Abstract: The present invention provides for compounds of formula (I) wherein R1, Y, X1, X2, R2, R3, R4, R5, R6, and m have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including inflammatory diseases, cancer, and AIDS. Also provided are pharmaceutical compositions comprising compounds of formula (I).

Abstract: An apparatus includes a first and second elongate member that can releasably couple together to in order to cooperate to clamp and staple tissue, a latch member that can latch the first and second elongate member to clamp tissue, a firing assembly that can sever and staple clamped tissue, and a clamp force measuring assembly. The clamp force measuring assembly can measure a parameter associated with a clamping force imparted on the first and second stapling surfaces while clamping tissue, and process and communicate the measured parameter to be compared with a predetermined limit associated with successful staple formation.

Abstract: A leaf spring for coupling a heat sink to an integrated circuit includes a central portion that has an aperture; a first spring arm that is formed on a first side of the central portion and includes a first through-hole for a first fastener; a second spring arm that is formed on a second side of the central portion and includes a second through-hole for a second fastener; a first bending axis that passes through the first side and is substantially perpendicular to a longitudinal axis of the leaf spring that passes through the first through-hole and the second through-hole; and a second bending axis that passes through the second side and is substantially perpendicular to the longitudinal axis of the leaf spring.

Abstract: Provided are system and methods for additive manufacturing, especially using regolith. A system comprises a vacuum chamber configured to contain a material, wherein the material includes a metal fuel and an oxidizer, and an ignition source configured to ignite the material to combustion. The metal fuel includes at least one of magnesium and aluminum. The oxidizer is at least one of lunar regolith, Martian regolith, or a regolith simulant. The systems and methods provide a mechanism for sustainable production of fuels from regolith materials, with limited or not resource requirements from Earth, resulting in more sustainable space exploration.

Abstract: In various examples, sensor data representative of an image of a field of view of a vehicle sensor may be received and the sensor data may be applied to a machine learning model. The machine learning model may compute a segmentation mask representative of portions of the image corresponding to lane markings of the driving surface of the vehicle. Analysis of the segmentation mask may be performed to determine lane marking types, and lane boundaries may be generated by performing curve fitting on the lane markings corresponding to each of the lane marking types. The data representative of the lane boundaries may then be sent to a component of the vehicle for use in navigating the vehicle through the driving surface.

Abstract: An electronic door system includes a door frame, a door hingedly coupled to the door frame, an electronic locking mechanism coupled to the door, one or more lights coupled to the door frame, a camera system including at least two of a camera, a proximity or motion sensor, or a doorbell, and a wiring harness extending through the door frame and the door. The wiring harness is coupled to the electronic locking mechanism, the one or more lights, and the camera system. The wiring harness is configured to electrically couple to an external power source.

Abstract: The disclosure relates, in certain aspects, to compounds that can be used to inhibit ?-lactamases, such as but not limited to OXA enzymes, such as but not limited to OXA-24, OXA-48, and/or OXA-58. In certain embodiments, these compounds can be used to inhibit activity of ?-lactamases in vitro and in vivo.

Abstract: Provided is a contactless connector that includes an antenna system and a wireless transceiver coupled to the antenna system and configured to simultaneously transmit a transmission signal and receive a received signal through the antenna system. The wireless transceiver includes a transformer, a wide-band phase shifter and a combiner. The transformer has a primary coil with a center tap to which the transmission signal is coupled and a first end that is coupled to the antenna system. The transmission signal also is coupled to an input of the wide-band phase shifter. The transformer also has a secondary coil, an output of the secondary coil is coupled to a first input of the combiner, an output of the wide-band phase shifter is coupled to a second input of a combiner, and an output of the combiner provides a self-interference-canceled version of the received signal.

Abstract: An example method of radiation therapy in a radiation therapy system that includes a gantry with a treatment-delivering X-ray source and an imaging X-ray source mounted thereon is described. The method includes rotating the gantry in a first direction at a first rotational velocity about an open bore and concurrently rotating an annular support structure at a second rotational velocity about the open bore, wherein the second rotational velocity is less than the first rotational velocity. While continuing to rotate the gantry in the first direction about the open bore from a first position to a treatment position, the method also includes generating multiple images of a target volume disposed in the bore using the imaging X-ray source. Upon rotating the gantry to the treatment position, the method includes initiating delivery of a treatment beam to the target volume with the treatment-delivering X-ray source.

Abstract: An object induction system is disclosed for assigning handling parameters to an object. The system includes an analysis system, an association system, and an assignment system. The analysis system includes at least one characteristic perception system for providing perception data regarding an object to be processed. The association system includes an object information database and assigns association data to the object responsive to commonality with of any of the characteristic perception data with any of the characteristic recorded data. The assignment system is for assigning programmable motion device handling parameters to the indicia perception data based on the association data, and includes a workflow management system as well as a separate operational controller.

Abstract: Cosmetic compositions are water-in-silicone emulsions that are free of D4 and D5. The external phase comprises a solvent system of methyltrimethicone and low viscosity dimethicone; a film former system comprising trimethylsiloxysilicate (TMS); rheology modifiers; a pigment system that comprises one or more pigments that are surface treated with triethoxycaprylylsilane; and a first part of a sebum-controlling system that comprises spherical and ellipsoidal silica shells. The aqueous phase may comprise a second part of the sebum-controlling system, water-soluble skin care actives and a preservative system.

Abstract: A cracking furnace for cracking a hydrocarbon feed, the furnace including a firebox having a single radiant zone including, a first plurality of cracking coils each having a first shape arranged within the firebox. The radiant zone includes a second plurality of cracking coils each having a second shape arranged within the radiant zone. A burner section positioned below the first plurality cracking coils and below the second plurality of cracking coils. A convection section is positioned on top of the firebox configured to recover residual heat from the firebox.

Abstract: Plant T-DNA expression vectors encoding a post-translational modification (PTM) enzyme wherein the nucleic acid encoding the PTM enzyme has neither a promoter nor a 5? untranslated region (UTR) are provided. Also provided are methods of optimizing expression and glycosylation of recombinant protein produced in plants by utilizing the plant T-DNA expression vectors.

Abstract: The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2? breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R1, R2, R3, R4, m, and n are defined herein.

Abstract: Plant T-DNA expression vectors encoding a post-translational modification (PTM) enzyme wherein the nucleic acid encoding the PTM enzyme has neither a promoter nor a 5? untranslated region (UTR) are provided. Also provided are methods of optimizing expression and glycosylation of recombinant protein produced in plants by utilizing the plant T-DNA expression vectors.

Abstract: Embodiments of the disclosure relate to methods using an oligomer film to protect a substrate surface. The oligomer film is formed on the substrate surface with a first feature and a second feature each having a feature depth. The first feature has a first critical dimension (CD) and the second feature has a second CD. The semiconductor substrate surface is exposed to one or more monomers to form the oligomer film, and the oligomer film forms selectively on the bottom and fills a portion of the feature depth. The oligomer film fills the feature depth to substantially the same or the same height in each of the first feature and the second feature. Methods of forming semiconductor devices using the oligomer film are also disclosed.

Abstract: Systems and methods for constructing a traction inverter of a vehicle are described. The traction inverter includes a positive bus bar and a negative bus bar that couple a capacitor and to a plurality of switches. The capacitor is formed from a plurality of individual capacitors that are stacked together.

Abstract: There is provided an inorganic hierarchical porous membrane comprising at least two layers, wherein each layer of the at least two layers comprises a different average pore size as compared to another layer of the at least two layers, and wherein the membrane comprises a patterned surface. There is also provided a method of forming the membrane.

Abstract: Biomanufacturing hygiene control in batch and fed-batch bioreactors is provided using a bioreactor employing a chlorite/Cld system, wherein the bioreactor comprises an engineered cultured cell expressing a recombinant cytoplasmic chlorite dismutase (cCld) sufficient to increase chlorite resistance of the cell, and chlorite sufficient to substantially inhibit growth of one or more contaminating microorganisms in the bioreactor yet not substantially inhibit growth of the cell.

Abstract: Methods of video streaming are generally described. In some examples, a camera device periodically captures an image, communicates encoded frame data representing that image to a server, and decodes and stores the previously encoded frame data as a background picture. The server receives the encoded frame data, decodes it, and stores the decoded frame in a buffer for future use. Subsequently, upon initiation of a streaming session, the camera device captures another image and encodes a predicted key frame based on differences between the captured image and the background picture. The camera device sends the predicted key frame to the server, which receives it and reconstructs a facsimile of the captured image utilizing the previously decoded frame stored in the buffer. Methods of acknowledging successfully decoded frames for use in selecting background pictures is also described.