Abstract: The present disclosure relates to an application system comprising a cartridge having at least one container with a respective outlet, and a closure element that can sealingly close the outlet of the at least one container when the cartridge is in the delivery state. When in the storage state, the cartridge sealingly closes the closure element. When the cartridge is in the state of use, the closure element can be removed therefrom and an accessory can be connected to the outlet of the at least one container. According to the invention, the cartridge or the closure element comprises, in the delivery state, a connecting element which cannot be removed without being damaged, and the cartridge or the closure element, in the storage state, is connected via a connecting element that cannot be removed without being damaged, to a closure element or the cartridge.

Abstract: The present disclosure relates to a mixer for mixing pasty components, comprising a mixing case extending along a longitudinal axis and having at least one inlet, preferably two inlets, and an outlet, and comprising at least one mixing element received in the mixing case, which defines a plurality of chambers together with the mixing case, said chambers being arranged successively and/or adjacently along a flow path from the inlets to the outlet.

Abstract: A working apparatus has a manual operating region, a tubular part extending away from the manual operating region, and an electric cable arrangement in the tubular part. The working apparatus includes a rod-shaped cable holder, which is inserted into and held in the tubular part and has a cable holding arrangement, by which the cable arrangement is held in a pre-mounted manner on the cable holder. An assembly method secures the cable arrangement on the cable holder by the cable holding arrangement, and inserts the cable holder, with the cable arrangement held thereon, into the tubular part. The working apparatus may be a battery-operated, hand-guided garden or forestry working apparatus.

Abstract: Anti-SIRP? antibodies, including multi-specific anti-SIRP? antibodies, are provided, as are related compositions and methods. The antibodies of the disclosure bind to SIRP? and can block the interaction of CD47 on one cell with SIRP? on a phagocytic cell.

Abstract: Influenza viruses for use in preparing human vaccines have traditionally been grown on embryonated hen eggs, although more modern techniques grow the virus in mammalian cell culture e.g. on Vero, MDCK or PER.C6 cell lines. The inventor has realised that the conditions used for influenza virus culture can increase the risk that pathogens other than influenza virus may grow in the cell lines and have identified specific contamination risks. Suitable tests can thus be performed during manufacture in order to ensure safety and avoid iatrogenic infections.

Abstract: Methods are provided for treating a subject with a therapeutic dose of anti-CD47 agent by administering a primer agent prior to administering a therapeutically effective dose of an anti-CD47 agent to the subject.

Abstract: An organ includes keys, a windchest in fluid flow communication with a wind supply. A windchest pallet disposed inside the windchest and connected to the key. An auxiliary chamber is independent from the windchest and in fluid flow communication with a wind regulator. An auxiliary pallet is disposed inside the auxiliary chamber and connected to the key. A first adjustment element controls wind generated from the wind regulator. A bias element urges the auxiliary pallet in a closed position. A second adjustment element controls tension exerted by the bias element on the auxiliary pallet.

Abstract: A method for forming a semiconductor device includes: forming, in a silicon carbide layer of a first conductivity type having a first side, a first silicon carbide region and a second silicon carbide region that forms a pn-junction with the first silicon carbide region; forming a contact region that forms an Ohmic contact with the second silicon carbide region; forming a barrier-layer on the contact region and the first silicon carbide region so that a Schottky-junction is formed between the barrier-layer and the first silicon carbide region and so that an Ohmic connection is formed between the barrier-layer and the contact region, the barrier-layer comprising molybdenum nitride; and forming a first metallization on the barrier-layer, and in Ohmic connection with the barrier-layer.

Abstract: Methods are provided for treating individuals with ovarian cancers with an anti-CD47 antibody and an anti PD-L1 antibody.

Abstract: A silicon carbide device includes a stripe-shaped trench gate structure extending from a first surface into a silicon carbide body. The gate structure has a gate length along a lateral first direction. A bottom surface and an active first gate sidewall of the gate structure are connected via a first bottom edge of the gate structure. The silicon carbide device further includes at least one source region of a first conductivity type. A shielding region of a second conductivity type is in contact with the first bottom edge of the gate structure across at least 20% of the gate length.

Abstract: The invention relates to an electromagnetic valve having a valve housing (2) and a valve opening (29) with a valve seat (8) and an electric drive coil (3) and a magnetic yoke (11) and a longitudinal centre axis (14). The magnetic yoke (11) is assigned a metallic plate armature (5) which is mounted movably and has an armature disc (48). The armature disc (48) lies sealingly with a sealing surface (9) against the valve seat (8) in a first switching position of the valve, and opens the valve seat (8) in a second switching position of the valve. According to the invention, the valve seat (8) is configured on a valve component (18), wherein the valve component (18) has at least one valve opening (29) which lies at a radial spacing (r) from the longitudinal centre axis (14). The valve seat (8) of the valve opening (29), which valve seat (8) corresponds with direct body contact with the sealing surface (9) of the armature disc (48) of the plate armature (7), consists of metal.

Abstract: Therapeutic and diagnostic methods are provided, which methods relate to the induction of expression of calreticulin on phagocytic cells. Specifically, the methods relate to macrophage-mediated programmed cell removal (PrCR), the methods comprising increasing PrCR by contacting a phagocytic cell with a toll-like receptor (TLR) agonist; or down-regulating PrCR by contacting a phagocytic cell with an inhibitor of Bruton's tyrosine kinase (BTK). In some embodiments, an activator of TLR signaling or a BTK agonist is provided in combination with CD4 7 blockade.

Abstract: The present disclosure relates to a releasable attachment comb (60) for a blade set (22) of a cutting head (20) of a hair cutting appliance (10), said attachment comb (60) comprising a supporting frame (62) comprising a first lateral grip bar (68), a second lateral grip bar (70), and at least one laterally extending supporting bar (64, 66) arranged between the first lateral grip bar (68) and the second lateral grip bar (70); a plurality of guide teeth (72) that define a skin contact front face (74); a plurality of snap-on mounting elements (78, 80); wherein the snap-on mounting elements (78, 80) are spaced away from the first lateral grip bar (68) and the second lateral grip bar (70); wherein at least one of the snap-on mounting elements (78, 80) is configured as a proximal snap-on mounting element (78) that is arranged on a first, proximal side (84); wherein at least one of the snap-on mounting elements (78, 80) is configured as a distal snap-on mounting element (80) that is arranged on a second, distal side

Abstract: A method of manufacturing a semiconductor device is proposed. A silicon carbide, SiC, semiconductor body is provided. Ions are introduced into the SiC semiconductor body through a first surface of the SiC semiconductor body by at least one ion implantation process. Thereafter, a SiC device layer is formed on the first surface of the SiC semiconductor body. Semiconductor device elements are formed in or over the SiC device layer.

Abstract: A tiltable mounting device is for mounting cylindrical objects with a top surface and a lateral surface, and for tilting the objects relative to a reference plane. The device has a frame, and one or more mandrels, each configured to mount a cylindrical object. Each mandrel is rotatable about a longitudinal axis, and is tiltable in the frame between first and second positions. The longitudinal axis of each mandrel in the first position is oriented perpendicularly to the longitudinal axis of the respective mandrel in the second position. In the first position, each mandrel is oriented with the top surface of the object in the reference plane, and in the second position, each mandrel is oriented such that the lateral surface of the cylindrical object is tangent to the reference plane.

Abstract: Filter media, filter elements, and methods for filtering an gas stream are described herein. In some embodiments, the filter media may comprise a fiber web comprising a plurality of fibers and having a particular oil repellency level. For instance, in certain embodiments, the surface chemistry of the fiber web may be tailored to impart a particular surface energy density that matches the surface energy density of the fluid (e.g., an oil, a lubricant, and/or a cooling agent) being removed from the gas stream. In some embodiments, the fiber web may be wrapped around a core. For example, the fiber web may be wrapped around the core such that it forms two or more layers around the core. In some cases, the fiber web may be perforated. In certain embodiments, an gas stream comprising a fluid (e.g., an oil, a lubricant, and/or a cooling agent) may be passed through the fiber web, filter media, and/or filter element such that at least a portion of the fluid coalesces on the fiber web.

Abstract: An organ includes keys, a windchest in fluid flow communication with a wind supply. A windchest pallet disposed inside the windchest and connected to the key. An auxiliary chamber is independent from the windchest and in fluid flow communication with a wind regulator. An auxiliary pallet is disposed inside the auxiliary chamber and connected to the key. A first adjustment element controls wind generated from the wind regulator. A bias element urges the auxiliary pallet in a closed position. A second adjustment element controls tension exerted by the bias element on the auxiliary pallet.

Abstract: The present invention relates to vaccine products for the treatment or prevention of viral infections. Further provided are methods of reducing contaminants associated with the preparation of cell culture vaccines. Residual functional cell culture DNA is degraded by treatment with a DNA alkylating agent, such as ?-propiolactone (BPL), thereby providing a vaccine comprising immunogenic proteins derived from a virus propagated on cell culture, substantially free of residual functional cell culture DNA.

Abstract: The invention provides co-administration regimes of immunotherapeutic agents specifically binding to c-kit or inhibiting CD47-SIRP? for ablation of endogenous HSPCs. Relatively low levels of anti-c-kit result in saturation of binding to c-kit on HSPCs without significant reduction of the levels HSPCs. Significant reduction of the level of HSPCs can be obtained when the action of anti-c-kit is promoted by an immunotherapeutic agent inhibiting CD47-SIRP?. HSPCs expressing c-kit can thus be reduced to an acceptable level an acceptable level to permit introduction of replacement HSPCs without detrimental delay during which a subject has inadequate HSPCs.