Abstract: A device including a memory cell and write assist circuit is disclosed. The memory cell includes a first inverter and a second inverter cross-coupled with the first inverter. The first inverter is operated with a first operational voltage and a third operational voltage, and the second inverter is operated with a second operational voltage and a fourth operational voltage. The write assist circuit is coupled to the memory cell. During a write operation of the memory cell, the write assist circuit is configured to adjust a voltage level of the first operational voltage, the second operational voltage, the third operation voltage, the fourth operation voltage, or a combination thereof, by a bias voltage difference.

Abstract: Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same.

Abstract: Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same.

Abstract: A device including a memory cell and write assist circuit is disclosed. The memory cell includes a first inverter and a second inverter cross-coupled with the first inverter. The write assist circuit is coupled to the memory cell. During a write operation of the memory cell, the write assist circuit is configured to adjust a voltage level of an operational voltage provided to the first inverter or the second inverter by a bias voltage difference.

Abstract: Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.

Abstract: A method and arrangement in a Radio Network Controller (RNC) for monitoring radio link (RL) synchronization for each RL as soon as it is added to a User Equipment's (UE's) Active Set. When a new RL is added, each RL in the Active Set sends an Active Set Update Complete message to the RNC. When the RNC determines that a Radio Link Restore Indication message is not received from the Target NodeB serving the new RL, the RNC starts an initRlSyncT timer set for a defined time period and monitors incoming messages to determine whether the Radio Link Restore Indication message is received for the new RL before the initRlSyncT timer expires. If so, the method ends; but if not, the RNC instructs associated NodeBs and the UE to remove the new RL from the UE's Active Set.

Abstract: Sense amplifier configurations for memories are described. In these configurations, the differential inputs are boosted proportional to the respective bitline voltage enabling a low-voltage, reliable, faster sense amplifier operation. Disclosed sense amplifiers are also capable of compensating the threshold mismatch between the sensing transistors.

Abstract: Systems and methods are disclosed for improving Physical Downlink Control Channel (PDCCH) allocation for improved downlink scheduling. In some embodiments, a method of operation of a network node in a cellular communications network comprises transmitting a downlink assignment to a wireless device, the downlink assignment comprising an indication of whether the downlink assignment applies to a single Transmit Time Interval (TTI) or multiple consecutive TTIs, and transmitting a downlink data transmission to the wireless device during a single TTI or multiple downlink data transmissions to the wireless device during multiple consecutive TTIs according to the downlink assignment. In this manner, the network node does not need to transmit, and the wireless device does not need to receive/decode, a separate downlink assignment in each TTI. This may be beneficial to, e.g., mitigate PDCCH congestion.

Abstract: Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.

Abstract: Peptide-grafted antibodies having agonist activity against a Class B GPCR and their uses, and methods for identifying same. Mammalian cell lines for high-throughput screening for agonists of a Class B GPCR are also provided that comprise a stably integrated recombinant nucleic acid construct comprising a reporter gene under control of a cAMP responsive promoter, the reporter gene encoding a cell surface expressed protein, and a stably integrated recombinant nucleic acid construct comprising a sequence encoding a Class B GPCR under control of a constitutive promoter.

Abstract: Sense amplifier configurations for memories are described. In these configurations, the differential inputs are boosted proportional to the respective bitline voltage enabling a low-voltage, reliable, faster sense amplifier operation. Disclosed sense amplifiers are also capable of compensating the threshold mismatch between the sensing transistors.

Abstract: Systems and methods are disclosed herein that relate to automated measurement and analysis of end-to-end performance of Voice over Long Term Evolution (VoLTE) service and, in some embodiments, automated network optimization for VoLTE service performance improvement. In some embodiments, a method of operation of a network node to perform automated end-to-end analysis of VoLTE sessions is provided. In some embodiments, the method of operation of the network node comprises correlating control and data plane messages across a nodes and interfaces in a VoLTE network to thereby provide data representative of end-to-end message flows for a plurality of VoLTE sessions. The method of operation further comprises configuring one or more nodes in the VoLTE network based on the data representative of the end-to-end message flows for the plurality of VoLTE sessions. In this manner, automated network optimization for VoLTE service performance improvement can be provided.

Abstract: A radio network controller (RNC) receives a request to activate a packet data protocol (PDP) context for a wireless device operating in a forward access channel state. The RNC sends the request to activate PDP context to a core network node (CN). The RNC receives a request to assign a radio access bearer from the CN. The RNC sends a response to the request to assign a radio access bearer to the CN and initiates a timer. If the CN accepts the request to activate the PDP context prior to timer expiry, the RNC stops the timer and sends the wireless device the accept message followed by a request to reconfigure a radio bearer. Otherwise, if the timer expires, the RNC sends the wireless device the request to reconfigure the radio bearer followed by the accept message.

Abstract: A gas turbine engine installation is provided that has a flexible printed circuit board (FPCB) harness to transfer electrical signals, including electrical power, around a gas turbine engine. The FPCB harness is held to the gas turbine engine installation using clips. The clips have a jaw that has two sets of opposing teeth extending from a base, and a mouth through which the FPCB harness is inserted. The teeth point in a direction that has a component from the mouth to the teeth. This means that the force required to insert the FPCB harness into the clip is lower than the force required to pull the FPCB harness out of the clip in the opposite direction. This means that the FPCB harness can be secured in place while aiding ease of assembly.

Abstract: A gas turbine engine installation is provided that has a plurality of flexible printed circuit board (FPCB) harnesses to transfer electrical signals, including electrical power, around a gas turbine engine. The plurality of FPCB harnesses is held to the gas turbine engine installation using generally U-shaped clips that have a base from which first and second sidewalls extend. The FPCB harness is held between the tips of base-teeth extending from the base, and side-teeth extending from the first and second sidewalls. In this way, the FPCB harness can be held securely in position by the clip.

Abstract: A system and method to sustain an on-going voice call or other service during a handover, HO, by preventing the handover to a target cell that fails to admit all the mandatory Radio Access Bearers, RABs, as part of supporting one or more Quality of Service Class Identifiers, QCIs, associated with the ongoing service. When the source evolved Node B, eNB, prevents the HO to the best target cell, it may attempt the HO to the next best target cell. If the next best cell fails to admit all the mandatory RABs and if there are no other intra-LTE or inter-LTE cells available for HO, the source eNB may perform an inter-Radio Access Technology, RAT, HO using the Single Radio Voice Call Continuity, SRVCC, procedure. By preventing “partial” handovers, the retainability of an ongoing service is significantly improved. The target cells causing failure of particular RABs can be tracked using new counters.

Abstract: Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same.

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract: A method and arrangement in a Radio Network Controller (RNC) for monitoring radio link (RL) synchronization for each RL as soon as it is added to a User Equipment's (UE's) Active Set. When a new RL is added, each RL in the Active Set sends an Active Set Update Complete message to the RNC. When the RNC determines that a Radio Link Restore Indication message is not received from the Target NodeB serving the new RL, the RNC starts an initRlSyncT timer set for a defined time period and monitors incoming messages to determine whether the Radio Link Restore Indication message is received for the new RL before the initRlSyncT timer expires. If so, the method ends; but if not, the RNC instructs associated NodeBs and the UE to remove the new RL from the UE's Active Set.