Abstract: Systems and methods are disclosed for improving Physical Downlink Control Channel (PDCCH) allocation for improved downlink scheduling. In some embodiments, a method of operation of a network node in a cellular communications network comprises transmitting a downlink assignment to a wireless device, the downlink assignment comprising an indication of whether the downlink assignment applies to a single Transmit Time Interval (TTI) or multiple consecutive TTIs, and transmitting a downlink data transmission to the wireless device during a single TTI or multiple downlink data transmissions to the wireless device during multiple consecutive TTIs according to the downlink assignment. In this manner, the network node does not need to transmit, and the wireless device does not need to receive/decode, a separate downlink assignment in each TTI. This may be beneficial to, e.g., mitigate PDCCH congestion.

Abstract: Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.

Abstract: Peptide-grafted antibodies having agonist activity against a Class B GPCR and their uses, and methods for identifying same. Mammalian cell lines for high-throughput screening for agonists of a Class B GPCR are also provided that comprise a stably integrated recombinant nucleic acid construct comprising a reporter gene under control of a cAMP responsive promoter, the reporter gene encoding a cell surface expressed protein, and a stably integrated recombinant nucleic acid construct comprising a sequence encoding a Class B GPCR under control of a constitutive promoter.

Abstract: Sense amplifier configurations for memories are described. In these configurations, the differential inputs are boosted proportional to the respective bitline voltage enabling a low-voltage, reliable, faster sense amplifier operation. Disclosed sense amplifiers are also capable of compensating the threshold mismatch between the sensing transistors.

Abstract: Systems and methods are disclosed herein that relate to automated measurement and analysis of end-to-end performance of Voice over Long Term Evolution (VoLTE) service and, in some embodiments, automated network optimization for VoLTE service performance improvement. In some embodiments, a method of operation of a network node to perform automated end-to-end analysis of VoLTE sessions is provided. In some embodiments, the method of operation of the network node comprises correlating control and data plane messages across a nodes and interfaces in a VoLTE network to thereby provide data representative of end-to-end message flows for a plurality of VoLTE sessions. The method of operation further comprises configuring one or more nodes in the VoLTE network based on the data representative of the end-to-end message flows for the plurality of VoLTE sessions. In this manner, automated network optimization for VoLTE service performance improvement can be provided.

Abstract: A radio network controller (RNC) receives a request to activate a packet data protocol (PDP) context for a wireless device operating in a forward access channel state. The RNC sends the request to activate PDP context to a core network node (CN). The RNC receives a request to assign a radio access bearer from the CN. The RNC sends a response to the request to assign a radio access bearer to the CN and initiates a timer. If the CN accepts the request to activate the PDP context prior to timer expiry, the RNC stops the timer and sends the wireless device the accept message followed by a request to reconfigure a radio bearer. Otherwise, if the timer expires, the RNC sends the wireless device the request to reconfigure the radio bearer followed by the accept message.

Abstract: A gas turbine engine installation is provided that has a flexible printed circuit board (FPCB) harness to transfer electrical signals, including electrical power, around a gas turbine engine. The FPCB harness is held to the gas turbine engine installation using clips. The clips have a jaw that has two sets of opposing teeth extending from a base, and a mouth through which the FPCB harness is inserted. The teeth point in a direction that has a component from the mouth to the teeth. This means that the force required to insert the FPCB harness into the clip is lower than the force required to pull the FPCB harness out of the clip in the opposite direction. This means that the FPCB harness can be secured in place while aiding ease of assembly.

Abstract: A gas turbine engine installation is provided that has a plurality of flexible printed circuit board (FPCB) harnesses to transfer electrical signals, including electrical power, around a gas turbine engine. The plurality of FPCB harnesses is held to the gas turbine engine installation using generally U-shaped clips that have a base from which first and second sidewalls extend. The FPCB harness is held between the tips of base-teeth extending from the base, and side-teeth extending from the first and second sidewalls. In this way, the FPCB harness can be held securely in position by the clip.

Abstract: A system and method to sustain an on-going voice call or other service during a handover, HO, by preventing the handover to a target cell that fails to admit all the mandatory Radio Access Bearers, RABs, as part of supporting one or more Quality of Service Class Identifiers, QCIs, associated with the ongoing service. When the source evolved Node B, eNB, prevents the HO to the best target cell, it may attempt the HO to the next best target cell. If the next best cell fails to admit all the mandatory RABs and if there are no other intra-LTE or inter-LTE cells available for HO, the source eNB may perform an inter-Radio Access Technology, RAT, HO using the Single Radio Voice Call Continuity, SRVCC, procedure. By preventing “partial” handovers, the retainability of an ongoing service is significantly improved. The target cells causing failure of particular RABs can be tracked using new counters.

Abstract: Methods of generating sequence diversity in a protein, such as a ligand-binding protein, are provided. The methods comprise targeted introduction of two or more recombination signal sequences (RSSs) into the protein coding sequence and introduction of the modified protein coding sequence into a recombination-competent host cell, specifically a recombination-competent host cell that is capable of expressing at least RAG-1 and RAG-2, thereby allowing for recombination of the protein coding sequence and expression of variant proteins. Also provided are polynucleotides comprising a nucleic acid sequence encoding a target protein, such as a ligand-binding protein, and comprising two or more RSSs, and compositions and host cells comprising same.

Abstract: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

Abstract: A method and arrangement in a Radio Network Controller (RNC) for monitoring radio link (RL) synchronization for each RL as soon as it is added to a User Equipment's (UE's) Active Set. When a new RL is added, each RL in the Active Set sends an Active Set Update Complete message to the RNC. When the RNC determines that a Radio Link Restore Indication message is not received from the Target NodeB serving the new RL, the RNC starts an initRlSyncT timer set for a defined time period and monitors incoming messages to determine whether the Radio Link Restore Indication message is received for the new RL before the initRlSyncT timer expires. If so, the method ends; but if not, the RNC instructs associated NodeBs and the UE to remove the new RL from the UE's Active Set.

Abstract: A radio network controller (RNC) receives a request to activate a packet data protocol (PDP) context for a wireless device operating in a forward access channel state. The RNC sends the request to activate PDP context to a core network node (CN). The RNC receives a request to assign a radio access bearer from the CN. The RNC sends a response to the request to assign a radio access bearer to the CN and initiates a timer. If the CN accepts the request to activate the PDP context prior to timer expiry, the RNC stops the timer and sends the wireless device the accept message followed by a request to reconfigure a radio bearer. Otherwise, if the timer expires, the RNC sends the wireless device the request to reconfigure the radio bearer followed by the accept message.

Abstract: Methods of generating fusion protein variants are provided that comprise introducing sequence diversity at the junction region or regions in the fusion and allows for the generation of variants having a desired activity. Examples include immunoglobulins comprising a domain or polypeptide inserted into, or replacing, a CDR. Also provided are polynucleotides encoding a fusion protein and comprising two or more RSSs, and compositions and host cells comprising same, as well as fusion proteins variants produced by the described methods.

Abstract: A gas turbine engine installation is provided that has a plurality of flexible printed circuit board (FPCB) harnesses to transfer electrical signals, including electrical power, around a gas turbine engine. The plurality of FPCB harnesses is held to the gas turbine engine installation using clips that have at least two jaws. Each jaw has two sets of opposing teeth that do not intermesh, and cannot intermesh when pushed together. This allows more than one FPCB harness to be held by one clip without the risk of damaging the FPCB harnesses. Preventing the teeth from intermeshing also allows subsequent FPCB harnesses to be inserted into the clip without undue difficulty even after a first FPCB harness has already been inserted.

Abstract: A method for managing content is provided. The method may include, by a content management apparatus, receiving a content request, searching for content information associated with the request, and causing writing of missing content information to an alert file. The method may provide default content information when content information is not otherwise located. A content request may comprise an application and context name. A response from a content management apparatus may comprise a location and map identifier used by a calling apparatus to locate and cause display of content. The method may provide synchronization capabilities in which content referenced by an application is searched for in order to track missing content in an alerts file, and to track the synchronization history or status of an application in a synchronization log. Corresponding systems, apparatuses, and computer program products are also provided.

Abstract: Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.

Abstract: The disclosure relates to antibodies or antigen binding fragments that specifically bind to CXCR4 and inhibit the biological activity of CXCR4 and uses of such agents. More specifically the disclosure relates to fully human antibodies or antigen binding fragments directed to CXCR4 that specifically bind to CXCR4 and uses of these antibodies. Aspects of the disclosure also relate to hybridomas or other cell lines expressing such antibodies. The disclosed antibodies (including antigen binding fragments) are useful as diagnostics and for the treatment of diseases associated with the activity and/or expression of CXCR4.

Abstract: The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to ErbB2, preferably human ErbB2. In another embodiment, the antibodies or antigen-binding portions thereof inhibit ErbB2. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins or portions thereof derived from human anti-ErbB2 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-ErbB2 antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.

Abstract: Human monoclonal antibodies directed against B7-H1 and uses of these antibodies in diagnostics and for the treatment of diseases associated with the activity and/or expression of B7-H1 are disclosed. Additionally, hybridomas or other cell lines expressing such antibodies are disclosed.