Abstract: A remote sensing system includes a transmitter for transmitting an online signal and first and second offline signals toward a target. A receiver receives a returned online signal and first and second returned offline signals from the target. A processor is provided for determining (a) a first ratio based on the returned online signal and first offline signal, and (b) a second ratio based on the returned online signal and second offline signal. A filter is also provided for correlating the first ratio with the second ratio for determining whether the returned online, first offline and/or second offline signals are useable. The returned online, first offline and second offline signals are used to compute first and second concentration path lengths (CPLs) of a column of air between a target and the remote sensing platform.

Abstract: Embodiments of a network architecture include a backbone node having a plurality of independent routers or switches connected in a matrix, wherein the matrix includes a plurality of stages of routers or switches, to form a node having a node switching capacity that is greater than the node switching capacity of the individual routers or switches. A method includes assigning one of a plurality of backbone networks to a destination network address, associating a next hop loopback address with the destination network address, and advertising the destination network address in combination with the next hop loopback address through the selected backbone network address.

Abstract: A method of determining the positions and orientations of the base (8) and platform (10) of a parallel manipulator using an iterative calculation in which successive iterations calculate estimates of said positions and orientations, each estimate being determined from the previous estimate using an inverse of a derivative of an error function (F), that function also being used to determine error values for each estimate, wherein if the error values are deemed unacceptable a new derivative is calculated and the iteration is repeated, whereas if the error values are deemed acceptable the same derivative is used in a subsequent iteration. Thus the derivative need not be re-calculate for each iteration, whereby the process can operate more rapidly, e.g. in real time.

Abstract: Embodiments of a network architecture include a backbone node having a plurality of independent routers or switches connected in a matrix, wherein the matrix includes a plurality of stages of routers or switches, to form a node having a node switching capacity that is greater than the node switching capacity of the individual routers or switches. A method includes assigning one of a plurality of backbone networks to a destination network address, associating a next hop loopback address with the destination network address, and advertising the destination network address in combination with the next hop loopback address through the selected backbone network address.

Abstract: The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae.

Abstract: Embodiments herein include methods and systems for use in delivering resources to a client device over a local network. An exemplary system comprises a plurality of caching devices operable to cache resources on behalf of a plurality of content providers, and a local caching device communicatively situated between an access network and the client device, wherein the access network is communicably situated between the plurality of caching devices and the local caching device. The local caching device is operable to retrieve a requested resource from at least one of the plurality of caching devices, deliver the requested resource to the client device over the local network, and store the requested resource for future requests by other client devices.

Abstract: A detonator sensitive explosive emulsion composition includes an oxidizing phase including a supersaturated solution of ammonium nitrate and a fuel phase including sufficient emulsifying agent to permit dispersion of the oxidizing phase in the fuel phase. The detonator sensitive explosive emulsion composition further includes a crystallization temperature depressant consisting essentially of at least one of an amine and an amine nitrate.

Abstract: A system for obtaining emission flux of a gas plume, emanating from a source, includes an airborne differential absorption lidar (DIAL) system for determining multiple concentration path length (CPL) values along a flight path; and an airborne wind measuring system (WMS) for determining a wind vector at the aircraft altitude. Also included is a processor for receiving the multiple CPL values determined by the DIAL system and the wind vector determined by the WMS. The processor uses the CPL values to compute either (a) an area-integrated concentration (AIC) value or (b) an average concentration value over a cross-plume extent, defined along the length dimension of the flight path. The processor also scales the wind vector to the near ground altitude level of the gas plume to obtain a scaled wind vector. The emission flux is obtained by multiplying either the AIC value or the average concentration value with a component of the scaled wind vector.

Abstract: Embodiments of a network architecture include a backbone node having a plurality of independent routers or switches connected in a matrix, wherein the matrix includes a plurality of stages of routers or switches, to form a node having a node switching capacity that is greater than the node switching capacity of the individual routers or switches. A method includes assigning one of a plurality of backbone networks to a destination network address, associating a next hop loopback address with the destination network address, and advertising the destination network address in combination with the next hop loopback address through the selected backbone network address.

Abstract: A system is provided for determining emission rate of a gas from a source. The system includes a selector for designating an in-plume area extending across a plume of gas. The in-plume area includes a length dimension greater than a width dimension. The system also includes a processor for determining an area-integrated concentration value for the in-plume area. The system further includes a wind vector received by the processor. The processor determines the emission rate of the gas based on the area-integrated concentration value and a vector component of the wind vector.

Abstract: Pharmaceutical compositions that include a poorly water-soluble therapeutic compound, an aqueous solvent, an chelator/antioxidant, a buffer or buffer component, and a bulking agent. The pharmaceutical compositions can be orally ingested or administered parenterally. The pharmaceutical compositions can further be lyophilized to form a pharmaceutically acceptable cake that can be administered orally, e.g., as a solid oral dosage form; or reconstituted and administered parenterally, e.g. as a single i.v. bolus or iv infusion, or administered orally, e.g. as a drink solution.

Abstract: Embodiments generally disclosed herein include a computer-implemented method for monitoring and correlating network traffic data associated with a primary network that is in communication with a plurality of secondary networks. The method generates a network traffic data set by monitoring network traffic between the primary network and the plurality of secondary networks. The method also determines a mapping of network connectivity by monitoring inter-network routing information between the primary network and the plurality of secondary networks. In addition, the method generates a traffic measurement data set by monitoring network utilization statistics between the primary network and the plurality of secondary networks. With the collected data sets, the method then calculates a relational network mapping between the primary network and the plurality of secondary networks by correlating the network traffic data set, the mapping of network connectivity, and the traffic measurement data set.

Abstract: Provided are compositions comprising aqueous solutions of valsartan suitable for oral administration, preferably in pediatric and geriatric populations. Methods for making such compositions and methods for their stabilization are provided.

Abstract: The present invention relates to newly identified open reading frames comprised within the genomic nucleotide sequence of Streptococcus pneumoniae, wherein the open reading frames encode polypeptides that are surface localized on Streptococcus pneumoniae. Thus, the invention relates to Streptococcus pneumoniae open reading frames that encode polypeptide antigens, polypeptides, preferably antigenic polypeptides, encoded by the Streptococcus pneumoniae open reading frames, vectors comprising open reading frame sequences and cells or animals transformed with these vectors. The invention relates also to methods of detecting these nucleic acids or polypeptides and kits for diagnosing Streptococcus pneumoniae infection. The invention finally relates to pharmaceutical compositions, in particular immunogenic compositions, for the prevention and/or treatment of bacterial infection, in particular infections with Streptococcus pneumoniae.

Abstract: A method of determining the positions and orientations of the base (8) and platform (10) of a parallel manipulator using an iterative calculation in which successive iterations calculate estimates of said positions and orientations, each estimate being determined from the previous estimate using an inverse of a derivative of an error function (F), that function also being used to determine error values for each estimate, wherein if the error values are deemed unacceptable a new derivative is calculated and the iteration is repeated, whereas if the error values are deemed acceptable the same derivative is used in a subsequent iteration. Thus the derivative need not be re-calculate for each iteration, whereby the process can operate more rapidly, e.g. in real time.

Abstract: A method of Nanoparticle-based therapy for a mammalian subject is disclosed. The method uses Nanoparticles and/or Nanoparticles with outer surfaces that contain an affinity moiety effective to bind specifically to a biological surface at which the therapy is aimed, and a hydrophilic polymer coating. The hydrophilic polymer coating is made up of polymer chains either covalently linked or surface adsorbed to the polymer components.

Abstract: A system for obtaining emission flux of a gas plume, emanating from a source, includes an airborne differential absorption lidar (DIAL) system for determining multiple concentration path length (CPL) values along a flight path; and an airborne wind measuring system (WMS) for determining a wind vector at the aircraft altitude. Also included is a processor for receiving the multiple CPL values determined by the DIAL system and the wind vector determined by the WMS. The processor uses the CPL values to compute either (a) an area-integrated concentration (AIC) value or (b) an average concentration value over a cross-plume extent, defined along the length dimension of the flight path. The processor also scales the wind vector to the near ground altitude level of the gas plume to obtain a scaled wind vector. The emission flux is obtained by multiplying either the AIC value or the average concentration value with a component of the scaled wind vector.

Abstract: Embodiments of a network architecture include a backbone node having a plurality of independent routers or switches connected in a matrix, wherein the matrix includes a plurality of stages of routers or switches, to form a node having a node switching capacity that is greater than the node switching capacity of the individual routers or switches. A method includes assigning one of a plurality of backbone networks to a destination network address, associating a next hop loopback address with the destination network address, and advertising the destination network address in combination with the next hop loopback address through the selected backbone network address.