Patents by Inventor Johannes Platzek

Johannes Platzek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the preparation of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro- 1-6-naphthyridine-3-carbox-amide and the purification thereof for use as an active pharmaceutical ingredient
    Patent number: 10059707
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: August 28, 2018
    Assignee: BAYER PHARMA AG
    Inventors: Johannes Platzek, Gunnar Garke, Alfons Grunenberg
  • METHOD FOR THE PREPARATION OF THE METABOLITES OF (4S)- AND (4R)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1,6-NAPHTHYRIDINE-3-CARBOXAMIDE AND THE USE THEREOF
    Publication number: 20180237414
    Abstract: The present invention relates to a novel method for preparing (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula 4R (I) and the metabolites of (4S)- and (4R)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I), the formulae M1a (S), M1b (R), M2a (S), M2b (R), M3a (S) and M3b (R) and use thereof.
    Type: Application
    Filed: August 15, 2016
    Publication date: August 23, 2018
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Johannes Platzek, Ludwig Zorn
  • NEW GADOLINIUM CHELATE COMPOUNDS FOR USE IN MAGNETIC RESONANCE IMAGING
    Publication number: 20180169274
    Abstract: The present invention relates to a new class of high relaxivity extracellular gadolinium chelate complexes, to methods of preparing said compounds, and to the use of said compounds as MRI contrast agents.
    Type: Application
    Filed: May 30, 2016
    Publication date: June 21, 2018
    Inventors: MARKUS BERGER, JESSICA LOHRKE, CHRISTOPH-STEPHAN HILGER, GREGOR JOST, THOMAS FRENZEL, DETLEV SUELZLE, JOHANNES PLATZEK, OLAF PANKNIN, HUBERTUS PIETSCH
  • PREPARATION OF HIGH-PURITY GADOBUTROL
    Publication number: 20180105537
    Abstract: A process for producing high-purity gadobutrol in a purity (according to HPLC) of more than 99.7 or 99.8 or 99.9% and the use for preparing a pharmaceutical formulation for parenteral administration is described. The process is carried out using specifically controlled crystallization conditions.
    Type: Application
    Filed: July 31, 2017
    Publication date: April 19, 2018
    Inventors: JOHANNES PLATZEK, WILHELM TRENTMANN
  • METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOX-AMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT
    Publication number: 20170217957
    Abstract: The present invention relates to a novel and improved process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I) and also the preparation and use of the crystalline polymorph I of (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (I).
    Type: Application
    Filed: July 29, 2015
    Publication date: August 3, 2017
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Johannes PLATZEK, Gunnar GARKE, Alfons GRUNENBERG
  • Process for the preparation of calcobutrol
    Patent number: 9447053
    Abstract: A process for the preparation of the calcium complex of 10-(2, 3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclodecane-4,7-triacetic acid, also known as Calcobutrol, starting from the pure gadolinium complex (Gadobutrol) is disclosed. Also disclosed is Calcobutrol with a hitherto unknown level of purity.
    Type: Grant
    Filed: November 2, 2010
    Date of Patent: September 20, 2016
    Assignee: Bayer Intellectual Property GMBH
    Inventors: Johannes Platzek, Wilhelm Trentmann
  • PREPARATION OF HIGH-PURITY GADOBUTROL
    Publication number: 20140107325
    Abstract: What is described is a process for producing high-purity gadobutrol in a purity (according to HPLC) of more than 99.7 or 99.8 or 99.9% and the use for preparing a pharmaceutical formulation for parenteral administration. The process is carried out using specifically controlled crystallization conditions. The more recent developments in the field of the gadolinium-containing MR contrast agents (EP 0448191 B1, CA Patent 1341176, EP 0643705 B1, EP 0986548 B1, EP 0596586 B1) include the MRT contrast agent gadobutrol (Gadovist® 1.0) which has been approved for a relatively long time in Europe and more recently also in the USA under the name Gadavist®.
    Type: Application
    Filed: April 17, 2012
    Publication date: April 17, 2014
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Johannes Platzek, Wilhelm Trentmann
  • Process for Preparing Crystalline 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic Acid and Use for Production of Primovist®
    Publication number: 20130158241
    Abstract: The invention relates to a method for producing crystalline 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula I by saponifying 3,6,9-triaza-3,6,9-tris(tert-butoxycarbonylmethyl)-4-(4-ethoxybenzyl)-undecanedioic acid di-tert-butyl ester of the formula II in an aqueous alkali metal hydroxide solution and using 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid of the formula I for producing the gadolinium complex of 3,6,9-triaza-3,6,9-tris(carboxymethyl)-4-(4-ethoxybenzyl)undecanedioic acid [(Gd-EOB-DTPA)=Primovist®].
    Type: Application
    Filed: June 6, 2011
    Publication date: June 20, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Johannes Platzek, Wilhelm Trentmann
  • Gadobutrol Preparation in a One-Pot Process by means of DMF Acetal and N-Methylimidazole
    Publication number: 20130116429
    Abstract: A process is described for preparation of the gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane “gadobutrol=Gadovist®” in a one-pot process by means of DMF acetal and N-methylimidazole. Gadovist is a gadolinium-containing contrast agent for nuclear spin tomography and has been approved since 2000 in Germany in the indication “contrast amplification in cranial and spinal magnetic resonance tomography”.
    Type: Application
    Filed: May 31, 2011
    Publication date: May 9, 2013
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventor: Johannes Platzek
  • PROCESS FOR THE PREPARATION OF CALCOBUTROL
    Publication number: 20120309962
    Abstract: The invention concerns a process for the preparation of the calcium complex of 0-(2,3-Dihydroxy-1-(hydroxymethyl)propyl)-1,4,7,10-tetraazacyclodecane-4,7-triacetic acid, also known as Calcobutrol, starting from the pure gadolinium complex (Gadobutrol). The invention furthermore concerns Calcobutrol with a hitherto unknown level of purity.
    Type: Application
    Filed: November 2, 2010
    Publication date: December 6, 2012
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Johannes Platzek, Wilhelm Trentmann
  • Process for preparing epothilone derivatives by selective catalytic epoxidation
    Patent number: 8314248
    Abstract: The present invention describes a novel process for preparing an epothilone derivative using substituted pyridines and methyltrioxorhenium as catalyst.
    Type: Grant
    Filed: November 30, 2011
    Date of Patent: November 20, 2012
    Assignee: Bayer Pharma AG
    Inventors: Johannes Platzek, Orlin Petrov, Stephan Prühs
  • Metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use
    Patent number: 8263040
    Abstract: The invention relates to the subjects characterized in the patent claims, namely metal chelates having a perfluorinated PEG radical, processes for their preparation, and their use, processes for their preparation and their use in NMR and X-ray diagnosis, radiodiagnosis and radiotherapy, and in MRT lymphography.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: September 11, 2012
    Assignee: Bayer Schering Pharma AG
    Inventors: Johannes Platzek, Heiko Schirmer, Hanns-Joachim Weinmann, Bernd Misselwitz, Ludwig Zorn
  • Process For Preparing Epothilone Derivatives By Selective Catalytic Epoxidation
    Publication number: 20120077984
    Abstract: The present invention describes a novel process for preparing an epothilone derivative using substituted pyridines and methyltrioxorhenium as catalyst.
    Type: Application
    Filed: November 30, 2011
    Publication date: March 29, 2012
    Inventors: Johannes Platzek, Orlin Petrov, Stephan Prühs
  • Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-Nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic Acid and Derivatives Thereof, Process for their Production and Use for the Production of Pharmaceutical Agents
    Publication number: 20120064002
    Abstract: Enantiomer-pure compounds of general formulas VIIa and VIIb in which A stands for a group —COO—, and Z and R have different meanings, as well as use thereof are described.
    Type: Application
    Filed: March 31, 2011
    Publication date: March 15, 2012
    Inventors: Lutz LEHMANN, Matthias FRIEBE, Thomas BRUMBY, Detlev SUELZLE, Johannes PLATZEK
  • Optically active, heteroaromatic ?-hydroxy esters and processes for their preparation from ?-keto esters and processes for the preparation of these ?-keto esters
    Patent number: 7935827
    Abstract: The present invention relates to new optically active heteroaromatic ?-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
    Type: Grant
    Filed: December 18, 2008
    Date of Patent: May 3, 2011
    Assignee: Bayer Schering Pharma AG
    Inventors: Johannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa, Orlin Petrov
  • NOVEL OPTICALLY ACTIVE, HETEROAROMATIC BETA-HYDROXY ESTERS AND PROCESSES FOR THEIR PREPARATION FROM BETA-KETO ESTERS AND PROCESSES FOR THE PREPARATION OF THESE BETA-KETO ESTERS
    Publication number: 20100248313
    Abstract: The present invention relates to new optically active heteroaromatic ?-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
    Type: Application
    Filed: December 18, 2008
    Publication date: September 30, 2010
    Inventors: Johannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa, Orlin Petrov
  • N-methyl-homocysteines and their use as well as process for their production
    Patent number: 7659364
    Abstract: The synthesis of N-methyl-homocysteines and their use are described.
    Type: Grant
    Filed: November 15, 2002
    Date of Patent: February 9, 2010
    Assignee: CIS Bio International
    Inventors: Marc Willuhn, Johannes Platzek, Eckhard Ottow, Orlin Petrov, Claudia Borm, Dirk Hinz, Gregor Mann, John Lister-James, David M. Wilson
  • Perfluoroalkyl-Containing Complexes, Process For Their Production As Well As Their Use
    Publication number: 20090297454
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Application
    Filed: May 20, 2009
    Publication date: December 3, 2009
    Inventors: Heiko SCHIRMER, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby
  • Optically active, heteroaromatic ?-hydroxy esters and processes for their preparation from ?-keto esters and processes for the preparation of these ?-keto esters
    Patent number: 7626035
    Abstract: The present invention relates to new optically active heteroaromatic ?-hydroxy esters useful in the synthesis of epothilone derivatives, to certain compounds used to produce these intermediates, as well as to processes for their production.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: December 1, 2009
    Assignee: Bayer Schering Pharma AG
    Inventors: Johannes Platzek, Ludwig Zorn, Bernd Buchmann, Werner Skuballa, Orlin Petrov
  • Perfluoroalkyl-containing complexes, process for their production as well as their use
    Patent number: 7618957
    Abstract: The invention relates to the subjects that are characterized in the claims, namely perfluoroalkyl-containing metal complexes with nitrogen-containing radicals of general formula I, process for their production and their use in NMR and x-ray diagnosis, radiodiagnosis, and radiotherapy, as well as in MRT lymphography and in blood-pool imaging.
    Type: Grant
    Filed: July 17, 2006
    Date of Patent: November 17, 2009
    Assignee: Bayer Schering Pharma Aktiengesellschaft
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Ludwig Zorn, Bernd Misselwitz, Joerg Meding, Heribert Schmitt-Willich, Thomas Brumby