Abstract: A fastener includes a shank having a first end and a second end. The fastener includes a first thread region adjacent to the first end having a first helical thread and a second helical thread interposed with the first helical thread in the first thread region. A second thread region is provided adjacent to the first thread region, the second thread region including only the second helical thread with the second helical thread having a diameter greater than a diameter of the first helical thread. A third thread region having a third helical thread is provided extending from the second thread region toward the second end. A head is provided on the second end and includes a disk and an octagonal boss between the disk and the third thread region, the boss including four major sides extending perpendicular to the disk and four chamfered sides, the chamfered sides being flush with a side edge of the disk.

Abstract: A fastener includes a shank having a point at a first end and a second, head end. One or more prolate cross-section regions is formed in the shank. Prolate cross-section regions may be formed in a threaded section and/or a thread free section of the fastener. Each prolate cross-section may have a polar diameter greater than the cylindrical diameter of the region in which it is formed and an equatorial diameter smaller than the corresponding cylindrical diameter of the region in which it is formed. Two generally adjacent prolate cross-section regions have cross-sections offset with respect to each other by an angle between zero and ninety-degrees.

Abstract: A laser diode array having submounts allowing thermal transmission from laser diode bars to a heat exchanger while electrically isolating the laser diode bars from the heat exchanger. The laser diode array has a plurality of laser diode bars supported by a corresponding plurality of submounts. Each of the submounts has a submount core having a top surface, an opposite bottom surface and side surfaces. An electrically conductive layer covers part of one side surface. The conductive layer is in electrical contact with one of the laser diode bars. Another electrically conductive layer covers part of a second side surface. An electrical connector connects the electrically conductive layers on the side surfaces. The electrically conductive layers leave an exposed area of the side surfaces adjacent to the bottom surface. The heat exchanger is in thermal contact with the bottom surface of each of the submount cores.

Abstract: A laser system that allows transverse arrangement of laser emitters around a laser medium. The system includes a laser medium with a coolant source and electrical controls. A pump layer has a mounting surface, an opposite bottom surface and a center aperture through which the laser medium is inserted. Laser diode emitters are disposed on the mounting surface circumferentially around the laser medium. An intermediate layer has at least one radial channel in fluid communication with the coolant conduit. The intermediate layer is in contact with the bottom surface. A middle layer has micro-channels formed therethrough and a center aperture. The micro-channels are radially arranged around the center aperture and the middle layer is in contact with the intermediate layer. The coolant source is fluidly coupled to the micro-channels to allow coolant to be directed through the microchannels and the radial channel to impinge on the bottom surface.

Abstract: A driveshaft assembly for a downhole motor comprises a housing and a driveshaft rotatably disposed within the housing. The driveshaft has a central axis and a first end. Further, the driveshaft assembly comprises a driveshaft adapter having a first end coupled to the first end of the driveshaft with a universal joint. The first end of the driveshaft adapter includes a counterbore. The first end of the driveshaft and the universal joint are disposed in the counterbore. Still further, the driveshaft assembly comprises an end cap disposed about the driveshaft and coaxially coupled to the adapter. Moreover, the driveshaft assembly comprises a seal boot disposed about the driveshaft and adapted to restrict fluid flow through a annular gap positioned between the driveshaft and the end cap. The driveshaft assembly also comprises a locking assembly adapted to restrict the end cap from moving axially relative to the adapter.

Abstract: Methods and apparatus for long read, label-free, optical nanopore long chain molecule sequencing. In general, the present disclosure describes a novel sequencing technology based on the integration of nanochannels to deliver single long-chain molecules with widely spaced (>wavelength), ˜1-nm aperture “tortuous” nanopores that slow translocation sufficiently to provide massively parallel, single base resolution using optical techniques. A novel, directed self-assembly nanofabrication scheme using simple colloidal nanoparticles is used to form the nanopore arrays atop nanochannels that unfold the long chain molecules. At the surface of the nanoparticle array, strongly localized electromagnetic fields in engineered plasmonic/polaritonic structures allow for single base resolution using optical techniques.

Abstract: A process for the preparation of pyrazolopyrolidines of structural formula I: and W is or P, wherein in P is an amine protecting group. These compounds are useful in the synthesis of dipeptidyl peptidase-IV inhibitors for the treatment of Type 2 diabetes. Also provided are useful intermediates obtained from the process.

Abstract: A fastener includes a shank having a first end and a second end. A first portion of a thread is formed with a first, symmetric thread angle and a second portion of the thread is formed with a second, asymmetric thread angle. The thread may be serrated or jagged over one or more portions of the fastener, including the area of the symmetric thread angle. A blunt end comprises the leading end of the fastener.

Abstract: The present specification describes a medicine dispensing system for automatically dispensing medication at a predetermined time. The system includes a cartridge that carries a strip of medicine pouches. When the cartridge is dropped into a dispensing unit, it automatically aligns with the dispensing unit without requiring any installation work from the user. The automatic alignment is enabled beacuse of self-aligning features manufactured in the cartridge housing.

Abstract: In one embodiment of the invention, a relocatable seat and removable and storable seating arrangement for use on a boat is provided. The relocatable seat has a frame, a seat bottom, a seat back, and at least one storage compartment. The removable and storable seating arrangement includes at least one removable support member, which can be stored in the storage compartment when not in use, and at least one removable seat member supported by the support member when in a use position and storable in the storage compartment in a stored position.

Abstract: A fastener includes a shank having a point at a first end and a second, head end. A first helical thread region is formed at the first end adjacent to the point and has having a first helical thread having a first effective diameter. A sub-region of a second helical thread formed within the first helical thread region adjacent to the first end. A head at the second end includes a cutting structure, the cutting structure positioned to intersect a bottom surface of the disk and the shank, the cutting structure has a square cross-section formed by four walls intersecting the disk. A third helical thread region may be provided between the first region and the head. The shank diameter in the sub-region and the first region is smaller than the other regions.

Abstract: A method of matching a first entity to a second entity by evaluating Boolean expressions includes identifying a set of criteria vertices for a second entity vertex by traversing a graph database in a manner constrained to fact vertices identified for the second entity. The graph database relates fact vertices to the criteria vertices by edges corresponding to Boolean expressions for satisfying criteria for matching first entities to second entities. The method additionally includes selecting one of the first entities based on the criteria vertices of the set. The method further includes matching the first entity to the second entity based on the selection.

Abstract: A fastener includes a shank having a first end and a second end. The fastener includes a first thread region adjacent to the first end having a first helical thread and a second helical thread interposed with the first helical thread in the first thread region. A second thread region is provided adjacent to the first thread region, the second thread region including only the second helical thread with the second helical thread having a diameter greater than a diameter of the first helical thread. A third thread region having a third helical thread is provided extending from the second thread region toward the second end. A head is provided on the second end and includes a disk and an octagonal boss between the disk and the third thread region, the boss including four major sides extending perpendicular to the disk and four chamfered sides, the chamfered sides being flush with a side edge of the disk.

Abstract: The disclosure describes a method for sequencing long portions of DNA sequence by assembling a plurality of shorter polynucleotide reads. Generally, The method includes annealing a plurality of primers to a denatured DNA molecule, appending a barcode polynucleotide to the 5? end of the primer, subjecting the DNA molecules to a plurality of cycles of (1) pooling, (2) dividing, and (3) appending a barcode polynucleotide to the 5? end of the primer, sequencing the barcode polynucleotides and the genomic DNA, and assembling the short read polynucleotide sequences having identical barcode polynucleotides.

Abstract: A method is provided for controlling a machine having a continuously variable transmission travelling on a ground surface. The method receives signals indicative of an inclination of the ground surface and a payload carried by the machine through an inclination sensor and a payload sensor respectively. The method further includes determining a retarding capability of the machine. The method determines a maximum allowable operating speed for the machine based at least on the inclination of the ground surface, a mass of the machine, the payload carried by the machine and the retarding capability of the machine.

Abstract: This disclosure describes, in one aspect, methods for DNA sequencing and performing epigenomic analyses. Generally, the methods include immobilizing a plurality of copies of a DNA molecule on a surface, stretching at least a portion of the immobilized DNA molecules, and sequencing at least a portion of the immobilized, stretched DNA molecules.

Abstract: Described is a method of processing biomass to separate it into a liquid fraction enriched in solubilized C5-sugar-containing oligomers and C-5 sugar monomers and a solid fraction enriched in substantially insoluble cellulose and C6-sugar-containing oligomers. The method includes the steps of reacting biomass with a solvent system comprising water, at least one lactone, or at least one furan, or at least one cyclic ether, and at least one acid, for a time and at a temperature to yield the liquid and solid fractions. The liquid and solid fractions may then be separated. Gamma-valeroloactone is a preferred lactone for use in the solvent system. Tetrahydrofuran is a preferred furan species for use in the solvent system.

Abstract: A fastener includes a shank having a pilot section and a threaded section. The pilot section includes a cutting tip and a drill section; the threaded section includes a first thread region having the same twist as the drill section and a reverse thread region. A helical ridge may be provided in the reverse thread region. A head at the second end includes a top portion such as a disk and an undercut region.

Abstract: A Policy- and Relevance-based User Interface (UI) for an enterprise suite Console provides a Console Operator access to information about systems on a network under management. By means of such UI, a user experience is dynamically constructed within product domains particular to the system under management using content elements that flow from content sites into the user environment, populating user interface and driving the Operator experience. Specifications distributed with the content determine how the local Console UI organizes and presents information. The UI is further determined by each Console operator's content access rights. The UI allows for re-flowing the Console UI without reinstalling or updating the Console application, seamlessly integrating new content in to the UI and targeting language to specific working areas.

Abstract: The present invention relates to polymorphic forms of a compound of formula A: This compound is useful as a glucagon receptor antagonist and serves as a pharmaceutically active ingredient for the treatment of type 2 diabetes and related conditions, such as hyperglycemia, obesity, dyslipidemia, and the metabolic syndrome. Hydrates, hemihydrates, anhydrates and similar polymorphic forms are included.