Abstract: There is provided an inorganic hierarchical porous membrane comprising at least two layers, wherein each layer of the at least two layers comprises a different average pore size as compared to another layer of the at least two layers, and wherein the membrane comprises a patterned surface. There is also provided a method of forming the membrane.

Abstract: Aspects and embodiments herein pertain to global ML prediction applied in a data security context. In some examples, a global prediction pertaining to a data item as a whole (the ‘original’ data item) is generated using an ML predictor. A data element is masked by removing it from the data item, or obscuring it in some way (e.g., through modification or replacement). The same ML predictor is applied to the perturbed data item. A change in global confidence between the original data item and the perturbed data item denotes local significance of the individual data item (or subset of data items) that have been masked. Other significance indicators (such as start and end markers of significant sections) are also considered. Other methods of estimating local significance are considered. In some examples, one or more such methods are used to generate training data for training a self-interpretation ML model.

Abstract: Novel antisense oligonucleotides that induce Exon-2 skipping in the CD33 gene during pre-mRNA splicing, and their use in the treatment of a neurodegenerative disease, such as Alzheimer's disease, are disclosed.

Abstract: In an illustrative embodiment, systems and methods for monitoring insurance claims include identifying, based on predetermined monitoring frequency, insurance claims identified for vulnerability detection processing. Vulnerability detection features may be extracted from data files of the claims, which provide an indication of claim handling deficiencies that can cause claim leakage. A trained vulnerability detection data model can be used to detect claim handling vulnerabilities within the extracted vulnerability detection features where each of the vulnerabilities may include a likelihood of the vulnerability resulting in claim leakage. The vulnerability detection data model may be trained with a data set customized to a respective insurance provider for each claim. Vulnerability scores indicating an overall likelihood of claim leakage can be calculated for the claims based on the detected claim handling vulnerabilities.

Abstract: This disclosure relates to synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E, methods of making such peptides, peptidomimetics, and complexes, and methods of using such peptides, peptidomimetics and complexes for blocking, inhibiting, or preventing the interaction of HLA-E with CD94/NKG2A or activation of CD94/NKG2A by HLA-E. The synthetic peptides, peptidomimetics, and complexes of synthetic peptides and peptidomimetics with HLA-E can further comprise warheads to introduce covalent linkages between the synthetic peptides and peptidomimetics with HLA-E.

Abstract: Various embodiments of an acoustic tube and a hearing device system that includes an acoustic tube are disclosed. The acoustic tube includes a body, a lumen disposed within the body that extends along a lumen axis between a first end and a second end of the body, and a magnetic coupler disposed adjacent to the first end and adapted to connect the acoustic tube to a housing of a hearing device. The acoustic tube further includes an outlet disposed adjacent to the first end and acoustically connected to the lumen, where the outlet is adapted to be acoustically connected to a microphone of the hearing device; and an inlet disposed adjacent to the second end and acoustically connected to the lumen. The acoustic tube is adapted to direct acoustic energy received by the inlet through the lumen and the outlet to the microphone of the hearing device.

Abstract: A saxophone mouthpiece is provided, comprising a main body. The main body includes an assembling portion and a mouthpiece portion. The mouthpiece portion defines a front end and a rear end relative to each other, and the rear end is connected with the assembling portion. One side of the mouthpiece portion has a window disposed thereon and is configured to be pressed against by a reed, and another side of the mouthpiece portion has a baffle disposed thereon. Two opposite sides of the window have two side rails facing outwardly, and each of the two side rails includes a first arcuate convex segment, a non-arcuate convex segment and a second arcuate convex segment arranged sequentially from the front end toward the rear end. Therefore, a reed arranged on the saxophone mouthpiece can be vibrated smoothly to produce expected tone and scale.

Abstract: The present invention relates to the field of controlling tape drive magnetic head spacing and the use of hard disk drive heads in a tape drive. The present invention is related to magnetic tape data storage and tape recorders that include components designed to minimize or eliminate head-to-tape contact to reduce or eliminate wear and contamination of the tape and the magnetic heads. Methods and apparatus of the present invention may control the head-to-media spacing by moving locations of magnetic heads relative to a tape. Such apparatus may include components designed to minimize magnetic spacing. This may be accomplished using actuators that move magnetic heads, or that move both magnetic heads and the tape of a tape drive. This may include supporting a back surface of the tape. The movement of the tape past the magnetic heads may be performed using mechanisms that contact and drive the back surface of the tape.

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).

Abstract: This disclosure concerns methods of fabricating porous ceramic supports and supported ceramic membranes, comprising mixing a ceramic powder, a clay powder and a binder to form a mixture, kneading the mixture in an aqueous or non-aqueous medium and a humectant to form a ceramic paste, and aging the ceramic paste for at least 24 h. The ceramic powder is about 70 wt % to about 80 wt % in the ceramic paste. The clay powder is about 5 wt % to about 15 wt % in the ceramic paste. The ceramic powder has an average particle size of about 5 ?m to about 20 ?m. This disclosure also concerns porous ceramic supports and supported ceramic membranes thereof.

Abstract: Discloses herein is an activated metal-organic framework of formula as defined in the application, and the metal organic framework has a BET surface area of from 250 to 1,000 m2/g as obtained from a 298 K CO2 sorption isotherm. In a particular embodiment, the activated metal-organic framework is aluminium formate (Al(HCOO)3) or vanadium formate (V(HCOO)3).

Abstract: The present invention relates to the field of controlling tape drive magnetic head spacing and the use of hard disk drive heads in a tape drive. The present invention is related to magnetic tape data storage and tape recorders that include components designed to minimize or eliminate head-to-tape contact to reduce or eliminate wear and contamination of the tape and the magnetic heads. Methods and apparatus of the present invention may control the head-to-media spacing by moving locations of magnetic heads relative to a tape. Such apparatus may include components designed to minimize magnetic spacing. This may be accomplished using actuators that move magnetic heads, or that move both magnetic heads and the tape of a tape drive. This may include supporting a back surface of the tape. The movement of the tape past the magnetic heads may be performed using mechanisms that contact and drive the back surface of the tape.

Abstract: A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).

Abstract: The present disclosure provides novel pladienolide compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancers, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful. Also provided herein are methods of treating cancers by administering at least one compound disclosed herein and at least one additional therapy.

Abstract: Gapmers or pharmaceutically acceptable salt of the gapmers and methods of making the gapmers are provided. The gapmers include a gap region that contains deoxyribonucleosides linked to each other by phosphorothioate bonds, a 5? wing region positioned at the 5? end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds, and a 3? wing region positioned at the 3? end of the gap region that contains morpholino monomers linked to each other by phosphorodiamidate bonds. Antisense oligonucleotides are also provided. These antisense oligonucleotides are useful in the preparation of gapmers for inhibition of Tau mRNA transcription.

Abstract: In an illustrative embodiment, methods and systems for automatically labeling unstructured data include accessing unstructured data representing data entry and analyzing the unstructured data by applying natural language processing to a text component of the unstructured data to obtain a set of term counts of words and/or phrases identified in the text component. Analyzing may include applying at least one clustering algorithm to the set of term counts to determine a term cluster, identifying a preexisting term cluster most closely matching the term cluster, and applying, to the unstructured data, a predefined label corresponding to the preexisting term cluster. The unstructured data may be analyzed to obtain formatting counts of formatting elements, and a formatting cluster may be determined and applied to match to a preexisting formatting cluster, thus deriving a predefined label corresponding to the preexisting formatting cluster.

Abstract: In an illustrative embodiment, systems and methods for monitoring insurance claims include identifying, based on predetermined monitoring frequency, insurance claims identified for vulnerability detection processing. Vulnerability detection features may be extracted from data files of the claims, which provide an indication of claim handling deficiencies that can cause claim leakage. A trained vulnerability detection data model can be used to detect claim handling vulnerabilities within the extracted vulnerability detection features where each of the vulnerabilities may include a likelihood of the vulnerability resulting in claim leakage. The vulnerability detection data model may be trained with a data set customized to a respective insurance provider for each claim. Vulnerability scores indicating an overall likelihood of claim leakage can be calculated for the claims based on the detected claim handling vulnerabilities.

Abstract: The present invention relates to the field of controlling tape drive magnetic head spacing and the use of hard disk drive heads in a tape drive. The present invention is related to magnetic tape data storage and tape recorders that include components designed to minimize or eliminate head-to-tape contact to reduce or eliminate wear and contamination of the tape and the magnetic heads. Methods and apparatus of the present invention may control the head-to-media spacing by moving locations of magnetic heads relative to a tape. Such apparatus may include components designed to minimize magnetic spacing. This may be accomplished using actuators that move magnetic heads, or that move both magnetic heads and the tape of a tape drive. This may include supporting a back surface of the tape. The movement of the tape past the magnetic heads may be performed using mechanisms that contact and drive the back surface of the tape.

Abstract: In an illustrative embodiment, systems and methods for monitoring insurance claims include identifying, based on predetermined monitoring frequency, insurance claims identified for vulnerability detection processing. Vulnerability detection features may be extracted from data files of the claims, which provide an indication of claim handling deficiencies that can cause claim leakage. A trained vulnerability detection data model can be used to detect claim handling vulnerabilities within the extracted vulnerability detection features where each of the vulnerabilities may include a likelihood of the vulnerability resulting in claim leakage. The vulnerability detection data model may be trained with a data set customized to a respective insurance provider for each claim. Vulnerability scores indicating an overall likelihood of claim leakage can be calculated for the claims based on the detected claim handling vulnerabilities.