Patents by Inventor James L. Holloway

James L. Holloway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Proteinase inhibitor ZSERP9
    Publication number: 20030166852
    Abstract: A novel proteinase inhibitor and materials and methods for making it are disclosed. The proteinase inhibitor comprises residues 3-425 of SEQ ID NO:2. The proteinase inhibitor may be used as components of cell culture media, in protein purification, and in certain therapeutic and diagnostic applications.
    Type: Application
    Filed: March 29, 2002
    Publication date: September 4, 2003
    Inventor: James L. Holloway
  • Human phermone polypeptides
    Publication number: 20030166070
    Abstract: Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new group of human pheromone polypeptides, collectively designated “ZHMUP-1.
    Type: Application
    Filed: May 9, 2002
    Publication date: September 4, 2003
    Inventors: Si Lok, James L. Holloway, Patrick J. O'Hara
  • Mammalian transforming growth factor beta-10
    Publication number: 20030166268
    Abstract: Novel mammalian Ztgf&bgr;-10 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods including antibodies and anti-idiotypic antibodies
    Type: Application
    Filed: May 29, 2001
    Publication date: September 4, 2003
    Inventor: James L. Holloway
  • Novel beta-defensins
    Publication number: 20030157638
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
    Type: Application
    Filed: October 15, 2002
    Publication date: August 21, 2003
    Inventors: David A. Adler, James L. Holloway, Nand Baindur, Stephanie Beigel-Orme, Paul O. Sheppard
  • Novel beta-defensins
    Publication number: 20030143671
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
    Type: Application
    Filed: March 5, 2002
    Publication date: July 31, 2003
    Inventors: David A. Adler, James L. Holloway, Nand Baindur, Stephanie Beigel-Orme, Paul O. Sheppard
  • Beta-defensins
    Patent number: 6576755
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zamp1, a novel member of the &bgr;-defensin family. The polypeptides, and polynucleotides encoding them, exhibit anti-microbial activity and may be used in the study or treatment of microbial infections. The present invention also includes antibodies to the zamp1 polypeptides.
    Type: Grant
    Filed: August 10, 2000
    Date of Patent: June 10, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: David A. Adler, James L. Holloway, Nand Baindur, Stephanie Beigel-Orme, Paul O. Sheppard
  • Galactosyltransferase homolog, ZNSSP11
    Publication number: 20030104398
    Abstract: Novel soluble, and membrane bound, Beta1,3 galactosyltransferase polypeptides, polynucleotides encoding the polypeptides, antibodies and related compositions and methods are disclosed. The polypeptides may be used for detecting anti-complementary molecules, agonists and antagonists. The polypeptides, polynucleotides and antibodies may also be used in methods that modulate cell-cell interactions, and glycoprotein and glycolipid modifications.
    Type: Application
    Filed: November 2, 2001
    Publication date: June 5, 2003
    Inventors: David A. Adler, James L. Holloway, Gayle Yamamoto
  • Crib protein ZMSE1
    Patent number: 6573069
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zmse1, a novel human CRIB protein. The polypeptides, and polynucleotides encoding them, may be used for detecting human chromosomal abnormalities and cancers. The present invention also includes antibodies to the zmse1 polypeptides.
    Type: Grant
    Filed: November 9, 2000
    Date of Patent: June 3, 2003
    Assignee: ZymoGenetics, Inc.
    Inventors: James L. Holloway, Zeren Gao, Theodore E. Whitmore
  • Kunitz domain polypeptide Zkun11
    Publication number: 20030100070
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by protease inhibitors that comprise a Kunitz domain. Zkun11 is a new member of the Kunitz domain protein family.
    Type: Application
    Filed: August 20, 2002
    Publication date: May 29, 2003
    Inventor: James L. Holloway
  • Zcys5: a member of the cystatin superfamily
    Publication number: 20030100096
    Abstract: The cystatin superfamily are inhibitors of cysteine proteinases, which function in a protective role with regard to various pathological actions of endogenous proteinases. Zcys5 is a new member of this superfamily.
    Type: Application
    Filed: September 4, 2002
    Publication date: May 29, 2003
    Inventor: James L. Holloway
  • Prostate, testis and uterine polypeptide zpep14
    Publication number: 20030083478
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zpep14, a novel secreted protein. The polynucleotides encoding zpep14, may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
    Type: Application
    Filed: February 3, 2000
    Publication date: May 1, 2003
    Inventors: James L. Holloway, Paul D. Bishop, Zeren Gao
  • Zvwf1: a member of the von Willebrand factor type a domain superfamily
    Publication number: 20030077751
    Abstract: Proteins comprising one or more copies of von Willebrand factor type A domain play important roles in host defense mechanisms, such as immune response, inflammation, and hemostasis. Zvwf1 is a new member of this superfamily.
    Type: Application
    Filed: April 19, 2002
    Publication date: April 24, 2003
    Inventor: James L. Holloway
  • Kunitz domain polypeptide Zkun11
    Patent number: 6544760
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by protease inhibitors that comprise a Kunitz domain. Zkun11 is a new member of the Kunitz domain protein family.
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: April 8, 2003
    Assignee: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Human phermone polypeptide
    Publication number: 20030049726
    Abstract: Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new human pheromone polypeptide, designated “ZHMUP-2.
    Type: Application
    Filed: September 6, 2001
    Publication date: March 13, 2003
    Inventors: James L. Holloway, Si Lok
  • Polynucleotide encoding human serpin
    Patent number: 6524822
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by serpins, serine protease inhibitors. Serpin dysfunction is associated with various disorders, including emphysema, blood clotting disorders, cirrhosis, Alzheimer disease, and Parkinson disease. Zserp11 is a new member of the serine protease inhibitor family.
    Type: Grant
    Filed: November 20, 2000
    Date of Patent: February 25, 2003
    Assignee: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Mammalian Wnt polypeptide-5
    Publication number: 20030017980
    Abstract: Mammalian Wnt Polypeptide-5 (Zwnt5), polynucleotides that encode the polypeptides, and antibodies that specifically bind to the polypeptides. The polypeptides, polynucleotides and antibodies can be used to detect breast cancer.
    Type: Application
    Filed: October 11, 2001
    Publication date: January 23, 2003
    Inventor: James L. Holloway
  • Secreted protein ZCMP2
    Publication number: 20020197699
    Abstract: The present invention relates to polynucleotide and polypeptide molecules encoding secreted protein zcmp2, having homolog to the complement family of proteins. The present invention also includes antibodies to the zcmp2 polypeptides.
    Type: Application
    Filed: December 7, 2000
    Publication date: December 26, 2002
    Inventor: James L. Holloway
  • Zcys9: a member of the cystatin superfamily
    Publication number: 20020192798
    Abstract: The cystatin superfamily includes inhibitors of cysteine proteinases, which function in a protective role with regard to various pathological actions of endogenous proteinases. Zcys9 is a new member of this superfamily.
    Type: Application
    Filed: August 2, 2001
    Publication date: December 19, 2002
    Inventor: James L. Holloway
  • Human vomeronasal receptor-5
    Publication number: 20020164691
    Abstract: In mammals, the vomeronasal organ, which detects phermones, resides in a blind-ended pouch within the septum of the nose. Vomeronasal organ-derived signals bypass higher cognitive centers and are processed directly in regions of the amygdala and hypothalamus, which have been implicated in the regulation of innate behavior, reproductive physiology, and other neuroendocrine responses. ZVNR5 encodes a human vomeronasal receptor.
    Type: Application
    Filed: September 7, 2001
    Publication date: November 7, 2002
    Inventors: James L. Holloway, Si Lok
  • Zcys5: a member of the cystatin superfamily
    Publication number: 20020164740
    Abstract: The cystatin superfamily are inhibitors of cysteine proteinases, which function in a protective role with regard to various pathological actions of endogenous proteinases. Zcys5 is a new member of this superfamily.
    Type: Application
    Filed: December 4, 2001
    Publication date: November 7, 2002
    Inventor: James L. Holloway