Patents by Inventor Jia-Ning Xiang

Jia-Ning Xiang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS AS NEUROKININ-1 RECEPTOR ANTAGONISTS AND USES THEREOF
    Publication number: 20200239416
    Abstract: The present invention relates compounds of Formula (A) as NK-1 receptor antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to NK-1 receptor in humans. More specifically, the compounds and/or pharmaceutical compositions of the present invention are believed to potentially offer therapeutic benefits to patients who suffer, among others, chemotherapy-induced nausea and vomit (CINV) and/or post-operative nausea and vomit (PONV).
    Type: Application
    Filed: March 6, 2020
    Publication date: July 30, 2020
    Inventors: JIA-NING XIANG, XUESONG XU, YI FENG, XIANBO LIU, WAI-SI ENG
  • KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF
    Publication number: 20200231540
    Abstract: Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.
    Type: Application
    Filed: April 2, 2020
    Publication date: July 23, 2020
    Applicant: XW LABORATORIES INC.
    Inventors: JIA-NING XIANG, XUESONG XU, HAO-WEI SHIH, WAI-SI ENG
  • PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF
    Publication number: 20200223783
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Application
    Filed: March 26, 2020
    Publication date: July 16, 2020
    Applicant: XW LABORATORIES INC.
    Inventors: JIA-NING XIANG, XUESONG XU, XUAN ZHANG
  • PREPARATION AND USE OF REACTIVE OXYGEN SPECIES SCAVENGER
    Publication number: 20200199108
    Abstract: A compound of Formula (I), pharmaceutically acceptable salts thereof, and individual enantiomers or diastereomers thereof. Compositions and methods useful for treatment or suppression of diseases, developmental delays and symptoms related to oxidative stress.
    Type: Application
    Filed: February 26, 2020
    Publication date: June 25, 2020
    Inventors: JIA-NING XIANG, ZUDE QI, DEZHENG NING, XIANBO LIU
  • Ketamine derivatives and compositions thereof
    Patent number: 10683262
    Abstract: Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: June 16, 2020
    Assignee: XW LABORATORIES INC.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Hao-Wei Shih, Wai-si Eng
  • COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF
    Publication number: 20200181112
    Abstract: The present invention relates compounds of Formula (A) as H3R antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of Histamine 3 Receptor (H3R) functions. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to H3R functions in humans.
    Type: Application
    Filed: February 18, 2020
    Publication date: June 11, 2020
    Inventors: JIA-NING XIANG, XUESONG XU, YI FENG, WAI-SI ENG
  • PREPARATION AND USES OF REACTIVE OXYGEN SPECIES SCAVENGER DERIVATIVES
    Publication number: 20200181194
    Abstract: Compounds of Formula (I)a or (I)b: including certain quinone derivatives, and the corresponding pharmaceutical compositions, which may serve to modulate ferroptosis in a subject. Also disclosed herein are the preparations of these compounds and pharmaceutical compositions and their potential uses in the manufacture of a medicament in reducing reactive oxygen species (ROS) in a cell and for preventing, treating, ameliorating certain related disorder or a disease.
    Type: Application
    Filed: February 10, 2020
    Publication date: June 11, 2020
    Inventors: JIA-NING XIANG, ZUDE QI, DEZHENG NING, XIANBO LIU
  • BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF
    Publication number: 20200181102
    Abstract: The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans.
    Type: Application
    Filed: February 14, 2020
    Publication date: June 11, 2020
    Inventors: JIA-NING XIANG, XUESONG XU, WEI ZHOU
  • Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
    Patent number: 10640451
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Grant
    Filed: October 15, 2019
    Date of Patent: May 5, 2020
    Assignee: XW LABORATORIES INC.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Xuan Zhang
  • Bicyclic heteroaryl derivatives and preparation and uses thereof
    Patent number: 10640476
    Abstract: The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: May 5, 2020
    Assignee: XW LABORATORIES INC.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Wei Zhou
  • Compounds as neuronal histamine receptor-3 antagonists and uses thereof
    Patent number: 10618886
    Abstract: The present invention relates compounds of Formula (A) as H3R antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of Histamine 3 Receptor (H3R) functions. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to H3R functions in humans.
    Type: Grant
    Filed: September 30, 2019
    Date of Patent: April 14, 2020
    Assignee: XW LABORATORIES INC.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Yi Feng, Wai-Si Eng
  • COMPOUNDS AS NEURONAL HISTAMINE RECEPTOR-3 ANTAGONISTS AND USES THEREOF
    Publication number: 20200102289
    Abstract: The present invention relates compounds of Formula (A) as H3R antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of Histamine 3 Receptor (H3R) functions. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to H3R functions in humans.
    Type: Application
    Filed: September 30, 2019
    Publication date: April 2, 2020
    Inventors: JIA-NING XIANG, XUESONG XU, YI FENG, WAI-SI ENG
  • PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF
    Publication number: 20200039917
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Application
    Filed: October 15, 2019
    Publication date: February 6, 2020
    Inventors: Jia-Ning Xiang, Xuesong Xu, Xuan Zhang
  • BICYCLIC HETEROARYL DERIVATIVES AND PREPARATION AND USES THEREOF
    Publication number: 20200017456
    Abstract: The present invention relates compounds of Formula (A), as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to uses of the compounds or pharmaceutical compositions in treating or preventing certain neurological and psychiatric disorders and diseases as well as cancer in humans.
    Type: Application
    Filed: September 30, 2019
    Publication date: January 16, 2020
    Inventors: JIA-NING XIANG, XUESONG XU, WEI ZHOU
  • Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
    Patent number: 10501401
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Grant
    Filed: February 13, 2019
    Date of Patent: December 10, 2019
    Assignee: XW LABORATORIES INC.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Xuan Zhang
  • Prodrugs of gamma-hydroxybutyric acid, compositions and uses thereof
    Patent number: 10457627
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Grant
    Filed: September 22, 2016
    Date of Patent: October 29, 2019
    Assignee: XW LABORATORIES INC.
    Inventors: Jia-Ning Xiang, Xuesong Xu, Xuan Zhang
  • KETAMINE DERIVATIVES AND COMPOSITIONS THEREOF
    Publication number: 20190322618
    Abstract: Ketamine derivatives and pharmaceutical compositions thereof are disclosed. When administered orally the ketamine derivatives provide increased bioavailability of ketamine in the systemic circulation. The ketamine derivatives can be used to treat neurological diseases, psychological diseases and pain.
    Type: Application
    Filed: July 3, 2019
    Publication date: October 24, 2019
    Inventors: Jia-Ning Xiang, Xuesong Xu, Hao-Wei Shih, Wai-si Eng
  • PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF
    Publication number: 20190218168
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Application
    Filed: February 13, 2019
    Publication date: July 18, 2019
    Inventors: Jia-Ning Xiang, Xuesong Xu, Xuan Zhang
  • PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF
    Publication number: 20190194120
    Abstract: The present disclosure discloses prodrugs of gamma-hydroxybutyric acid as well as compositions and uses thereof.
    Type: Application
    Filed: September 22, 2016
    Publication date: June 27, 2019
    Inventors: Jia-Ning Xiang, Xuesong Xu, Xuan Zhang
  • Methods of using prodrugs of pregabalin
    Patent number: 8367722
    Abstract: The present invention provides prodrugs of GABA analogs, pharmaceutical compositions of prodrugs of GABA analogs and methods for making prodrugs of GABA analogs. The present invention also provides methods for using prodrugs of GABA analogs and methods for using pharmaceutical compositions of prodrugs of GABA analogs for treating or preventing common diseases and/or disorders.
    Type: Grant
    Filed: October 14, 2011
    Date of Patent: February 5, 2013
    Assignee: Xenoport, Inc.
    Inventors: Mark A. Gallop, Kenneth C. Cundy, Cindy X. Zhou, Fenmei Yao, Jia-Ning Xiang