Abstract: This disclosure describes detecting four genetically distinct kinds of inherited myopathy in horses, referred to as Polysaccharide Storage Myopathy type 2 (PSSM2), or in some cases as Myofibrillar Myopathy (MFM).

Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract: Techniques for rendering animations on a display of a data processing system herein can be used with a messaging application to provide animations associated with one or more messages of a messaging session. These techniques include receiving a signal reflecting a user input to invoke an animation associated with a message displayed on a user interface of a display of a computing device, determining via a processor an animation point at a preset location specified relative to dimensions of the user interface or the display and not based on a location of the message, establishing via the processor an animation path that includes the animation point and a target display location relative to the location of the message, such that at least a portion of the animation is rendered from the animation point to the target display location relative to the message, and rendering the animation on the user interface according to the animation path.

Abstract: The authenticity of a compressed archive is verified without decompressing the files and/or directories contained therein and without impeding existing archive reader tools and utilities. A container is produced that includes a signature component and a compressed archive component. The signature component contains a digital signature of the compressed archive and the compressed archive component contains the compressed archive. The signature component and the compressed archive component are constructed as independent components so that existing software tools that operate on a compressed archive can still function in their normal course of operation.

Abstract: Methods, systems, and apparatus, including computer programs encoded on computer storage media, for dynamically injecting secrets in a pipeline integration system. One of the methods includes receiving, by a pipeline controller, a job identifying a pipeline for executing a plurality of tasks. A preparatory task is invoked for the pipeline that obtains one or more original task definitions for the identified pipeline and generates one or more modified task definitions for the pipeline, wherein each modified task definition references one or more variablized secret names specified as the value of the reserved variable of the one or more configuration files. One or more subsequent execution tasks are invoked using each respective modified task definition. One or more retrieved secrets are injected into an execution environment for each particular execution task.

Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.

Abstract: This disclosure describes detecting genetically distinct kinds of inherited myopathies in horses, variously referred to as Polysaccharide Storage Myopathy type 2 (PSSM2), Myofibrillar Myopathy (MFM), or idiopathic myopathy.

Abstract: A throttling system measures current latency and bandwidth of a network connection. Latency and bandwidth may be measured by sending an unthrottled packet train and measuring a rate of receipt of the packet train as well as overall latency for the packet train. A percentage of available bandwidth is calculated according to a function of a previous percentage of available bandwidth and current latency and bandwidth measurements. The percentage of available bandwidth may decrease with increasing latency. The percentage of available bandwidth is calculated every N packets in order to adapt to changing conditions in a network. The rate of packet transmission may be throttled by increasing a period between transmissions of packets in order to use the percentage of available bandwidth.

Abstract: Systems and methods for ransomware protection in collaboration systems. One embodiment operates in conjunction with a collaboration system that manages one or more user devices that store device-local copies of content objects in storage areas of the one or more user devices. The collaboration system is accessed by the one or more user devices to facilitate collaboration activity over the content objects. Patterns of collaboration activity are classified, and in some cases, such patterns are deemed to be indicative of ransomware. If ransomware is indicated to be running on a user device, the collaboration system is notified that a ransomware process has been detected on the user device. The collaboration system delivers a prevention policy to other user devices that interface with the collaboration system. The prevention policy is in turn enforced by the other user devices to prevent synchronization of content object changes made by the ransomware.

Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

Abstract: A fastener includes a shank having a point at a first end and a second, head end. A head structure at the head end includes a top portion and having a cutting structure, the cutting structure comprising four planar walls, each wall engaging the shank at an angle, each wall adjoining an adjacent wall by a rounded edge.

Abstract: Light emitter packages, systems, and methods having improved performance are disclosed. In one aspect, a light emitter package can include a submount that can include an anode and a cathode. A light emitter chip can be disposed over the submount such that the light emitter chip is mounted over at least a portion of the cathode and wirebonded to at least a portion of the anode.

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, the method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5? end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5? end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

Abstract: Methods for attaching clips to decking. The clip includes a bottom and a removable top insert. The clip has a bottom made from a material that is different than the material used for the top. The clip has a generally T shape in a side view with a central bore passing through the top member and the bottom member to receive a screw or other fastening member, and a plurality of apertures through the top surface of the bottom member that engage the top member. The body of the bottom member has a transverse planar upper member and at least one perpendicularly positioned planar lower member or keel. The deck board fastener can also have a lip that projects upward from the upper surface of the transverse planar member. The lip can be positioned about an exterior edge of the transverse planar member or along the upper surface.

Abstract: This invention provides novel processes for the preparation of compounds such as 3-[(1S,2S)-2-hydroxycyclohexyl]-6-[(6-methylpyridin-3-yl)methyl]benzo[h]-quinazolin-4(3H)-one, salts and derivatives thereof. The compounds synthesized by the processes of the invention are useful for treating Alzheimer's disease and other diseases (e.g., cognitive impairment, schizophrenia, pain disorders, and sleep disorders) mediated by the muscarinic M1 receptor.

Abstract: The authenticity of a compressed archive is verified without decompressing the files and/or directories contained therein and without impeding existing archive reader tools and utilities. A container is produced that includes a signature component and a compressed archive component. The signature component contains a digital signature of the compressed archive and the compressed archive component contains the compressed archive. The signature component and the compressed archive component are constructed as independent components so that existing software tools that operate on a compressed archive can still function in their normal course of operation.

Abstract: The present invention relates to a method for preparing monomers via depolymerisation from lignocellulose-containing biomass.