Patents by Inventor Johannes Platzek

Johannes Platzek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Protected 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production
    Publication number: 20050267306
    Abstract: The invention relates to 3,5-dihydroxy-2,2-dimethyl-valeronitriles for the synthesis of epothilones and epothilone derivatives and process for the production of these new intermediate products in the synthesis and the use for the production of epothilones or epothilone derivatives.
    Type: Application
    Filed: July 26, 2005
    Publication date: December 1, 2005
    Inventors: Jurgen Westermann, Johannes Platzek, Orlin Petrov
  • Process for the production of dendritic trimesic acid triamides
    Publication number: 20050238615
    Abstract: A new process for the production of dendritic trimesic acid triamides is described.
    Type: Application
    Filed: December 16, 2004
    Publication date: October 27, 2005
    Inventors: Johannes Platzek, Klaus-Dieter Graske
  • 1,4,7,10-tetraazacyclododecane butyltriols, processes for their production and pharmaceutical agents containing them
    Patent number: 6951639
    Abstract: 1,4,7,10-Tetraazacyclodedecane butyltriols of general formula IA in which R1 means hydrogen or a metal ion equivalent independent of one another and R2 means a butyltriol radical as well as their salts with organic or inorganic bases or amino acids are valuable pharmaceutical agents.
    Type: Grant
    Filed: April 9, 2002
    Date of Patent: October 4, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Heinz Gries, Hanns-Joachim Weinmann, Gabriele Schuhmann-Giampieri, Wolf-Rüdiger Press
  • Protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use
    Patent number: 6933385
    Abstract: The invention relates to new protected 3,5-dihydroxy-2,2-dimethyl-valeroamides for the synthesis of epothilones and derivatives and process for the production and the use of the new compounds for the production of epothilones or epothilone derivatives.
    Type: Grant
    Filed: August 5, 2002
    Date of Patent: August 23, 2005
    Assignee: Schering AG
    Inventors: Jurgen Westermann, Johannes Platzek, Orlin Petrov
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Patent number: 6916461
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Grant
    Filed: July 18, 2002
    Date of Patent: July 12, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Radüchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Metal complexes that contain perfluoroalkyl, process for their production and their use in NMR diagnosis
    Publication number: 20050147563
    Abstract: The invention relates to new, monomeric, perfluoroalkyl-substituted metal complexes, processes for their production, and their use in diagnosis and therapy. The compounds according to the invention are suitable especially as in vivo contrast media in nuclear spin tomography (MRT). They can preferably be used as blood-pool agents and as lymphographic agents.
    Type: Application
    Filed: October 5, 2004
    Publication date: July 7, 2005
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert
  • Process for the production of perbenzylated 1-O-glycosides
    Patent number: 6908989
    Abstract: The invention relates to a process for the production of perbenzylated 1-O-glycosides of general formula I or salts thereof in which sugar1 is a monosaccharide that is functionalized in 1-OH-position, R represents benzyl, n means 2, 3 or 4, X means —COO— or —NH— and L means a straight-chain, branched, saturated or unsaturated C1-C30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of perbenzylated saccharides with 1-O-functionalized side chains on an industrial scale.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: June 21, 2005
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Klaus-Dieter Graske
  • Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
    Publication number: 20050118105
    Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
    Type: Application
    Filed: September 30, 2004
    Publication date: June 2, 2005
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
  • Process for the production of triiodotrimesic acid
    Publication number: 20050113598
    Abstract: A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
    Type: Application
    Filed: July 14, 2004
    Publication date: May 26, 2005
    Inventors: Heiko Schirmer, Ulrich Niedballa, Johannes Platzek, Jose Martin, Juan Harto, Jose Carretero, Hannelore Niedballa
  • Lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane, their production and use
    Patent number: 6894151
    Abstract: The invention relates to crystalline lithium complexes of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane, their production and the recovery of the salt-free gadolinium complex of N-(1-hydroxymethyl-2,3-dihydroxypropyl)-1,4,7-triscarboxymethyl-1,4,7,10 tetraazacyclododecane from the latter without the use of ion exchangers.
    Type: Grant
    Filed: December 13, 2001
    Date of Patent: May 17, 2005
    Assignee: Shering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Blaszkiewicz, Orlin Petrov, Holger Hoffmann
  • Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
    Publication number: 20050074409
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration<10?3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 I/mmol.s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Application
    Filed: June 2, 2004
    Publication date: April 7, 2005
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Process for the production of triiodotrimesic acid
    Publication number: 20050070735
    Abstract: A new process for the production of triiodotrimesic acid that is used as an intermediate product for the synthesis of x-ray contrast media is described.
    Type: Application
    Filed: July 14, 2004
    Publication date: March 31, 2005
    Inventors: Johannes Platzek, Ulrich Niedballa, Heiko Schirmer, Heinz Gries
  • Cascade polymer complexes, process for their production and pharmaceutical agents containing said complexes
    Patent number: 6861043
    Abstract: Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
    Type: Grant
    Filed: May 6, 2002
    Date of Patent: March 1, 2005
    Assignee: Schering AG
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Radüchel, Andreas Mühler, Thomas Frenzel
  • Cascade polymer bound complexing compounds, their complexes and conjugates, processes for their production, and pharmaceutical agents containing them
    Patent number: 6855309
    Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
    Type: Grant
    Filed: December 11, 2002
    Date of Patent: February 15, 2005
    Assignee: Schering, AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
  • Trimeric macrocyclic substituted benzene derivatives
    Publication number: 20040265236
    Abstract: The metal complexes of general formula I 1
    Type: Application
    Filed: February 19, 2004
    Publication date: December 30, 2004
    Inventors: Heiko Schirmer, Hanns-Joachim Weinmann, Johannes Platzek, Jose Luis Martin, Juan R. Harto, Bjoern Riefke
  • (Ethylene)-( propylene)-triaminepentaacetic acid derivatives, process for their production, and their use for the production of pharmaceutical agents
    Publication number: 20040258620
    Abstract: The invention relates to a novel class of ligands, complexes comprising such ligands and a metal ion, and adducts of these metal complexes and a macromolecule. Pharmaceutical compositions and methods of making and using the ligand-metal complexes are also described. The invention also relates to the use of macromolecular adducts for enhancement of diagnostic imaging. In particular, the invention relates to (ethylene)-(propylene)-triaminepentaacetic acid (EPTPA) derivatives, a process for their production, and their use for the production of pharmaceutical agents for NMR diagnosis or radiodiagnosis or radiotherapy.
    Type: Application
    Filed: August 19, 2004
    Publication date: December 23, 2004
    Inventors: Lutz Lehmann, Ulrich Niedballa, Hannelore Niedballa, Johannes Platzek, Matthias Friebe, Christoph Hilger, Andre E Merbach, Eva Jakab Toth, Robert Ruloff, Sabrina Laus
  • Process for the production of peracylated 1-0-glycosides
    Patent number: 6831164
    Abstract: The invention relates to a process for the production of peracylated 1-O-glycosides of general formula I or salts thereof in which sugar1 is a monosaccharide that is functionalized in 1-OH-position, R represents methyl, ethyl, propyl, isopropyl, tbutyl, phenyl, n means 2, 3 or 4, X means —COO— or —NH—and L means a straight-chain, branched, saturated or unsaturated C1-C30 carbon chain, which optionally is interrupted or substituted by groups. The process according to the invention starts from economical starting materials, provides good yields and allows the production of peracylated saccharides with 1-O-functionalized side chains on an enlarged scale.
    Type: Grant
    Filed: July 11, 2002
    Date of Patent: December 14, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Klaus-Dieter Graske, Ulrich Niedballa
  • Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of plaque, tumors and necroses
    Patent number: 6818203
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R1)>10 l/mmol·s) as contrast media in MR imaging for visualization of plaque, lymph nodes, infarcted and necrotic tissue and for independent visualization of necrotic tissue and tumor tissue.
    Type: Grant
    Filed: August 10, 2001
    Date of Patent: November 16, 2004
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Bernd Misselwitz
  • Enantiomer-pure (4S,8S)- and (4R,8R)-4-p-nitrobenzyl-8-methyl-3,6,9-triaza-3N,6N,9N-tricarboxymethyl-1,11-undecanedioic acid and derivatives thereof, process for their production and use for the production of pharmaceutical agents
    Publication number: 20040208828
    Abstract: Enantiomer-pure compounds of general formulas VIIa and VIIb 1
    Type: Application
    Filed: February 4, 2004
    Publication date: October 21, 2004
    Inventors: Lutz Lehmann, Matthias Friebe, Thomas Brumby, Detlev Suelzle, Johannes Platzek
  • Use of perfluoroalkyl-containing metal complexes as contrast media in MR-imaging for visualization of intravascular thrombi
    Publication number: 20040131546
    Abstract: The invention relates to the use of perfluoroalkyl-containing metal complexes that have a critical micelle formation concentration <10−3 mol/l, a hydrodynamic micelle diameter (2 Rh)>1 nm and a proton relaxivity in plasma (R)>10 l/mmol s as contrast media in MR imaging for visualization of intravascular thrombi.
    Type: Application
    Filed: July 10, 2003
    Publication date: July 8, 2004
    Applicant: Schering AG
    Inventors: Bernd Misselwitz, Johannes Platzek, Yoko Kawata, Hanns-Joachim Weinmann, Takashi Yokawa, Ulrich Niedballa