Abstract: The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.

Abstract: Technology for classifying a data set includes extracting one or more features from items of the data set, computing a specificity measure for the extracted features, and measuring the similarity of the extracted features to a set of characteristic features associated with the property of one or more reference models.

Abstract: The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.

Abstract: Mathematical technologies for recommending content to a user based on a user's preferences are disclosed. Embodiments of these technologies can generate a probabilistic representation of a data set, and then adjust the probabilistic representation to reflect a user-specific weighting scheme. The user preference-adjusted representation of the data set can be used to recommend content to the user.

Abstract: The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.

Abstract: A method of manufacturing and an apparatus for making an aqueous chlorine solution having a pH between 3.0 and 6.5 and a stability such that after 6 weeks storage at 20 degrees Celsius the pH remains in the range 3.0 to 6.5 and the amount of chlorine lost from the solution is less than 10%, such that the method includes: (a) Providing a source of water having an electrical conductivity at 20 degrees Celsius of no more than 50 (and preferably no more than 4.3) ?Scm-1 (b) Reacting the water with solid calcium hypochlorite having a purity of at least 60%; and (c) Adjusting the pH to between 3.0 and 6.5.

Abstract: The present invention is directed to a method and method which analyzes large amounts of information on a real-time basis with no previous static data set. Attributes of the data, which can be thought of as data concepts, that are present in the data stream are detected and isolated. These concepts are referred to as clusters and are used to ultimately determine the semantics of the data stream. The streaming clusters have no “current membership” in the existing state of the clustering and thus the cluster sets, and their relationship to each other, must be generated and updated as the data is being received.

Abstract: The present invention provides compositions and methods of use pertaining to rAAV-mediated delivery of therapeutically effective molecules for treatment of diseases such as Pompe disease. These compositions in combination with various routes and methods of administration result in targeted expression of therapeutic molecules in specific organs, tissues and cells.

Abstract: An apparatus may include a first support, a first cleaning material coupled to a first side of the first support, a second support rotatably coupled to the first support at a first edge of the second support, the second support defining a first opening disposed adjacent to a second edge of the second support opposite the first edge, a second cleaning material coupled to a first side of the second support, and a latch coupled to the first support, the latch to engage the first opening of the second support to maintain the first side of the first support in a substantially fixed relationship with respect to the first side of the second support.

Abstract: The present inventors concerns vectors carrying a truncated chimeric CMV-chicken ?-actin (smCBA) promoter in which the hybrid chicken ?-actin/rabbit ?-globin intron is greatly shortened, and their use to deliver to an operatively linked polynucleotide to host cells in vitro or in vivo, resulting in expression of the polynucleotide in the host cells. In one embodiment, the vector carrying the smCBA promoter is administered to the eye. In another embodiment, the vector carrying the smCBA promoter is a self-complementary adeno-associated virus (AAV). The AAV vector may be of any serotype (e.g., type 1, type 2, type 3, type 4, type 5, type 6, type 7, type 8, type 9, type 10). In another embodiment, a self-complementary vector carrying the smCBA promoter is administered to the eye. Another aspect of the invention concerns host cells carrying a vector of the invention.

Abstract: A refueling apparatus. The refueling apparatus having a combination float control module and fluid flow control valve for use in high pressure, high flow rate refueling systems. The refueling apparatus further having a fluid flow control valve module, a fluid level sensor module having a sensor, and a testing module.

Abstract: A photoresponsive ionogel comprising a photo-responsive polymer polymerised within an ionic liquid matrix is described. This solid-state electrolyte material maintains its ionic liquid characteristics but these characteristics can be altered upon irradiation of the gel with light of a particular wavelength. By suitably configuring the ionogel through the incorporation of specific ions within the gel it is possible to cause dramatic changes in properties of the ionogel such as viscosity, conductivity, acidity, basicity and polarity using light as the stimulus.

Abstract: An apparatus may include a first support, a first cleaning material coupled to a first side of the first support, a second support rotatably coupled to the first support at a first edge of the second support, the second support defining a first opening disposed adjacent to a second edge of the second support opposite the first edge, a second cleaning material coupled to a first side of the second support, and a latch coupled to the first support, the latch to engage the first opening of the second support to maintain the first side of the first support in a substantially fixed relationship with respect to the first side of the second support.

Abstract: Disclosed is a stabilized chlorine dioxide generating composition containing an oxy-chlorine salt, an acid source, optionally a free halogen source, and an endothermic agent. The endothermic agent neutralizes heat evolved by exothermic reaction of the oxy-chlorine salt by the endothermic reaction of the endothermic agent. Since the endothermic reaction eliminates and/or mitigates propagation of the exothermic reaction of the oxy-chlorine salt from a localized area through the total mass of the material, the chlorine dioxide generating composition is thereby stabilized during making, storing, or shipping the composition.

Abstract: A method and system for coupling to a palmtop computer that supports both mobile computing and desktop use. A palmtop computer docking system is disclosed that includes a cable assembly and a base. The cable assembly includes a palmtop computer connection mechanism that is connected to a USB connector and that is connected to a power connection mechanism via an electrical cable. Power is provided via the power connection mechanism. The cable assembly is adapted to engage the base so as to produce a fully functional docking cradle. In operation, once the cable assembly is engaged with the base, the USB connector is then coupled to the desired computing device (typically either a portable computer or a full-size computer). The resulting docking cradle facilitates desktop use such as, for example, communication with a full size computer. The cable assembly can be removed from the base and can be used independently of the base for mobile computing.

Abstract: A combination float control module and fluid flow control valve for use in high pressure, high flow rate refueling systems.

Abstract: A device for processing harvested dermal tissue includes a body having a cutting head portion and a handle portion extending from the cutting head portion. The cutting head portion defines a chamber. A cutting assembly is disposed in the chamber and includes a plurality of blades and a flexible spacer member disposed on the axle such that the blades rotate as the axle rotates. Each of the plurality of blades is separated from an adjacent blade by a spacer disposed on the axle. A grill assembly is coupled to the body and includes a grill and a grill cap. The grill has a plurality of spaced apart slots sized and configured to receive the blades and maintain the blades in a position with respect to the body. The grill cap is sized and configured to couple the grill to the cutting head portion of the body.

Abstract: A photoresponsive ionogel comprising a photo-responsive polymer polymerised within an ionic liquid matrix is described. This solid-state electrolyte material maintains its ionic liquid characteristics but these characteristics can be altered upon irradiation of the gel with light of a particular wavelength. By suitably configuring the ionogel through the incorporation of specific ions within the gel it is possible to cause dramatic changes in properties of the ionogel such as viscosity, conductivity, acidity, basicity and polarity using light as the stimulus.

Abstract: Compositions and methods of use include therapeutically effective molecules for treatment of diseases in mammals including glycogen storage diseases (e.g., Pompe disease). These compositions in combination with various routes and methods of administration result in targeted uptake and expression of therapeutic molecules in specific organs, tissues and cells resulting in correction of a disease such as a glycogen storage disease (e.g., Pompe disease).

Abstract: A data processing system (1) is programmed with objects (2) according to the object-oriented architecture. Each object (2) is for implementing an event, which for financial securities processing is often referred to as a corporate action. An object (2) has a container (3) containing a series of masks (4), all at the same level in a flat structure. Each mask has four binary bit flags, each switching on or off a pre-stored unit (5) of executable code for an asynchronous transaction. Initialization or modifications of the system involves only processing through a series of decisions and setting mask flags accordingly.