Abstract: This specification provides a multi-party database including a central node and a plurality of databases. The central node has a disclosed first interface. Each of a plurality of query engines corresponding to the plurality of databases includes a second interface configured to interact with the first interface. The central node can determine a plurality of target databases related to a query request from the plurality of databases based on the query request; and send a query indication to a plurality of target query engines corresponding to the plurality of target databases through the first interface. The plurality of target query engines can receive the query indication from second interfaces in the plurality of target query engines, and execute the query indication to obtain a query result; and send the query result to the first interface in the central node through the second interfaces.

Abstract: An electronic device may have one or more displays that produce images for a user. The display may include an array of light-emitting diodes. Each light-emitting diode in the array of light-emitting diodes may include a plurality of vias. The vias may be arranged in an array of rows and columns. The light-emitting diodes in the array may share a common cathode. The common cathode may include a conductive layer formed from a reflective material. The conductive layer may be formed in a grid that defines a plurality of openings for the light-emitting diodes or may be formed around the periphery of the array. The array may include light-emitting diodes of two different colors in a head-to-tail arrangement, connected in series, or that share a common cathode. The array may include light-emitting diodes of three different colors that are vertically stacked.

Abstract: Optoelectronic structures and methods of fabrication are described in which an array of micro LEDs is arranged in the array of pixels that includes a defective pixel. An array of optical elements is formed over the array of micro LEDs, where the array of optical elements includes a modified optical element with a local perturbation over the defective pixel, while all other optical elements of the array of optical elements have a common shape. In this manner the local perturbation may facilitate optical crosstalk for compensation of the defective pixel.

Abstract: A method of treating rhabdomyosarcoma in a subject is described that includes administering a therapeutically effective amount of a PROTAC compound that results in the degradation of FOXO1 or a PAX3-FOXO1 fusion protein. A method of studying the chromatin-level effects of switching defective and sucrose nonfermenting (SWI/SNF) inactivators, comprising degrading ATPase using a PROTAC compound, and measuring the biological effect of the loss of SWI/SNF complexes is also described.

Abstract: Disclosed are to bifunctional compounds that target PRMT5 for degradation, compositions, and methods for treating diseases or conditions mediated by aberrant arginine methyltransferase 5 (PRMT5) activity.

Abstract: Disclosed herein are compounds that target SMARCA2, SMARCA4 or BRM, causing their degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and disease.

Abstract: This specification provides example data query methods, apparatuses, and systems for a multi-party secure database. In an example computer-implemented method, a central node receives a data query request from a data requester, where the data query request relates to one or more pieces of target data stored at one or more data providers. The central node determines whether the data query request satisfies respective security requirements of the one or more pieces of target data. In response to determining that the data query request satisfies respective security requirements of the one or more pieces of target data, the central node processes the one or more pieces of target data to obtain result data; and sends the result data to the data requester. The central node can restrict query of the target data by the data requester based on the security requirement of the target data stored at the data provider.

Abstract: Disclosed herein are compounds that target SMARCA2, SMARCA4 or BRM, causing their degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

Abstract: Optoelectronic structures and methods of assembly are described. In an embodiment, an optoelectronic structure includes a frontplane directly bonded to a backplane, and a cover window attached to the frontplane so that a cavity forms between the cover window and an optical layer of the frontplane. In an embodiment, the width of the cover window is less than the width of the backplane. In an embodiment, the width of the cover window is equal to the width of the backplane.

Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

Abstract: Provided herein are bifunctional compounds with a moiety or domain that is a binder of the ubiquitin receptor RPN13 and another moiety or domain that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one domain of the bifunctional compound is a binder of the ubiquitin receptor RPN13 and another domain of the compound is a binder of the target protein DOT1L in a subject.

Abstract: An electronic device may include a display having a monolithic array of light-emitting diodes mounted to a surface of a substrate layer. The diodes may include contact pads. Driver circuitry may independently drive each of the diodes in the array using drive signals. The driver circuitry may be formed on a driver integrated circuit. Bond pads may be formed on a surface of the integrated circuit. Copper pillars may be grown on the bond pads. In another suitable arrangement, the driver circuitry may be formed on a driver printed circuit board coupled to an interposer by a flexible printed circuit. The interposer may include bond pads and copper pillars grown on the bond pads. The contact pads on each of the diodes may be simultaneously bonded to the copper pillars. A surface of the substrate layer may be patterned to form light redirecting elements if desired.

Abstract: An electronic device such as a voice-controlled speaker device may have a cylindrical shape. The electronic device may include a housing, a speaker in the housing configured to emit sound, and a display in the housing. The display may include a substrate, light-emitting components mounted on the substrate, an opaque support structure mounted on the substrate, a diffuser that is mounted to the opaque support structure and that overlaps the light-emitting components, a display cover layer that overlaps the diffuser, and foam that is interposed between the opaque support structure and the display cover layer. The light-emitting components may be arranged in groups that have the same layout and orientations that vary as a function of angular position relative to the center of the display. The foam and/or an adhesive layer may be formed from two or more discrete pieces that have footprints with complementary protrusions.

Abstract: Disclosed are bispecific compounds (degraders) that target EP300/CBP for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: Disclosed herein are compounds that target SMARCA2 and SMARCA4, causing their degradation. Also disclosed herein are compositions and methods of use in treating associated disorders and diseases.

Abstract: Disclosed are bifunctional compounds (degraders) that target HAT EP300 for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: Disclosed are bifunctional compounds (degraders) that target HAT EP300 for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: A display may include light-emitting diode (LED) pixels. Each LED pixel may include both narrow-viewing-angle subpixels and wide-viewing-angle subpixels. Each LED pixel may include driver circuits that each drive a narrow-viewing-angle subpixel and a wide-viewing-angle subpixel of the same color. An emission logic circuit may direct a drive current from a drive circuit to one or both of a narrow-viewing-angle subpixel and a wide-viewing-angle subpixel of the same color. To correct for off-axis color shift, a pixel may include a green subpixel with two or more overlapping microlenses, a blue subpixel with two or more overlapping microlenses, and a red subpixel without any overlapping microlenses.

Abstract: An electronic device may include a projection display that has a high transparency when the display is turned off. The high off-state transparency may create the appearance of the display being invisible in the off-state, which may be desirable in certain electronic devices. The projection display may include an adjustable diffuser, a spatial light modulator that projects images onto the adjustable diffuser, a mirror that reflects the images from the spatial light modulator to the adjustable diffuser, and a light source that provides light to the spatial light modulator. The projection display may also include an adjustable opacity layer that is controlled based on detected ambient light levels. The projection display may also include an adjustable reflectivity layer. The adjustable diffuser and/or light source may be pixelated to increase contrast in the projection display.