Abstract: The present invention generally relates to macromolecules of dendrimer-drug conjugates. In particular, the invention relates to macromolecules comprising a pharmaceutically active agent, such as a protein or peptide, attached to a core of a dendrimer derived from branched building units, such as lysine or lysine analogues. The invention also relates to the synthesis of the dendrimers and macromolecules, and the use of such macromolecules, particularly in therapeutic applications, and pharmaceutical compositions comprising them.

Abstract: The invention described herein relates to a therapeutic, moisturizing coating composition for elastomeric articles which is applied directly onto the skin-contacting surface of the article as part of the manufacturing process. The coating composition is thermally stable and subsequently hydrates when contacted with a moisturized skin surface to convert into a liquid “lotion” form during wearing of the article. The coating composition provides therapeutic benefits to the wearer's skin as a result of wearing the article, such as improved skin moisturization, softness of feel, improved skin elasticity and firmness, and reduced redness and irritation. The invention is particularly useful in medical gloves, including examination and surgical gloves.

Abstract: A method for reducing the amount of mobile surface molecules present on a substrate surface includes providing a substrate having an area of interest, where the substrate is disposed within a controlled environment (e.g., a UHV environment). In some embodiments, a mask is positioned in a first position over the area of interest. Thereafter, a first deposition of a reactive material from a reactive material source is performed onto a first substrate region. The mask, while in the first position, blocks deposition of the reactive material within the area of interest. The mask may then positioned in a second position over the area of interest. In some embodiments, a second deposition of the reactive material from the reactive material source is performed to circumscribe the area of interest with the reactive material. In various embodiments, mobile surface molecules are captured using the deposited reactive material.

Abstract: Systems, methods, and non-transitory computer-readable media can train a model to define relatedness ratings for a plurality of terms. A posted content item and a comment to the posted content item are received. A relevance rating for the comment and the posted content item is determined based on the model. The comment is ranked among a plurality of comments based on the relevance rating.

Abstract: A method of operating a charged particle microscope comprising: Providing a specimen on a specimen holder; Using a source to produce a beam of charged particles, and irradiating the specimen with said beam; Using a detector to detect X-ray radiation emanating from the specimen in response to said irradiation, and to produce a spectrum comprising X-ray characteristic peaks on a Bremsstrahlung background, comprising the following additional steps: Using an elemental decomposition algorithm to analyze the characteristic peaks in said spectrum, thereby determining a reference group of major chemical elements contributing to the spectrum; Calculating an average atomic number for said reference group, and using this in a predictive model to generate a calculated Bremsstrahlung profile for the reference group; Fitting said calculated Bremsstrahlung profile to the Bremsstrahlung background in said spectrum, and attributing a discrepancy between the latter and the former to a residual element absent from, or inc

Abstract: Systems, methods, and non-transitory computer-readable media can generate a set of clusters using sample content items in which a set of user features are represented, the sample content items being clustered based at least in part on their similarity to one another; obtain one or more content items that capture a set of user features corresponding to a given user; determine that the user corresponds to a given cluster in the set of clusters based at least in part on the features of the user; and assign an avatar associated with the cluster to the user.

Abstract: An electric power assisted steering apparatus comprises an upper column shaft that in use is operatively connected to a steering wheel of the vehicle; and a lower column shaft that in use is operatively connected to the road wheels of the vehicle. A torsion bar interconnects the upper column shaft and the lower column shaft; and an electric motor is connected to the lower column shaft of the torque sensor assembly.

Abstract: A system for deploying software includes a processor programmed to identify a collection of deployable elements for use in deploying the software. The instructions also include instructions to receive information associating, with the collection of deployable elements, an item and an activity that is to be performed, using the item, when the software is deployed to a specified type of computing system. The instructions also include instructions to, using at least one of the collection of deployable elements, deploy the software to the specified type of computing system, and in response to a deployment of the software to the specified type of computing system, initiate performance of the activity.

Abstract: A system and method for performing licensing monitoring and compliance within a service provider platform are provided. The system comprises a memory and a processor configured to execute instructions stored within the memory. The system further comprises a central instance that executes on the processor and comprises a license repository containing licensing data for application components. The system further comprises a customer instance that includes a third-party application component installed within the customer instance from an application store. The system further includes a licensing module. The third-party application component is switchable between a monitor mode in which the licensing module reports usage of the third-party application component to the central instance and an enforcement mode in which the usage is controlled on the customer instance based on the license repository.

Abstract: In one embodiment, a method includes retrieving comments associated with a content object on a social-networking system, determining a score for each of the comments, where the score is based on one or more signals associated with the comment, the signals are related to one or more audience interactions with the comment, and each of the audience interactions includes an interaction by a respective audience member with the comment. The method further includes ordering the comments based on the respective scores, and presenting the ordered comments to a target user. Each of the audience interactions may include one or more responses to the audience interaction by an author of the comment. The signals may be based on existence of an edge between a user node representing the audience member and a user node representing an author of the comment in a social graph on the social-networking system.

Abstract: Methods, devices, and systems for controlling a scanning tunneling microscope system are provided. In some embodiments, the methods, devices, and systems of the present disclosure utilize a control system included in or added to a scanning tunneling microscope (STM) to receive data characterizing a tunneling current between a tip of the scanning tunneling microscope system and a sample, to estimate, in real-time, a work function associated with the scanning tunneling microscope system, and to adjust, by a control system, a position of the tip based on an estimated work function. Associated systems are described herein.

Abstract: An electric power assisted steering system includes an upper column shaft connected to a steering wheel, a lower column shaft connected to road wheels, a torsion bar interconnecting the upper column shaft and the lower column shaft, and a processor that produces a torque signal indicative of torsion bar torque. An electric motor is connected to the lower column shaft, and a motor position sensor provides a motor position signal dependent on the angular position of the motor rotor that repeats after the motor rotates through an angular range. The processor determines a base motor position at start up by comparing the motor position signal with a signal from a sensor associated with the upper column shaft to determine three candidates and, during subsequent unpowered motion of the steering system rules out two candidates until only one plausible candidate for the base motor position remains.

Abstract: A system for deploying software includes a processor programmed to identify a collection of deployable elements for use in deploying the software. The instructions also include instructions to receive information associating, with the collection of deployable elements, an item and an activity that is to be performed, using the item, when the software is deployed to a specified type of computing system. The instructions also include instructions to, using at least one of the collection of deployable elements, deploy the software to the specified type of computing system, and in response to a deployment of the software to the specified type of computing system, initiate performance of the activity.

Abstract: A system and method for performing licensing monitoring and compliance within a service provider platform are provided. The system comprises a memory and a processor configured to execute instructions stored within the memory. The system further comprises a central instance that executes on the processor and comprises a license repository containing licensing data for application components. The system further comprises a customer instance that includes a third-party application component installed within the customer instance from an application store. The system further includes a licensing module. The third-party application component is switchable between a monitor mode in which the licensing module reports usage of the third-party application component to the central instance and an enforcement mode in which the usage is controlled on the customer instance based on the license repository.

Abstract: Systems, methods, and non-transitory computer-readable media can receive a comment to a posted content item. One or more user interactions with the comment are received. An interaction-to-impression ratio for the comment is determined. The comment is ranked among a plurality of comments based on the interaction-to-impression ratio.

Abstract: Systems and techniques for deploying resources within a computing infrastructure are herein disclosed as comprising, in an implementation, executing a first deployment agent to perform a first deployment action, the first deployment agent configured to deploy a first resource to a first device; changing a deployment state of the first deployment agent responsive to performing the first deployment action; and executing a second deployment agent to perform a second deployment action, the second deployment agent configured to deploy a second resource to a second device. The second deployment agent performs the second deployment action in response to a change in a deployment state of an arbitrary deployment agent not explicitly identified within the second deployment agent. A deployment plan configured to cause the execution of the first and second deployment agents includes an identification of the first deployment agent as the arbitrary deployment agent.

Abstract: An aquarium system includes a tank, a motion sensor, and a light source. The motion sensor is adapted to sense motion within a predetermined distance from the tank. The light source has a controllable intensity projecting light into the tank. The intensity varies responsive to motion sensed by the motion sensor. When the motion sensor senses movement, the light is on at 100% intensity. After some period of no-motion, such as about 60 seconds, the lighting slowly dims to around 20% of full brightness. When it senses movement again, the lighting slowly ramps up to 100% intensity.

Abstract: Provided are systems for analyzing cellular distribution in an engineered tissue sample, which optionally is a bioprinted organ or tissue sample. In some embodiments, the systems include an ultrasound imaging system and a processing unit configured with software that permits analysis of images acquired from the engineered tissue sample in order to output desired characteristics thereof. In some embodiments, the systems also include a bioreactor for engineering a tissue sample and a pump configured to regulate flow of fluids and reagents into and out of the bioreactor, wherein at least one surface of the bioreactor includes a window that is acoustically transparent to ultrasound waves. Also provided are systems for analyzing cell distribution in an engineered tissue sample and methods for analyzing distribution of cells in an engineered tissue sample present within a bioreactor.