Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.

Abstract: Methods for amplifying nucleic acids are provided. The methods can be used to minimize sequence specific bias caused by the preferential amplification of certain nucleic acid sequences. Methods are described which can lower the efficiency of AT rich templates relative to GC rich templates, thereby minimizing GC bias during amplification reactions with multiple templates of different sequence. The methods are suited to solid phase amplification, for example, utilizing flow cells.

Abstract: Disclosed herein are compositions and methods for sequencing nucleic acids.

Abstract: Compounds of formula (I) defined herein exhibit human neutrophil elastase inhibitory properties and are useful for treating diseases and conditions in which HNE is implicated.

Abstract: The present technology relates to molecular sciences, such as genomics. More particularly, the present technology relates to nucleic acid sequencing.

Abstract: The present invention provides a method of creating an array of features. The method can include steps of (a) providing a plurality of beads, wherein each bead in the plurality of beads includes probe content; (b) contacting the plurality of beads with a surface to produce a layer of beads on the surface; and (c) transferring the probe content from the beads to the surface to create an array of spatially discrete features on the surface, wherein each spatially discrete feature includes probe content from a bead in the plurality of beads.

Abstract: Methods of firing a cordierite green body to form a fired cordierite body. The green body comprises cordierite-forming raw materials and organic material, the body having a core portion and a skin portion. The green body is pre-heated to a pre-heat temperature that is less than a thermal decomposition temperature of the organic material. The green body is maintained at the pre-heat temperature for a period of time sufficient to minimize a temperature differential between the core portion and the skin portion. The green body is heated to a low firing temperature in a firing atmosphere sufficient to reduce a content of the organic material and to substantially remove chemically bound water from hydrous alumina. The green body is heated to a high firing temperature in a firing atmosphere sufficient to reduce the content of the organic material prior to a substantial removal of chemically bound water from clay.

Abstract: A fluid container is disclosed for retaining and dispensing a fluid into the mouth of an individual. The fluid container comprises a deformable body and defining an exterior surface and an interior chamber. An output end has an output orifice for positioning the fluid exterior to the interior chamber. A valve engages the output orifice for controlling the fluid flowing through the output orifice.

Abstract: The present invention relates to the field of molecular biology, and more specifically to methods for reducing the complexity of a nucleic acid sample.

Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.

Abstract: A patient support apparatus, such as a bed, cot, stretcher, or the like, uses the ability to communicate with a device via near field communication to determine that the device is physically proximate the support apparatus. The support apparatus uses this determination to associate itself with the device. In some instances, the associated device is a mattress positioned on the support apparatus; a footboard on the support apparatus; a medical device used with a patient supported on the support device; a nearby piece of furniture; another patient support apparatus; or an ID tag worn by a caregiver or patient, or attached to a piece of equipment. After the support apparatus and device are associated, they communicate information between each other using far field communication, which supports higher data transfer rates. Flux concentrators are added in some embodiments to extend and/or shape the range of near the field communication.

Abstract: A rotary engine rotor (10) comprises a body (12) comprising an outer surface (18), an inner surface (22), an insert (14) and a fixing 31 member (16). The outer surface (18) comprises three rotor sides (20) arranged in an equilateral triangle shape. The inner surface (22) comprises a location portion (24) at the midpoint of each rotor side (20), the location portions (24) together defining a location aperture (26). One location portion (24) is provided with a first fixing socket (28) extending radially from the inner surface (22) of the body (12), towards the outer surface (18) of the body (12). Cooling channels (30) are provided axially through the body (12) in the region of each apex (31). The insert (14) is provided in the location aperture (26) and comprises a bearing part (38) with a second fixing socket (40) extending radially through the insert (14) and in alignment with the first fixing socket (28).

Abstract: A fluid application system includes a diluent reservoir, a chemical container, a sprayer housing, a manifold located in the sprayer housing, and a pump assembly in fluid communication with an outlet of the manifold. The manifold includes a diluent inlet in fluid communication with the diluent reservoir, a chemical inlet in fluid communication with the container, a mixing chamber in fluid communication with the diluent inlet and the chemical inlet and the outlet of the manifold. The pump assembly draws a mixture of the chemical and the diluent from the manifold and sprays the mixture of the chemical and the diluent from the nozzle.

Abstract: The invention relates to new derivatives of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such derivatives; pharmaceutical compositions comprising such derivatives; such derivatives as a medicament; such derivatives for the treatment of chronic pain.

Abstract: Improved compositions, methods, apparatus, and kits for high-throughput nucleic acid amplification, detection and sequencing are disclosed. A nucleic acid cluster having an identifiable center is produced by generating on a solid support an immobilized nucleic acid complement from a template, one of which comprises a detectable label; and amplifying the complement and the template to obtain a nucleic acid cluster on the support, the cluster having a substantially central location marked by the detectable label and a surrounding region comprising immobilized copies. Also disclosed are nucleotide sequence determination in nucleic acid clusters so produced, center position annotation in the clusters, assignment of sequence information to overlapping clusters, and related compositions and methods.

Abstract: Novel forms of atorvastatin magnesium salt designated Form A, Form B, Form C, Form D, Form E, and Form F, pharmaceutical compositions containing such compounds, methods for their preparation and methods utilizing the compounds for treatment of hyperlipidemia, hypercholesterolemia, osteoporosis, benign prostatic hyperplasia (BPH) and Alzheimer's disease are described.

Abstract: The present disclosure provides methods and systems for determining and/or characterizing one or more haplotypes and/or phasing of haplotypes in a nucleic acid sample. In particular, the disclosure provides methods for determining a haplotype and/or phasing of haplotypes in a nucleic acid sample by incorporating synthetic polymorphisms into fragments of a nucleic acid sample and utilizing the synthetic polymorphisms in determining one or more haplotypes and/or phasing of haplotypes.