Abstract: The present invention generally relates to golf bags having a lightweight and durable top frame can be made of a lightweight metal and can have different structures. The lightweight top frame assembly can have handle and leg sub-assemblies. Three-dimensional printing methods can be used to form structures in the top frame having various shapes and geometric patterns, for example, a lattice having a top frame (cuff) with club dividers. The walls of the top cuff can be made of a lightweight metal and can have a sidewall, open loop, closed loop, or other structure. The top cuff includes club dividers for storing and organizing clubs in different compartments. The club dividers can be made of a cord material.

Abstract: A location detection system identifies the locations of medical devices such as patient support apparatuses and/or patient care devices within a medical facility. The devices communicate via a wired connection to one or more medical facility systems (e.g. nurse call system, computer network, etc.), and/or via a wireless connection to such systems. The location detection system automatically determines location information of the devices and communicates the location information so that the recipient of any outgoing alerts and/or other information sent from the devices is apprised of the location of the particular device sending the alert or other information. Caregivers are thereby able to respond to the correct location of an alert, and software systems such as EMR systems, admission discharge and transfer (ADT) systems, etc. are able to correlate transmitted device data with the location and/or patient assigned to that location.

Abstract: An electric connector connectable to a mating electric connector includes and inner part, an outer part and a self-locking mechanism. The inner part is adapted to be connected to an electrical conductor. The outer part is adapted to connect to the mating electric connector. The inner and outer parts are connected coaxially and rotatably to one another. The self-locking mechanism selectively blocks rotation of one of the inner or outer parts with respect to the other one of the inner or outer parts in a first circumferential direction, and permits rotation of one of the inner or outer parts with respect to the other one of the inner or outer parts in a second circumferential direction opposite the first circumferential direction.

Abstract: A device is provided that humidifies breathing gas. The device has a chamber with an inlet and an outlet. A chemical heater is positioned within the chamber and a trigger activates the heater. The chamber can be a conduit with an inner wall and an outer wall with a reservoir defined therebetween. The chemical heater can be positioned within the reservoir.

Abstract: Embodiments relate to a device for mounting on a wall for monitoring an environment. In one embodiment the device comprises: a body comprising: an active reflected wave detector; and a processor coupled to the active reflected wave detector, the processor configured to: control the active reflected wave detector to measure wave reflections from the environment to accrue measured wave reflection data, and identify a status of a person in the environment based on the measured wave reflection data, wherein the processor assumes, for said identification, that the active reflected wave detector is at an operating height above a floor of the environment. The device comprises a cord extending from the body, the cord having a length for ending at the floor when the device is mounted with the active reflected wave detector at said operating height and the cord is freely hanging and straight.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, bonds a, b, c and d, X1, X2, X3, X4, R2, and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The present disclosure is concerned with compositions and methods for reducing the steps used in the generation of monoclonal clusters by combining the enzymes used for linearization and removal of unused surface primers.

Abstract: The present invention relates to compounds of formula I that function as inhibitors of RET (rearranged during transfection) kinase enzyme activity: wherein HET, X1, X2, X3, X4, integer a and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which RET kinase activity is implicated.

Abstract: The present invention relates to a sequencing method which allows for increased rates of sequencing and an increase in the density of sequencing data. The system may be based on next generation sequencing methods such as sequencing by synthesis (SBS) but uses multiple primers bound at different positions on the same nucleic acid strand.

Abstract: This invention relates to a breath indicator that is receivable by a part of a breathing assistance apparatus that supplies gas to a patient. The indicator comprises an elongate body having a gas sampling end and an attachment end. The attachment end is adapted to attach to a part of a breathing assistance apparatus and for locating the gas sampling end. The gas sampling end is to be located in a region where gas from the patient is to be exhaled. The gas sampling end being in communication with a sensor comprising a detector material changeable between a first visual indicator state relating to an inhalation phase of the patient, and a second visual indicator state relating to an exhalation phase of the patient. The detector material is capable of changing between the visual indicator states at a sufficient rate to substantially correspond with the inhalation and exhalation phases of the patient.

Abstract: Provided herein, inter alia, are substituted imidazo[1,5-?]pyrazine compounds, compositions and methods for treating or preventing an IRE1?-related disease or disorder. In certain embodiments, the disease or disorder is selected from the group consisting of a neurodegenerative disease, a demyelinating disease, cancer, an eye disease, a fibrotic disease, and diabetes.

Abstract: The present disclosure is concerned with compositions and methods for the paired-end sequencing of target nucleic acids, and more particularly to obtaining nucleotide sequence information from two separate regions of target nucleic acids using amplification sites having a single type of surface primer.

Abstract: The present disclosure is concerned with compositions and methods for the paired-end sequencing of target nucleic acids, and more particularly to obtaining nucleotide sequence information from two separate regions of target nucleic acids using amplification sites having a single type of surface primer.

Abstract: Systems and methods of planning and scheduling resources of an airline include using machine learning models to generate custom behavioral characteristics for a plurality of operational components of the airline based on operations data. The custom behavioral characteristics are used to define inputs and outcomes in simulations of the operational components of the airline. The simulation outputs performance indicators and a feedback loop captures previously ignored interactions between the operational components of the airline based on the performance indicators and custom behavioral characteristics of inputs and outcomes corresponding to the plurality of operational components of the airline.

Abstract: There are provided methods and systems for making or repairing a specified part. For example, there is provided a method for creating an optimized manufacturing process to make or repair the specified part. The method includes receiving data from a plurality of sources, the data including as-designed, as-manufactured, as-simulated, and as-tested data relative to one or more parts similar to the specified part. The method includes updating, in real time, a surrogate model corresponding with a physics-based model of the specified part, wherein the surrogate model forms a digital twin of the specified part. The method includes further updating the surrogate model with a model of manufactured variance associated with at least one of inspection and in-operation data of a similar part. The method includes executing, based on the digital twin, the optimized manufacturing process to either repair or make the specified part.

Abstract: The present disclosure provides methods and systems for determining and/or characterizing one or more haplotypes and/or phasing of haplotypes in a nucleic acid sample. In particular, the disclosure provides methods for determining a haplotype and/or phasing of haplotypes in a nucleic acid sample by incorporating synthetic polymorphisms into fragments of a nucleic acid sample and utilizing the synthetic polymorphisms in determining one or more haplotypes and/or phasing of haplotypes.

Abstract: Embodiments relate to using an active reflected wave detector to classify the state of a person in an environment and optionally respond accordingly. In one embodiment there is provided a computer implemented method of determining a state of a person comprising: receiving an output of an active reflected wave detector; classifying a state of the person as being in a safe supported state based on the output using measurements of reflections associated with the person, wherein said classifying is based at least on: a height metric associated with at least one reflection from the person conveyed in the output of the active reflected wave detector; and a plurality of velocity magnitude measurements of the person corresponding to different times, each of said velocity magnitude measurements determined using the reflections associated with the person conveyed in the output of the active reflected wave detector.