Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to sequences of electronic messages to drive user engagement. For example, a method may include determining a set of messages including at least a first message and a second message; transmitting the first and second messages as an initial message to a first plurality of devices and a second plurality of devices, respectively; determining a first and second performance indicator at least based on one or more responses to the first and second messages transmitted as the initial message, respectively; comparing the first performance indicator and the second performance indicator; and sorting a sequence of the set of messages based on the comparison of the first performance indicator to the second performance indicator.

Abstract: The present disclosure provides methods and systems for determining and/or characterizing one or more haplotypes and/or phasing of haplotypes in a nucleic acid sample. In particular, the disclosure provides methods for determining a haplotype and/or phasing of haplotypes in a nucleic acid sample by incorporating synthetic polymorphisms into fragments of a nucleic acid sample and utilizing the synthetic polymorphisms in determining one or more haplotypes and/or phasing of haplotypes.

Abstract: The present disclosure provides methods and systems for determining and/or characterizing one or more haplotypes and/or phasing of haplotypes in a nucleic acid sample. In particular, the disclosure provides methods for determining a haplotype and/or phasing of haplotypes in a nucleic acid sample by incorporating synthetic polymorphisms into fragments of a nucleic acid sample and utilizing the synthetic polymorphisms in determining one or more haplotypes and/or phasing of haplotypes.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: Systems and techniques are provided for forecasting for time series with limited data. A computing device may determine a distance between the long-term time series or section and a short-term time series may be determined for each long-term time series and section in a repository. The computing device may determine which of the long-term time series and sections from the repository has the shortest distance between that long-term series or section and the short-term time series. The computing device may generate forecasted data points for the short-term time series based on the long-term time series or section determined to have the shortest distance between that long-term time series or section and the short-term time series. The computing device may store the forecasted data points for the short-term time series with the short-term time series.

Abstract: This invention relates to a breath indicator for providing an indication of an inhalation and/or exhalation state of a user. Said breath indicator comprising a body comprising a gas sampling portion configured for receipt of a user's inhalation and/or exhalation gases, and an indicator portion. Said gas sampling portion in fluid communication with said indicator portion. Said indicator portion comprising at least a first region and at least a second region, the first region comprising a gas parameter detecting material capable of changing between an initial visual state and a subsequent visual state indicative of detection of a gas parameter of inhalation and/or exhalation gases of said user; and wherein said initial visual state and/or said subsequent visual state of the first region visually contrasts with a visual state of at least said second region.

Abstract: A system for generating a graphical user interface in a client device. The system may include a processor in communication with the client device and a database. The processor may execute: receiving a request for occupancy information of a specified merchant; obtaining a plurality of credit card authorizations associated with the merchant; generating a posted transaction array based on the credit card authorizations; removing outlier members of the posted transaction array by applying a threshold filter; generating a transaction frequency array based on the posted transaction array, the transaction frequency array comprising weekdays and aggregated transactions associated with the weekdays; modifying the transaction frequency array by applying a transformation to the aggregated transactions; generating a smoothed array by applying a kernel density estimate to the transaction frequency array; and generating a graphical user interface displaying information in the smoothed array.

Abstract: Provided herein is a method for sequencing a polynucleotide molecules. The method includes the steps of providing a plurality of polynucleotide molecules attached to a surface, wherein a first portion of each polynucleotide molecule is attached to a first location of the surface and a second portion of each polynucleotide molecule is attached to a second location of the surface, the relative proximity of the first and second locations being correlated with the probability that the first and second portions are paired, separating the first and second portions of the polynucleotide molecules on the surface, determining the sequences of the first and second portions of the polynucleotide molecules and comparing the relative proximities and the sequences to determine which first and second portions are paired and to determine the sequence of the target polynucleotide molecules.

Abstract: The present disclosure provides methods and systems for determining and/or characterizing one or more haplotypes and/or phasing of haplotypes in a nucleic acid sample. In particular, the disclosure provides methods for determining a haplotype and/or phasing of haplotypes in a nucleic acid sample by incorporating synthetic polymorphisms into fragments of a nucleic acid sample and utilizing the synthetic polymorphisms in determining one or more haplotypes and/or phasing of haplotypes.

Abstract: A method including (a) providing an amplification reagent including an array of sites, and a solution having different target nucleic acids; and (b) reacting the amplification reagent to produce amplification sites each having a clonal population of amplicons from a target nucleic acid from the solution. The reacting can include simultaneously transporting the nucleic acids to the sites at an average transport rate, and amplifying the nucleic acids that transport to the sites at an average amplification rate, wherein the average amplification rate exceeds the average transport rate. The reacting can include producing a first amplicon from a nucleic acid that transports to each of the sites, and producing subsequent amplicons from the nucleic acid or from the first amplicon, wherein the average rate at which the subsequent amplicons are generated exceeds the average rate at which the first amplicon is generated.

Abstract: The present invention relates to methods of imaging template hybridisation for estimating cluster numbers prior to solid phase amplification and sequencing. More particularly, an initial round of imaging is carried out at the single molecule template hybridisation stage which allows a general estimation of cluster numbers prior to clusters being formed. Amplification of the signal allows single molecule imaging to be carried out using standard sequencing imaging apparatus.

Abstract: A navigation system includes a first and second tracker supports independently affixed to a rigid object and separated by a distance. A first plurality of trackable elements are secured to the first tracker support and a second plurality of trackable elements are secured to the second tracker support. A localizer tracks the trackable elements and controller(s) define a tracking arrangement to be tracked based on a combination of the first and second plurality of trackable elements. A geometry of the tracking arrangement is registered relative to the rigid object and the controller(s) track the rigid object by detecting the registered geometry. The controller(s) identify a condition wherein at least one trackable element has been displaced relative to the registered geometry, and in response, generate an instruction to a manipulator controller to interrupt operation of a robotic manipulator.

Abstract: A system for generating a graphical user interface in a client device. The system may include a processor in communication with the client device and a database. The processor may execute: receiving a request for occupancy information of a specified merchant; obtaining a plurality of credit card authorizations associated with the merchant; generating a posted transaction array based on the credit card authorizations; removing outlier members of the posted transaction array by applying a threshold filter; generating a transaction frequency array based on the posted transaction array, the transaction frequency array comprising weekdays and aggregated transactions associated with the weekdays; modifying the transaction frequency array by applying a transformation to the aggregated transactions; generating a smoothed array by applying a kernel density estimate to the transaction frequency array; and generating a graphical user interface displaying information in the smoothed array.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: Disclosed are methods, systems, and non-transitory computer-readable medium for optimizing user experience with respect to email journeys. For example, a method may include determining a first development subset, a first quality assurance subset, and a first production subset of a first plurality of user identifiers; determining and transmitting a first development set of messages, a first quality assurance set of messages, and a first production set of message; determining a development performance indicator, a quality assurance performance indicator, and a production performance indicator based on one or more messages received in response to the transmitted first development set of messages, first quality assurance set of messages, and first production set of message, respectively.

Abstract: The invention relates to an apparatus with magnets of a unique configuration to secure devices to non-ferromagnetic material, such as the windshield of a car. The invention permits the perimeter structure of the non-ferrous material to optionally be used to provide additional stability to secured devices. At least two magnets clamp opposite sides of the non-ferromagnetic material, magnetically associating the two magnets. The magnets are of a shape conducive to avoiding collision with windshield wipers, when mounted onto a car windshield, while maintaining sufficient volume to provide acceptable magnetic force to support devices mechanically attached to magnets. Example attached devices include a phone, GPS, camera, or tablet.

Abstract: A patient interface can have a frame supporting a sealing member. Various features of the sealing member can improve comfort and sealing performance in the context of forming seals with the nares of a user, as well as contact with other facial surfaces. The sealing member can include convex portions, concave portions and thickness variations for providing various sealing, comfort, and deformability effects.

Abstract: A zinc-air battery cell assembly comprising: a layer of anode material; one or more layers of cathode material; a separator directly between and engaging both the layer of anode material and the layer of cathode material that acts as both an electronic insulator and an ion conductive path between the layer of anode material and the layer of cathode material; and a diffusion member directly engaging the layer of cathode material.