Abstract: A portable electronic device determines a battery available power for the device's battery and manages device power usage based upon the battery available power. The device includes a battery and a controller. The controller is configured to receive a first voltage value for the battery at a first time, a first current value for the battery, a second voltage value for the battery at a second time, and a second current value for the battery. It is determined that a time difference between the first time and the second time exceeds a predetermined time threshold. An estimated resistance of the battery is determined based at least on a first difference between the first current value and the second current value and a second difference between the first voltage value and the second voltage value. Real-time power usage of the device is controlled based on the estimated resistance of the battery.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: A method includes receiving a signal associated with an electronic meeting invitation for users to attend the electronic meeting. The users include members of an organization and at least one nonmember of the organization. Responsive to receiving the signal, an online collaborative team is automatically created within an online chat environment. The team members of the online collaborative team include the members and the at least one nonmember. In some embodiments, an online collaborative team account is automatically created for the at least one nonmember responsive to determining that the at least one nonmember has no online collaborative team account.

Abstract: The present disclosure provides a novel solid state form of pladienolide pyridine compounds having Formula I, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.

Abstract: A mesoporous, nanocrystalline, metal oxide construct particularly suited for capacitive energy storage that has an architecture with short diffusion path lengths and large surface areas and a method for production are provided. Energy density is substantially increased without compromising the capacitive charge storage kinetics and electrode demonstrates long term cycling stability. Charge storage devices with electrodes using the construct can use three different charge storage mechanisms immersed in an electrolyte: (1) cations can be stored in a thin double layer at the electrode/electrolyte interface (non-faradaic mechanism); (2) cations can interact with the bulk of an electroactive material which then undergoes a redox reaction or phase change, as in conventional batteries (faradaic mechanism); or (3) cations can electrochemically adsorb onto the surface of a material through charge transfer processes (faradaic mechanism).

Abstract: A system enables tool to process remote log files as if the log files were located locally. The system relies on technology, such a file system in user space (FUSE), to add log file search results to the local file system. In some embodiments, the log file search results are associated with virtual files in the local file system. A remote data store system communicates with the local system to provide the search results in response to a search query.

Abstract: Processes for producing 2,5-dichlorophenol and 3,6-dichloro-2-methoxybenzoic acid are described. Various processes for isomerizing 2,4-dichlorophenol over a zeolite catalyst to form 2,5-dichlorophenol are provided. Processes for preparing 2,5-dichlorophenol including hydroxylating 1,4-dichlorobenzene are also described. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid.

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract: In an illustrative embodiment, systems and methods for monitoring insurance claims include identifying, based on predetermined monitoring frequency, insurance claims identified for vulnerability detection processing. Vulnerability detection features may be extracted from data files of the claims, which provide an indication of claim handling deficiencies that can cause claim leakage. A trained vulnerability detection data model can be used to detect claim handling vulnerabilities within the extracted vulnerability detection features where each of the vulnerabilities may include a likelihood of the vulnerability resulting in claim leakage. The vulnerability detection data model may be trained with a data set customized to a respective insurance provider for each claim. Vulnerability scores indicating an overall likelihood of claim leakage can be calculated for the claims based on the detected claim handling vulnerabilities.

Abstract: A system and method for operating a portable electronic device are presented. The device includes a battery and a controller. The controller is configured to execute instructions for determining a first resistance value for the battery during a first power cycle of the battery, and determining a second resistance value for the battery during a second power cycle of the battery. The second power cycle is after the first power cycle. The controller is configured to execute instructions for determining that a first difference equal to the first resistance value subtracted from the second resistance value is less than a first predetermined threshold value, and electrically isolating the battery. In an embodiment, the first resistance value and the second resistance values are determined at the same state of charge for the battery.

Abstract: An autonomous cleaning robot includes a controller configured to execute instructions to perform one or more operations. The one or more operations includes operating a drive system to move the cleaning robot in a forward drive direction along a first obstacle surface with a side surface of the cleaning robot facing the first obstacle surface, then operating the drive system to turn the cleaning robot such that the side surface of the cleaning robot faces a second obstacle surface, then operating the drive system to move the cleaning robot in a rearward drive direction along the second obstacle surface, and then operating the drive system to move the cleaning robot in the forward drive direction along the second obstacle surface.

Abstract: An apparatus 300 for simulating a pulsed pressure induced cavitation technique (PPCT) from a pressurized working fluid (F) provides laboratory research and development for enhanced geothermal systems (EGS), oil, and gas wells. A pump 304 is configured to deliver a pressurized working fluid (F) to a control valve 306, which produces a pulsed pressure wave in a test chamber 308. The pulsed pressure wave parameters are defined by the pump 304 pressure and control valve 306 cycle rate. When a working fluid (F) and a rock specimen 312 are included in the apparatus, the pulsed pressure wave causes cavitation to occur at the surface of the specimen 312, thus initiating an extensive network of fracturing surfaces and micro fissures, which are examined by researchers.

Abstract: Systems and methods for intelligently implementing an autonomous agent include: implementing a computer-based control circuit that generates computer-based control signals for controlling a driving operation of an autonomous agent; enabling a non-computer control source that provides non-computer-based control signals for controlling the operation of the autonomous agent; implementing a dedicated arbiter circuit that selectively passes control signals from either the computer-based control circuit or the non-computer control source to lower-level driving mechanisms; and implementing a takeover circuit that source s a takeover signal to the dedicated arbiter circuit based on detecting non-computer-based control signals having non-nominal control values from the non-computer control source, wherein in response to the takeover signal, the dedicated arbiter circuit dynamically switches from passing the computer-based control signals from the computer-based control circuit to passing non-computer-based control sig

Abstract: An acute ischemia detection device comprises a 12-lead electrocardiograph (ECG) device (12), an electronic data processing device (12), and a display component (22). The electronic data processing device applies 12-lead ECG to vessel-specific lead (VSL) transforms (50) to 12-lead ECG data acquired by the 12-lead ECG device to generate VSL lead data (e.g., LAD, LCX, and RCA vessel-specific lead data), determines ST values for the VSL lead data, and decides whether the 12-lead ECG data acquired by the 12-lead ECG device indicates acute ischemia by comparing the ST values for the VSL lead data with VSL lead ST thresholds (60). The display component may display an acute ischemia alarm or warning if the decision is the 12-lead ECG data acquired by the 12-lead ECG device indicates acute ischemia, and/or may display the generated VSL lead ECG traces.

Abstract: Processes for producing 2,5-dichlorophenol and 3,6-dichloro-2-methoxybenzoic acid are described. Various processes for isomerizing 2,4-dichlorophenol over a zeolite catalyst to form 2,5-dichlorophenol are provided. Processes for preparing 2,5-dichlorophenol including hydroxylating 1,4-dichlorobenzene are also described. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid.

Abstract: The invention relates to use of non-surfactant compounds including, for example, polyoxyethylene (POE) sorbitans and polyethylene glycols (PEGs), for stabilizing protein-containing formulations and for the prevention of aggregation of proteins in such formulations.

Abstract: Provided herein are compounds of Formula I useful as FGFR4 inhibitors, as well as methods of use of the same.

Abstract: Disclosed herein are compounds, or pharmaceutically acceptable salts thereof, and methods of using the compounds for treating breast cancer by administration to a subject in need thereof a therapeutically effective amount of the compounds or pharmaceutically acceptable salts thereof. The breast cancer may be an ER-positive breast cancer and/or the subject in need of treatment may express a mutant ER-? protein.