Patents by Inventor Johannes Platzek

Johannes Platzek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6248306
    Abstract: Cascade polymer complexes containing a) complexing ligands of general formula I A—{X—[Y—(Z—( W—Kw)z)y]x}a  (I)  in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different and that 16≦a·x·y·z·w≦64 holds true for the product of the multiplicities, b) at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83 and c) optionally cations of inorganic and/or organic bases, amino acids or amino acid amides are valuab
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: June 19, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Andreas Muhler, Thomas Frenzel, Wolfgang Ebert
  • Patent number: 6194566
    Abstract: Metalloporphyrin-metal complex conjugates are prepared by reacting a porphyrin-metal complex conjugate with a metal acetylacetoane in a solvent or solvent mixture at a temperature from room temperature to 150° C. in concentrations of 3-30% in the metalloporphyrin-metal complex conjugate.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: February 27, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa
  • Patent number: 6193950
    Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: February 27, 2001
    Assignee: Schering AG
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
  • Patent number: 6183724
    Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: February 6, 2001
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schumann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
  • Patent number: 6180113
    Abstract: Pharmaceutical agents that contain perfluoroalkyl-containing metal complexes are useful in tumor therapy and interventional radiology.
    Type: Grant
    Filed: February 19, 1997
    Date of Patent: January 30, 2001
    Assignee: Schering AG
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Rad{umlaut over (u)}chel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel
  • Patent number: 6177060
    Abstract: Cascade polymer complexes with at least 16 ions of an element of atomic numbers 20 to 29, 39, 42, 44 or 57-83, useful NMR or x-ray lymphography imaging.
    Type: Grant
    Filed: March 19, 1998
    Date of Patent: January 23, 2001
    Assignee: Schering Aktiengeseuschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Rad{umlaut over (u)}chel, Andreas M{umlaut over (u)}hler, Thomas Frenzel
  • Patent number: 6166200
    Abstract: Cascade polymer complexes that containa) complexing ligands of general formula IA--{X--[Y--(Z--W--K.sub.W .sub.z).sub.y ].sub.x}.sub.a (I),in whichA stands for a nitrogen-containing cascade nucleus of base multiplicity a,X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y,Z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w,K stands for the radical of a complexing agent,a stands for numbers 2 to 12,x, y, z and w, independently of one another, stand for numbers 1 to 4,provides that at least two reproduction units are different and that for the product of the multiplicities,16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: December 26, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Raduchel, Andreas Muhler, Thomas Frenzel
  • Patent number: 6156890
    Abstract: A new single-pot process for the production of cyclene is described.
    Type: Grant
    Filed: December 1, 1999
    Date of Patent: December 5, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Karsten Hoyer, Klaus-Dieter Graske, Bernd Raduechel
  • Patent number: 6136841
    Abstract: 3-,8-substituted deuteroporphyrin derivatives with various substituents in the 13- and 17-positions of the porphyrin skeleton are suitable as pharmaceutical agents for use in photodynamic therapy (PDT) and for MRI therapy monitoring.
    Type: Grant
    Filed: June 2, 1999
    Date of Patent: October 24, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduechel, Wolfgang Ebert, Hanns-Joachim Weinmann, Thomas Frenzel
  • Patent number: 6114321
    Abstract: The invention relates to new porphyrin complex compounds, pharmaceutical agents that contain the latter, and the use of porphyrin complexes for the production of agents for photodynamic therapy and MRI diagnosis.
    Type: Grant
    Filed: July 2, 1999
    Date of Patent: September 5, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduechel, Hanns-Joachim Weinmann, Thomas Frenzel, Wolfgang Ebert
  • Patent number: 6113880
    Abstract: The invention relates to polyrotaxanes that contain metal complexes or iodine-containing benzene derivatives as imaging components for MRT diagnosis and x-ray diagnosis.
    Type: Grant
    Filed: December 17, 1998
    Date of Patent: September 5, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heribert Schmitt-Willich
  • Patent number: 6083479
    Abstract: The invention relates to new compounds that are suitable as contrast media especially for infarction and necrosis imaging, process for their production and pharmaceutical agents that contain these compounds.
    Type: Grant
    Filed: September 22, 1998
    Date of Patent: July 4, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduechel, Wolfgang Ebert, Hanns Joachim Weinmann
  • Patent number: 6080785
    Abstract: The invention relates to new monofunctionalized ethylenediaminetetraacetic acid, diethylenetriaminepentaacetic acid and triethylenetetraaminehexaacetic acid derivatives, their production and their use for the production of pharmaceutical agents.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: June 27, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Peter Mareski, Ulrich Niedballa, Bernd Raduchel
  • Patent number: 6068831
    Abstract: The invention relates to new metal complex-containing or iodine-containing benzene derivatives that contain pseudopolyrotaxanes. They are valuable compounds for diagnosis. The pseudopolyrotaxane complexes have general formula (I), in which n represents the numbers 6, 7 or 8; m represents the numbers 2 to 50; X represents a direct bond or the radical --O--CO--CH(CH.sub.3)--; R.sub.1 and Y have the meaning that is indicated in the description and represent R.sub.3 --Y--R.sub.4 polyalkylene glycols.
    Type: Grant
    Filed: December 30, 1998
    Date of Patent: May 30, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heribert Schmitt-Willich
  • Patent number: 6063361
    Abstract: Cascade polymer complexes having a complexing ligand with at least two different reproduction units and having a complexing agent which is a macrocyclic group having an amide grouping or a linear DTPA-type group having a linkage to the polymer through the central nitrogen.
    Type: Grant
    Filed: March 18, 1998
    Date of Patent: May 16, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Raduchel, Andreas Muhler, Thomas Frenzel
  • Patent number: 6057419
    Abstract: Cascade polymer complexes that contain a) complexing ligands of general formula (I), in which A stands for a nitrogen-containing cascade nucleus of base multiplicity a, X and Y, independently of one another, stand for a direct bond or a cascade reproduction unit of reproduction multiplicity x or y, z and W, independently of one another, stand for a cascade reproduction unit of reproduction multiplicity z or w, K stands for the radical of a complexing agent, a stands for numbers 2 to 12, x, y, z and w, independently of one another, stand for numbers 1 to 4, provided that at least two reproduction units are different, and that 16.ltoreq.a.multidot.x.multidot.y.multidot.z.multidot.w.ltoreq.
    Type: Grant
    Filed: June 4, 1998
    Date of Patent: May 2, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Bernd Raduchel, Hanns-Joachim Weinmann, Wolfgang Ebert, Bernd Misselwitz, Andreas Muhler, Thomas Frenzel
  • Patent number: 6054117
    Abstract: Cascade polymers, containing complex-forming ligands, optionally at least five ions of an element of atomic numbers 21-29, 39, 42, 44 or 57-83, as well as, if desired, cations of inorganic and/or organic bases, amino acids or amino acid amides, are valuable complexing compounds and complexes for diagnostics and therapy.
    Type: Grant
    Filed: September 17, 1998
    Date of Patent: April 25, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Heribert Schmitt-Willich, Heinz Gries, Gabriele Schuhmann-Giampieri, Hubert Vogler, Hanns-Joachim Weinmann, Hans Bauer
  • Patent number: 6045776
    Abstract: The invention relates to a process for the production of metal-complex carboxylic acid amides, characterized in that a metal-complex carboxylic acid mixture that consists of the metal-complex carboxylic acid and at least one solubilizing substance in dimethyl sulfoxide (DMSO) is pretreated with a dehydrating reagent, optionally with the addition of a coupling adjuvant, and is then reacted with an amine of general formula IA(NH.sub.2).sub.n (I),in whichA stands for the radical of a natural or synthetic amine, andn stands for numbers 1 to 100.
    Type: Grant
    Filed: December 2, 1997
    Date of Patent: April 4, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Bernd Raduchel, Heribert Schmitt-Willich, Klaus-Dieter Graske
  • Patent number: 6039931
    Abstract: Compounds of general Formula I ##STR1## wherein Z.sup.1 and Z.sup.2 in each case independently mean the residue--(CH.sub.2).sub.m --(C.sub.6 H.sub.4).sub.q --(O).sub.k --(CH.sub.2).sub.n --(C.sub.6 H.sub.4).sub.l --(O).sub.r --R,whereinm and n means the numbers 0-20,k, l, q and r means the numbers 0 and 1, andR means a hydrogen atom, an optionally OR.sup.1 -substituted C.sub.1 -C.sub.6 -alkyl residue, or a CH.sub.2 COOR.sup.1 group with R.sup.1 meaning it hydrogen atom, a C.sub.1 -C.sub.6 -alkyl residue, or a benzyl group,X means a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21-29, 42, 44 or 57-83,with the provisos that at least two the substituents X stand for a metal ion equivalent; that one of the substituents Z.sup.1 and Z.sup.2 stands for a hydrogen and the other is not H; that--if n and l each mean the number 0--k and r do not simultaneously mean the number 1; that --(O).sub.r --R is not --OH; and that Z.sup.1 and Z.sup.2 are not --CH.sub.2 --C.sub.6 H.sub.4 --O--CH.sub.
    Type: Grant
    Filed: October 6, 1994
    Date of Patent: March 21, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Heribert Schmitt-Willich, Johannes Platzek, Heinz Gries, Gabrielle Schumann-Giampieri, Hanns-Joachim Weinmann, Hubert Vogler, Julius Deutsch, Juergen Conrad
  • Patent number: 6019959
    Abstract: Oligomeric compounds that contain perfluoroalkyl of general formula IA--R.sup.F (I)in whichA is a molecule portion that contains 2-6 metal complexes that are connected directly or via a linker to a nitrogen atom of an annular skeleton chain, andR.sup.F is a perfluorinated, straight-chain or branched carbon chain with formula --C.sub.n F.sub.2n E, in which E represents a terminal fluorine, chlorine, bromine, iodine, or hydrogen atom and n stands for numbers 4-30,are valuable compounds for diagnosis, especially as in-vivo contrast media.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: February 1, 2000
    Assignee: Schering Aktiengesellschaft
    Inventors: Johannes Platzek, Ulrich Niedballa, Bernd Raduchel, Wolfgang Schlecker, Hanns-Joachim Weinmann, Thomas Frenzel, Bernd Misselwitz, Wolfgang Ebert