Abstract: Disclosed are compounds of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a monocyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

Abstract: Disclosed are compounds of Formula (I) or a salt thereof, wherein R1 is (II) or (III); each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3, L1, L2, R1a, R1b, R1c, and n are define herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, the method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5? end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5? end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are biased agonists, or ?-Arrestin agonists of the angiotensin II receptor, which may be used as medicaments.

Abstract: A computer-implemented method for processing test financial transactions that includes executing a mobile application API at an electronic device and receiving a command to initiate a transaction at the mobile application API, the command including transaction data. A payment application is executed at the electronic device to generate additional transaction data comprising a cryptogram based at least in part on the transaction data. The cryptogram and a corresponding post transaction command are transmitted. A web service API executed at a web service server receives the cryptogram and the corresponding post transaction command. A transaction request including at least some of the transaction data is generated at the web service API, according to interchange standards of a payment network, and transmitted to the payment network.

Abstract: A computer-implemented method for processing test financial transactions that includes accessing, via a remote-control server, transaction data corresponding to a test run. The transaction data is transmitted via the remote-control server and received at a mobile application API of an electronic device. The transaction data is passed to a payment application of the electronic device. A cryptogram corresponding to the transaction data is generated via the payment application and transmitted for submission to a payment network. A transaction response corresponding to the test run is received at the remote-control server.

Abstract: An apparatus is provided that includes a plurality of reflectors arranged over an area, and a plurality of transceivers. A first of the transceivers is configured to transmit radiation at each of the plurality of reflectors at a first wavelength and a second wavelength, and receive radiation reflected from each of the plurality of reflectors. A second of the plurality of transceivers is configured to transmit radiation at each of the plurality of reflectors at a third wavelength and a fourth wavelength and receive radiation reflected from each of the plurality of reflectors. The apparatus includes a processor configured to calculate a change in concentration of a gas within the area between a first time and a second time based upon signals received from the transceivers.

Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

Abstract: This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.

Abstract: An electronic shelf label system comprising a plurality of electronic shelf labels is provided. A central computing system transmits data transmissions to the plurality of electronic shelf labels at a first power level. A candidate electronic shelf label from the plurality of electronic shelf labels periodically activate from a sleep mode to identify whether there is an existing master electronic shelf label from the plurality of electronic shelf labels. The candidate electronic shelf label becomes a new master electronic shelf label based on a set of specified conditions to transmit programming instructions received from the central computing system to one or more electronic shelf labels.

Abstract: Systems and methods for improving vehicular safety are disclosed. According to embodiments, an electronic device may collect or accumulate various sensor data associated with operation of a vehicle by an individual, including image data, telematics data, and/or data indicative of a condition of the individual. The electronic device may analyze the sensor data to determine whether the individual is distracted and whether the vehicle is approaching a location that may be prone to incidents. The electronic device may accordingly generate and present a notification to the individual to mitigate any posed risks.

Abstract: Methods for attaching clips to decking. The clip includes a bottom and a removable top insert. The clip has a bottom made from a material that is different than the material used for the top. The clip has a generally T shape in a side view with a central bore passing through the top member and the bottom member to receive a screw or other fastening member, and a plurality of apertures through the top surface of the bottom member that engage the top member. The body of the bottom member has a transverse planar upper member and at least one perpendicularly positioned planar lower member or keel. The deck board fastener can also have a lip that projects upward from the upper surface of the transverse planar member. The lip can be positioned about an exterior edge of the transverse planar member or along the upper surface.

Abstract: A screening machine includes a rotary trommel screen having an overall length. The rotary trommel screen has an inlet and an outlet end. The screening machine includes a first collection area proximate to the inlet end and under the rotary trommel screen. The first collection area corresponds to at least 65 percent of the overall length of the trommel screen. The screening machine includes a second collection area proximate to the outlet end and under the rotary trommel screen. The second collection area corresponds to the remainder of the overall length of the trommel screen not corresponding to the first collection area. The first and second collection areas are configured to separate a first and second product respectively. Sections of the trommel screen corresponding to the first and second collection areas are configured such that a size of the first product is different than a size of the second product.

Abstract: The authenticity of a compressed archive is verified without decompressing the files and/or directories contained therein and without impeding existing archive reader tools and utilities. A container is produced that includes a signature component and a compressed archive component. The signature component contains a digital signature of the compressed archive and the compressed archive component contains the compressed archive. The signature component and the compressed archive component are constructed as independent components so that existing software tools that operate on a compressed archive can still function in their normal course of operation.

Abstract: A stormwater filter comprising: a vessel having an inlet and an outlet; and a screen disposed within the vessel and arranged to divide at least part of the vessel into an upper section and a lower section. The stormwater filter further comprises: a flow splitter positioned adjacent the inlet of the vessel and/or a substantially vertical screen disposed adjacent the outlet in the upper section of the vessel. The flow splitter comprises an inclined leading edge and first and second deflecting surfaces extending from the leading edge. The first and second deflecting surfaces are angled relative to one another so as to direct incoming flow laterally away from an axis between the inlet and the outlet. The vertical screen comprises first and second screen portions which are angled relative to one another. The first and second screen portions are each hingedly connected to the vessel and are detachably coupled to one another at their distal ends.

Abstract: Techniques for enforcing data security in a cleanroom data processing environment are described herein. In one or more embodiments, a virtual private cloud environment stores a first set of data provided by a first user account and a second set of data provided by a second user account, where the first user account is associated with a first set of one or more security credentials and the second user account is associated with a second set of security credentials and where the first user account is prevented from accessing at least the second set of data and the second user account is prevented from accessing at least the first set of data. In response to receiving, from the first user account or the second user account, a request to destroy the virtual private cloud environment, at least the first set of data and the second set of data are deleted.