Abstract: A nonlinear optical crystal of guanidinium tetrafluoroborate has a chemical formula of [C(NH2)3]BF4 and a molecular weight of 146.89, belongs to the trigonal crystal system, has a space group of R3m; has lattice parameters of a=7.4634(10)?, b=7.4634(10)?, c=9.1216(19) (6)?, and Z=3; has an ultraviolet cutoff edge of 200 nm; and has a frequency-multiplication response that is 4-5 times that of the commercialized nonlinear optical crystal KDP. A hydrothermal method, a room-temperature solution method, an evaporation method or a solvothermal method is used to grow the crystal in a centimeter-scaled size. The crystal can produce frequency-doubling, frequency-tripling, frequency-quadrupling, frequency-quintupling or frequency-sextupling harmonic light output from the fundamental frequency light of 1064 nm generated by a Nd:YAG laser, and/or can produce ultraviolet and deep-ultraviolet frequency-multiplication light output below 200 nm.

Abstract: The present disclosure provides a display panel, a manufacturing method and a display device. The display panel includes a first substrate, a second substrate and liquid crystal molecules. Each sub-pixel includes n domains, and at least two of the n domains are arranged in a first direction. An alignment film is arranged on one or both of the first substrate and the second substrate and provided with alignment directions, and/or slit electrodes each with a slit are arranged on one or both of the first substrate and the second substrate. The alignment directions in at least two adjacent domains in the n domains are different and/or extension directions of the slits in any two adjacent domains are different, so that the liquid crystal molecules in different domains are provided with different pretilt angles.

Abstract: Disclosed is a method for amplifying and detecting polynucleotides which can provide sensitive, specific detection of multiple targets from a clinical specimen within a relatively short time.

Abstract: Disclosed is a method for amplifying RNA and/or DNA from immune cell populations and using the amplified products to produce an immune response profile and evaluate the possible correlation between a normal or abnormal immune response and the development of a disease such as an autoimmune disease, cancer, diabetes, or heart disease.

Abstract: This application provides a call transfer method and a terminal device that are applied to a system including a main terminal device and a first auxiliary terminal device. The main terminal device and the first auxiliary terminal device are connected to a same local area network and log in with a same user account, thereby improving flexibility of a call transfer between the main terminal device and the first auxiliary terminal device and improving call efficiency and user experience.

Abstract: The present disclosure provides a prime lens module and an in-vehicle camera system. From an object side to an imaging side thereof, the prime lens module sequentially includes: a first lens with a negative focal power, a second lens with a negative focal power, a third lens with a positive focal power, a fourth lens with a positive focal power, a fifth lens with a positive focal power, a sixth lens with a negative focal power, and a seventh lens with a positive focal power. The first lens is a meniscus spherical lens. The second lens is a biconcave spherical lens. The third lens is a biconvex spherical lens and bonded to the second lens. The fourth lens is a biconvex spherical lens or a biconvex aspheric lens. The fifth lens is a biconvex spherical lens. The sixth lens is a biconcave spherical lens and bonded to the fifth lens.

Abstract: Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data.

Abstract: The application disclosed concerns a method of treating pneumonia in a patient who is not mechanically ventilated comprising administering an IL-6 antagonist (e.g. tocilizumab) to the patient in an amount effective to prevent the patient from dying or receiving mechanical ventilation. The disclosure is based on the results of the EM PACTA clinical trial.

Abstract: Disclosed is a method for correlating at least one amino acid sequence from an antibody isolated from human or animal blood with at least one DNA sequence corresponding to the antibody in the immunorepertoire of the human or animal. The method also provides a means for pairing heavy and light chains to produce synthesized monoclonal antibodies.

Abstract: An LED drive circuit, comprising: a Flyback circuit that has a current-limiting mode and a constant-voltage mode, a non-isolated DC-DC circuit, and a control circuit. The control circuit is used to detect the output voltage of the Flyback circuit, and, when the output voltage of the Flyback circuit is greater than or equal to a first preset voltage value, control the Flyback circuit to operate in the constant-voltage mode; the control circuit is further used to detect the switch transistor current or output current of the Flyback circuit, and, when the output current of the Flyback circuit is greater than a first preset current value, control the Flyback circuit to operate in the current-limiting mode.

Abstract: An LED drive circuit, comprising: a Flyback circuit that has a current-limiting mode and a constant-voltage mode, a non-isolated DC-DC circuit, and a control circuit. The control circuit is used to detect the output voltage of the Flyback circuit, and, when the output voltage of the Flyback circuit is greater than or equal to a first preset voltage value, control the Flyback circuit to operate in the constant-voltage mode; the control circuit is further used to detect the switch transistor current or output current of the Flyback circuit, and, when the output current of the Flyback circuit is greater than a first preset current value, control the Flyback circuit to operate in the current-limiting mode.

Abstract: The present disclosure provides the synthesis and application of respiratory syncytial virus inhibitor, being a compound of formula I or a pharmaceutically acceptable salt, ester, isomer, solvate, prodrug or isotope label thereof. Compared with the existing inhibitors, the compounds of formula I have the advantages of superior activity and higher exposure in vivo.

Abstract: The present disclosure relates to methods for amplifying nucleic acids that avoid problems associated with primer-dimer formation. The present methods are referred to herein as dimer avoided multiplex polymerase chain reaction (dam-PCR). The methods disclosed herein generally comprise the steps of reverse transcribing at least one first strand of DNA, for example cDNA from an RNA sample, wherein each first strand of DNA incorporates a reverse common primer binding site; selecting each first strand of DNA; synthesizing at least one second strand of DNA from each of the at least one first strand of DNA, wherein each second strand of DNA incorporates a forward common primer binding site; selecting each second strand of cDNA; and amplifying the DNA strands using common primers. Alternatively, the method may be performed using a gDNA template.

Abstract: Disclosed is a method for amplifying and detecting polynucleotides which can provide sensitive, specific detection of multiple targets from a clinical specimen within a relatively short time.

Abstract: This disclosure generally relates a method of amplifying TCR alpha chain VDJ and/or TCR beta chain VDJ sequences by reverse transcribing at least one first strand of cDNA from mRNA containing at least one target sequence using an oligo-dT primer, using a multiplex primer mix of primers configured to bind to TCR alpha chain VDJ and/or TCR beta chain VDJ sequences to amplify the cDNA, using probe capture to capture TCR VDJ-specific amplicons and elute non-TCR VDJ-specific amplicons, performing an additional round of PCR to further enrich TCR alpha chain VDJ and TCR beta chain VDJ amplicons, and sequencing the resulting amplicons using next generation sequencing.

Abstract: The present disclosure generally pertains to a method for developing diagnostic tests that are based on the immune response and the resulting immune repertoire. The presently disclosed method increases the signal and reduces the background to allow the identification of shared CDR3s that can be used to produce a disease signature. The presently disclosed method may be used to develop a diagnostic test for different diseases including, but not limited to, cancer, autoimmune disease, inflammatory disease and infectious disease.

Abstract: A visual recognition system for wind turbines, including an intelligent analysis unit configured to analyze and determine data information, an intelligent service unit configured to transmit image data, a telecontrol platform, a graphic workstation, an intelligent processing unit configured to process video files, a router, a video storage unit configured to store video information, an intelligent binocular perception terminal, an intelligent perception terminal and an intelligent recognition terminal, where the intelligent binocular perception terminal, the intelligent perception terminal and the intelligent recognition terminal are connected to the video storage unit and the intelligent processing unit through optical fibers and the router.

Abstract: The present disclosure relates to systems and methods for assessing the immunorepertoire and wellness of an individual. This disclosure contemplates an individual submitting: (a) identifying information (such as family medical history, age, gender, and other identifying information) to a database on or accessible by a server by connecting a device, such as a smartphone, to a web application; and (b) a blood sample for immune repertoire processing and submission of the resulting data to the database. The data are processed by a server, which accesses a database. The individual may then access a customized report using a web application accessible by a smartphone or other Internet-connected device. The customized report displays the individuals immunorepertoire indexes. Three immunorepertoire indexes disclosed herein include the: (1) clonotype index; (2) essential index; and (3) diversity index.

Abstract: The present disclosure provides a series of dihydroisoquinoline compounds or a pharmaceutically acceptable salt, ester, isomer, solvate, hydrate, prodrug, or isotopically labeled compounds thereof, having the structure of general formula I: (I). The compounds have an extremely strong activity for inhibiting Hepatitis B surface antigen and has an extremely strong activity for inhibiting Hepatitis B virus DNA. In addition, the compounds feature high bioavailability and can exhibit efficacy with a low dosage, which reduces the potential toxicity of the compounds.