Abstract: Disclosed herein are systems and methods for graft delivery with accurate dispensing. For example, a device for delivering graft material to a target site includes an actuation mechanism and a tube. The tube defines a lumen and an open end and is configured to receive graft material through the open end. The tube includes a pressure relief opening and a dosage window. The pressure relief opening is disposed in a wall of the tube, defining a pressure chamber between the open end and the pressure relief opening. The device further includes a plunger positioned within the lumen of the tube and coupled to the actuation mechanism such that at least a portion of the plunger (or the actuation mechanism) is visible through the dosage window. The actuation mechanism is configured to advance the plunger toward the open end to deliver graft material through the open end.

Abstract: The invention relates to specified benzamide compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of ?1-antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: The invention relates to specified benzamide compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of ?1-antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: A parachute retention system may include a container and a replaceable flap. The container can be attached to a vehicle and can hold a parachute. The container may have a first attachment member. A replaceable flap may have a second attachment member that connects to the first attachment member and that has a flexible barrier portion for enclosing at least a portion of the container to retain the parachute therein.

Abstract: A method of conducting a game of skill includes providing a game device having a display for use by a player; inputting a quantity of points into the game device in a player account by the player inserting a physical item into an acceptor wherein the physical item has cash value; selecting a quantity of points per play by the player by using at least one player input button; and displaying on the display a game view and a preview view for viewing by the player.

Abstract: The invention relates to oxopyrimidinyl-methyl-benzamide derivatives, for example in a pharmaceutically acceptable salt form or crystal form, pharmaceutical compositions comprising the derivatives, and their medical use, in particular for use in the treatment of ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: A pair of ground planes arranged in parallel, a dielectric medium disposed in between the pair of ground planes, and a set of at least four signal conductors disposed in the dielectric medium, the set of at least four signal conductors having (i) a first pair of signal conductors arranged proximate to a first ground plane of the pair of ground planes and (ii) a second pair of signal conductors arranged proximate to a second ground plane of the pair of ground planes, each signal conductor of the set of at least four signal conductors configured to carry a respective signal corresponding to a symbol of a codeword of a vector signaling code.

Abstract: A catheter securement device comprising a base (110) in contact with the skin of a patient and a pad for securing a catheter, a catheter assembly or a portion of a catheter assembly. The base includes perforations (120) for case of removal of the catheter securement device from the skin of a patient without disrupting the catheter insertion region.

Abstract: A head wearable air purifier includes a headgear, an air purifier assembly supported by the headgear, a nozzle assembly and a mask body. The air purifier assembly includes a filter and an airflow generator for generating an airflow through the filter. The nozzle assembly is configured to extend in front of a face of a wearer in use. The nozzle assembly includes an inlet aperture configured to receive a filtered airflow from the air purifier assembly, and an air outlet for emitting the filtered airflow from the nozzle assembly. The mask body detachably connects to the nozzle assembly and defines a cavity for receiving a mouth and/or nose of the wearer. The cavity is in fluid communication with the air outlet.

Abstract: The invention relates to 4-((6-oxopyrimidin-1(6H)-yl)methyl)benzoic acid, compositions thereof, and uses of either, for example in the treatment of ?1-antitrypsin deficiency (A1AD or AATD).

Abstract: A method is disclosed herein. The method includes receiving, by a processor, a first acceleration data from an accelerometer, calculating, by the processor, a change in velocity based on the first acceleration data, the change in velocity being calculated over a first period of time, and adjusting, by the processor, a timing sequence based on the change in velocity.

Abstract: The invention relates to pharmaceutical compositions comprising (S)-1-(2-(trifluoromethyl)phenyl)sulfonyl)piperidine-3-carboxylic acid and their medical use, for example for use in the treatment of ?1-antitrypsin deficiency (AATD).

Abstract: The present disclosure provides a method of creating a label for labeling an intravenous infusion line. Further, the method may include receiving an information associated with one or more intravenous infusion lines from input devices, analyzing the information, determining label content of labels associated with the intravenous infusion lines, determining label content formats of the label content, generating a label information for the labels based on the label content and the label content formats, and printing the label information on label sheets based on the generating of the label information. Further, the printing of the label information creates the labels for the intravenous infusion lines.

Abstract: A parachute retention system may include a container and a replaceable flap. The container can be attached to a vehicle and can hold a parachute. The container may have a first attachment member. A replaceable flap may have a second attachment member that connects to the first attachment member and that has a flexible barrier portion for enclosing at least a portion of the container to retain the parachute therein.

Abstract: A photonic integrated circuit (PIC) die includes a silicon nitride optical component over an active region. Multiple interconnect layers are over the silicon nitride optical component, each of the multiple interconnect layers including a metal interconnect therein. At least one optical deflector is over the multiple interconnect layers and over the silicon nitride optical component. The optical deflector(s) may also include a contact passing therethrough to the interconnect layers, but do not include any other electrical interconnects. Each optical deflector may deflect light within an ambient light range of less than 570 nanometers (nm) to protect the silicon nitride optical component from light-induced degradation.

Abstract: Disclosed herein are systems and methods for graft delivery with accurate dispensing. For example, a device for delivering graft material to a target site includes an actuation mechanism and a tube. The tube defines a lumen and an open end and is configured to receive graft material through the open end. The tube includes a pressure relief opening and a dosage window. The pressure relief opening is disposed in a wall of the tube, defining a pressure chamber between the open end and the pressure relief opening. The device further includes a plunger positioned within the lumen of the tube and coupled to the actuation mechanism such that at least a portion of the plunger (or the actuation mechanism) is visible through the dosage window. The actuation mechanism is configured to advance the plunger toward the open end to deliver graft material through the open end.

Abstract: The invention relates to specified benzamide compounds of formula (1), and pharmaceutical compositions containing the compounds. The compounds may be inducers of ?1-antitrypsin (A1AT), and may be used in the treatment of a disease or disorder such as ?1-antitrypsin deficiency (A1AD or AATD).