Abstract: The present disclosure a method for activating immunocytes in vitro by VAK technique. Autologous immunocytes of the cancer patient can be activated in vitro by the VAK technique, and by re-infusing these activated immunocytes into the patient's body, a good anti-tumor effect can be achieved, and because these immunocytes are autologous immunocytes, there is no rejection, being safe and reliable.

Abstract: A molecular imaging agent including a detectable moiety, a chelation moiety, and a carrier moiety is provided. In one embodiment, the detectable moiety is coupled to the chelation moiety and the chelation moiety is linked to the carrier moiety. In another embodiment, the detectable moiety is 99mTc; the chelation moiety includes HYNIC; and the carrier moiety includes from N-terminus to C-terminus: a His6 purification tag, a human VEGFA polybasic tag sequence, and a human Fc stabilization segment.

Abstract: A method for identifying a shape of a borehole may comprise disposing a measurement assembly into the borehole, transmitting a pressure pulse from the at least one transducer, recording the echo with the at least one transducer producing data points based at least in part on the echo to determine a distance from an inner wall of the borehole to the measurement assembly; performing a kurtosis on the data points; comparing a result of the kurtosis to a pre-determined threshold; and producing one or more repositioning results based at least in part on the comparing the result of the kurtosis to the pre-determined threshold. A system may comprise a measurement assembly which may include at least one transducer connected to the measurement assembly and an information handling system.

Abstract: The invention relates to quinazoline compounds, the preparation method, use, and the pharmaceutical composition thereof. The said quinazoline compounds, which are represented by Formula (I), are phosphatidylinositol 3-kinase (PI3K) inhibitors, and can be applied to prevent and/or treat PI3K activity-related diseases, such as cancer, immune diseases, cardiovascular diseases, viral infections, inflammation, metabolism/endocrine function disorders or neurological diseases.

Abstract: The present invention relates to vaccine compositions, most notably vaccine compositions wherein the antigenic component is large, for example over 50 kDa, or multimeric, i.e. comprised of subunits. Such antigenic components are of particular interest, because they may represent antigenic components from pathogens that currently it is not possible to vaccinate against. The invention relates to a composition comprising a particle displaying an antigenic component, wherein said composition comprises an antigenic component comprising a first peptide tag, and a moiety comprising a second peptide tag, wherein the antigenic component and the moiety are linked via an isopeptide bond between said first and second peptide tags, and wherein the antigenic component is over 50 kDa, or alternatively is multimeric.

Abstract: Ringdown noise can be estimated and removed from a waveform captured by a downhole tool. Ringdown may be estimated by calculating a median of waveforms from a number of tool firings. The estimated ringdown may then be subtracted from a waveform currently being processed. The resulting waveform contains a more accurate representation of a true echo signal reflected from the borehole wall or formation. In some embodiments, the acoustic transducer's deterministic waveform may be learned by statistical analysis of other waveforms near in time to the presently measured waveform. In other embodiments, the deterministic waveform may be learned via previously acquired waveforms now stored in memory, or through predictive waveforms developed in laboratory testing conditions similar to those experienced downhole.

Abstract: A method for identifying a leak for dynamic logging may comprise estimating a Stoneley wave slowness, separating a Stoneley wave into an up-going Stoneley wave and a down-going Stoneley wave, estimating an amplitude of the up-going Stoneley wave and the down-going Stoneley wave, identifying a difference between the amplitude of the up-going Stoneley wave and the down-going Stoneley wave, forming an amplitude summation curve or an amplitude difference curve, and identifying a location of the leak.

Abstract: A downhole tool is placed in a borehole of a subsurface formation. The downhole tool comprises a plurality of calipers arranged around a circumference of the downhole tool. A plurality of standoff measurements is received for different rotation angles of the downhole tool, wherein each standoff measurement is indicative of a distance between one of the plurality of calipers and a wall of the borehole. A plurality of apparent diameters of the borehole is determined for the different rotation angles of the downhole tool based on the plurality of standoff measurements and a radius of the downhole tool. A probability function is determined based on the plurality of apparent diameters and at least one of a semiminor axis, semimajor axis, and ellipticity of the borehole is identified based on the probability function.

Abstract: A biometric verification system is disclosed. The system includes a portable device which stores a biometric reference template and authentication preferences, The portable device can be used with an access device. The access device can prompt the user for a biometric sample, The access device may create a biometric sample template from the biometric sample, and the biometric sample template can be compared to the biometric reference template to determine if a user is authentic.

Abstract: A well tool can be used in a wellbore that can measure characteristics of an object in the wellbore. The well tool includes an ultrasonic transducer for generating an ultrasonic wave in a medium of the wellbore. The ultrasonic transducer includes a front layer, a rear layer, backing material coupled to the rear layer, and piezoelectric material coupled to the front layer and to the backing material. The rear layer can improve signal-to-noise ratio of the transducer in applications such as imaging and caliper applications.

Abstract: Systems and methods allow for incident data collection and management system based on unmanned aerial vehicles (UAVs), that is, drones to help accelerate the data collection and analytics, information dissemination, and decision support at incident sites. The system architecture may include onsite, server, and offline components including flight planning subsystem, flight execution and mission control subsystem, information dissemination subsystem to travelers and traveler information services, the interface with traffic management center, and the data analytic, visualization, and training subsystems. Other embodiments include the video-based 3D incident site reconstruction methods, site positioning and scaling methods with pre-collected static background infrastructure data, data management and user charging methods, and training methods with the generated 3D model.

Abstract: Multi-directional ultrasonic transducers useful for small downhole applications where two or more separate or larger transducers are too large. The transducer includes a backing material having two or more piezoelectric elements attached thereto. The piezoelectric elements are attached to the backing such that each elements transmit ultrasounds in different directions. An encapsulating material surrounds both the piezoelectric elements and the backing. Since the piezoelectric elements share the same backing and the same encapsulation, the form factor of the multi-directional transducer is greatly reduced in comparison to conventional transducer designs.

Abstract: The subject disclosure provides for a method of eccentricity correction of a borehole shape computation. The method includes deploying a caliper tool into a borehole penetrating a subterranean formation and acquiring field measurements with the deployed caliper tool. The method includes applying, in a processor circuit, an eccentricity correction algorithm to one or more standoff samples from the obtained field measurements, wherein the eccentricity correction algorithm produces a shape fitted curve that represents a measured borehole with a least number of points outside of the shape fitted curve and a least amount of error. The method includes determining eccentricity-corrected borehole coordinates with the applied eccentricity correction algorithm and determining a borehole shape from the eccentricity-corrected borehole coordinates. The method includes determining tool location coordinates relative to the borehole with the determined borehole shape.

Abstract: Methods, systems and devices are disclosed for controlling self-induced acoustic interference. In one embodiment, a first piezoelectric transducer to which a first excitation signal is applied, generates back side acoustic waves that are transmitted from a back side of the first piezoelectric transducer into a backing material layer. A second piezoelectric transducer coupled to a back side of the backing material layer generates a first calibration response to the back side acoustic waves. An interference signal profile is generated based, at least in part, on the first calibration response and may be used to filter interference signal components and/or to generate a control signal to be applied to the second piezoelectric transducer during measurement cycles.

Abstract: Some embodiments provide systems and methods for confidentially and securely provisioning data to an authenticated user device. A user device may register an authentication public key with an authentication server. The authentication public key may be signed by an attestation private key maintained by the user device. Once the user device is registered, a provisioning server may send an authentication request message including a challenge to the user device. The user device may sign the challenge using an authentication private key corresponding to the registered authentication public key, and may return the signed challenge to the provisioning server. In response, the provisioning server may provide provisioning data to the user device. The registration, authentication, and provisioning process may use public key cryptography while maintaining confidentiality of the user device, the provisioning server, and then authentication server.

Abstract: A process for authenticating a communication device may include receiving an authentication request including an access credential having a timestamp generated by the communication device may be received by the server. A determination can be made as to whether the communication device had successfully executed a predetermined shutdown sequence by determining whether the access credential has reliable timestamp information. The communication device can be authenticated when the timestamp has a non-reset value indicating that the communication device had successfully executed the predetermined shutdown sequence, and that the access credential has not expired. Step-up authentication for the communication device can be requested when the access credential has unreliable timestamp information indicating that the communication device did not successfully execute the predetermined shutdown sequence.

Abstract: The present invention relates to a benzamide compound and a preparation method, use and pharmaceutical composition thereof. The benzamide compound represented by formula (I) is a STAT3 inhibitor, and can be used to prevent and/or treat a disease related to STAT3 activity, such as a tumor, autoimmune disease, renal disease, cardiovascular disease, inflammation, metabolic/endocrine dysfunction, and neurological disease.

Abstract: A transducer, method, and downhole tool for acoustic logging. The acoustic transducer comprises a piezoelectric material comprising a body and grooves formed on the body. The grooves comprise a first groove that intersects with a second groove on the body. The method of acoustic logging a wall comprises transmitting an acoustic pulse at the wall using the acoustic transducer. The method also comprises generating a signal indicative of a reflection of the pulse using the acoustic transducer; and determining an acoustic parameter based on the signal using a processor. The acoustic logging tool is locatable in a wellbore intersecting a subterranean earth formation. The acoustic logging tool comprises the acoustic transducer and a processor configured to determine an acoustic parameter based on a signal generated by the acoustic transducer, the signal being indicative of the acoustic wave.

Abstract: The present invention relates to a multidimensional ecological preservation technology for sweet potatoes, including the following steps: collecting mature tuberous roots in proper time; and performing BTH soak cleaning to promote callus, and performing callus treatment as follows: pretreatment before storage, disinfection in a cellar, sand storage, tent air conditioning, and performing secondary cobalt ray irradiation at an irradiation dose of 0.1-0.5 kGy before the end of storage and marketing, thereby achieving dual guarantee of storage period and shelf life. In the present invention, the traditional sand is replaced with a sandy material (having a particle size of 1-3 mm), and the sandy material is lightweight, breathable, and high in water absorbing and retaining property, thermal insulation and heat preservation.

Abstract: The present invention relates to a method for three-dimensional microwave air-jet drying of persimmon slices, comprising steps of grading and cleaning, slicing, microwave heating, steam de-astringency, hot-air reverse primary drying, negative-pressure intermittent secondary drying, cooling and packaging. In the present invention, high-temperature (60-70° C.) high-pressure annularly sprayed citric acid and 40% alcohol vapor (rotating at 360°) are adopted to remove astringency of persimmons, wherein high temperature causes more intense Brownian motion of liquid molecules; high pressure improves permeation and diffusion speed of de-astringency liquid in the persimmon slices; citric acid plays a membrane breaking role on persimmon cell membranes; and 40% alcohol vapor is allowed to rapidly diffuse into cells, so that tannin is polymerized into insoluble gel from a soluble state, thereby achieving a uniform and rapid de-astringency effect.