Patents by Inventor Jia-Ning Xiang

Jia-Ning Xiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF
    Publication number: 20100267946
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Application
    Filed: July 1, 2010
    Publication date: October 21, 2010
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fayang G. Qiu, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollmann
  • Acyloxyalkyl carbamate prodrugs of ?-amino acids, methods of synthesis and use
    Patent number: 7799829
    Abstract: Acyloxyalkyl carbamate prodrugs of ?-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of ?-amino acids and methods of using acyloxyalkyl carbamate prodrugs of ?-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of ?-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.
    Type: Grant
    Filed: April 1, 2009
    Date of Patent: September 21, 2010
    Assignee: XenoPort, Inc.
    Inventors: Xuedong Dai, Archana Gangakhedkar, Jia-Ning Xiang, Mark A Gallop
  • Prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 7790708
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: May 22, 2006
    Date of Patent: September 7, 2010
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fayang G. Qiu, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollmann
  • LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF
    Publication number: 20100197953
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: February 2, 2009
    Publication date: August 5, 2010
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • LEVODOPA DIMETHYL-SUBSTITUTED DIESTER PRODRUGS, COMPOSITIONS, AND METHODS OF USE
    Publication number: 20100173992
    Abstract: Levodopa dimethyl-substituted diester prodrugs pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.
    Type: Application
    Filed: March 18, 2010
    Publication date: July 8, 2010
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Cindy X. Zhou, Fenmei Yao, Mark Q. Nguyen
  • Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use
    Patent number: 7709527
    Abstract: Levodopa dimethyl-substituted diester prodrugs pharmaceutical, compositions comprising levodopa dimethyl-substituted diester prodrugs, and methods of using such prodrugs and pharmaceutical compositions for treating diseases such as Parkinson's disease are provided.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: May 4, 2010
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Cindy X. Zhou, Fenmei Yao, Mark Q. Nguyen
  • Levodopa prodrugs, and compositions and uses thereof
    Patent number: 7671089
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Grant
    Filed: December 11, 2007
    Date of Patent: March 2, 2010
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • Levodopa Prodrugs, and Compositions and Uses Thereof
    Publication number: 20100004332
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: September 14, 2009
    Publication date: January 7, 2010
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy
  • Levodopa Prodrug Mesylate, Compositions Thereof, and Uses Thereof
    Publication number: 20090326067
    Abstract: (2R)-2-Phenylcarbonyloxypropyl(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.
    Type: Application
    Filed: June 22, 2009
    Publication date: December 31, 2009
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Xuedong Dai, Cindy X. Zhou, Jianhua Li, Mark Q. Nguyen
  • CYCLIC 1-(ACYLOXY)-ALKYL PRODRUGS OF GABA ANALOGS, COMPOSITIONS AND USES THEREOF
    Publication number: 20090270493
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Application
    Filed: June 30, 2009
    Publication date: October 29, 2009
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • METHODS FOR SYNTHESIS OF PRODRUGS FROM 1-ACYL-ALKYL DERIVATIVES AND COMPOSITIONS THEREOF
    Publication number: 20090239950
    Abstract: The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
    Type: Application
    Filed: June 8, 2009
    Publication date: September 24, 2009
    Applicant: XenoPort, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat, Cindy X. Zhou
  • Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 7569576
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Grant
    Filed: January 12, 2006
    Date of Patent: August 4, 2009
    Assignee: XenoPort, Inc.
    Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • Acyloxyalkyl Carbamate Prodrugs of Alpha-Amino Acids, Methods of Synthesis and Use
    Publication number: 20090192225
    Abstract: Acyloxyalkyl carbamate prodrugs of ?-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of ?-amino acids and methods of using acyloxyalkyl carbamate prodrugs of ?-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of ?-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.
    Type: Application
    Filed: April 1, 2009
    Publication date: July 30, 2009
    Applicant: XenoPort, Inc.
    Inventors: Xuedong Dai, Archana Gangakhedkar, Jia-Ning Xiang, Mark A. Gallop
  • Levodopa prodrug mesylate, compositions thereof, and uses thereof
    Patent number: 7563821
    Abstract: (2R)-2-Phenylcarbonyloxypropyl(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.
    Type: Grant
    Filed: December 4, 2006
    Date of Patent: July 21, 2009
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Xuedong Dai, Cindy X. Zhou, Jianhua Li, Mark Q. Nguyen
  • Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
    Patent number: 7560483
    Abstract: The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
    Type: Grant
    Filed: June 21, 2005
    Date of Patent: July 14, 2009
    Assignee: XenoPort, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat, Cindy X. Zhou
  • LEVODOPA PRODRUG MESYLATE, COMPOSITIONS THEREOF, AND USES THEREOF
    Publication number: 20090156679
    Abstract: (2R)-2-Phenylcarbonyloxypropyl (2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate mesylate and crystalline form thereof, methods of making the same, pharmaceutical compositions thereof, and methods of using the same to treat diseases or disorders such as Parkinson's disease are provided.
    Type: Application
    Filed: December 31, 2008
    Publication date: June 18, 2009
    Inventors: Jia-Ning Xiang, Xuedong Dai, Cindy X. Zhou, Jianhua Li
  • LEVODOPA PRODRUGS, AND COMPOSITIONS AND USES THEREOF
    Publication number: 20090137834
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: February 2, 2009
    Publication date: May 28, 2009
    Applicant: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • Levodopa prodrugs, and compositions and uses thereof
    Patent number: 7534813
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Grant
    Filed: January 10, 2008
    Date of Patent: May 19, 2009
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Cindy X. Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth C. Cundy, Nelson L. Jumbe
  • Acyloxyalkyl carbamate prodrugs of ?-amino acids, methods of synthesis and use
    Patent number: 7531572
    Abstract: Acyloxyalkyl carbamate prodrugs of ?-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of ?-amino acids and methods of using acyloxyalkyl carbamate prodrugs of ?-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of ?-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.
    Type: Grant
    Filed: July 26, 2007
    Date of Patent: May 12, 2009
    Assignee: XenoPort, Inc.
    Inventors: Xuedong Dai, Archana Gangakhedkar, Jia-Ning Xiang, Mark A Gallop
  • Peptide deformylase inhibitors
    Patent number: 7456211
    Abstract: The present invention involves novel anti-bacterial compounds represented by Formula (I), pharmaceutical compositions thereof, their use as PDF inhibitors, and their use in the treatment of bacterial infections.
    Type: Grant
    Filed: March 7, 2007
    Date of Patent: November 25, 2008
    Assignee: SmithKline Beecham Corp
    Inventors: Kelly M. Aubart, Jia-Ning Xiang, Siegfried B. Christensen, IV, Xiangmin Liao, Maxwell D. Cummings