Abstract: Provided herein are dendrimers comprising a core unit, five generations of building units being a lysine residue or analogue thereof, a plurality of first terminal groups each comprising a residue of a nucleoside analogue, and a plurality of second terminal groups each comprising a hydrophilic polymeric group. Also provided herein are pharmaceutical compositions comprising the dendrimer, and methods and uses of the dendrimers in therapy of disorders such as cancers.

Abstract: A humidification system can include a heater base, a chamber, and a breathing circuit. The heater base includes a heater plate positioned in a recessed region, and a heat conductive portion of the chamber is configured to contact the heater plate. The heater base includes a guard configured to control movement of the chamber into and out of the recessed region. The guard includes an anti-racking mechanism. The chamber includes an inlet port, an outlet port. A downward extension extends into the chamber from the inlet port, and a baffle is disposed at a lower end of the downward extension. A component of the breathing circuit can include a conduit hanging end cap for shipping and storage. The end cap can include a hanging component to allow the breathing circuit component to be hung from a medical stand. The system can detect when breathing circuits are connected in reverse.

Abstract: The present disclosure provides systems and techniques for authenticating biometric data while protecting user privacy. Aspects of the present disclosure include collecting biometric query data at a biometric sensor of the gun, generating a set of query features from the biometric query data, each query feature of the set of query features including a first number of dimensions, generating a projection matrix, each element of the projection matrix being drawn independently from an identical distribution having zero mean and unit variance, transforming the set of query features into a transformed set of query features according to the projection matrix, retrieving a transformed set of enrollment features from memory of the gun, identifying a data match based on the transformed set of query features and the transformed set of enrollment features satisfying a similarity threshold, and unlocking the gun in response to the identifying the data match.

Abstract: The present disclosure provides systems and techniques that can be implemented in a gun, such as an electromechanical gun. The gun may charge a capacitor bank, identify a trigger break based on an output generated by a trigger sensor, and transmit a signal based on the trigger break. Transmitting the signal may result in the capacitor bank discharging electric charge such that electric current is directed at an actuator mechanism so as to cause displacement of the actuator mechanism, and the displacement of the actuator mechanism may result in the propulsion of a projectile through a barrel of the gun. The gun may determine that a projectile has been fired based on an output of an accelerometer or a gyroscope, and the gun may recharge the capacitor bank in response to determining that the projectile has been fired.

Abstract: An electric power assisted steering apparatus comprises a steering mechanism which operatively connects a steering wheel to the road wheels of a vehicle, an electric motor operatively connected to the steering mechanism, a torque signal generator adapted to produce a torque signal, a column angular position signal generator for producing a column angle signal and a signal processing unit adapted to receive the column torque signal and the column angle signal and to produce therefrom a torque demand signal representative of a torque to be applied to the steering mechanism. A torque demand signal generating circuit adapted to produce the torque demand signal is a function of both the friction compensating torque and the assistance torque signal, at least partially assists the driver in overcoming the effects of static and/or kinetic friction.

Abstract: The present disclosure provides systems and techniques for determining whether a user is holding a gun. The gun may include a sensor, such as a laser proximity sensor, a capacitive proximity sensor, a load cell, an accelerometer, or a biometric sensor, and the gun may determine whether a user is holding the gun based on an output generated by the sensor. A processor housed in the gun may identify activation of a proximity sensor, determine that a user is holding the gun based on the activation of the proximity sensor, and perform an action in response to determining that the user is holding the gun. The action performed by the processor may include performing a boot procedure, performing a health check procedure, visually indicating state information about the gun, audibly indicating state information about the gun, or tactilely indicating state information about the gun.

Abstract: The present disclosure provides systems and techniques for determining whether a user is holding a gun. The gun may include a sensor, such as a laser proximity sensor, a capacitive proximity sensor, a load cell, an accelerometer, or a biometric sensor, and the gun may determine whether a user is holding the gun based on an output generated by the sensor. A processor housed in the gun may identify activation of a proximity sensor, determine that a user is holding the gun based on the activation of the proximity sensor, and perform an action in response to determining that the user is holding the gun. The action performed by the processor may include performing a boot procedure, performing a health check procedure, visually indicating state information about the gun, audibly indicating state information about the gun, or tactilely indicating state information about the gun.

Abstract: The present disclosure provides systems and techniques for an attachment that can be fastened to a gun. The attachment may include a top surface having a longitudinal axis and an aiming sight that is parallel with the longitudinal axis, a front surface having a latitudinal axis that is perpendicular to the longitudinal axis, the front surface including a muzzle aperture, a left surface, a right surface, and a fastening system. The fastening system may include a first mounting aperture of the left surface, a second mounting aperture of the right surface, and a locking pin capable of being positioned in the first mounting aperture and in the second mounting aperture such that the locking pin fastens the attachment to the gun. The attachment may be fastened to the gun such that the longitudinal axis is parallel with a longitudinal bore axis of the gun.

Abstract: The present disclosure provides systems and techniques for an attachment that can be fastened to a gun. The attachment may include a top surface having a longitudinal axis and an aiming sight that is parallel with the longitudinal axis, a front surface having a latitudinal axis that is perpendicular to the longitudinal axis, the front surface including a muzzle aperture, a left surface, a right surface, and a fastening system. The fastening system may include a first mounting aperture of the left surface, a second mounting aperture of the right surface, and a locking pin capable of being positioned in the first mounting aperture and in the second mounting aperture such that the locking pin fastens the attachment to the gun. The attachment may be fastened to the gun such that the longitudinal axis is parallel with a longitudinal bore axis of the gun.

Abstract: The present disclosure provides systems and techniques for an electromechanical sear that is implementable in a gun. The gun may include a fire control manager, and the fire control manager may identify a trigger break based on a trigger sensor, transmit, based on the trigger break, a first signal to a first actuator located in a displacement path of a sear, so as to cause the first actuator to be displaced in a first direction, and transmit, based on the trigger break, a second signal to a second actuator located in the displacement path of the sear, so as to cause the second actuator to be displaced in a second direction. The transmitting the first signal to the first actuator and the transmitting the second signal to the second actuator may cause displacement of the sear and firing of the gun.

Abstract: The present disclosure provides systems and techniques for authenticating biometric data while protecting user privacy. Aspects of the present disclosure include collecting biometric query data at a biometric sensor of the gun, generating a set of query features from the biometric query data, each query feature of the set of query features including a first number of dimensions, generating a projection matrix, each element of the projection matrix being drawn independently from an identical distribution having zero mean and unit variance, transforming the set of query features into a transformed set of query features according to the projection matrix, retrieving a transformed set of enrollment features from memory of the gun, identifying a data match based on the transformed set of query features and the transformed set of enrollment features satisfying a similarity threshold, and unlocking the gun in response to the identifying the data match.

Abstract: The invention relates to method and system configured for material analysis and mineralogy. At least one image based on first emission from a sample is provided. First spectra of the sample based on second emissions from the second scan locations of the image are provided. A confidence score is calculated for every first spectrum, and second scan location(s) with confidence score(s) below a threshold value are selected. Second emissions from the selected second scan location(s) are acquired to provide new image and determine new second scan locations within the respective new image.

Abstract: The present disclosure provides systems and techniques for authenticating a user at gun. The gun may include an authentication manager capable of implementing logic, processing signals, or executing instructions. The authentication manager may receive first query data from a first authentication sensor of the gun, receive second query data from a second authentication sensor of the gun, perform an authentication procedure to determine whether the first query data or the second query data matches enrollment data, where a match is determined based on the first query data or the second query data and the enrollment data satisfying a similarity threshold. The authentication manager may determine that the user is authorized to operate the gun and transmit a signal in response to the determining that the user is authorized to operate the gun. The signal may cause the gun to enter an active state which allows the gun to be fired.

Abstract: The present disclosure provides systems and techniques for an electromechanical sear that is implementable in a gun. The gun may include a fire control manager, and the fire control manager may identify a trigger break based on a trigger sensor, transmit, based on the trigger break, a first signal to a first actuator located in a displacement path of a sear, so as to cause the first actuator to be displaced in a first direction, and transmit, based on the trigger break, a second signal to a second actuator located in the displacement path of the sear, so as to cause the second actuator to be displaced in a second direction. The transmitting the first signal to the first actuator and the transmitting the second signal to the second actuator may cause displacement of the sear and firing of the gun.

Abstract: The present disclosure provides techniques, systems, and devices that support indicating gun state information. One or more electronic components may be used to indicate the gun state information, and the electronic components may be coupled with a gun. The gun may identify a state of the gun based on a compute component including a data signal, and the compute component may be coupled with the gun. The gun may select a representation of the state of the gun, where the representation of the state of the gun is compatible with an electronic component coupled with the gun. The gun may indicate, at the electronic component and based on the compute component, the state of the gun with the representation of the state of the gun. Indicating the state of the gun may include displaying an icon, illuminating the electronic component with a color, or pulsating the electronic component.

Abstract: Systems, methods, and non-transitory computer readable media configured to determine a value associated with at least one signal indicative of objectionable material in a content item. The value associated with the at least one signal indicative of objectionable material can be compared with a threshold value associated with the at least one signal. A demotion value can be determined in response to satisfaction of the threshold value associated with the at least one signal.

Abstract: Systems, methods, and non-transitory computer readable media configured to determine a value associated with at least one signal indicative of objectionable material in a content item. The value associated with the at least one signal indicative of objectionable material can be compared with a threshold value associated with the at least one signal. A demotion value can be determined in response to satisfaction of the threshold value associated with the at least one signal.

Abstract: Methods and systems for high dynamic range (HDR) charged particle analysis using clustering processes include accessing a plurality of instances of image data for a region of a sample, where each instance of image data was captured with different parameters by a charged particle microscope. The difference in parameters may include one or more of a difference in contrast, brightness, beam strength, beam type, gamma, and/or a combination thereof. An HDR charged particle microscopy data structure is then generated using the captured image data, and one or more features of the sample are identified based on the HDR charged particle microscopy data structure. In some methods according to the present invention, the methods further include performing EDS analysis on the sample based on the determined one or more identified features.

Abstract: Systems and techniques for deploying resources within a computing infrastructure are herein disclosed as comprising, in an implementation, executing a first deployment agent to perform a first deployment action, the first deployment agent configured to deploy a first resource to a first device; changing a deployment state of the first deployment agent responsive to performing the first deployment action; and executing a second deployment agent to perform a second deployment action, the second deployment agent configured to deploy a second resource to a second device. The second deployment agent performs the second deployment action in response to a change in a deployment state of an arbitrary deployment agent not explicitly identified within the second deployment agent. A deployment plan configured to cause the execution of the first and second deployment agents includes an identification of the first deployment agent as the arbitrary deployment agent.