Abstract: An electronic lock with a latch assembly, an interior assembly, and an exterior assembly. The latch assembly includes a bolt movable between an extended position and a retracted position. The assembly includes an internal spring actuating mechanism. The assembly also includes a touch keypad subassembly configured to detect touches to at least a portion of its surface.

Abstract: An adapter for either a handle set or a lever set door lever is equipped with a pair of springs to provide a pre-load on the spindle. The pre-load prevents sagging of the lever due to the large mass of the lever. A sleeve in the adapter is formed out of a compressible material that accepts the spindle in a press-fit configuration. This allows for greater manufacturing tolerances while still providing a solid and secure engagement between the spindle and the adapter. As a result, any free play in the lever is eliminated and the lever is maintained in a horizontal, home position when the lever is not in use. Following use through rotation of the lever, the springs promptly return the lever back to the home position while the sleeve prevents any slop or free-play in the lever's motion.

Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

Abstract: An electronic lock with a latch assembly, an interior assembly, and an exterior assembly. The latch assembly includes a bolt movable between an extended position and a retracted position. The assembly includes an internal spring actuating mechanism. The assembly also includes a touch keypad subassembly configured to detect touches to at least a portion of its surface.

Abstract: A method of training a custom hotword model includes receiving a first set of training audio samples. The method also includes generating, using a speech embedding model configured to receive the first set of training audio samples as input, a corresponding hotword embedding representative of a custom hotword for each training audio sample of the first set of training audio samples. The speech embedding model is pre-trained on a different set of training audio samples with a greater number of training audio samples than the first set of training audio samples. The method further includes training the custom hotword model to detect a presence of the custom hotword in audio data. The custom hotword model is configured to receive, as input, each corresponding hotword embedding and to classify, as output, each corresponding hotword embedding as corresponding to the custom hotword.

Abstract: There are disclosed compounds of the following formula (I) or a stereoisomer or pharmaceutically acceptable salt thereof, wherein all substituents are as defined herein, which are useful in the modulation of IL-12, IL-23 and/or IFN?, by acting on Tyk-2 to cause signal transduction inhibition. The compounds of the invention may be useful for treating neurodegenerative diseases or disorders.

Abstract: A rekeyable lock cylinder with a cylinder body and a plug assembly. The lock cylinder includes a plurality of key followers and a corresponding plurality of racks disposed in the plug assembly. The lock cylinder includes, for example, a locking bar for blocking rotation of the plug assembly with respect to the cylinder body to prevent unlocking of the rekeyable lock cylinder with an unauthorized object. In some embodiments, the locking bar is configured such that torqueing the plug assembly with an unauthorized object applies force to the locking bar without translating such force to the plurality of racks. This type of arrangement enhances torque resistance of the lock cylinder against attempted forced entry.

Abstract: Systems and methods for database configuration management are provided. For example, a method for database configuration management comprises: obtaining user input corresponding to a target database state for the database; generating, based on the user input, a target state configuration for the database; determining a current state configuration for the database; generating a set of steps to change the configuration of the database from the current state configuration to the target state configuration; and implementing the set of steps, thereby configuring the database according to the target state configuration.

Abstract: A method of forming lock cylinder plug using metal injection molding includes injecting a material that has a metal component and a plastic component into a mold. The metal component of the material is at least partially steel. The method includes molding the material into a lock cylinder plug having a key way passage. The method includes debinding the lock cylinder plug and supporting a portion of the lock cylinder plug using at least one ceramic support before increasing the density of the lock cylinder plug by performing a sintering heating process. The method includes inspecting the lock cylinder by inserting a key way portion of a key way gauge into the key way passage of the lock cylinder plug. Inspecting also includes classifying the lock cylinder plug as acceptable, at least in part, if the key way portion of the key way gauge is insertable entirely within the key way passage.

Abstract: A rekeyable lock cylinder with a cylinder body and a plug assembly. The lock cylinder includes a plurality of key followers and a corresponding plurality of racks disposed in the plug assembly. The lock cylinder includes, for example, a locking bar for blocking rotation of the plug assembly with respect to the cylinder body to prevent unlocking of the rekeyable lock cylinder with an unauthorized object. In some embodiments, the locking bar is configured such that torqueing the plug assembly with an unauthorized object applies force to the locking bar without translating such force to the plurality of racks. This type of arrangement enhances torque resistance of the lock cylinder against attempted forced entry.

Abstract: Decellularized matrix microspheres comprising a polymeric material and a donor tissue are provided. Also disclosed are structures containing a plurality of decellularized matrix microspheres incorporating a first polymer and a donor tissue; and a second polymer, wherein the decellularized matrix microspheres and the second polymer are in the form of a filament. Methods of treating a tissue injury employing the matrix microspheres and structures described as well as their methods of manufacture are also provided.

Abstract: A trim surround is installable around a trim plate of a door latching assembly. The trim surround may have a shape complementary to and installable around an outer perimeter of a trim plate. The trim surround can have a front edge and a rear edge, and a retaining mechanism. The trim surround may be ring shaped to be complementary to a round trim plate of the door latching assembly. In some cases, the retaining mechanism can include a flange that extends inwardly of the trim plate such that the flange retains the trim surround in place around the trim plate when the door latching assembly is mounted to a door.

Abstract: An electronic lock includes a latch assembly that includes a bolt that is movable between an extended position and a retracted position. The electronic lock includes a keypad for receiving a keypad input event. The electronic lock includes a processing unit being configured to control the movement of the bolt between the extended position and the retracted position responsive to receiving a valid keypad input event. The processing unit is configured to capture the keypad input event. Based at least in part on a characteristic of the keypad input event, the processing unit indicates if a tampering event exists. The characteristic includes at least one of an input location on the keypad, an input duration on the keypad, and an input timestamp.

Abstract: A voltage regulator circuit can include two feedback loops, such as to reduce or suppress an unwanted transient condition in an output voltage during transient conditions such as during startup or during load current demand transients. One of the two feedback loops can include a shunt device arranged to provide a temporary current pathway during the transient condition to change current provided to a load connected to an output of the voltage regulation circuit. In addition, or instead, the voltage regulator circuit can include an open-loop regulation circuit separate from a loop corresponding to the first error amplifier. The open-loop regulator circuit can operate in a lower-power mode as compared to a closed-loop regulator circuit. A portion or an entirety of the voltage regulator circuit can be implemented in an integrated circuit, such as monolithically.

Abstract: An adapter for either a handle set or a lever set door lever is equipped with a pair of springs to provide a pre-load on the spindle. The pre-load prevents sagging of the lever due to the large mass of the lever. A sleeve in the adapter is formed out of a compressible material that accepts the spindle in a press-fit configuration. This allows for greater manufacturing tolerances while still providing a solid and secure engagement between the spindle and the adapter. As a result, any free play in the lever is eliminated and the lever is maintained in a horizontal, home position when the lever is not in use. Following use through rotation of the lever, the springs promptly return the lever back to the home position while the sleeve prevents any slop or free-play in the lever's motion.

Abstract: A computer-implemented method and a computer system for retrieving relevant records from a database. A project request is received from a user device over a computer network, the project request including a description of a project for which an expert consultation is desired. The request is parsed for categories and keywords. Relevant prediction models are determined based on the categories, each of the plurality of prediction models being based on a different aspect of expert search. Each of the relevant prediction models is applied to at least one of the keywords to obtain search criteria that is used to query the database.

Abstract: Controlled release hydrogel formulations of one or more simvastatin metabolites 3?-hydroxy simvastatin (hSV), 6?-exomethylene simvastatin (eSV), 3?,5?-dihydrodiol simvastatin, 3?,5?-dihydrodiol simvastatin (dSV), simvastatin-beta-hydroxy acid (SVA), and methods for the treatment of patients suffering from injured or degenerating substantially avascular cartilaginous tissue.

Abstract: The present invention provides compositions comprising optimized ratios of Red clover phytoestrogens as determined by a proprietary physiologically based pharmacokinetic and pharmacodynamic model. The compositions are useful for modulating, preventing or treating postmenopausal or climacteric symptoms, which include but are not limited to bone loss, bone remodeling, hot flushes and vaginal atrophy. The present invention also provides methods for modulating, preventing or treating postmenopausal or climacteric symptoms using the compositions disclosed herein.

Abstract: Computing systems methods, and non-transitory storage media are provided for obtaining an audio stream, converting the audio stream to an intermediate representation, performing diarization on the audio stream, separating the audio stream into individual speech constructs, performing speech recognition on the individual speech constructs by mapping each of the individual speech constructs, or consecutive individual speech constructs, to entries within a dictionary, to generate a transcription of the audio stream, generating an output indicative of the transcription and a result of the diarization, transforming the output into an object-based representation, and performing one or more operations on the object-based representation

Abstract: An electronic lock with a latch assembly, an interior assembly, and an exterior assembly. The latch assembly includes a bolt movable between an extended position and a retracted position. The assembly includes an internal spring actuating mechanism. The assembly also includes a touch keypad subassembly configured to detect touches to at least a portion of its surface.