Abstract: The present invention pertains to the use of a PKC inhibitor in the treatment of an ocular disorder.

Abstract: The present invention relates to a cylinder head cover for covering a cylinder head of a combustion engine. Such cylinder head covers often comprise an oil separator for separating oil and/or oil spray from the blow-by gas of combustion engines. With the present invention the oil separator is formed as a flow-through tube (10) through which the gas with the oil and/or oil spray to be separated flows. The flow-through tube (10) with its longitudinal axis (14) in the flow-through direction lies essentially in the plane of extension of the cylinder head cover (1). A worm-like segment is arranged in the flow-through tube (10), and its thread surfaces (21) form a spiral flow path (2). At the same time the cross section of the flow path lies between 1 mm2 and 800 mm2.

Abstract: A compound of formula I wherein R, Ra, Rb, Rc, Rd and Re are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.

Abstract: The invention relates to a method for controlling the start-up phase of a motor vehicle driven by an internal combustion engine (12). The internal combustion engine (12) is started by an electrical machine (16) that can be operated as a motor, and there is a preferably automatically actuatable clutch (50) in the drive train (11) between the internal combustion engine (12) and the electrical machine (16). A faster start-up response can be achieved if the internal combustion engine (12) is driven by the electrical machine (16) when the clutch (50) is engaged during start-up, and if the clutch capacitance (MK) is reduced according to a defined parameter, preferably the engine speed, the time or the torque (ME) of the electrical machine (16) or similar.

Abstract: This invention relates to PKC inhibitors which are able to selectively inhibit e.g. the and optionally 0, isoforms of PKC, and their use in particular in transplantation.

Abstract: The invention relates to a method for controlling the start-up phase of a motor vehicle driven by an internal combustion engine (12). The internal combustion engine (12) is started by an electrical machine (16) that can be operated as a motor, and there is a preferably automatically actuatable clutch (50) in the drive train (11) between the internal combustion engine (12) and the electrical machine (16). A faster start-up response can be achieved if the internal combustion engine (12) is driven by the electrical machine (16) when the clutch (50) is engaged during start-up, and if the clutch capacitance (MK) is reduced according to a defined parameter, preferably the engine speed, the time or the torque (ME) of the electrical machine (16) or similar.

Abstract: A compound of formula I wherein R, Ra and Rb are as defined in the specification, processes for their production, their uses, in particular in transplantation, and pharmaceutical compositions containing them.

Abstract: The invention relates to a piston pump for conveying fluids. The piston pump includes a piston, and a pressure chamber located between an intake valve and a discharge valve. The intake valve is arranged between the pressure chamber and a low-pressure zone of the piston pump. The intake valve has a valve body, a closing element, a device for preloading the closing element, and a device for fastening the intake valve to the piston. The fastening device encompasses at least two fastening elements which protrude from the valve body toward the piston. The fastening elements are positioned at a distance from one another, and are fitted with inlets therebetween for supplying fluid. The invention further relates to a piston pump having an intake valve without a spring-biased element.

Abstract: Provided are compounds of Formula (I), which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infraction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of (I) are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders or autoimmune diseases e.g.

Abstract: Disclosed is a method for producing cyclic phosphonic acid anhydrides of formula (III) by a) reacting phosphonic acid derivatives of formula (I) with acetic anhydride at a temperature ranging between 30 and 150° C. while separating a mixture of ethanoic acid and acetic anhydride by means of distillation, b) then reactively distilling the oligomeric phosphonic acid anhydrides of formula (II) obtained in step a) and transforming the same into the corresponding cyclic trimeric phosphonic acid anhydrides of formula (III), wherein n represents a number between 0 and 300 while R represents allyl, aryl, or open-chain, cyclic, or branched C1 to C8 alkyl radicals, aryloxy, allyloxy, or alkoxy comprising open-chain, cyclic, or branched C1 to C8 alkyl radicals. Preferably the cyclic trimeric phosphonic acid anhydrides formed in step b) are immediately dissolved in an organic solvent that exhibits an inert behavior relative thereto.

Abstract: A device for plane-parallel attachment of a first module to a sidewall of a second module includes at least one coupling element with clamping projections having beveled end sections. The coupling element includes a guide element with two opposing guide tabs, a locking element, and a stop element, wherein the guide tabs, the locking element, and the stop element abut sidewalls of the connecting element so that the two guide tabs extend from a first opposing pair of the sidewalls, and the locking element and the stop element extend from another opposing pair of the sidewalls perpendicular to the first pair. The first module includes an interlock for captivating the coupling element or elements in the sidewall of the first module, whereas the second module has a receiving part capable of receiving the coupling element or elements captivated in the sidewall of the first module.

Abstract: A separator for separating liquid components, in particular oil components, from a gas flow is disclosed including a cyclone and a tank. The liquid separator has a cyclone 1 with a separating chamber 2 including gas supply 3 and gas discharge 4 and a tank 5 which is connected to the cyclone 1 via a connection opening 6. The interior of the tank 5 is filled at least partially with a porous open-pore material 7 in order to interrupt the flow, dampen the flow, dampen the oscillations and/or discharge the liquid.

Abstract: A vacuum pump for producing low or high vacuum has a housing having a gas inlet and a gas outlet, a pumping system located in the housing, a motor for driving the pumping system, and a control electronics for controlling operation of the pump and likewise located in the housing, with the pumping system and the control electronics being located in separate housing sections of the housing.

Abstract: A lubricant-tight vane rotary vacuum pump, includes a pump stage (17) having a pump stage housing (10) with a gas inlet, compression chamber (11), and a gas outlet (51), a channel (50) connecting the compression chamber (11) with the gas outlet (51), and a groove (54) at least partially surrounding a mouth of the connecting channel (50) that opens into the gas outlet (51), so that lubricant, which is tossed out of the compression chamber, is collected in the groove (54) and re-entry of the lubricant back into the compression chamber (11) is prevented.

Abstract: A vacuum pump includes a pumping system (30) located in a pump housing (1) and a hood (1) at least partially surrounding the pump housing at least in the region of the pumping system to provide for at least partial dissipation of heat generated in the pumping system.

Abstract: A lubricant-tight vane rotary vacuum pump includes at least one pump stage (17, 18) having a safety valve (3) for controlling gas flow to the pump stage, a lubricant pump, a lubricant reservoir (30) at least partially surrounding the pump stage housing (10, 40), and a hydraulic conduit (31) connecting the lubricant pump outlet (22) with the safety valve (3), with a pressurized lubricant flow through the hydraulic conduit (31) opening the safety valve (3), and a channel (32) branching from the hydraulic conduit (31) for delivering a pressurized lubricant into the lubricant reservoir (30).

Abstract: A vacuum pump for producing low or high vacuum includes a housing (1?) having an inlet (9) and an outlet (9), a pumping system (30) for compressing gas, a motor (25, 26) for driving the pumping system (30), and a fan (6) for cooling the pump and having its own motor (6a) for driving the fan (6).

Abstract: Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g.

Abstract: A drive arrangement for a vacuum pump includes a separation member arranged between the motor stator and the motor rotor, and at least two, coaxial with each other and axially spaced from each other, guide surfaces, the separation member being formed as a separation sleeve which is supported and centered between the at least two guide surfaces, with the guide surfaces contacting an outer surface of the separation sleeve.