Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts, thereof: which inhibit coronavirus replication activity. The invention further relates to pharmaceutical compositions comprising a compound of Formula (I) or a pharmaceutically acceptable salt thereof, and methods of treating or preventing a coronavirus infection in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract: An online monitoring method for dynamic changes in positions of transmission line conductors based on electromagnetic signals of ground wires and an apparatus are provided. The method includes: monitoring electromagnetic signals of ground wires; in response to changing in the electromagnetic signals, sending waveforms of the electromagnetic signals of the ground wires before and after changing to a data processing end; deducing change situations of mutual inductances between the ground wires and conductors based on values of conductor currents and the change situations of the electromagnetic signals of the ground wires, and further deducing position change situations of the conductors based on the change situations of the mutual inductances between the ground wires and the conductors; and obtaining dynamic changes in positions and movement statuses of the transmission line conductor based on the position change situations of the conductors.

Abstract: The present disclosure relates to systems, methods, and non-transitory computer readable media that utilize machine learning to generate subject lines from subject line keywords. In one or more embodiments, the disclosed systems receive, from a client device, one or more subject line keywords. Additionally, the disclosed systems generate, utilizing a subject generation machine-learning model having learned parameters, a subject line by selecting one or more words for the subject line from a word distribution based on the one or more subject line keywords. The disclosed systems further provide, for display on the client device, the subject line.

Abstract: Disclosed are a method for adjusting a signal of a display panel, a time controller integrated circuit, a display panel, and a storage medium. The method includes: converting first data into a first data voltage signal using a first data voltage, in response to a set condition being reached, sending the first data voltage signal to a chip on film integrated circuit, the chip on film integrated circuit identifies the first data voltage signal to obtain a second data; acquiring the second data from the chip on film integrated circuit, determining that the chip on film integrated circuit fails to identify the first data in response to the second data being different from the first data; and adjusting the first data voltage until a second data voltage signal converted from the first data using a second data voltage after adjustment being successfully identified by the chip on film integrated circuit.

Abstract: The present invention discloses compounds of Formula (I), and pharmaceutically acceptable salts and esters thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which is associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH).

Abstract: A power transfer system to facilitate the transfer of electrical power between tree trunk sections of an artificial tree is disclosed. The power transfer system can advantageously enable neighboring tree trunk sections to be electrically connected without the need to rotationally align the tree trunk sections. Power distribution subsystems can be disposed within the trunk sections. The power distribution subsystems can comprise a male end, a female end, or both. The male ends can have prongs and the female ends can have voids. The prongs can be inserted into the voids to electrically connect the power distribution subsystems of neighboring tree trunk sections. In some embodiments, the prongs and voids are designed so that the prongs of one power distribution subsystem can engage the voids of another power distribution subsystem without the need to rotationally align the tree trunk sections.

Abstract: Disclosed is a follow focus. The follow focus includes the gear box, the handwheel assembly and the follow focus assembly. The handwheel assembly includes a handwheel body and an active worm, the active worm is fixed to the handwheel body and extends toward the gear box, and the active worm is provided with a first worm gear; and a follow focus assembly includes a follow focus gear and a driven worm, the driven worm is fixed to the follow focus gear and extends toward the gear box, the driven worm is provided with a second worm gear, an angle between the active worm and the driven worm is 90°, and the first worm gear is meshed with the second worm gear.

Abstract: Systems and methods for customer journey optimization in email marketing are described. The systems and methods may identify a plurality of messages for a first time period, wherein the plurality of messages are categorized according to a plurality of messages types, identify user information for a customer, wherein the user information includes user interaction data, determine a message type from the plurality of message types for the first time period based on the user information, wherein the message type is determined using a decision making model comprising a deep Q-learning neural network, select a message from the plurality of messages based on the determined message type, and transmit the message to the customer during the first time period based on the selection.

Abstract: The present invention discloses a extra thick hot rolled H section steel and a production method therefor. The extra thick hot rolled H section steel contains, by mass, the following chemical components: 0.04-0.11% of C, 0.10-0.40% of Si, 0.40-1.00% of Mn, 0.40-1.00% of Cr, 0.10-0.40% of Cu, 0.020-0.060% of Nb, 0.040-0.100% of V, 0.010-0.025% of Ti, 0.010-0.030% of Al, 0.0060-0.0120% of N, not more than 0.015% of P, not more than 0.005% of S, not more than 0.0060% of O, and the balance Fe and trace residual elements, wherein 0.090%?Nb+V+Ti?0.170%, 6.5?(V+Ti)/N?10.5, and 0.30%?CEV?0.48%. The extra thick hot rolled H section steel has a flange thickness of 90 mm-150 mm, has excellent comprehensive mechanical properties, and can well meet the needs for heavy supporting structural parts of high-rise buildings, large squares, bridge structures, etc.

Abstract: The present disclosure provides a bimetallic coordination metal-organic framework material, a preparing method thereof, and an application thereof. In the bimetallic coordination metal-organic framework material, carboxyl groups and soft groups of ligands are coordinated with coordination metal ions to assemble a structure having space and functions divided into covalent charge carrier layers and charge storage ion layers. Further, through the conjugation effect, the bimetallic coordination metal-organic framework material has unique electromagnetic properties, good electrical conductivity, and magnetic coupling performance. Thus, the bimetallic coordination metal-organic framework material is used as superconducting materials, conductive materials, semiconductor materials, or electromagnetic materials.

Abstract: A device for removing unwanted objects from cut tobacco in a cut tobacco production line is disclosed, which includes: a raw cut tobacco feeding and conveying unit (N1), a heavy unwanted object removal unit (N2), a cut tobacco dispersion and recovery unit (N3), a moderate unwanted object removal unit (N4), a cut tobacco humidification unit (N5) and a light unwanted object removal unit (N6). An unwanted object removal method using the cut tobacco unwanted object removal device is also disclosed. The device and method of the disclosure can effectively remove unwanted objects from cut tobacco.

Abstract: An interface obtains basic page information from another interface. The basic page information includes N bits, the N bits include an FEC function indicator bit sequence including an FEC ability indicator bit and an FEC requested indicator bit. The interface determines, based on values of a plurality of bits in the N bits, an operation mode supported by the another interface. The FEC function indicator bit sequence includes a first FEC function indicator bit corresponding to m FEC abilities; or the FEC function indicator bit sequence includes a first FEC ability indicator bit corresponding to n FEC abilities, where both m and n are greater than or equal to 1. Because one FEC function indicator bit indicates more FEC abilities, N bits in a basic page can carry more information, so that a process of increasing auto-negotiation pages is slowed down, thereby avoiding impact on auto-negotiation efficiency.

Abstract: Various aspects of the present disclosure generally relate to wireless communication. In some aspects, a user equipment (UE) may receive information indicating a condition for a conditional handover, and an indication to communicate on a source cell after transmitting a message on a target cell, associated with the conditional handover, and before receiving an additional message on the target cell. The UE may transmit the message on the target cell responsive to the condition for the conditional handover being satisfied. Numerous other aspects are described.

Abstract: Provided are a high temperature-resistant composite nanofiltration membrane and a preparation method thereof. The high temperature-resistant composite nanofiltration membrane includes a base membrane and a polyamide membrane arranged on the base membrane; wherein the polyamide membrane is prepared from raw materials comprising: an amine, an inorganic salt, a silane additive, a polyacyl chloride, and an oil phase solvent; and the silane additive is at least one selected from the group consisting of 3-aminopropyltriethoxysilane, divinyltriaminopropyltrimethoxysilane, N-cyclohexyl-?-aminopropyltrimethoxysilane, and trimethoxy[3-(phenylamino)propyl]silane.

Abstract: A storage and transportation device, which relates to the technical field of storage and transportation apparatuses are disclosed. The storage and transportation device comprises a cover, a supporting plate and a sealant. The supporting plate covers an opening of the cover to form a space for accommodating an item to be transported. The storage and transportation device further comprises a first sealant groove and a second sealant groove arranged at a sealed junction between the cover and the supporting plate, the sealant is contained in each of the first sealant groove and the second sealant groove, and the two parts of the sealant are connected.

Abstract: A method of promoting adhesion between a dielectric layer of a semiconductor device and a metal fill deposited within a trench in the dielectric layer, including performing an ion implantation process wherein an ion beam formed of an ionized dopant species is directed into the trench at an acute angle relative to a top surface of the dielectric layer to form an implantation layer in a sidewall of the trench, and depositing a metal fill in the trench atop an underlying bottom metal layer, wherein the metal fill adheres to the sidewall.

Abstract: A genetically engineered strain of Z. mobilis and uses thereof are provided. The genetically engineered strain named ZMNP is obtained by knockouts of four endogenous plasmids of pZM32, pZM32, pZM36, pZM33, and pZM39 from strain ZM4-Cas12a. ZMNP contains a reduced genome and has a series of excellent traits, such as high transformation efficiency, enhanced tolerance to inhibitors, improved capability to use secondary mother liquor and other excellent performance. ZMNP can be used as a chassis cell to construct diverse cell factories for biochemical production using different feedstocks especially the lignocellulosic biomass.

Abstract: A display panel and a display device.

Abstract: A Fresnel lens in a lens body, the lens body is provided with a light incident surface and a light exit surface opposite to each other along a first direction, and the light exit surfaces are adjacently arranged in a second direction perpendicular to the first direction. There are several protruding teeth, and the protruding teeth are formed by an effective surface and an ineffective surface, and the ineffective surface is inclined at an acute angle relative to the first direction. The invention makes the light passing through the lens body reach the effective surface as much as possible, thereby reducing stray light and enhancing light efficiency.

Abstract: A sugar-reduced sweetener can be a high-intensity sweetener, a bulk sweetener, or a one sugar sweetener. The dosages of the high-intensity sweetener and the bulk sweetener satisfy a condition that the sweetness of the two compounded approaches to that of the sugar sweetener. Flavor, sweetness, taste and efficacy of original sugar sweet substances, for example, common sugar varieties in life such as sucrose and brown sugar can be reserved, and the sugar-reduced sweetener can replace sucrose perfectly. During use, according to the requirements of the sugar reduction ratio, the sugar sweetening substances can be added in any proportion, which can greatly reduce the sugar content so as to achieve the purpose of lowering and reducing sugar. In a preparation method of the sugar-reduced sweetener of the present invention, an intermittent spraying method is adopted, so that the quality of a final product is stable.