Abstract: Apparatuses, systems, and methods for preclinical ultrasound imaging of subjects are provided. In one aspect, the apparatus can include a platform on which a subject is positionable and at least one motion stage for controlling a spatial position of at least one ultrasound transducer relative to the platform in order to acquire ultrasound image data of the subject. Methods for preclinical ultrasound raster scanning of at least one organ or tissue in a subject are also provided, where the at least one organ or tissue is a heart.

Abstract: Provided herein is a dendrimer comprising: i) a core unit (C); and ii) building units (BU), wherein the core unit is covalently attached to at least two building units; the dendrimer having from two to six generations of building units; wherein building units of different generations are covalently attached to one another; and the dendrimer further comprising: iii) one or more first terminal groups attached to an outermost building unit, wherein each first terminal group comprises a radionuclide-containing moiety; and iv) one or more second terminal groups attached to an outermost building unit, wherein each second terminal group comprises a pharmacokinetic-modifying moiety; or a salt thereof. Also provided are compositions comprising the dendrimers, and methods of using the dendrimers and compositions in diagnostic and therapeutic applications.

Abstract: Provided herein are dendrimers comprising: a core unit, five generations of building units which are lysine residues or analogues thereof, first terminal groups comprising a residue of a camptothecin active covalently attached to a diglycolyl linker group, and second terminal groups comprising a PEG group. Also provided herein are pharmaceutical compositions comprising the dendrimer, and methods and uses of the dendrimers in therapy of disorders such as cancers. Processes for making the dendrimers and intermediates are also provided.

Abstract: A system and method for performing licensing monitoring and compliance within a service provider platform are provided. The system comprises a memory and a processor configured to execute instructions stored within the memory. The system further comprises a central instance that executes on the processor and comprises a license repository containing licensing data for application components. The system further comprises a customer instance that includes a third-party application component installed within the customer instance from an application store. The system further includes a licensing module. The third-party application component is switchable between a monitor mode in which the licensing module reports usage of the third-party application component to the central instance and an enforcement mode in which the usage is controlled on the customer instance based on the license repository.

Abstract: A method of evaluating a stress state of a wellbore isolation barrier with an evaluation application receiving a data set, obtained from wellbore sensors, from a remote data source by one or more communication methods. The data set comprises periodic wellbore data indicative of the stress state of the wellbore isolation barrier. The evaluation application may determine a modeled stress state of the wellbore isolation barrier by evaluating a data set consisting of the received data. The evaluation application may generate an alert if the model stress state exceeds a user threshold.

Abstract: Provided herein are dendrimers comprising: a core unit, five generations of building units which are lysine residues or analogues thereof, first terminal groups comprising a cabazitazel residue covalently attached to a diglycolyl linker group, and second terminal groups comprising a PEG group. Also provided herein are pharmaceutical compositions comprising the dendrimers, and methods and uses of the dendrimers in therapy of disorders such as cancers. Processes for making the dendrimers and intermediates are also provided.

Abstract: Provided herein are dendrimers comprising: a core unit, five generations of building units which are lysine residues or analogues thereof, first terminal groups comprising a cabazitazel residue covalently attached to a diglycolyl linker group, and second terminal groups comprising a PEG group. Also provided herein are pharmaceutical compositions comprising the dendrimers, and methods and uses of the dendrimers in therapy of disorders such as cancers. Processes for making the dendrimers and intermediates are also provided.

Abstract: A humidification system comprises a first sensor and a second sensor. The first and second sensors are adapted to sense flow characteristics within the system. The first and second sensors are isolated from the flow by barriers formed by respective first and second sealing members. The sealing members extend through apertures formed in the system and have a portion that contacts the sensing elements of the respective first and second sensors. A cartridge can hold the sensors and provide repeatable penetration depths into a flow passage of the system. A medical tube has a composite structure made of two or more distinct components that are spirally wound to form an elongate tube. One component can be a spirally wound elongate hollow body; the other component can be an elongate structural component spirally wound between turns of the spirally wound hollow body.

Abstract: A system for deploying software includes a processor programmed to identify a collection of deployable elements for use in deploying the software. The instructions also include instructions to receive information associating, with the collection of deployable elements, an item and an activity that is to be performed, using the item, when the software is deployed to a specified type of computing system. The instructions also include instructions to, using at least one of the collection of deployable elements, deploy the software to the specified type of computing system, and in response to a deployment of the software to the specified type of computing system, initiate performance of the activity.

Abstract: A humidification system comprises a first sensor and a second sensor. The first and second sensors are adapted to sense flow characteristics within the system. The first and second sensors are isolated from the flow by barriers formed by respective first and second sealing members. The sealing members extend through apertures formed in the system and have a portion that contacts the sensing elements of the respective first and second sensors. A cartridge can hold the sensors and provide repeatable penetration depths into a flow passage of the system. A medical tube has a composite structure made of two or more distinct components that are spirally wound to form an elongate tube. One component can be a spirally wound elongate hollow body; the other component can be an elongate structural component spirally wound between turns of the spirally wound hollow body.

Abstract: Systems and methods are directed to release tools and deployment tools for software applications. A computing device includes a processor operatively coupled to a memory. The processor identifies one or more environments and a plurality of deployment operations to be performed to deploy a software application to the one or more environments. The processor generates a deployment plan having instructions to execute the one or more deployment operations. The processor executes the deployment plan to deploy the one or more release environments. The processor sends signals to a display to display progression through the deployment plan during deployment of the one or more release environments.

Abstract: An electric power assisted steering apparatus comprises an upper column shaft that is connected to a steering wheel of the vehicle; and a lower column shaft. A torsion bar interconnects the upper column shaft and the lower column shaft; and an electric motor is connected to the lower column shaft of the torque sensor assembly. A first sensor circuit generates a first torque signal based on angular deflection of the torsion bar, and a second sensor circuit generating a second torque signal based on angular deflection of the torsion bar, the apparatus further including: an error determining circuit which produces two error signals, each indicative of the validity of a respective torque signal, and a torque plausibility estimator which generates two plausibility signals each indicative of the plausibility of a respective one of the two torque signals.

Abstract: Systems and techniques for deploying resources within a computing infrastructure are herein disclosed as comprising, in an implementation, executing a first deployment agent to perform a first deployment action, the first deployment agent configured to deploy a first resource to a first device; changing a deployment state of the first deployment agent responsive to performing the first deployment action; and executing a second deployment agent to perform a second deployment action, the second deployment agent configured to deploy a second resource to a second device. The second deployment agent performs the second deployment action in response to a change in a deployment state of an arbitrary deployment agent not explicitly identified within the second deployment agent. A deployment plan configured to cause the execution of the first and second deployment agents includes an identification of the first deployment agent as the arbitrary deployment agent.

Abstract: An apparatus to handle and relocate rolled fire hose, the apparatus includes a frame, a rotating platform mounted to the frame, a pair of leg members joined by a pivot that splays and retracts the frame, and wheels mounted on the lower portion of each leg. The rotating platform is operable to rotate around an axis perpendicular to the splaying plane created by the legs. The collapsible apparatus, when upright, provides a two tined fork for straddling and lifting the lower perimeter of a rolled fire hose. When tilted rearwards onto the apparatus' wheels, the fork raises the rolled hose off the ground and thus enables “dollying” the rolled hose to any location. When the apparatus is oriented horizontally, the apparatus provides a means for easy, yet controlled uncoiling of the hose roll as the hose is fed to firefighters reloading the hose back onto fire truck's hose bed.

Abstract: An electric power steering apparatus includes a steering mechanism, an electric motor, a torque signal generator, a column angular position signal generator and a signal processing unit. The steering mechanism operatively connects a steering wheel to the road wheels of the vehicle. The electric motor may be operatively connected to the steering mechanism. The torque signal generator may produce a torque signal indicative of the torque carried by a portion of the steering mechanism. The column angular position signal generator may produce a column angle signal indicative of the angular position of the steering wheel or steering column. The signal processing unit may receive the column torque signal and the column angle signal and may produce therefrom a torque demand signal representative of a torque to be applied to the steering mechanism by the motor.

Abstract: Systems and techniques for deploying resources within a computing infrastructure are herein disclosed as comprising, in an implementation, executing a first deployment agent to perform a first deployment action, the first deployment agent configured to deploy a first resource to a first device; changing a deployment state of the first deployment agent responsive to performing the first deployment action; and executing a second deployment agent to perform a second deployment action, the second deployment agent configured to deploy a second resource to a second device. The second deployment agent performs the second deployment action in response to a change in a deployment state of an arbitrary deployment agent not explicitly identified within the second deployment agent. A deployment plan configured to cause the execution of the first and second deployment agents includes an identification of the first deployment agent as the arbitrary deployment agent.

Abstract: Systems and methods are directed to release tools and deployment tools for software applications. A computing device includes a processor operatively coupled to a memory. The processor identifies one or more environments and a plurality of deployment operations to be performed to deploy a software application to the one or more environments. The processor generates a deployment plan having instructions to execute the one or more deployment operations. The processor executes the deployment plan to deploy the one or more release environments. The processor sends signals to a display to display progression through the deployment plan during deployment of the one or more release environments.

Abstract: A system for provisioning resources within a computer network includes a processor and a memory. The memory stores instructions executable by the processor to cause the processor to identify a set of properties associated with a resource type based on a configuration item representative of a resource within a configuration management database (CMDB), determine a subset of the set of properties based on one or more deployment rules, wherein the subset of the set of properties comprises one or more properties of a parent configuration item of the configuration item, and provision, via a deployment agent, a new resource of the computer network, wherein the new resource has the subset of the set of properties.

Abstract: An electric power assisted steering apparatus comprises a steering mechanism which operatively connects a steering wheel to the road wheels of a vehicle, an electric motor operatively connected to the steering mechanism, a torque signal generator adapted to produce a torque signal, a column angular position signal generator for producing a column angle signal and a signal processing unit adapted to receive the column torque signal and the column angle signal and to produce therefrom a torque demand signal representative of a torque to be applied to the steering mechanism. A torque demand signal generating circuit adapted to produce the torque demand signal is a function of both the friction compensating torque and the assistance torque signal, at least partially assists the driver in overcoming the effects of static and/or kinetic friction.