Abstract: Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g.

Abstract: A twin-shaft vacuum pump includes two shafts and two rotors supported on respective shafts and cooperating with each other for producing a pumping effect, with each rotor being formed of a plurality of discoid components.

Abstract: A cover plate device for a heat exchanger device, especially for a vehicle heater, includes a receiving zone (14) intended to be arranged on the heat exchanger device and to receive a fluid stream leaving the heat exchanger device in a first direction of flow (S1), a mixing zone (22) for mixing the partial fluid streams (F1, F2, F3) leaving the heat exchanger device in different areas and entering the receiving zone (14), and at least two delivery zones (24, 26) for delivering the fluid stream leaving the mixing zone (22) from the cover plate device (10).

Abstract: A twin-shaft vacuum pump includes two shafts and two rotors supported on respective shafts and cooperating with each other for producing a pumping effect, with each rotor being formed of a plurality of discoid components.

Abstract: A slide ring seal for sealing a rotatable shaft includes a non-rotating slide ring formed as a cylinder having a variable inner diameter that defines a profile forming a cross-section of the slide ring and corresponding to a matching profile of the shaft for engagement therewith.

Abstract: A heating system for a vehicle comprises a heating air fan for producing a heating air flow to be introduced into a vehicle interior, a heating device with a heat exchanger arrangement for heating the heating air flow delivered by the heating air fan, a vehicle interior temperature sensor arrangement for producing an output in connection with the temperature in the vehicle interior, a vehicle interior reference temperature presetting arrangement, a heating air flow temperature sensor arrangement for producing a second output in connection with the outlet temperature of the heating air flow heated by the heating device, and also a control device which is arranged so as to set the delivery capacity of the heating air fan in dependence on the first output and on the vehicle interior reference temperature predetermined by the vehicle interior reference temperature presetting arrangement, and to set the heating capacity of the heating device in dependence on the second output.

Abstract: The invention relates to immunoadsorbers for use in sepsis therapy, in particular for removal of complement factors and lipopolysaccharides (LPS) and, if need be, further sepsis mediators such as TNF and interleukins from body fluids, methods for their production and their use.

Abstract: A burner arrangement for a heating device, particularly a vehicle heating device, comprising a combustion chamber (18) and a flame tube (22) conducting the combustion products away from the combustion chamber (18), having an inlet region (28) near the combustion chamber (18) at which combustion products enter the flame tube (22) and an outlet region (36) at which combustion products leave the flame tube (22). At least one intermediate outlet region (42) between the inlet region (28) and the outlet region (36), in which intermediate outlet region (42) a portion of the combustion products can emerge from the flame tube (22).

Abstract: Indolylmaleimide derivatives comprising either a substituted phenyl, naphthyl, tetrahydronaphthyl, quinazolinyl, quinolyl, isoquinolyl or pyrimidinyl residue have interesting pharmaceutical properties, e.g. in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory diseases or disorders, autoimmune diseases, graft rejection or cancer.

Abstract: Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.

Abstract: Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.

Abstract: A ventilating system for a vehicle cab includes a blower which draws fresh air from the exterior of the cab into the interior of the cab. A filter housing is inserted generally transverse to the direction of air flow through a service opening in the ventilating system into the channel through which the fresh air flows. The filter housing encloses a fresh air filter. The blower also draws recirculating air from the interior of the cab through a recirculating air intake opening and blows it back through a recirculating air filter into the cab through an outlet opening. The recirculating air filter is also mounted in the filter housing. A filter insert includes a filter housing which contains the fresh air filter and the recirculating air filter, which are adjacent each other on either side of a separating wall, fresh air and recirculating air are separately filtered.

Abstract: Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapten complex. The resultant catalytic antibodies employ a catalytic mechanism which mimics the catalytic mechanism employed by natural class I aldolase enzymes.

Abstract: According to a remote control method, sound waves are output by a transmitter as short and long remote control pulses. These pulses are evaluated according to their duration. In order to largely avoid disturbances in the evaluation due to superimposition with reflected remote control signals, defined parameters, particularly at least one evaluation time of the remote control method, are adapted to variations in the duration of the remote control pulses output by the transmitter which are possible due to superimposition. Furthermore, a blanking is proposed which has a variable blanking duration that automatically adapts to a pause duration between two remote control pulses, which is varied due to a reflection.

Abstract: An analyzer is described comprising a device for scanning containers filled with body fluid and held in a tray, the openings of which are sealed by means of a sealing member, e.g. a stopper or cup. The opto-electronic scanning device consists of a receiver and a transmitter comprising a plurality of vertically arranged receiver elements and transmitter elements, respectively, facing each other in a registered manner. Receiver and transmitter are arranged on a pivotable transport path for the containers between an input station and two processing stations. During the transport of container through the scanning device, the intensity of the scanning beam of the transmitter elements can be controlled from a low to a high level by means of a control unit comprising a microprocessor. Shape and/or size of the sealing member is thereby detected by means of the low intensity and transmittance or type of the sealing member by means of the high intensity.

Abstract: In an arrangement to prevent the intrusion of foreign matter into a transducer which extends with a projection provided with an opening into a sound channel of a hearing aid, a reduced need for space as well as simpler construction, compared with the state of the art, are achieved by means of the following characterizing features: A membrane made of pore-free material is provided, which has at least one bore for the passage of sound of from a few hundredths to a few tenths of a millimeter diameter, and in which the wall thickness of the membrane is small with respect to the diameter of the bore.

Abstract: A circuit arrangement for suppressing oscillations, such as acoustic feedback in a hearing aid, has a circuit which recognizes the presence of oscillations in a useful signal, an oscillatory frequency search circuit, and an oscillation modifying circuit controlled by the search circuit. The oscillation modifying circuit suppresses oscillations by filtering. Drift effects are avoided by a frequency clamp-on sub-circuit in the search circuit, which retains the frequency of the recognized oscillation at the modifying circuit, even when the oscillatory signal at the input of the search circuit disappears.

Abstract: An actuating device for a disc brake, in particular for automotive vehicles, has a rotatably supported actuating member and a transforming device for transforming a rotary motion into an axial motion. A part of the transforming device may be held by a holding element whereby the transforming device may be non-rotatable and axially displaceable. The holding element has a rotatably supported part fixed to the brake housing. Friction-reducing means is provided between the rotatable part and the element fixed to the housing.

Abstract: A circuit arrangement for suppressing oscillations, such as acoustic feedback in a hearing aid, has a circuit which recognizes the presence of oscillations in a useful signal, an oscillatory frequency search circuit, and an oscillation modifying circuit controlled by the search circuit. The oscillation modifying circuit suppresses oscillations by filtering. Drift effects are avoided by a frequency clamp-on sub-circuit in the search circuit, which retains the frequency of the recognized oscillation at the modifying circuit, even when the oscillatory signal at the input of the search circuit disappears.