Patents by Inventor Jia-Ning Xiang

Jia-Ning Xiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Carbidopa prodrugs and derivatives, and compositions and uses thereof
    Patent number: 7101912
    Abstract: Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.
    Type: Grant
    Filed: December 8, 2003
    Date of Patent: September 5, 2006
    Assignee: XenoPort, Inc.
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Kenneth C. Cundy, Jianhua Li, Feng Xu, Cindy X. Zhou, Laxminarayan Bhat
  • Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof
    Publication number: 20060122125
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Application
    Filed: January 12, 2006
    Publication date: June 8, 2006
    Inventors: Mark Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • Cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 7026351
    Abstract: The present invention provides cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs, methods of making cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs. The present invention also provides methods of using cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs and compositions of cyclic 1-(acyloxy)-alkyl prodrugs of GABA analogs.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: April 11, 2006
    Assignee: Xenoport, Inc.
    Inventors: Mark A Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat
  • Peptide deformylase inhibitors
    Patent number: 7019003
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: March 28, 2006
    Assignee: Smithkline Beecham Corporation
    Inventors: Jia-Ning Xiang, Siegfried B. Christensen, IV, Jinhwa Lee, Daniel J. Mercer
  • Peptide deformylase inhibitors
    Publication number: 20060025412
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: October 14, 2005
    Publication date: February 2, 2006
    Inventors: Kelly Aubart, Jia-Ning Xiang, Siegfried Christensen, Xiangmin Liao, Maxwell Cummings
  • Levodopa prodrugs, and compositions and uses thereof
    Publication number: 20060020028
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: June 3, 2005
    Publication date: January 26, 2006
    Inventors: Jia-Ning Xiang, Mark Gallop, Cindy Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth Cundy
  • Levodopa prodrugs, and compositions and uses thereof
    Publication number: 20050282891
    Abstract: Prodrugs of levodopa, methods of making prodrugs of levodopa, methods of using prodrugs of levodopa, and compositions of prodrugs of levodopa are disclosed.
    Type: Application
    Filed: June 3, 2005
    Publication date: December 22, 2005
    Inventors: Jia-Ning Xiang, Mark Gallop, Cindy Zhou, Mark Nguyen, Xuedong Dai, Jianhua Li, Kenneth Cundy, Nelson Jumbe
  • Prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 6972341
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: December 6, 2005
    Assignee: Xeno Port, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fayang G. Qiu, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollman
  • Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
    Publication number: 20050239725
    Abstract: The present invention provides a method for synthesizing 1-(acyloxy)-alkyl derivatives from 1-acyl-alkyl derivatives, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amendable to scale-up. The current invention also provides 1-acyl-alkyl derivatives of known drug components and methods for synthesizing these 1-acyl-alkyl derivatives.
    Type: Application
    Filed: June 21, 2005
    Publication date: October 27, 2005
    Inventors: Mark Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat, Cindy Zhou
  • Methods for synthesis of prodrugs from 1-acyl-alkyl derivatives and compositions thereof
    Patent number: 6927036
    Abstract: Disclosed is a method for synthesizing 1-(acyloxy)-alkyl derivatives of primary or secondary amine drugs from 1-acyl-alkyl derivatives of primary or secondary amine drugs, which typically proceeds stereospecifically, in high yield, does not require the use of activated intermediates and/or toxic compounds and is readily amenable to scale-up. For example, 1-acyl-alkyl derivatives of gabapentin and pregabalin are oxidized to yield 1-(acyloxy)-alkyl derivatives of gabapentin and pregabalin, respectively.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: August 9, 2005
    Assignee: Xero Port, Inc.
    Inventors: Mark A. Gallop, Jia-Ning Xiang, Fenmei Yao, Laxminarayan Bhat, Cindy X. Zhou
  • Peptide deformylase inhibitors
    Patent number: 6897233
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: May 24, 2005
    Assignee: SmithKline Beecham Corporation
    Inventors: Jia-Ning Xiang, Siegfried B. Christensen, IV, Xiangmin Liao, Maxwell D. Cummings
  • Prodrugs of GABA analogs, compositions and uses thereof
    Patent number: 6818787
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: June 11, 2002
    Date of Patent: November 16, 2004
    Assignee: Xenoport, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fenmei Yao, Jia-Ning Xiang
  • Peptide deformylase inhibitors
    Patent number: 6797730
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: September 28, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Jia-Ning Xiang, Siegfried B. Christensen, IV, Jinhwa Lee
  • Carbidopa prodrugs and derivatives, and compositions and uses thereof
    Publication number: 20040167216
    Abstract: Prodrugs of carbidopa, derivatives of carbidopa prodrugs, methods of making prodrugs of carbidopa and derivatives thereof, methods of using prodrugs of carbidopa and derivatives thereof, and compositions of prodrugs of carbidopa and derivatives thereof are disclosed.
    Type: Application
    Filed: December 8, 2003
    Publication date: August 26, 2004
    Inventors: Jia-Ning Xiang, Mark A. Gallop, Kenneth C. Cundy, Jianhua Li, Feng Xu, Cindy X. Zhou, Laxminarayan Bhat
  • PEPTIDE DEFORMYLASE INHIBITORS
    Publication number: 20040133001
    Abstract: Novel PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: February 18, 2004
    Publication date: July 8, 2004
    Inventors: Jia-Ning Xiang, Siegfried B. Christensen IV, Jinhwa Lee
  • Peptide deformylase inhibitors
    Publication number: 20040097732
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: August 28, 2003
    Publication date: May 20, 2004
    Inventors: Kelly M Aubart, Jia-Ning Xiang, Siegfried B Christensen, XIangmin Liao, Maxwell D Cummings
  • Peptide deformylase inhibitors
    Publication number: 20040087585
    Abstract: Nobel PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: August 28, 2003
    Publication date: May 6, 2004
    Inventors: Jia-Ning Xiang, Siegfried B Christensen, Jinhwa Lee, Daniel J Mercer
  • Peptide deformylase inhibitors
    Publication number: 20040077856
    Abstract: PDF inhibitors and novel methods for their use are provided.
    Type: Application
    Filed: August 29, 2003
    Publication date: April 22, 2004
    Inventors: Jia-Ning Xiang, Siegfried B. Christensen IV, Xiangmin Liao, Maxwell D. Cummings
  • Prodrugs of GABA analogs, compositions and uses thereof
    Publication number: 20040077553
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Application
    Filed: December 6, 2002
    Publication date: April 22, 2004
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fayang G. Qiu, Fenmei Yao, Jia-Ning Xiang, Ian R. Ollmann
  • Fatty acid synthase inhibitors
    Patent number: 6723749
    Abstract: This invention relates to the use of compounds as inhibitors of the fatty acid synthase FabH.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: April 20, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Siegfried B. Christensen, Daniel J. Mercer, Jia-Ning Xiang