Patents by Inventor James L. Holloway

James L. Holloway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Zvwf1: a member of the von willebrand factor type A domain superfamily
    Publication number: 20020004228
    Abstract: Proteins comprising one or more copies of von Willebrand factor type A domain play important roles in host defense mechanisms, such as immune response, inflammation, and hemostasis. Zvwf1 is a new member of this superfamily.
    Type: Application
    Filed: December 7, 2000
    Publication date: January 10, 2002
    Inventor: James L. Holloway
  • Human semaphorin ZSMF-16
    Publication number: 20010049432
    Abstract: Semaphorin polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptide is expressed in breast cancer, and neuronal tissues. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities and cancers. The polypeptides may be used within methods for detecting receptors that mediate neurite outgrowth, modulate cellular proliferation and/or differentiation, and immune response. The present invention also includes antibodies to the ZSMF-16 polypeptides and uses therefore.
    Type: Application
    Filed: December 6, 2000
    Publication date: December 6, 2001
    Inventors: James L. Holloway, Kevin P. Foley
  • Educational kit and method using tumor necrosis factor-stimulated gene and protein
    Publication number: 20010036643
    Abstract: An educational kit containing Ztsg1 gene and optionally, a Ztsg1 polypeptide, antibody, and anti-idiotypic antibody. Tumor necrosis factor-stimulated protein (Ztsg1), polynucleotides that encode it and antibodies, which bind to it. Ztsg1 can be administered to an individual to stimulate the immune system. Antibodies to Ztsg1 can be used to diagnose rheumatoid arthritis in an individual.
    Type: Application
    Filed: December 1, 2000
    Publication date: November 1, 2001
    Inventor: James L. Holloway
  • Nuclear receptor polypeptide ZPPAR4
    Patent number: 6262234
    Abstract: The present invention relates to ZPPAR4 polynucleotide molecules and ZPPAR4 polypeptide molecules. ZPPAR4 is a novel member of the nuclear receptor superfamily. The novel ZPPAR4 nuclear receptor can be used to examine ZPPAR4-related complex transcriptional networks and biological processes. The disclosed ZPPAR4 polynucleotides and polypeptides provide a means to identify the natural ligand for ZPPAR4, as well as agonists and antagonists thereof.
    Type: Grant
    Filed: June 26, 1998
    Date of Patent: July 17, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: James L. Holloway, Laura J. Jelinek, Diane M. Durnam, Hal Blumberg
  • Testis-specific cystatin-like protein cystatin T
    Patent number: 6245529
    Abstract: The present invention relates to cystatin T (also known as zcys3) polypeptides and polynucleotides encoding the same. Cystatin T polypeptide is testis specific and homologous to cystatin-related epididymal specific gene (CRES) and type 2 cystatins. The polypeptides would be useful for modulating spermatogenesis and may be used to study or modulate that function in in vitro or in vivo systems. The present invention also includes antibodies to the cystatin T polypeptides.
    Type: Grant
    Filed: July 17, 2000
    Date of Patent: June 12, 2001
    Assignee: ZymoGenetics, Inc.
    Inventors: James L. Holloway, Andrew L. Feldhaus
  • Testis-specific cystatin-like protein cystatin T
    Patent number: 6235708
    Abstract: The present invention relates to cystatin T (also known as zcys3) polypeptides and polynucleotides encoding the same. Cystatin T polypeptide is testis specific and homologous to cystatin-related epididymal specific gene (CRES) and type 2 cystatins. The polypeptides would be useful for modulating spermatogenesis and may be used to study or modulate that function in in vitro or in vivo systems. The present invention also includes antibodies to the cystatin T polypeptides.
    Type: Grant
    Filed: November 1, 1999
    Date of Patent: May 22, 2001
    Assignee: ZymoGenetics, Inc
    Inventors: James L. Holloway, Andrew L. Feldhaus