Abstract: Disclosed is a method for calculating a Polymerase Preference Index (PPI) for potential primers for DNA sequencing and/or amplification, and thereby increasing the efficiency of DNA sequencing and/or amplification performed using primers selected according to their PPI number.

Abstract: A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.

Abstract: The present disclosure relates to methods for amplifying nucleic acids that avoid problems associated with primer-dimer formation. The present methods are referred to herein as dimer avoided multiplex polymerase chain reaction (dam-PCR). The methods disclosed herein generally comprise the steps of reverse transcribing at least one first strand of DNA, for example cDNA from an RNA sample, wherein each first strand of DNA incorporates a reverse common primer binding site; selecting each first strand of DNA; synthesizing at least one second strand of DNA from each of the at least one first strand of DNA, wherein each second strand of DNA incorporates a forward common primer binding site; selecting each second strand of cDNA; and amplifying the DNA strands using common primers. Alternatively, the method may be performed using a gDNA template.

Abstract: The present invention pertains to methods for determining the change in the immune repertoire of an individual suffering from disease or undergoing therapy for the treatment of a disease. The methods use the difference between the change in the level of immune cell diversity seen in an individual before, during or after a health event to determine the effect of the disease, or the effect of a treatment regime, on the individual. The difference in the level of immune cell diversity is referred to as the Delta Index and is defined as the quantitative and qualitative change (gain or loss of clones) of an individual's most dynamic immune cells over time.

Abstract: A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.

Abstract: Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data.

Abstract: A data forwarding method is provided for a data forwarding apparatus. The method includes, when a first port receives a to-be-forwarded data packet, executing a network adapter driver corresponding to the first port to read the to-be-forwarded data packet from a network adapter cache corresponding to the first port. The network adapter cache stores address forwarding information obtained from an operating system kernel bridge. The method also includes searching the address forwarding information in the network adapter cache for address forwarding information corresponding to the data packet and, when the address forwarding information corresponding to the data packet is found, determining a target network adapter driver for forwarding the data packet based on the found address forwarding information, and directly sending the data packet to the target network adapter driver, such that the target network adapter driver forwards the data packet through a second port.

Abstract: A method and apparatus for distinguishing voice signals that are played together over the same speaker employs spectral reshaping of one or more of the audio signals. The spectral reshaping shifts modifies the timber of the voice signal while not modifying the pitch of the voice signal. Additional techniques can be used to further distinguish voice signals, such as dynamic gain offset and frequency shifting. After processing one or more signals to spectrally reshape them, they can be played over the same speaker. A user hearing the resulting acoustic signal will be more able to distinguish between the multiple voice signals being played.

Abstract: The present invention encompasses a stabilized parasiticidal granule composition comprising a macrocyclic lactone compound and an insect growth regulator. The invention also encompasses methods of making and methods of using the granule for treating, controlling or preventing parasitic infestation or parasitic infection in an animal.

Abstract: The present disclosure generally pertains to a multiplex method for analyzing samples comprising using polynucleotide amplification to produce amplified products wherein one or more target sequences are tagged with a non-interfering, non-canceling target-specific polynucleotide identification tag, pyrosequencing the amplified products through the non-canceling target-specific polynucleotide identification tag sequence to detect the presence of one or more specific polynucleotide identification tags. The presence of a specific polynucleotide identification tag being correlated with the presence of a specific target sequence.

Abstract: An apparatus for driving an e-paper display is provided. The display includes a plurality of segments. The apparatus includes: a memory module for each segment; a SEG 4-to-1 multiplexor connected with the memory module for each segment; a 2-to-1 multiplexor connected with the SEG 4-to-1 multiplexor for each segment; a SEG waveform generator connected with the SEG 4-to-1 multiplexor; a COM waveform generator connected with the 2-to-1 multiplexor; a SEG waveform table connected with the SEG waveform generator; and a COM waveform table connected with the COM waveform generator. The memory module for each segment includes an old Data corresponding to a current state of the segment of the display, a new Data corresponding to a new state to be driven for the segment in a display update period, and a COM_Option memory corresponding to an option state. A method for driving an e-paper display is also provided.

Abstract: A method and apparatus for distinguishing voice signals that are played together over the same speaker employs spectral reshaping of one or more of the audio signals. The spectral reshaping shifts modifies the timber of the voice signal while not modifying the pitch of the voice signal. Additional techniques can be used to further distinguish voice signals, such as dynamic gain offset and frequency shifting. After processing one or more signals to spectrally reshape them, they can be played over the same speaker. A user hearing the resulting acoustic signal will be more able to distinguish between the multiple voice signals being played.

Abstract: An apparatus for driving an e-paper display is provided. The display includes a plurality of segments. The apparatus includes: a memory module for each segment; a SEG 4-to-1 multiplexor connected with the memory module for each segment; a 2-to-1 multiplexor connected with the SEG 4-to-1 multiplexor for each segment; a SEG waveform generator connected with the SEG 4-to-1 multiplexor; a COM waveform generator connected with the 2-to-1 multiplexor; a SEG waveform table connected with the SEG waveform generator; and a COM waveform table connected with the COM waveform generator. The memory module for each segment includes an old Data corresponding to a current state of the segment of the display, a new Data corresponding to a new state to be driven for the segment in a display update period, and a COM_Option memory corresponding to an option state. A method for driving an e-paper display is also provided.

Abstract: A method and apparatus for collaboration among two-way radio devices allows a portable two-way radio device and a mobile two-way radio device to each enter into a collaboration mode while the are paired with each other over a short range wireless radio network. While in the collaboration mode, when the user keys the portable two-way radio device audio is routed from the portable two-way radio device to the mobile two-way radio device over the short range wireless network and the mobile two-way radio device transmits the audio on behalf of the portable two-way radio device.

Abstract: Provided area deep ultraviolet non-linear optical crystal of barium borate hydrate, a preparation method therefor and the use thereof. The chemical formula of the crystal is Ba2B11O22H7, belonging to monoclinic system, with the space group thereof being P21, the crystal cell parameters thereof being a=6.7719(10) ?, b=21.1195(4) ?, c=6.8274(10) ?, ?=119.3950(10) °, and the molecular weight thereof being 752.65. The non-linear optical crystal of borate is obtained by means of programmed cooling or natural cooling using a hydrothermal method. The crystal powder has a frequency-doubled effect of about 2 times that of KDP (KH2PO4) and an ultraviolet cut-off edge of below 175 nm and can be used as a deep ultraviolet non-linear optical crystal. The growth process of the crystal has advantages such as simple, a low cost, a low toxicity, a short growth cycle, stable physical and chemical properties, etc.

Abstract: The present disclosure generally pertains to a method for comparing the immunorepertoire diversity of a patient to the shared immunorepertoire of a group of individuals to identify whether the immunorepertoire diversity of the patient is normal or abnormal relative to the shared immunorepertoire of the group of individuals.

Abstract: The present disclosure generally pertains to a method for developing diagnostic tests that are based on the immune response and the resulting immune repertoire. The presently disclosed method increases the signal and reduces the background to allow the identification of shared CDR3s that can be used to produce a disease signature. The presently disclosed method may be used to develop a diagnostic test for different diseases including, but not limited to, cancer, autoimmune disease, inflammatory disease and infectious disease.

Abstract: A method and apparatus for collaboration among two-way radio devices allows a portable two-way radio device and a mobile two-way radio device to each enter into a collaboration mode while the are paired with each other over a short range wireless radio network. While in the collaboration mode, when the user keys the portable two-way radio device audio is routed from the portable two-way radio device to the mobile two-way radio device over the short range wireless network and the mobile two-way radio device transmits the audio on behalf of the portable two-way radio device.

Abstract: The present invention pertains to methods for determining the change in the immune repertoire of an individual suffering from disease or undergoing therapy for the treatment of a disease. The methods use the difference between the change in the level of immune cell diversity seen in an individual before, during or after a health event to determine the effect of the disease, or the effect of a treatment regime, on the individual. The difference in the level of immune cell diversity is referred to as the Delta Index and is defined as the quantitative and qualitative change (gain or loss of clones) of an individual's most dynamic immune cells over time.

Abstract: Disclosed is a method for amplifying RNA from T and B-cell populations and using the amplified RNA products to evaluate the possible correlation between a normal or abnormal immune response and the development of a disease such as an autoimmune disease, cancer, diabetes, or heart disease.