Abstract: A housing is integrated into a tubing string having a straight through passage and a lateral wall exist. Inside the passage is a flow responsive member with an applied preload force. Flow corresponding to a predetermined differential pressure in the housing will not move the valve member so all flow will go straight through in a downhole direction. As flow increases, the preload bias is overcome to align the passage through the housing and openings in the valve member with wall openings. As flow into the housing increases, more lateral wall opening area is aligned with the passage to increase circulation flow while holding through flow downhole constant. Dropping a ball on the valve member blocks through flow and allows opening of total bypass passages. The ball can be removed by blowing it through the seat or otherwise failing or disintegrating it.

Abstract: A one trip method of cleaning a portion of the borehole and then setting a tool such as a packer or a bridge plug locates the cleanup tools above the plug with a ported sub to allow circulation of loosened debris. The debris is directed uphole from above the plug and does not have to pass around the sealing element of the plug or through bypass ports in the plug body. The plug is then positioned in the cleaned portion and set. The cleaning tools are released from the set plug and brought to the surface. These tools could be used to clean the portion of the borehole where the tool is set or clean the entire section above the tool on the trip out of the borehole. Cleaning tools can be filter, scrapers both fixed and movable, magnets, brushes and associated tools that centralize the assembly for more effective operation.

Abstract: A one trip method of cleaning a portion of the borehole and then setting a tool such as a packer or a bridge plug locates the cleanup tools above the plug with a ported sub to allow circulation of loosened debris. The debris is directed uphole from above the plug and does not have to pass around the sealing element of the plug or through bypass ports in the plug body. The plug is then positioned in the cleaned portion and set. The cleaning tools are released from the set plug and brought to the surface. These tools could be used to clean the portion of the borehole where the tool is set or clean the entire section above the tool on the trip out of the borehole. Cleaning tools can be filter, scrapers both fixed and movable, magnets, brushes and associated tools that centralize the assembly for more effective operation.

Abstract: Novel tumor necrosis factor receptor (TNFR) polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting ligand, as well as agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate tumor growth, metastasis, and immunity such as separating resting from stimulated immune cells.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the ?-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the ?-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the ?-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.

Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by serpins, serine protease inhibitors. Serpin dysfunction is associated with various disorders, including emphysema, blood clotting disorders, cirrhosis, Alzheimer disease, and Parkinson disease. Zserp11 is a new member of the serine protease inhibitor family.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.

Abstract: A novel proteinase inhibitor and materials and methods for making it are disclosed. The proteinase inhibitor comprises residues 3-425 of SEQ ID NO:2. The proteinase inhibitor may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.

Abstract: The present invention provides a solution to the needs described above through a system and method for efficiently detecting near identities in large DNA databases. The system and method disclosed herein make use of an algorithm used to construct and maintain unique DNA databases wherein the unique database contains no two DNA sequences such that one is nearly identical to a region of the other. The system and method are applicable to problems such as an all against all comparison of all the DNA sequences in a large DNA database, clustering and assembling ESTs into the cDNAs that generated the ESTs, mapping assembled ESTs onto genomic sequence, mapping cDNAs onto genomic sequences and locating alternately spliced cDNAs.

Abstract: The present invention provides a solution to the needs described above through a system and method for efficiently detecting near identities in large DNA databases. The system and method disclosed herein make use of an algorithm used to construct and maintain unique DNA databases wherein the unique database contains no two DNA sequences such that one is nearly identical to a region of the other. The system and method are applicable to problems such as an all against all comparison of all the DNA sequences in a large DNA database, clustering and assembling ESTs into the cDNAs that generated the ESTs, mapping assembled ESTs onto genomic sequence, mapping cDNAs onto genomic sequences and locating alternately spliced cDNAs.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.

Abstract: Interferons represent an important class of biopharmaceutical products, which have a proven track record in the treatment of a variety of medical conditions, including the treatment of certain autoimmune diseases, the treatment of particular cancers, and the enhancement of the immune response against infectious agents. To date, five types of interferons have been found in humans: interferon-&agr;, interferon-&bgr;, interferon-&ggr;, interferon-&ohgr;, and interferon-&egr;. The present invention provides a new form of human interferon, “Zinf2,” which has applications in diagnosis and therapy.

Abstract: Chemokines are implicated in inflammation, ischemia and reperfusion injury, wound healing, allergies, as well as bacterial and viral pathogenesis. Moreover, chemokines may be involved in chronic diseases such as arthritis, asthma, and atherosclerosis. The present invention provides a new form of chemokine, designated as “Zchemo14.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp4, a secreted protein having tandem C1q globular domains. Zacrp4 is highly expressed in neuronal and reproductive tissues and may be used in the study cell-cell communication and the regulation of cellular processes therein. The present invention also includes antibodies to the zacrp4 polypeptides.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.

Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.

Abstract: A novel proteinase inhibitor and materials and methods for making it are disclosed. The proteinase inhibitor comprises residues 3-425 of SEQ ID NO:2. The proteinase inhibitor may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.