Abstract: The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: A system may have a display that includes a plurality of light sources such as light-emitting diodes. The display may be an exterior display that is routinely operated in daytime conditions where ambient light levels are very high. To increase contrast in an exterior display, the display may include a sunlight blocking element. A static sunlight blocking element may include a louver film with asymmetric light blocking portions. The system may include an ambient light sensor that is configured to determine ambient light levels. Based on the detected ambient light level, control circuitry in the system may adjust one or more adjustable components in the display. The display may include an adjustable diffuser that has at least two states with different haze levels. The display may include an adjustable tint layer that has at least two states with different transmission levels.

Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 105) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.

Abstract: An electronic device may be provided with a display. The display may be overlapped by an antiglare film. The antiglare film may have a rough surface to diffuse incident light, thereby reducing glare. Additionally, the antiglare film may have a smooth portion that forms a transparent window and allows light to pass through undiffused. The electronic device may include a light-based component, such as a camera, that receives undiffused light through the transparent window. By overlapping the light-based component with the transparent window, the light-based component may receive the light in an unimpeded manner, thereby making more accurate measurements of the light. The display may have one or more display layers, such as opaque masking layers or polarizers, with openings that are aligned with the transparent window. The light-based component may receive the light through these openings so that the light is not absorbed or polarized before reaching the component.

Abstract: The application relates to a compound of Formula (I): which modulates the activity of TRIM33, a pharmaceutical composition comprising the compound, and a method of treating or preventing a disease in which TRIM33 plays a role.

Abstract: Implementations of this specification provide query optimization methods, apparatuses, and systems for secure multi-party databases. In an implementation, a method includes: receiving a current query associated with a plurality of target database of a multi-party database system, generating a plurality of execution plans for the current query, determining, for each execution plan, a respective cost computation formula of a plurality of cost computation values for computing an execution cost of jointly executing the execution plan by the plurality of target databases, receiving a secure computation result from each of a plurality of query engines corresponding to the plurality of target databases, and determining an optimal execution plan having a lowest cost value in the plurality of cost computation formulas based on the secure computation result.

Abstract: This specification provides example data query methods, apparatuses, and systems for a multi-party secure database. In an example computer-implemented method, a central node receives a data query request from a data requester, where the data query request relates to one or more pieces of target data stored at one or more data providers. The central node determines whether the data query request satisfies respective security requirements of the one or more pieces of target data. In response to determining that the data query request satisfies respective security requirements of the one or more pieces of target data, the central node processes the one or more pieces of target data to obtain result data; and sends the result data to the data requester. The central node can restrict query of the target data by the data requester based on the security requirement of the target data stored at the data provider.

Abstract: An electronic device may include a projection display that has a high transparency when the display is turned off. The high off-state transparency may create the appearance of the display being invisible in the off-state, which may be desirable in certain electronic devices. The projection display may include an adjustable diffuser, a spatial light modulator that projects images onto the adjustable diffuser, a mirror that reflects the images from the spatial light modulator to the adjustable diffuser, and a light source that provides light to the spatial light modulator. The projection display may also include an adjustable opacity layer that is controlled based on detected ambient light levels. The projection display may also include an adjustable reflectivity layer. The adjustable diffuser and/or light source may be pixelated to increase contrast in the projection display.

Abstract: A privacy film may have a light-blocking layer that is interposed between first and second transparent substrates. The light-blocking layer may have a plurality of opaque portions and a plurality of transparent portions. The opaque portions may be shaped to ensure light from the display is directed only to the primary viewer of the display. Each opaque portion of the light-blocking layer may extend along a respective longitudinal axis between the first and second transparent substrates. Privacy films used to cover curved displays may have opaque portions that extend along longitudinal axes that have different angles relative to the transparent substrates. Opaque portions in the edge of the privacy film may have longitudinal axes that are at non-perpendicular angles with respect to the transparent substrates. A privacy film for a curved display may also include a light-redirecting layer such as a prism layer or a liquid crystal layer.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes (LEDs) on a printed circuit board. The display may have a notch to accommodate an input-output component. Reflective layers may be included in the notch. The backlight may include a color conversion layer with a property that varies as a function of position. The light-emitting diodes may be covered by a slab of encapsulant with recesses in an upper surface.

Abstract: The present application relates to compounds comprising an ester, a thioester, or a hydrazide moiety and methods of synthesizing these compounds. The present application also relates to pharmaceutical compositions containing the compounds and methods of treating cell proliferative disorders mediated by the Hedgehog (Hh) signaling pathway, such as cancer, by administering the compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: A dielectric barrier discharge plasma generator includes a ground electrode and a high voltage electrode which are configured to form a circuit to receive a power input for plasma generation, a dielectric barrier having a first surface attached to the high voltage electrode, and a second surface facing the ground electrode, and discharge gap being formed between the second surface of the dielectric barrier and the ground electrode for plasma generation, and a resiliently deformable mechanism operative to bias the high voltage electrode against the first surface of the dielectric barrier.

Abstract: Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. Also provided are methods and kits involving the compounds or compositions disclosed herein for treating and/or preventing proliferative diseases, cancers, carcinoma lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, leukemia, sarcoma and/or cardiovascular diseases in a subject in need thereof. In certain embodiments, the sarcoma is Ewing's sarcoma. Provided are methods of inhibiting a histone demethylase in a subject and/or in a cell, tissue, or biological sample. In certain embodiments, the histone demethylase is a KDM. In certain embodiments, the KDM is KDM5. In certain embodiments the biological sample is a cell. In certain embodiments, the biological sample is a tissue.

Abstract: A system may have an external display that presents content to viewers outside of the system. The external display may have a display panel with an array of pixels formed from light-emitting diodes. Optical films that help collimate and homogenize light from the light-emitting diode pixels may overlap the light-emitting diodes. A transparent cover may overlap the display. The transparent cover may have an outer surface and an opposing inner surface. The outer surface and inner surface may be planar or may have a curved cross-sectional profile. An optical louver layer or other solar rejection layer may be interposed between the inner surface of the transparent cover and the display panel. The louver layer may have a series of elongated parallel louvers formed from an opaque polymer or other material. The louvers may be configured to block sunlight reflections while allowing images on the display panel to be viewed.

Abstract: A privacy film may have a light-blocking layer that is interposed between first and second transparent substrates. The light-blocking layer may have a plurality of opaque portions and a plurality of transparent portions. The opaque portions may be shaped to ensure light from the display is directed only to the primary viewer of the display. Each opaque portion of the light-blocking layer may extend along a respective longitudinal axis between the first and second transparent substrates. Privacy films used to cover curved displays may have opaque portions that extend along longitudinal axes that have different angles relative to the transparent substrates. Opaque portions in the edge of the privacy film may have longitudinal axes that are at non-perpendicular angles with respect to the transparent substrates. A privacy film for a curved display may also include a light-redirecting layer such as a prism layer or a liquid crystal layer.

Abstract: An electronic device may have one or more displays that produce images for a user. The display may include an array of light-emitting diodes. Each light-emitting diode in the array of light-emitting diodes may include a plurality of vias. The vias may be arranged in an array of rows and columns. The light-emitting diodes in the array may share a common cathode. The common cathode may include a conductive layer formed from a reflective material. The conductive layer may be formed in a grid that defines a plurality of openings for the light-emitting diodes or may be formed around the periphery of the array. The array may include light-emitting diodes of two different colors in a head-to-tail arrangement, connected in series, or that share a common cathode. The array may include light-emitting diodes of three different colors that are vertically stacked.

Abstract: An electronic device may have one or more displays that produce images for a user. The display may include an array of light-emitting diodes. Each light-emitting diode in the array of light-emitting diodes may include a plurality of vias. The vias may be arranged in an array of rows and columns. The light-emitting diodes in the array may share a common cathode. The common cathode may include a conductive layer formed from a reflective material. The conductive layer may be formed in a grid that defines a plurality of openings for the light-emitting diodes or may be formed around the periphery of the array. The array may include light-emitting diodes of two different colors in a head-to-tail arrangement, connected in series, or that share a common cathode. The array may include light-emitting diodes of three different colors that are vertically stacked.

Abstract: Provided herein are bifunctional compounds that bind a target protein (e.g., a selected protein) and/or induce ubiquitination for degradation of the target protein. In particular, provided are compounds that bind a bromodomain or bromodomain-containing protein (e.g., BET proteins) or histone methyltransferases (HMTs, e.g., enhancer of zeste homolog 1 (EZH1), or FKBP12) and can promote its degradation by recruiting it to the ubiquitin receptor RPN13 (e.g., RA190), for proteasomal degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating and/or preventing diseases (e.g., proliferative diseases, cancers, benign neoplasms, pathological angiogenesis, inflammatory diseases, and autoimmune diseases) and musculoskeletal diseases, and methods of inducing the degradation of a target (e.g., a target protein) by recruiting it to the ubiquitin receptor RPN13 of the proteasome in a subject by administering a compound or composition described herein.

Abstract: The present disclosure provides a silicone-modified dicyclopentadiene-derived hydroxy aromatic compound, which includes a structure represented by formula (I). Formula (I) is defined as in the specification. The present disclosure further provides a manufacturing method for a silicone-modified dicyclopentadiene-derived hydroxy aromatic compound and a curable product, wherein the curable product is obtained by mixing the silicone-modified dicyclopentadiene-derived hydroxy aromatic compound and a modified polyphenylene oxide resin, and then adding a peroxide to perform a curing reaction.

Abstract: Disclosed in the present invention are a stent apparatus having a self-pleated skirt, a processing method therefor, a skirt pleating method, and a cardiac valve. The stent apparatus comprises a stent, and is further provided with a flexible skirt. The skirt comprises: an unfolded state, where the skirt extends axially and surrounds the periphery of the stent before release; and a stacked state, where the skirt is driven by deformation during release of the stent, and gathers and is stacked along an axial direction of the released stent to form an annular perivalvular leakage blocking part. The stent apparatus is further provided with a pull-wire which is merely threaded on the skirt, and the pull-wire may react to the radial deformation during the release of the stent to drive the skirt to enter the stacked state.