Abstract: Provided herein are methods for generating a non-naturally occurring, broadly reactive, pan-epitopic antigen derived from a pathogen, such as a virus, bacterium, and the like, that is immunogenic and is capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against the pathogen following introduction into a subject. Also provided is a non-naturally occurring immunogen generated using the methods, and vaccines and compositions comprising the immunogen. Methods of generating an immune response in a subject by administering the immunogen, vaccine, or composition are provided. In particular, the immunogen comprises the hemagglutinin (HA) or neuraminidase (NA) protein of influenza virus strains.

Abstract: The present disclosure provides for a system and method for remote image projection. The system may comprise a compact optical system to provide remote projections of images. The system may comprise an image correction subsystem, an image motion and positioning subsystem, an image relay and deflection subsystem, a source image, a warped image, a remotely projected image. The method may comprise processing the source image with a dewarping algorithm. The image correction subsystem may comprise a source image, a dewarping algorithm. When the system comprises an intermediate image plane, the warped image may be configured to project on the target projection surface upon arrival to the intermediate image plane. The image relay and deflection subsystem may comprise passive mechanical relay optics to refine the remotely projected image and direct the remotely projected image to the target projection surface.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer-storage media, for a lighting controller for sea lice detection. In some implementations, fish are contained within an elliptical tank filled with water. An imaging station located on the elliptical tank is used to capture an image of a fish from which image analysis can be performed to detect sea lice or other skin features, including lesions, on the fish. Pairs of imaging assemblies coordinate pulsing light of at least a first and a second color and capturing images of the fish while the fish is illuminated by at least the first and the second color. By using the captured images with different color light, computers can detect features on the body of a fish including sea lice, skin lesions, shortened operculum or other physical deformities and skin features. Detection results can aid in mitigation techniques or be stored for analytics.

Abstract: Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.

Abstract: A system includes a first body of a fluid-handling component and a second body of a fluid-handling component. The system also includes a fastener configured to couple the first body to the second body, and an annular sleeve configured to surround a portion of the fastener that is positioned at an interface between the first body and the second body when the first body and the second body are coupled to one another.

Abstract: A compound according to Formula IA and IB, reversibly convertible under photochromic and electrochromic conditions between a ring-open isomer A and a ring-closed isomer B is provided. For substitutent groups, Z is N, O or S; each R1 is independently selected from the group consisting of H, or halo; each R2 is independently selected from the group consisting of H, halo, a polymer backbone, alkyl or aryl; or, when both R2 together form —CH?CH— and form part of a polymer backbone; each R3 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl; each R4 is aryl; and each R5 is independently selected from the group consisting of H, halo, alkyl, alkoxy, thioalkyl or aryl.

Abstract: Systems and methods are provided for synchronizing data. The systems and methods include operations for: storing a synchronization entry for a messaging application feature, the synchronization entry comprising a last update timestamp associated with a first update to content of the messaging application feature received from a first source; receiving a second update to the content of the messaging application feature from the first source; determining that the second update was received within a write window of the last update timestamp; in response to determining that the second update was received within the write window of the last update timestamp, preventing updating the last update timestamp; and sending the first update and the second update to a client device in response to receiving a synchronization request from the client device based on the last update timestamp.

Abstract: The invention provides a compound of formula (I): or tautomer or a solvate or a pharmaceutically acceptable salt thereof, wherein the various substituents are as defined in the claims. Also provided are pharmaceutical compositions containing the compounds of formula (I), processes for making the compounds and the medical uses of the compounds.

Abstract: New 7xx aluminum casting alloys are disclosed. The aluminum casting alloys generally include from 3.0 to 8.0 wt. % Zn, from 1.0 to 3.0 wt. % Mg, where the wt. % Zn exceeds the wt. % Mg, from 0.35 to 1.0 wt. % Cu, where the wt. % Mg exceeds the wt. % Cu, from 0.05 to 0.30 wt. % V, from 0.01 to 1.0 wt. % of at least one secondary element (Mn, Cr, Zr, Ti, B, and combinations thereof), up to 0.50 wt. % Fe, and up to 0.25 wt. % Si, the balance being aluminum and other elements, wherein the aluminum casting alloy include not greater than 0.05 wt. % each of the other elements, and wherein the aluminum casting alloy includes not greater than 0.15 wt. % in total of the other elements.

Abstract: A method and system are provided for customizing integration flow templates. The method can include can include monitoring user interaction with a plurality of systems external to an integration system to read data changes at the external systems and identifying at least one event pair, wherein each event pair is between two external systems having a same data change event in the two external systems. The identified event pairs are filtered for inclusion in an events chain and the external systems of the filtered event pairs are ordered in the events chain based on timestamps of the data change events. The method outputs integration flow templates based on the ordered external systems of the event pairs that define a flow trigger and at least one flow node.

Abstract: A computer-implemented system and method detect an error in an application comprising a component having a control that is displayed in a first state on a display device. Responsive to the detecting of the error, the method comprises associating the error with the control, and, upon making this association, the method comprises automatically modifying the component at application run-time. This modification indicates that the control is no longer functional. A display operation of the component is performed where the modified component has: a) the control displayed in a second state on the component, or b) the control is removed from the component. The method may be repeated when other errors occur, and the control may be restored when the underlying error is resolved.

Abstract: A subterranean coring assembly can include a body having at least one wall that forms a cavity, wherein the cavity has a top end and a bottom end. The subterranean coring assembly can also include a first flow regulating device movably disposed within the cavity, where the first flow regulating device is configured to move from a first default position to a first position within the cavity based on first flow characteristics of fluid that flows into the top end of the cavity toward the bottom end of the cavity.

Abstract: Provided herein are methods for generating a non-naturally occurring, broadly reactive, pan-epitopic antigen derived from H3 influenza virus that is capable of eliciting a broadly reactive immune response, such as a broadly reactive neutralizing antibody response, against H3 virus following administration to a subject. Also provided is a non-naturally occurring immunogen generated using the methods, and vaccines and compositions comprising the immunogen. Methods of generating an immune response in a subject by administering the immunogen, vaccine, or composition are provided. In particular, the immunogen comprises the hemagglutinin (HA) protein of H3 influenza vims strains.

Abstract: A downhole on-demand power source system can include at least one first energy storage device located within a wellbore disposed in a subterranean formation in a first inactive state. The system can also include at least one first trigger that initiates the at least one first energy storage device from the first inactive state to a first active state. The at least one first energy storage device, once initiated, can provide a first power to an electrical load disposed in the wellbore proximate to the at least one first energy storage device. The at least one first energy storage device, when in the first inactive state, is incapable of providing the first power.

Abstract: A personal care product that includes a personal care composition disposed in a package and a user-friendly ingredient label disposed on the package. The user-friendly ingredient label includes a first portion containing a formal ingredient name for each ingredient in the product and a second portion containing at least one of an informal ingredient name and additional ingredient information related an ingredient in the product. The ingredient label configuration allows a product manufacturer to comply with governmental regulations and/or industry standards for labeling products and still provide additional salient ingredient information that is desired by consumers for the ingredients in the product.

Abstract: A method for energy generation includes receiving, at a carbon negative energy generation system, input including calcium oxide and water and reacting, within a reaction chamber of the carbon negative energy generation system, the calcium oxide and water to release energy and generate calcium hydroxide. The method further includes directing, by the carbon negative energy generation system, the released energy to facilitate propulsion or onboard electricity generation and dispensing, by the carbon negative energy generation system, the calcium hydroxide into the ocean to sequester atmospheric CO2.

Abstract: A method for ship ballasting includes receiving, at a carbon negative energy storage system, input comprising calcium oxide and water and reacting, within a reaction chamber of the carbon negative energy storage system, the calcium oxide and water to release energy and generate calcium hydroxide. The method includes directing, by the carbon negative energy storage system, the released energy to a requesting end user and providing, by the carbon negative energy storage system, the calcium hydroxide to a marine vessel ballasting system. The method includes releasing a mixture of the calcium hydroxide and ballast water from the marine vessel ballasting system into the ocean to sequester atmospheric COCO2.

Abstract: A foam dispenser having a metal housing has a spool valve socket therein. A metal handle extends from the housing. A spool valve is disposable within the spool valve socket. A trigger couplable to the spool valve enables the spool valve to be rotated between open and closed orientations within the housing. The spool valve has internal channels for selectively passing liquids through the spool valve in the open orientation and not in the closed orientation. The spool valve also has a channel for selectively passing a gas through the spool valve in both the open and closed orientations.

Abstract: A foam dispenser having a metal housing has a spool valve socket therein. A metal handle extends from the housing. A spool valve is disposable within the spool valve socket. A trigger couplable to the spool valve enables the spool valve to be rotated between open and closed orientations within the housing. The spool valve has internal channels for selectively passing liquids through the spool valve in the open orientation and not in the closed orientation. The spool valve also has a channel for selectively passing a gas through the spool valve in both the open and closed orientations.

Abstract: A method for use in a headend communications device, the method including receiving an input data signal over a fiber optic port, switching the input data signals to a plurality of data signals, converting the data signals to output coaxial cable signals and transmitting the output coaxial cable signals.