Abstract: The present disclosure relates to systems and methods for assessing the immunorepertoire and wellness of an individual. This disclosure contemplates an individual submitting: (a) identifying information (such as family medical history, age, gender, and other identifying information) to a database on or accessible by a server by connecting a device, such as a smartphone, to a web application; and (b) a blood sample for immune repertoire processing and submission of the resulting data to the database. The data are processed by a server, which accesses a database. The individual may then access a customized report using a web application accessible by a smartphone or other Internet-connected device. The customized report displays the individuals immunorepertoire indexes. Three immunorepertoire indexes disclosed herein include the: (1) clonotype index; (2) essential index; and (3) diversity index.

Abstract: The present disclosure provides a series of dihydroisoquinoline compounds or a pharmaceutically acceptable salt, ester, isomer, solvate, hydrate, prodrug, or isotopically labeled compounds thereof, having the structure of general formula I: (I). The compounds have an extremely strong activity for inhibiting Hepatitis B surface antigen and has an extremely strong activity for inhibiting Hepatitis B virus DNA. In addition, the compounds feature high bioavailability and can exhibit efficacy with a low dosage, which reduces the potential toxicity of the compounds.

Abstract: The present disclosure relates to methods and devices for the collection of exhaled aerosols. In some embodiments, the device disclosed herein comprises a cup and an attachable lid, wherein the cup has a conical base and the lid includes a pipette access port with a removable cap and a sealed buffer reservoir. In some embodiments, the method for a subject to collect exhaled aerosols disclosed herein comprises the steps of placing a collection cup against the subject's mouth, the subject coughing into the collection cup at least once, immediately closing the device by reattached a lid to the collection cup, placing the collection cup in a transport bag, and providing the transport bag to a processor.

Abstract: A wide-angle lens in the following order from an object side toward an image plane includes: a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens, a seventh lens, an optical reflecting member, and an optical filter. The first lens has negative refractive power and a concave image side surface. The second lens has negative refractive power and a concave image side surface. The third lens has positive refractive power. The fourth lens has positive refractive power and a concave image side surface. The fifth lens has negative refractive power, a concave object side surface, and a concave image side surface. The sixth lens has positive refractive power, a convex object side surface, and a convex image side surface. The seventh lens has positive refractive power, a convex object side surface, and a convex image side surface. Each of the first lens and the third lens is a spherical lens.

Abstract: A data forwarding method is provided for a data forwarding apparatus. The method includes, when a first port receives a to-be-forwarded data packet, executing a network adapter driver corresponding to the first port to read the to-be-forwarded data packet from a network adapter cache corresponding to the first port. The network adapter cache stores address forwarding information obtained from an operating system kernel bridge. The method also includes searching the address forwarding information in the network adapter cache for address forwarding information corresponding to the data packet and, when the address forwarding information corresponding to the data packet is found, determining a target network adapter driver for forwarding the data packet based on the found address forwarding information, and directly sending the data packet to the target network adapter driver, such that the target network adapter driver forwards the data packet through a second port.

Abstract: A wide-angle lens in the following order from an object side toward an image plane includes: a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens, a seventh lens, an optical reflecting member, and an optical filter. The first lens has negative refractive power and a concave image side surface. The second lens has negative refractive power and a concave image side surface. The third lens has positive refractive power. The fourth lens has positive refractive power and a concave image side surface. The fifth lens has negative refractive power, a concave object side surface, and a concave image side surface. The sixth lens has positive refractive power, a convex object side surface, and a convex image side surface. The seventh lens has positive refractive power, a convex object side surface, and a convex image side surface. Each of the first lens and the third lens is a spherical lens.

Abstract: The present invention encompasses a stabilized parasiticidal granule composition comprising a macrocyclic lactone compound and an insect growth regulator. The invention also encompasses methods of making and methods of using the granule for treating, controlling or preventing parasitic infestation or parasitic infection in an animal.

Abstract: The present disclosure generally pertains to a method for comparing the immunorepertoire diversity of a patient to the shared immunorepertoire of a group of individuals to identify whether the immunorepertoire diversity of the patient is normal or abnormal relative to the shared immunorepertoire of the group of individuals.

Abstract: A system for performing a chemical and/or biological process has a pipette for processing material used in the process. The pipette can have a tip that can pierce a sealing material of a chamber and then be placed in contact with the bottom surface of the chamber that is housing a material used in the process. The tip has a plurality of passageways with openings located along the outer perimeter of the tip. The placement of the openings at the outer perimeter permits the tip to be placed on the bottom surface of a chamber such that most of the material in the chamber can be extracted by the pipette. In addition, the placement of the tip on the bottom surface of the chamber with openings along the outer perimeter of the tip permits the pipette to agitate existing material in the chamber when the pipette is providing additional material into the chamber.

Abstract: Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data.

Abstract: The present disclosure provides a prime lens module and an in-vehicle camera system. From an object side to an imaging side thereof, the prime lens module sequentially includes: a first lens with a negative focal power, a second lens with a negative focal power, a third lens with a positive focal power, a fourth lens with a positive focal power, a fifth lens with a positive focal power, a sixth lens with a negative focal power, and a seventh lens with a positive focal power. The first lens is a meniscus spherical lens. The second lens is a biconcave spherical lens. The third lens is a biconvex spherical lens and bonded to the second lens. The fourth lens is a biconvex spherical lens or a biconvex aspheric lens. The fifth lens is a biconvex spherical lens. The sixth lens is a biconcave spherical lens and bonded to the fifth lens.

Abstract: Disclosed is a method for calculating a Polymerase Preference Index (PPI) for potential primers for DNA sequencing and/or amplification, and thereby increasing the efficiency of DNA sequencing and/or amplification performed using primers selected according to their PPI number.

Abstract: A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.

Abstract: The present disclosure relates to methods for amplifying nucleic acids that avoid problems associated with primer-dimer formation. The present methods are referred to herein as dimer avoided multiplex polymerase chain reaction (dam-PCR). The methods disclosed herein generally comprise the steps of reverse transcribing at least one first strand of DNA, for example cDNA from an RNA sample, wherein each first strand of DNA incorporates a reverse common primer binding site; selecting each first strand of DNA; synthesizing at least one second strand of DNA from each of the at least one first strand of DNA, wherein each second strand of DNA incorporates a forward common primer binding site; selecting each second strand of cDNA; and amplifying the DNA strands using common primers. Alternatively, the method may be performed using a gDNA template.

Abstract: The present invention pertains to methods for determining the change in the immune repertoire of an individual suffering from disease or undergoing therapy for the treatment of a disease. The methods use the difference between the change in the level of immune cell diversity seen in an individual before, during or after a health event to determine the effect of the disease, or the effect of a treatment regime, on the individual. The difference in the level of immune cell diversity is referred to as the Delta Index and is defined as the quantitative and qualitative change (gain or loss of clones) of an individual's most dynamic immune cells over time.

Abstract: A compound of general formula I: is disclosed. The compound be used to prevent or treat hepatitis B virus infection.

Abstract: Embodiments of the present disclosure generally pertain to systems and methods for performing amplicon rescue multiplex polymerase chain reaction (arm-PCR). In one embodiment, the system comprises a processor and a reader coupled to a control element. The control element is configured to control the operation of the processor and the reader based on a variety of settings. The processor is configured to receive a self-contained cassette for performing PCR amplification of DNA and/or RNA obtained from an organic specimen. The processor engages with the cassette and manipulates reagents within the cassette in order to amplify and detect the DNA from the specimen. The processor also causes the cassette to deposit the DNA on a microarray within the cassette. The reader is configured to receive the cassette after it has been processed by the processor and to capture an image of the microarray for transmission to the control element as test data.

Abstract: A data forwarding method is provided for a data forwarding apparatus. The method includes, when a first port receives a to-be-forwarded data packet, executing a network adapter driver corresponding to the first port to read the to-be-forwarded data packet from a network adapter cache corresponding to the first port. The network adapter cache stores address forwarding information obtained from an operating system kernel bridge. The method also includes searching the address forwarding information in the network adapter cache for address forwarding information corresponding to the data packet and, when the address forwarding information corresponding to the data packet is found, determining a target network adapter driver for forwarding the data packet based on the found address forwarding information, and directly sending the data packet to the target network adapter driver, such that the target network adapter driver forwards the data packet through a second port.

Abstract: A method and apparatus for distinguishing voice signals that are played together over the same speaker employs spectral reshaping of one or more of the audio signals. The spectral reshaping shifts modifies the timber of the voice signal while not modifying the pitch of the voice signal. Additional techniques can be used to further distinguish voice signals, such as dynamic gain offset and frequency shifting. After processing one or more signals to spectrally reshape them, they can be played over the same speaker. A user hearing the resulting acoustic signal will be more able to distinguish between the multiple voice signals being played.