Abstract: Methods and systems for dental treatment are provided. In some embodiments, a method includes receiving a plurality of treatment stages for repositioning a patient's teeth from an initial tooth arrangement toward a target tooth arrangement, where each treatment stage is associated with a target position for a tooth of the patient. The method can include determining, for one or more treatment stages, an overcorrected movement corresponding to an overcorrected position for the tooth that is different from the target position, where at least some of the one or more treatment stages include different magnitudes of overcorrected movements. The method can further include outputting fabrication instructions for one or more dental appliances corresponding to the one or more treatment stages, each dental appliance including an overcorrected tooth receiving cavity corresponding to the overcorrected position for the respective treatment stage.

Abstract: The present invention relates to rice grain with thickened aleurone. Also provided is a rice plant comprising at least one genetic variation which reduces the activity of at least one ROS1a gene in the plant. Grain of the invention, or aleurone therefrom, has improved nutritional properties, and hence is particularly useful for human and animal feed products.

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

Abstract: Series of apparatuses for expanding a patient's palate (“palatal expanders”), including rapid palatal expanders, wherein a left tooth engagement region and a right tooth engagement region are configured to add anti-tipping torque to at least one tooth. Left and right tooth engagement regions may include lingual surfaces with at least one lingual protrusion. Left and right tooth engagement regions may have buccally rotated cavities.

Abstract: An object processing system is disclosed that includes a mobile system for moving from a proximal base toward a plurality of objects to be processed, and a programmable motion device supported on the mobile unit at a proximal end of the programmable motion device, the programmable motion device including an end-effector at a distal end thereof, the end-effector including a first stationary portion that remains stationary with respect to the distal end of the programmable motion device, and a second movable portion that moves with respect to the first stationary portion, the second movable portion for contacting at least one object of the plurality of objects for urging the at least one object from the plurality of objects toward the mobile system.

Abstract: Systems and methods for synchronization of radio frequency (RF) generators are described. One of the methods includes receiving, by a first RF generator, a first recipe set, which includes information regarding a first plurality of pulse blocks for operating the first RF generator. The method further includes receiving, by a second RF generator, a second recipe set, which includes information regarding a second plurality of pulse blocks for operating a second RF generator. Upon receiving a digital pulsed signal, the method includes executing the first recipe set and executing the second recipe set. The method further includes outputting a first one of the pulse blocks of the first plurality based on the first recipe set in synchronization with a synchronization signal. The method includes outputting a first one of the pulse blocks of the second plurality based on the second recipe set in synchronization with the synchronization signal.

Abstract: A fractional-N phase-locked loop (PLL) that maintains phase coherence for an output signal with a plurality of possible output frequencies. The fractional-N PLL includes an oscillator, a phase detector to receive a reference clock signal and a feedback signal, and a multi-modulus divider coupled in a feedback path between the oscillator and the phase detector. A multi-modulus pattern generator supplies a drive pattern to the multi-modulus divider to achieve a desired change in frequency of the output signal. The multi-modulus pattern generator initiates the drive pattern at a boundary time to cause the output signal to have a substantially repeatable phase when restarting switching from any one of the output frequencies to any other of the output frequencies.

Abstract: A series of palatal expanders and methods of designing palatal expanders, including rapid palatal expanders, where outer occlusal surfaces of a palatal expander are shaped to conform to a geometry of corresponding teeth surfaces of the patient's lower jaw to provide occlusion between occlusal surfaces and the corresponding teeth surfaces.

Abstract: Methods and systems for image segmentation and analysis are described. A predictive model may be trained to identify and/or extract a rich set of image features with extensive prognostic value. For example, the predictive model may be trained to identify and/or extract features that that may be visualized to identify areas of interest (e.g., high-risk regions, etc.) within or adjacent to an object of interest, such a tumor. The predictive model may be trained to identify and/or extract features that that may predict a health related outcome, such as cancer patient survival/death, and modify therapeutic outcomes, such as diagnosis and treatment.

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

Abstract: Improved formulations of electrophoretic media that can be incorporated into displays, front plane laminates, inverted front plane laminates, or color changing films. The formulations include a non-polar fluid, a plurality of first charged particles, and charge control agents (CCA) including a quaternary amine and an unsaturated polymeric tail comprising monomers of at least 10 carbon atoms in length. The formulations show improved switching speeds, as well as a larger dynamic range at low temperatures (i.e., below about 0° C.), where compared to state-of-the-art electrophoretic media.

Abstract: Embodiments of the present disclosure relate to methods of preparation of templates for polynucleotide sequencing. In particular, the disclosure relates to linearization of clustered polynucleotides in preparation for sequencing by cleavage of one or more first strands of double-stranded polynucleotides immobilized on a solid support by a transition metal complex, for example, a palladium complex or a nickel complex. Further disclosure relate to linearization of clustered polynucleotides by cleaving one or more second strands of double double-stranded polynucleotides immobilized on a solid support comprising azobenzene linker by Na2S2O4. Nucleotides and oligonucleotides comprising a 3? phosphate moiety blocking group, and methods of removing the same using a fluoride reagent are also disclosed.

Abstract: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have a general Formula I?: wherein the variables of Formula I? are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.

Abstract: A solid polymer electrolyte including a cross-linked ionic liquid (IL) matrix having functional group capable of interacting with lithium ions; polymerizable PEM formulations containing polymerizable ionic liquid (IL) materials (monomers) having functional group capable of interacting with lithium ions and a reactive polymerizable functional group capable of crosslinking; electrolytes prepared from a polymerizable formulation including a lithium conducting salt, a plasticizer, a cross-linker, and a polymerizable IL compound that contains at least one functional group capable of interacting with lithium ions and a reactive polymerizable functional group capable of crosslinking; electrochemical cells containing the electrolytes incorporating these solid PEMs containing the polymerized ionic liquid (IL) materials; and methods thereof are disclosed.

Abstract: Compounds, particles, and cathode active materials that include lithium, cobalt, manganese, nickel, aluminum, and other elements can be used in lithium ion batteries. The cathode active materials include compounds having the general Formula (I): compound represented by Formula (I): Li?CO1-x-y-zMewMnxNiyAlzO?, as well as Formula (II): Li?CO1-s-u-vMesMntNiuAlyO?.

Abstract: A thermally conductive composition includes a non-silicone polymer resin curable in place along a thermal dissipation pathway. The composition exhibits a low density for particular use in weight-sensitive applications that require a thermal conductivity of at least 1.5 W/m*K.

Abstract: A ball nut assembly comprises a spindle having a longitudinal axis, a ball nut, and bearing elements supporting the ball nut on the spindle. First, second, third, and fourth ball nut deflectors are between the ball nut and the spindle. First, second, and third planes extend parallel to the axis. The first and fourth ball nut deflectors are in the first plane, the second ball nut deflector is in the second plane, the third ball nut deflector is in the third plane. Furthermore, the second and third ball nut deflectors are on opposite sides of the first plane. A first acute angle is between the first and second planes and a second acute angle is between the first and third planes.

Abstract: The present disclosure provides an orthodontic article including the reaction product of the polymerizable composition. Further, the present disclosure provides polymerizable compositions and methods of making an orthodontic article. The method includes obtaining a polymerizable composition and selectively curing the polymerizable composition to form an orthodontic article. Further, methods are provided, including receiving, by a manufacturing device having one or more processors, a digital object comprising data specifying an orthodontic article; and generating, with the manufacturing device by an additive manufacturing process, the orthodontic article based on the digital object. A system is also provided, including a display that displays a 3D model of an orthodontic article; and one or more processors that, in response to the 3D model selected by a user, cause a 3D printer to create a physical object of an orthodontic article.