Abstract: Systems and methods for optical multi-path interference (MPI) compensation are provided. In an embodiment, a mean MPI signal representing a mean amplitude of the MPI in an input signal is generated and subtracted from a first estimate of transmitted amplitude of the input signal to generate a mean MPI compensated estimate of transmitted amplitude. The mean MPI compensated estimate of transmitted amplitude is sliced to generate a decision of transmitted amplitude of the input signal. The mean MPI signal can be generated using a mean MPI feedback loop or using an iterative feed-forward process. In another embodiment, mean MPI levels corresponding to respective transmitted intensity levels are generated and used to control slice levels of a slicer in order to compensate for MPI.

Abstract: The present invention provides novel pladienolide pyridine compounds, pharmaceutical compositions containing such compounds, and methods for using the compounds as therapeutic agents. These compounds may be useful in the treatment of cancer, particularly cancers in which agents that target the spliceosome and mutations therein are known to be useful.

Abstract: An energy generating device utilizing mechanical vibration power is provided. The energy generating device includes a first body for reciprocating according to vibration motions; an anchored second body; a rack coupled to one of the first body and the anchored second body; a gear assembly engaged with the rack and coupled to the other one of the first body and the anchored second body such that the gear assembly drives a generator via a rotational movement in a single direction according to each of upward and downward movement of the rack relative to the gear assembly; and the generator engaged with the gear assembly for receiving the rotational movement output from the gear assembly and outputting a direct current according to the rotational input from the gear assembly.

Abstract: A rotary shutter valve 500 is used for geothermal reservoir stimulation. The valve 500 includes a pressure chamber 520 for holding a working fluid (F) under pressure. A rotatable shutter 532 is turned with a powering device 544 to periodically align one or more windows 534 with one or more apertures 526 in a bulkhead 524. When aligned, the pressurized working fluid (F) flows through the bulkhead 524 and enters a pulse cavity 522, where it is discharged from the pulse cavity 522 as pressure waves 200. The pressure wave propagation 200 and eventual collapse of the bubbles 202 can be transmitted to a target rock surface 204 either in the form of a shock wave 206, or by micro jets 208, depending on the bubble-surface distance. Once cavitation at the rock face begins, fractures are initiated in the rock to create a network of micro-fissures for enhanced heat transfer.

Abstract: An apparatus 300 for simulating a pulsed pressure induced cavitation technique (PPCT) from a pressurized working fluid (F) provides laboratory research and development for enhanced geothermal systems (EGS), oil, and gas wells. A pump 304 is configured to deliver a pressurized working fluid (F) to a control valve 306, which produces a pulsed pressure wave in a test chamber 308. The pulsed pressure wave parameters are defined by the pump 304 pressure and control valve 306 cycle rate. When a working fluid (F) and a rock specimen 312 are included in the apparatus, the pulsed pressure wave causes cavitation to occur at the surface of the specimen 312, thus initiating an extensive network of fracturing surfaces and micro fissures, which are examined by researchers.

Abstract: A drilling system for drilling vertical holes in a mine roof includes a chuck configured to be driven in rotation by a motorized drill head. The chuck is cylindrical has a bore having a first polygonal inside perimeter. A drill member has an elongated hollow body with a cross section defining a circular outside perimeter over most of its length and a constant, second polygonal inside perimeter along substantially the entire length of the drill member. The drill member has at least one end region having a first polygonal outside perimeter that is sized to fit into the first polygonal inside perimeter to rotationally engage the drill member with the chuck. Drill bits having a bit fixture having a cross section with a second polygonal outside perimeter are sized and configured to fit snugly inside the second polygonal inside perimeter to be mounted to the drill member opposite the chuck.

Abstract: A user device receives a mobile application that defines multiple environments associated with the mobile application and launches the mobile application. After the launching the mobile application, the user device retrieves an environment selector value for the mobile application and initializes the mobile application with configuration data for a particular environment of the multiple environments. The particular environment is selected from the multiple environments based on the environment selector value.

Abstract: Embodiments for improving the Signal to Noise and Distortion (SINAD) ratio in Pulse Amplitude Modulation (PAM)-M optical intensity modulation systems, to enable higher data rate communications, are provided. Embodiments can be used to improve the linearity and reduce the distortion of electrical and electro-optics components (including optical modulators) in optical intensity modulation systems. Embodiments are well suited for use with PAM-M optical intensity modulators, such as segmented Vertical Cavity Surface Emitting Laser (WSEL) and segmented Mach-Zehnder Modulator (MZM), for example.

Abstract: A method of operating a robot includes electronically receiving images and augmenting the images by overlaying a representation of the robot on the images. The robot representation includes user-selectable portions. The method includes electronically displaying the augmented images and receiving an indication of a selection of at least one user-selectable portion of the robot representation. The method also includes electronically displaying an intent to command the selected at least one user-selectable portion of the robot representation, receiving an input representative of a user interaction with at least one user-selectable portion, and issuing a command to the robot based on the user interaction.

Abstract: A network update interface is presented to a user on a network to display network updates from other users of a mutual social-networking site. The network updates shared by the other users are gathered in a stream and supplied to a facet-filtering system including a network update interface. The user controls the display of certain network update items according to facet-filter characteristics enabled in facet-filter selection panels in the network update interface. The facet-filter characteristics are used by a facet filter to select certain network updates for display to the user in the network update interface. Trending links to further articles with content corresponding to the facet-filter characteristics are displayed to the user according to greatest popularity among the other users. Links to the profiles of the users sharing the articles are also provided in the network update interface.

Abstract: In some variations, an apparatus provides real-time monitoring of voltage and differential voltage of both anode and cathode in a battery configured with at least one reference electrode. Voltage monitors are connected to a computer programmed for receiving anode voltage signals; receiving cathode voltage signals; calculating the derivative of the anode voltage with respect to time or with respect to capacity; and calculating the derivative of the cathode voltage with respect to time or with respect to capacity. Other variations provide an apparatus for real-time assessment of capacities of both anode and cathode in a battery, comprising a computer programmed for receiving electrode voltage signals; estimating first and second electrode open-circuit voltages at two different times, and correlating the first and second electrode open-circuit voltages to first and second electrode states of charge, respectively, for each of anode and cathode. The anode and cathode capacities may then be estimated independently.

Abstract: Systems and methods are provided for calibrating an analog to digital converter (ADC) using one or more feedback mechanisms. In an embodiment, a capture memory module captures a portion of ADC data and post-processes the captured data using a microprocessor to perform calibration. Using the microprocessor, the capture memory module calibrates the ADC until the output of the ADC is within a desired range. In an embodiment, the capture memory module also captures a portion of data output from a digital correction module and post-processes this captured data using the microprocessor. Using the microprocessor, the capture memory module calibrates the digital correction module until the output of the digital correction module is within a desired range.

Abstract: Systems and methods that facilitate on-chip testing are provided. An integrated circuit can include a transmitter configured to transmit a communications signal via a communications channel. The integrated circuit can also include a receiver configured to receive the communications signal via the communications channel. A jitter creation module also can form part of the integrated circuit and can introduce jitter into the system thereby allowing for on-chip jitter testing. The jitter creation module can form either part of the transmitter or receiver and can introduce the jitter by phase interpolation.

Abstract: A network update interface is presented to a user on a network to display network updates from other users of a mutual social-networking site. The network updates shared by the other users are gathered in a stream and supplied to a facet-filtering system including a network update interface. The user controls the display of certain network update items according to facet-filter characteristics enabled in facet-filter selection panels in the network update interface. The facet-filter characteristics are used by a facet filter to select certain network updates for display to the user in the network update interface. Trending links to further articles with content corresponding to the facet-filter characteristics are displayed to the user according to greatest popularity among the other users. Links to the profiles of the users sharing the articles are also provided in the network update interface.

Abstract: Systems and methods are provided for calibrating an analog to digital converter (ADC) using one or more feedback mechanisms. In an embodiment, a capture memory module captures a portion of ADC data and post-processes the captured data using a microprocessor to perform calibration. Using the microprocessor, the capture memory module calibrates the ADC until the output of the ADC is within a desired range. In an embodiment, the capture memory module also captures a portion of data output from a digital correction module and post-processes this captured data using the microprocessor.

Abstract: The current thickness limitations of battery electrodes are addressed. An electrode includes an electrically conductive porous foam layer, an energy-storage material in contact with the porous foam layer, and electrically conductive porous foam protrusions extending from the porous foam layer into the energy-storage material. The energy-storage material is not contained within the pores of the foam layer or the foam protrusions. These electrodes allow lithium ions (and other metal ions, if desired) to diffuse deeper into a thick energy-storage material layer, compared to conventional planar electrodes. In particular methods, fluidic foam precursors can be templated in a mold, followed by conversion into a solid conductive foam that includes the electrically conductive porous foam protrusions. The result is batteries with surprisingly high energy densities.

Abstract: An apparatus and system is described for storing high-pressure fluids such as hydrogen. An inner tank and pre-stressed concrete pressure vessel share the structural and/or pressure load on the inner tank. The system and apparatus provide a high performance and low cost container while mitigating hydrogen embrittlement of the metal tank. System is useful for distributing hydrogen to a power grid or to a vehicle refueling station.

Abstract: Disclosed herein are methods and systems providing improvements enhancing speed and accuracy in interpreting the electrocardiogram (ECG) for ischemia identification using a graphical presentation. An ischemia criteria and ST segment measurements to be tested are graphically presented simultaneously. The graphical presentation allows the violation of the ischemia criteria to be visualized without any ambiguity. To further ensure that such a condition will not be overlooked, additional graphical highlighting is provided. This graphical approach can be used to improve the detection of conditions that fulfill the specified ischemia criteria and reduce the variation of individual interpretation for patients with border-line ST segment changes.

Abstract: A lithium-ion battery structure with a third electrode as reference electrode is disclosed. The reference electrode may be fabricated from lithium metal, lithiated carbon, or a variety of other lithium-containing electrode materials. A porous current collector allows permeation of reference lithium ions from the reference electrode to the cathode or anode, enabling voltage monitoring under actual operation of a lithium-ion battery. The reference electrode therefore does not need to be spatially between the battery anode and cathode, thus avoiding a shielding effect. The battery structure includes an external reference circuit to dynamically display the anode and cathode voltage. The battery structure can result in improved battery monitoring, enhanced battery safety, and extended battery life.

Abstract: The internal temperature of an electrochemical device may be probed without a thermocouple, infrared detector, or other auxiliary device to measure temperature. Some methods include exciting an electrochemical device with a driving profile; acquiring voltage and current data from the electrochemical device, in response to the driving profile; calculating an impulse response from the current and voltage data; calculating an impedance spectrum of the electrochemical device from the impulse response; calculating a state-of-charge of the electrochemical device; and then estimating internal temperature of the electrochemical device based on a temperature-impedance-state-of-charge relationship. The electrochemical device may be a battery, fuel cell, electrolytic cell, or capacitor, for example. The procedure is useful for on-line applications which benefit from real-time temperature sensing capabilities during operations. These methods may be readily implemented as part of a device management and safety system.