Abstract: Various embodiments of the systems, methods, and devices are provided for controlled operation of an intravascular lithotripsy (“IVL”) system for breaking up calcified lesions in an anatomical conduit. More specifically, control arrangements are disclosed concerning managing and/or providing and/or assessing the electrical energy needed to generate an electrical arc between a set of spaced-apart electrodes disposed within a fluid-fillable member.

Abstract: A system for modifying at least one valve leaflet of a heart valve may include an elongate shaft, an expandable balloon, and an expandable structure disposed radially outward of the balloon. In an expanded configuration, the expandable structure is configured to separate the at least one valve leaflet into discrete pieces. A system may include an expandable structure comprising an elongate finger and a clamping jaw disposed proximate a distal end of the finger. In an expanded configuration, the elongate finger is offset radially outward from the elongate shaft and is configured to separate the at least one valve leaflet into discrete pieces. A system may include an electrode disposed within the balloon and configured to energize the inflation fluid. In an inflated configuration, energized inflation fluid ejected through a plurality of small apertures in the balloon is configured to separate the at least one valve leaflet into discrete pieces.

Abstract: Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, 7-aza- and 4,7-diaza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Abstract: This disclosure relates to, inter alia, cells expressing both a chimeric antigen receptor (CAR) and membrane bound IL-12 and the use of these cells to target and treat cancers (e.g., solid tumors and cancers expressing CD19, CD22, BCMA, PSCA, HER2, TAG-72, and PSCA). The disclosure also relates to cells expressing a membrane bound IL-12.

Abstract: An apparatus for cooling one or more samples includes a cryostat with a first wall forming an inner chamber with an opening for receiving the one or more samples. A second wall forms an outer chamber adapted to insulate the inner chamber and a channel leading to the opening of the inner chamber. A seal selectively seals the opening to the inner chamber, and a cryocooler thermally links to the inner chamber, such as by way of a flexible strap. The inner chamber may entirely surround the outer chamber, and yet via the channel allow for the removal of the one or more samples from the inner chamber while maintaining the evacuated outer chamber. The inner chamber may also be fully contained within the outer chamber, which may be evacuated. Related methods are also disclosed.

Abstract: In an automated liquid processing system, a first centrifuge performs a centrifuging cycle on a plurality of first inserts, a pairing robot to places first tubes, including pairs of first tubes, from the first inserts on a pairing platform, an excising station excises labels on the first tubes, captures an image of the excised first tubes, and determines, using an image analysis process, a height of a portion of the liquid within the first tubes. A first liquid handling station combines a portion of the liquid within first tubes, including pairs of first tubes, into a second tube. A second centrifuge performs a second centrifuging cycle, and a second liquid handling station aspirates liquid from the second tube and dispenses the liquid into an output container.

Abstract: Methods and systems are described herein for inspection of a workpiece, such as a honeycomb body. The methods and systems include collecting a plurality of images of the honeycomb body, extracting measurement data from each of the plurality of images, converting the measurement data extracted from each image into a common frame of reference, and combining the measurement data together.

Abstract: In an approach to managing telematic data transmission using a global navigation satellite system, one or more computer processors monitor an internet connectivity of a computing device associated with a vehicle. One or more computer processors determine the internet connectivity has failed. One or more computer processors retrieve health data associated with the vehicle. One or more computer processors transform the health data to a format associated with a global navigation satellite system (GNSS). One or more computer processors generate a message in the format associated with the GNSS that includes the transformed health data. One or more computer processors generate a message in the format associated with the GNSS that includes the transformed health data. One or more computer processors transmit the message from the computing device associated with the vehicle to a satellite. One or more computer processors transmit the message from the satellite to a service provider.

Abstract: A method for automatically identifying important and urgent news (IUN) in a large set of data comprises obtaining the large set of data in a textual-format, the large set of textual-data data contain a plurality of individual texts; clustering the textual-format data into a plurality of clusters; for each cluster, calculating the distances to all other clusters in the plurality of clusters and from those calculated distances determining a radius and a median of those calculated distances and then obtaining a difference between the radius and the median; and using the difference to identify important and urgent news in the large set of data.

Abstract: A method for a Matter compute architecture with smart discovery and opportunistic allocation of IoT device resources includes obtaining a device identifier for each of a plurality of devices within an ecosystem of a vehicle, each device identifier including resource capabilities and resource needs of the device. For each device, the method also includes validating the device based on the obtained device identifier, and classifying the device based on the resource capabilities and the resource needs of the device. The method also includes generating a device controller matrix by identifying an ecosystem resource requirement for the plurality of devices, predicting an ecosystem resource availability for the plurality of devices, and prioritizing the resource capabilities and the resource needs of each device based on the ecosystem resource requirement and the ecosystem resource availability.

Abstract: A bearing assembly for a linear electromagnetic machine includes a sleeve having a surface configured to provide a bearing between the surface and a translator, a front plate coupled to the sleeve, a support block, and a plurality of flexures coupled to the support block. Each flexure is coupled between the support block and one of the front plate or a stator. For example, a load path extends from a stator to the support block via a first set of flexures of the plurality of flexures, from the support block to the front plate via a second set of flexures of the plurality of flexures, and from the front plate to the sleeve. In the example of four flexures, two flexures are affixed to the support block and front plate, while two other flexures are affixed to the support block and the stator.

Abstract: An electric motor includes a stator having a stator core constructed from a ferromagnetic material and having an external stator surface. The stator core includes a stator core body and a plurality of stator teeth extending therefrom. The plurality of stator teeth define conductor slots therebetween. The stator also includes a plurality of stator conductors arranged within the conductor slots. The stator additionally includes a slot liner arranged within each conductor slot and surrounding the corresponding stator conductors. A first gap is established between each stator conductor and the corresponding slot liner, and a second gap is established between each slot liner and the neighboring stator teeth. A predetermined amount of varnish arranged within the first and second gaps to limit an amount of open space within the first and second gaps that is free from the varnish and regulate viscous damping of the electric motor.

Abstract: This application relates to methods and apparatus for driving a transducer. A transducer driver has a switch network that is operable to selectively connect a driver output to any of a first set of at least three different switching voltages which are, in use, maintained throughout a switching cycle of the driver apparatus. The switch network is also operable to selectively connect the driver output to flying capacitor driver. A controller is configured to control the switch network and flying capacitor driver to generate a drive signal at the driver output based on an input signal, wherein in one mode of operation the driver output is switched between two of the first set of switching voltages with a controlled duty cycle and in another mode of operation the driver output is connected to the flying capacitor driver which is switched between first and second states with a controlled duty cycle.

Abstract: A computer implemented method for algorithmically editing digital video content is disclosed. A video file containing source video is processed to extract metadata. Label taxonomies are applied to extracted metadata. The labelled metadata is processed to identify higher-level labels. Identified higher-level labels are stored as additional metadata associated with the video file. A clip generating algorithm applies the stored metadata for selectively editing the source video to generate a plurality of different candidate video clips. Responsive to determining a clip presentation trigger on a viewer device, a clip selection algorithm is implemented that applies engagement data and metadata for the candidate video clips to select one of the stored candidate video clips. The engagement data is representative of one or more engagement metrics recorded for at least one of the stored candidate video clips. The selected video clip is presented to one or more viewers via corresponding viewer devices.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a first network function device receives an access traffic rule for a multi-access protocol data unit (MA PDU) session of a user equipment (UE) from a second network function device, where the access traffic rule defines information on how to handle a traffic flow associated with the MA PDU session over multiple data paths corresponding to different access networks. The first network function device receives network performance data related to the access traffic rule from a third network function device and performs access traffic controlling of the traffic flow over the multiple data paths in accordance with the access traffic rule and the network performance data.

Abstract: An integrated circuit device comprises a metal-oxide-semiconductor (MOS) transistor comprising a gate stack formed over a channel region thereof and a bipolar junction transistor (BJT) comprising a layer stack formed over a collector region thereof. Some features of the MOS transistor and the BJT are co-fabricated such that they have common physical characteristics.

Abstract: A method of treating an appendage using acoustic shock waves includes: providing an appendage in need of an acoustic shock wave treatment; placing an acoustic shock wave applicator on a surface of the appendage; placing a gaseous filled membrane on an opposite surface of the appendage; activating an acoustic shock wave generator or source to emit acoustic shock waves from an acoustic shock wave applicator; and wherein the acoustic shock waves are transmitted from the acoustic shock wave applicator through the surface sending the emitted acoustic shock waves into the tissue of the appendage and exiting the opposite surface of the appendage to the gaseous filled membrane where a reflection of the acoustic shock waves occurs sending reflected acoustic shock waves back through the appendage. A dose of formation-mitigating treatment composition may be delivered into a region of the appendage at which a material formation (e.g., collagen-containing plague) is located.

Abstract: A surgical apparatus comprises a body, an ultrasonic transducer, a shaft, and an end effector. The ultrasonic transducer is operable to convert electrical power into ultrasonic vibrations. The body comprises a pivotal trigger. The shaft couples the end effector and the body together. The end effector comprises a clamp arm and an ultrasonic blade in acoustic communication with the ultrasonic transducer. The ultrasonic blade is operable to deliver ultrasonic vibrations to tissue. Pivotal movement of the trigger causes movement of the clamp arm. The trigger includes a compliant feature configured to limit the amount of force delivered to tissue by the clamp arm. The flexible feature may comprise a flexible band, living hinge, a series of living hinges, or a flexible tab.

Abstract: A trochanteric nailing system makes use of a lag screw operatively connectable to a trochanteric nail. The lag screw has a helical thread disposed over a suitable surgical length on the outer surface of the shaft of the lag screw. The helical thread includes undercuts formed therein to improve resistance to cutout or lag screw migration. The lag screw may also include a variable-width thread to improve fixation and resistance to migration or cut out. Helical flutes reduce torque forces exerted on bone during insertion, while maintaining the improved fixation of other features about the entire circumference of the lag screw. The lag screw may also be equipped with tapered set screw grooves which engaging opposing portions of a set screw of the trochanteric nail when received therein to resist migration or cutout.

Abstract: Disclosed herein is a system and method for generating a 3D map of a bone of a patient undergoing a total joint arthroplasty showing various volumes of the bone having different bone quality and/or patient characteristics and predicting, for each volume, a force threshold. The force threshold is used to automatically regulate the power output of a powered surgical tool depending on which volume of risk the tool is in contact with.