Abstract: Wireless sensors are included within zones of a physical space. A memory stores feature description data. A processor, in communication with the memory and the wireless sensors, is programmed to send, to a mobile device connected to one of the wireless sensors, a subset of the feature description data applicable to one of the zones in which the mobile device is located. The processor also is programmed to receive a request to update a feature of the one of the zones based on the feature description data, and apply the setting update when the mobile device has permission. The zones of a physical space may be seating zones of a vehicle, and the wireless sensors may be included within doors to the seating zones of the vehicle. The mobile device may determine a seating zone of the vehicle in which the mobile device is located using the wireless sensors.

Abstract: A memory stores a message map associating requests with human-machine interface (HMI) notifications. A vehicle receives a request from a secondary-connected device, and sends an HMI notification to a primary-connected device, constructed based on the message map and the request, to simulate user input to the vehicle to cause the primary-connected device to perform the request. A secondary-connected device connected to a vehicle computing platform receives a command, constructs a request message describing the command; and sends the request message to the computing platform, to cause the computing platform to send a HMI notification to a primary-connected device to simulate user input to the vehicle requesting the primary-connected device to perform the command.

Abstract: Provided herein are nucleic acids, recombinant adeno-associated viral particles, compositions and methods related to treating Friedreich's ataxia. In some examples, the nucleic acids, recombinant adeno-associated viral particles, compositions and methods involve use of a FXN coding sequence, a truncated FXN 3? UTR, and a promoter.

Abstract: The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.

Abstract: Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc further include isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Abstract: Values may be tracked from wireless sensors of a vehicle that indicate distances between the mobile device and the sensors. When the signal strength values indicate the mobile device is within the vehicle, the device may be associated with a seating zone of the vehicle corresponding to the one of the sensors that provided signal strength values that peaked earliest in time. The mobile device may be determined to be within the vehicle by using a hypothesis test comparing a threshold signal strength value to the signal strength values.

Abstract: Values may be tracked from wireless sensors of a vehicle that indicate distances between the mobile device and the sensors. When the signal strength values indicate the mobile device is within the vehicle, the device may be associated with a seating zone of the vehicle corresponding to the one of the sensors that provided signal strength values that peaked earliest in time. The mobile device may be determined to be within the vehicle by using a hypothesis test comparing a threshold signal strength value to the signal strength values.

Abstract: A mobile device may advertise an application human-machine interface (HMI) service responsive to connection to a computing platform of a vehicle as the primary mobile device. One or more secondary mobile devices may connect to the application HMI service of the primary mobile device. The primary mobile device may provide a user interface of a connected application executed by the primary mobile device to the computing platform and to the at least one secondary mobile device, each secondary device executing the connected application.

Abstract: Methods of producing and isolating 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc and solution targets for use in the methods are disclosed. The methods of producing 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61Cu, 99mTc, 45Ti, 13N, 52Mn, or 44Sc include irradiating a closed target system with a proton beam. The closed target system can include a solution target. The methods of producing isolated 68Ga, 89Zr, 64Cu, 63Zn, 86Y, 61CU, 99mTC, 45-Ti, 52Mn, or 44Sc by ion exchange chromatography. An example solution target includes a target body including a target cavity for receiving the target material; a housing defining a passageway for directing a particle beam at the target cavity; a target window for covering an opening of the target cavity; and a coolant gas flow path disposed in the passageway upstream of the target window.

Abstract: Provided herein are methods related to co-packaging of multiple rAAV particles, e.g., by introducing multiple nucleic acid vectors encoding proteins or polypeptides or RNAs of interest into a single cell preparation.

Abstract: A vehicle may display a user interface of an application based on command information received from a primary-connected device, and send the command information to a secondary-connected device providing an auxiliary user interface. The vehicle may also forward a command message received based on user input to the auxiliary user interface to the application of the primary-connected device. The vehicle may also access paired device data to confirm that the secondary-connected device is authorized to command the application; and forward the user input to the primary-connected device if the secondary-connected device is authorized to command the application.

Abstract: Wireless sensors are included within zones of a physical space. A memory stores feature description data. A processor, in communication with the memory and the wireless sensors, is programmed to send, to a mobile device connected to one of the wireless sensors, a subset of the feature description data applicable to one of the zones in which the mobile device is located. The processor also is programmed to receive a request to update a feature of the one of the zones based on the feature description data, and apply the setting update when the mobile device has permission. The zones of a physical space may be seating zones of a vehicle, and the wireless sensors may be included within doors to the seating zones of the vehicle. The mobile device may determine a seating zone of the vehicle in which the mobile device is located using the wireless sensors.

Abstract: A memory stores a message map associating requests with human-machine interface (HMI) notifications. A vehicle receives a request from a secondary-connected device, and sends an HMI notification to a primary-connected device, constructed based on the message map and the request, to simulate user input to the vehicle to cause the primary-connected device to perform the request. A secondary-connected device connected to a vehicle computing platform receives a command, constructs a request message describing the command; and sends the request message to the computing platform, to cause the computing platform to send a HMI notification to a primary-connected device to simulate user input to the vehicle requesting the primary-connected device to perform the command.

Abstract: A vehicle infotainment system includes a vehicle processor connected to a transceiver and programmed to transmit human-machine interface (HMI) data to a connected mobile device using websockets via the transceiver. The vehicle processor is further programmed to, in response to the connected mobile device via the transceiver, receive a message requesting HMI data being outputted at a vehicle display. The vehicle processor is further programmed to transmit the HMI data to the mobile device via websockets and receive a parameter adjustment via a remote procedure call for a parameter associated with the HMI data.

Abstract: A plurality of media-sharing devices may each be in communication with one another over a local-area network of a vehicle and in communication with a server over a wide-area network. A media-sharing application may be installed to each of the media-sharing devices. The media sharing application may be programmed to cause the media-sharing devices to identify one of the media-sharing devices to be a master media-sharing device. The master media-sharing device may be programmed to identify, from the server, a portion size of a resource to be downloaded, and send download requests over the local-area network to cause each of the media-sharing devices to download a different content portion of a resource from the server over the wide-area network, each content portion of the portion size.

Abstract: A vehicle system includes a processor programmed to receive a suggested infotainment setting via occupant input. The processor is further programmed to transmit the suggested infotainment setting to one or more devices for occupant feedback and control an infotainment feature in response to the received occupant feedback to accept, reject, or modify the suggested infotainment setting.

Abstract: Provided herein are compositions and methods related to purification of recombinant adeno-associated virus (rAAV) particles.

Abstract: A vehicle computing system includes a processor connected to a transceiver and programmed to prompt an occupant via a user interface to pair a device detected by the transceiver. The processor is further programmed to receive input at the user interface to associate the device with a pre-approval setting for enabling a vehicle start request when the device having the pre-approval setting and a vehicle key are detected by the processor.

Abstract: A vehicle infotainment system includes a vehicle processor connected to a transceiver and programmed to transmit human-machine interface (HMI) data to a connected mobile device using websockets via the transceiver. The vehicle processor is further programmed to, in response to the connected mobile device via the transceiver, receive a message requesting HMI data being outputted at a vehicle display. The vehicle processor is further programmed to transmit the HMI data to the mobile device via websockets and receive a parameter adjustment via a remote procedure call for a parameter associated with the HMI data.

Abstract: Provided herein are compositions, kits and methods related to permitting a human or non-human primate subject to receive multiple doses of recombinant adeno-associate virus (rAAV) vectors. In some aspects, provided herein are methods comprising administering an anti-CD20 antibody, optionally in combination with an mTOR inhibitor, to the subject to permit multiple doses of an rAAV vector to be administered.