Abstract: The present disclosure provides bifunctional compounds of Formula (I), and pharmaceutically acceptable salts, isotopic forms, isolated stereoisomers, or mixtures of stereoisomers thereof, as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.

Abstract: Described are medical devices including expandable tubular bodies configured to be implanted into a lumen, wherein the outer surface of the expandable tubular bodies are coupled to a polymer(s).

Abstract: An information handling system may include at least one processor and a memory. The information handling system may be configured to: receive a request to perform a management operation on a target information handling system, wherein the request is received from a mobile device via a mobile network, and wherein the request includes data retrieved from a visual identifier associated with the target information handling system; and perform the management operation by communicating with the target information handling system via a management network other than the mobile network.

Abstract: Described herein are CD73 inhibitors and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful for the treatment of cancer, infections, and neurodegenerative diseases.

Abstract: A system includes a server that converts proxies of assets into virtual assets and hosts a session to exchange the virtual assets independent of users to which the proxies belong. The server can perform a decoupled asymmetric exchange based on the virtual assets over one or more network links between a user device and the server and between the user device and an issuer of the proxies. An agent server is delegated by the server to authorize the decoupled asymmetric exchange and route communications over the separate network links based on one or more conditions being satisfied. The system can then allocate the assets to the user device, independent of the users to which the proxies belong.

Abstract: A system can receive an indication from a user of a user device to participate in a session of an electronic exchange. The indication includes an indication of interest to perform a transaction with a participant of the temporary session. The system can predict, as an output of a machine learning (ML) model, a range of values for a valuation of the asset, receive an indication that the user selected a particular value of the range of values to configure a first side of the transaction, and automatically match a second side for the transaction with the first side of the transaction. The system further can perform an exchange of the asset between the first side and the second side of the transaction based on the particular value of the range of values.

Abstract: A class of pyrimidoheterocyclic compounds, and specifically disclosed is a compound represented by formula (III) or a pharmaceutically acceptable salt thereof.

Abstract: A wearable device includes an elastically compliant body having a side for attaching to skin of a patient, a plurality of accelerometers for receiving acoustic wave data from acoustic waves transmitted by a transducer, a short-range radio transmitter for transmitting the acoustic wave data to a computing device, a processor for receiving the acoustic wave data from the plurality of accelerometers and providing the acoustic wave data to the short-range radio transmitter, and a battery for providing power to the processor, the plurality of accelerometers, and the short-range radio transmitter. A distance between each accelerometer of the plurality of accelerometers is predetermined. The processor, the plurality of accelerometers, the short-range radio transmitter, and the battery are embedded within the elastically compliant body.

Abstract: A system and method for determining a center of resistance of a tooth may include receiving a 3D digital representation of an initial arrangement and a final arrangement of a patient's teeth and determining a 3D treatment plan. The 3D treatment plan may include a plurality of 3D stages for rearranging the teeth from the initial arrangement toward the final arrangement. The method may also include determining, in accordance with the 3D treatment plan, an intended movement of the teeth for each of the stages and deriving, using a 3D resistance model, an applied force system for achieving the intended movement of the teeth for each of the stages. The method may also include deriving 3D geometries of oral appliances for the stages in response to the applied force system. Various other systems and methods are also disclosed.

Abstract: An electrolyte additive containing a silyl-group compound useful for reducing battery resistance and improving high-temperature performance; an electrolyte containing the silyl-group compound additive; and an electrochemical energy storage device containing the electrolyte are disclosed.

Abstract: The present disclosure provides an orthodontic article including the reaction product of the polymerizable composition. Further, the present disclosure provides polymerizable compositions and methods of making an orthodontic article. The method includes obtaining a polymerizable composition and selectively curing the polymerizable composition to form an orthodontic article. Further, methods are provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an orthodontic article; and generating, with the manufacturing device by an additive manufacturing process, the orthodontic article based on the digital object. A system is also provided, including a display that displays a 3D model of an orthodontic article; and one or more processors that, in response to the 3D model selected by a user, cause a 3D printer to create a physical object of an orthodontic article.

Abstract: Test structures and methods of testing pixel driver chip donor wafers are described. In an embodiment, a redistribution layer is formed over a pixel driver chip donor wafer and probed to determine known good dies, followed by removal of the RDL. In other embodiments, test routing is formed in the pixel driver chip using a polycide material or doped region in the semiconductor wafer.

Abstract: A robotic cleaner includes a housing, a suction conduit with an opening, and a leading roller mounted in front of a brush roll. An inter-roller air passageway may be defined between the leading roller and the brush roll wherein the lower portion of the leading roller is exposed to a flow path to the suction conduit and an upper portion of the leading roller is outside of the flow path. Optionally, a combing unit includes a plurality of combing protrusions extending into the leading roller and having leading edges not aligned with a center of the leading roller. Optionally, a sealing strip is located along a rear side of the opening and along a portion of left and right sides of the opening. The underside may define side edge vacuum passageways extending from the sides of the housing partially between the leading roller and the sealing strip towards the opening.

Abstract: The present disclosure relates to systems and methods to generate user or user group behavior similarities based on computing distances between individual users or user groups and without using demographic data, e.g., based on anonymized data. The methods include creating a multidimensional vector representation for each user in a group by summarizing user's behaviors across various categories. Based on the created vectors, distance calculation and nearest neighbor search are performed to locate users that are most similar to target users. The resulting distance metrics may be used to rank similarities. Additionally, dimensionality reduction may be performed to further distill the behavior information to make the disclosed methods suitable for a variety of analytics and modeling tasks.

Abstract: The invention provides a transgenic Glycine max event MON87751, plants, plant cells, seeds, plant parts, progeny plants, and commodity products comprising event MON87751. The invention also provides polynucleotides specific for event MON87751, plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides for event MON87751. The invention also provides methods related to event MON87751.

Abstract: Aspects of a charging system may involve altering the duty cycle of the shaped charge signal over a period of time to alter an average current supplied to an electrochemical device while maintain the maximum current of the charge signal. For example, the average current of the charge signal used to charge a battery may be adjusted by varying the duty cycle or peak current of the shaped charge signal, and may be based, in some instances, on the state of charge, temperature, and/or impedance of the battery. In some instances, control over the average or total current of the charge signal is constrained by the maximum current that the system can supply, such that altering the duty cycle of the charge signal provides control over an average current of the charge signal without needing to supply additional current sources.

Abstract: The present disclosure relates to radio frequency (RF) chip packages and, more particularly, to improved thermal performance of RF chip packages and methods of manufacture. The structure includes: a board; a chip substrate; a pattern of solder bumps between the board and the chip substrate; and a thermal conductive material between the chip substrate and the board in depopulated regions of solder bumps of the chip substrate.

Abstract: Methods, devices, apparatuses and systems are disclosed for performing mammography, such as utilizing tomosynthesis in combination with breast biopsy.