining the workpiece (2); and, during the machining process, when one or more criteria are satisfied: interrupting the machining process and, without machining the workpiece (2), moving the cutting tool (6) to the exit point of the current segment (26) and then along the exit path (38) of the current segment (26).

Abstract: There is disclosed an apparatus for use in an electroetching or electrodeposition process in which material is etched from or deposited onto the surface of an electrically conductive component. The apparatus comprises a support for supporting the component within a tank containing an electrolytic solution; and a first-polarity electrode arranged to be located within the tank and immersed in the electrolytic solution and shaped to surround at least a part of the component in a contactless manner. In use, an electric field produced by the first-polarity electrode results in an electric variance between at least a part of the component and a second-polarity electrode having a polarity opposite to that of the first-polarity electrode. An electroetching and an electrodeposition process are also disclosed.

Abstract: A sensor may include a substrate defining a flow channel that extends through the substrate, and a plurality of bond pads on the substrate. A first housing may be disposed along the substrate and may permit at least some fluid to flow from a fluid inlet to a fluid outlet along at least part of the flow channel. A second housing may be disposed along the substrate. A sense die may be disposed between the second housing and the substrate and may include a sensing side facing the substrate with a sense element in registration with the flow channel and a plurality of bond pads on the sensing side that are in registration with, and bump bonded to, the plurality of bond pads on the substrate. An adhesive or other material may be disposed between the sensing side of the sense die and the substrate.

Abstract: An apparatus for applying forces to a pelvis of a person is disclosed. The apparatus includes a garment having at least a pelvic portion for location around the pelvis of a person, and a belt including a fastening member for fastening together two different parts of the belt when the belt surrounds the garment. The apparatus also includes a first attachment mechanism configured to fix a first part of the belt at a first location on the pelvic portion of the garment to prevent the first part of the belt from sliding in any direction from the first location.

Abstract: The present invention provides compounds of the formula Formula I or a salt thereof: and the uses of such compounds for the treatment of a disease or disorder involving oxidative damage, for preventing UV damage to the skin of a mammal and for preventing or reversing the effects of ageing, or for treating or preventing dry skin.

Abstract: A laser rod assembly includes a first and second laser rod embedded in a cladding material. The assembly has a first end and a second end. The laser rods generate laser light at ?laser (?laser light) when pumped by pump power at ?pump. A reflecting outer surface at ?pump is on or over a majority of an outer surface of the cladding material. Fold optic(s) on the second end provides optical coupling between the laser rods. An optical resonator includes a highly reflecting (HR) mirror at ?laser over an end of the first laser rod on the first end and an output coupler over an end of the second laser rod also on the first end.

Abstract: In an exemplary embodiment, a method of reinforcing a round structural member of a lattice structure comprises locating a reinforcement member having at least four facets on the round structural member, wherein each of the at least four facets forms a point of contact with the round structural member; and securing the reinforcement member to the round structural member.

Abstract: A combination tool for installing and crimping a cleat for fastening sections of ductwork, and for adjusting the threaded on support rods of strut channel for leveling the ductwork. The tool has an installing plate for holding a cleat and a removable handle that threads to the back of the installing plate. The handle has a hollow tubular body with a nut driver formed in the other end, for engaging and driving a threaded nut. The nut driver end is made by milling a rectangular slot transverse the axis of the hollow tubular body to form a pair of nut-engaging. A shank can be provided for attachment to the chuck of a power drill for rapid driving of the nuts. The tool also has a hinged crimping plate with threaded set screws for crimping the cleat securely to the flanges of the ductwork.

Abstract: A security sensor system comprises one or more laser detection and ranging (LADAR) sensors configured for accumulation of three-dimensional image data. In one embodiment, the one or more LADAR sensors each comprise a LADAR device, such as a MEMS device, configured to transmit a plurality of laser pulses, and a microprocessor operatively coupled to the LADAR device. One or more data storage devices is operatively coupled to the microprocessor and configured to store the three-dimensional image data, as well as predetermined protected area boundary and fixed object definitions. A GPS receiver can be operatively coupled to the microprocessor and a GPS antenna. The microprocessor is configured to perform a LADAR image analysis that compares the three-dimensional image data with the protected area boundary and fixed object definitions to identify one or more potential intruders.

Abstract: A financial institution can provide financial services to a plurality of remote devices, such as personal computers, personal data assistants, screen phones, automatic teller machines, external service providers, and internally to staff terminals and individual branches. By separating the components of the system into independent components, the system and method can be developed and tested on a component level rather than the entire system level, thereby reducing the development and maintenance cycle time. The system and method operate in sessions and can employ a dialog component for gathering information from a customer, a rule broker component for providing answers to the various legal and regulatory rules in a particular country, a language man component for selecting appropriate language, a transaction executor component for performing transactions, and a presentation manager component for formatting outputs to the customer.

Abstract: Methods, systems, and apparatus for removing flash from contact lens mold members are described. Flash is removed from contact lens mold members by cutting the flash from the mold member. The flash is removed by rotating a deflashing element or rotating a mold member, or both. After the flash is removed, the unfinished contact lens attached to the mold member can be further processed, which may include cutting an optical surface onto the contact lens.

Abstract: Drilling apparatus and method, the apparatus comprising: a first robot (10); a first member (30) (e.g. a pressure foot) and a drilling tool (38) both coupled to the first robot (10); a second robot (12); and a second member (52) coupled to the second robot (12); wherein the apparatus is arranged to press the members (30, 52) against opposite sides of a part to be drilled (2, 100) (e.g. an aircraft panel) so as to hold the part (2, 100) and prevent deflection of at least a portion of the part (2, 100); and the first member (30) and the drilling tool (38) are arranged such that the drilling tool (38) may drill into the portion of the part (2, 100) of which deflection is opposed from the side of the part (2, 100) pressed against by the first member (30). The robots (10, 12) may be robotic arms.