Patents by Inventor James L. Holloway

James L. Holloway has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human vomeronasal receptor
    Publication number: 20020160449
    Abstract: In mammals, the vomeronasal organ, which detects phermones, resides in a blind-ended pouch within the septum of the nose. Vomeronasal organ-derived signals bypass higher cognitive centers and are processed directly in regions of the amygdala and hypothalamus, which have been implicated in the regulation of innate behavior, reproductive physiology, and other neuroendocrine responses. Zvnh1 encodes a human vomeronasal seven-transmembrane domain receptor.
    Type: Application
    Filed: July 23, 2001
    Publication date: October 31, 2002
    Inventors: James L. Holloway, Si Lok
  • Mammalian glycoprotein hormone-1
    Publication number: 20020160953
    Abstract: Mammalian glycoprotein hormone-1 (Zlut1) polypeptides, polynucleotides encoding the polypeptides, antibodies that specifically bind to the polypeptides, expression vectors comprised of the polynucleotides, and host cells transformed with the expression vectors.
    Type: Application
    Filed: August 30, 2001
    Publication date: October 31, 2002
    Inventors: James L. Holloway, Philippa J. Webster, Edward C. Thayer
  • Adipocyte complement related protein zacrp13
    Publication number: 20020156244
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zacrp13, a novel member of the family of proteins bearing a collagen-like domain and a C1q domain. Novel zacrp13 polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. Also disclosed are antibodies to the zacrp13 protein or fragments thereof.
    Type: Application
    Filed: November 29, 2001
    Publication date: October 24, 2002
    Inventors: Brian A. Fox, James L. Holloway
  • Placental protein having multiple EGF-like domains
    Publication number: 20020150974
    Abstract: Epidermal growth factor-like domains appear in a large number of proteins that perform critical biological functions, such as the regulation of cellular differentiation. Zneu2 is a new member of this group of proteins.
    Type: Application
    Filed: July 9, 2001
    Publication date: October 17, 2002
    Inventors: James L. Holloway, Jane K. Heffernan, David W. Taft
  • Human serine protease
    Publication number: 20020151029
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Zfaix1 is a new member of the serine protease family.
    Type: Application
    Filed: October 16, 2001
    Publication date: October 17, 2002
    Inventor: James L. Holloway
  • Human vomeronasal receptor-3
    Publication number: 20020146766
    Abstract: In mammals, the vomeronasal organ, which detects phermones, resides in a blind-ended pouch within the septum of the nose. Vomeronasal organ-derived signals bypass higher cognitive centers and are processed directly in regions of the amygdala and hypothalamus, which have been implicated in the regulation of innate behavior, reproductive physiology, and other neuroendocrine responses. ZVNR3 encodes a human vomeronasal seven-transmembrane domain receptor.
    Type: Application
    Filed: September 6, 2001
    Publication date: October 10, 2002
    Inventors: James L. Holloway, Si Lok
  • Human vomeronasal receptor
    Publication number: 20020147308
    Abstract: In mammals, the vomeronasal organ, which detects phermones, resides in a blind-ended pouch within the septum of the nose. Vomeronasal organ-derived signals bypass higher cognitive centers and are processed directly in regions of the amygdala and hypothalamus, which have been implicated in the regulation of innate behavior, reproductive physiology, and other neuroendocrine responses. Zvnh2 encodes a human vomeronasal receptor.
    Type: Application
    Filed: September 6, 2001
    Publication date: October 10, 2002
    Inventors: James L. Holloway, Si Lok
  • Human V2 vomeronasal receptor
    Publication number: 20020146418
    Abstract: In mammals, the vomeronasal organ, which detects phermones, resides in a blind-ended pouch within the septum of the nose. Vomeronasal organ-derived signals bypass higher cognitive centers and are processed directly in regions of the amygdala and hypothalamus, which have been implicated in the regulation of innate behavior, reproductive physiology, and other neuroendocrine responses. Zvn2R1 encodes a human vomeronasal receptor.
    Type: Application
    Filed: November 15, 2001
    Publication date: October 10, 2002
    Inventors: Si Lok, James L. Holloway
  • Human vomeronasal receptor-4
    Publication number: 20020143148
    Abstract: In mammals, the vomeronasal organ, which detects phermones, resides in a blind-ended pouch within the septum of the nose. Vomeronasal organ-derived signals bypass higher cognitive centers and are processed directly in regions of the amygdala and hypothalamus, which have been implicated in the regulation of innate behavior, reproductive physiology, and other neuroendocrine responses. ZVNR4 encodes a human vomeronasal seven-transmembrane domain receptor.
    Type: Application
    Filed: September 6, 2001
    Publication date: October 3, 2002
    Inventors: Si Lok, James L. Holloway
  • Mammalian cystatin-8 and its use to inhibit cancer procoagulant protein
    Publication number: 20020142396
    Abstract: Mammalian Cystatin-8 (Zcys8) polypeptides, polynucleotides encoding the polypeptides, antibodies that specifically bind to the polypeptides, expression vectors comprised of the polynucleotides, and host cells transformed with the expression vectors.
    Type: Application
    Filed: August 29, 2001
    Publication date: October 3, 2002
    Inventors: James L. Holloway, Zeren Gao, Paul D. Bishop
  • Anti-angiogenic intestinal peptides, zdint5
    Publication number: 20020142439
    Abstract: The present invention relates to polynucleotide and polypeptide molecules, and variants thereof, for zdint5, a novel member of the Disintegrin Proteases. The polypeptides, and polynucleotides encoding them, are cell-cell interaction modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the zdint5 polypeptides.
    Type: Application
    Filed: February 9, 2001
    Publication date: October 3, 2002
    Inventors: James L. Holloway, Paul O. Sheppard, Gayle Yamamoto
  • Human phermone polypeptides
    Publication number: 20020137159
    Abstract: Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides a new group of human pheromone polypeptides, collectively designated “ZHMUP-1.
    Type: Application
    Filed: August 22, 2001
    Publication date: September 26, 2002
    Inventors: Si Lok, James L. Holloway, Patrick J. O'Hara
  • Human Wnt gene
    Publication number: 20020123103
    Abstract: The Wnt proteins are a family of secreted glycoproteins, which, in many organisms, have a role in the morphological development of tissues in both embryonic and adult contexts. The present invention provides a new form of human Wnt, designated “Zwnt3.
    Type: Application
    Filed: December 3, 2001
    Publication date: September 5, 2002
    Inventor: James L. Holloway
  • Kunitz domain polypeptide Zkun11
    Publication number: 20020111460
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. The enzymatic activity of the serine proteases is regulated in part by protease inhibitors that comprise a Kunitz domain. Zkun11 is a new member of the Kunitz domain protein family.
    Type: Application
    Filed: December 18, 2000
    Publication date: August 15, 2002
    Inventor: James L. Holloway
  • Use of human phermone polypeptides
    Publication number: 20020098497
    Abstract: Human phermones may be used to alleviate anxiety, promote beneficial moods, and to alter hypothalamic functions, such as satiety, energy balance, and reproductive biology. The present invention provides methods for using Zlipo1 and glycodelin as pheromone polypeptides.
    Type: Application
    Filed: September 12, 2001
    Publication date: July 25, 2002
    Inventors: Si Lok, Donald C. Foster, James L. Holloway
  • Human serine protease
    Patent number: 6423526
    Abstract: Members of the serine protease family play a role in carefully controlled processes, such as blood coagulation, fibrinolysis, complement activation, fertilization, and hormone production. These enzymes are also used in a variety of diagnostic, therapeutic, and industrial contexts. Zfaix1 is a new member of the serine protease family.
    Type: Grant
    Filed: November 17, 2000
    Date of Patent: July 23, 2002
    Assignee: ZymoGenetics, Inc.
    Inventor: James L. Holloway
  • Human secretin-like receptor
    Publication number: 20020095022
    Abstract: G protein-coupled receptors have proven usefulness as therapeutic targets. The present invention provides a new G protein-coupled receptor designated as “Zgpr1.
    Type: Application
    Filed: December 7, 2000
    Publication date: July 18, 2002
    Inventor: James L. Holloway
  • Human chemokine
    Publication number: 20020091239
    Abstract: Chemokines are implicated in inflammation, ischemia and reperfusion injury, wound healing, allergies, as well as bacterial and viral pathogenesis. Moreover, chemokines may be involved in chronic diseases such as arthritis, asthma, and atherosclerosis. The present invention provides a new form of chemokine, designated as “Zchemo12.
    Type: Application
    Filed: October 3, 2001
    Publication date: July 11, 2002
    Inventor: James L. Holloway
  • Insulin homolog polypeptide zins4
    Publication number: 20020012967
    Abstract: The present invention relates to polynucleotide and polypeptide molecules for zins4, a novel polypeptide having homology to the relaxins. The polynucleotides encoding zins4, may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses thereof and antibodies thereto.
    Type: Application
    Filed: February 9, 2001
    Publication date: January 31, 2002
    Inventors: James L. Holloway, Si Lok, Stephen R. Jaspers
  • Zcys5: a member of the cystatin superfamily
    Publication number: 20020006656
    Abstract: The cystatin superfamily are inhibitors of cysteine proteinases, which function in a protective role with regard to various pathological actions of endogenous proteinases. Zcys5 is a new member of this superfamily.
    Type: Application
    Filed: December 18, 2000
    Publication date: January 17, 2002
    Inventor: James L. Holloway