Abstract: Textured cover assemblies for electronic devices are disclosed. The textured cover assemblies may be placed over a display and may provide anti-glare and anti-reflection properties to the electronic device.

Abstract: A stent device with skirt folds and a processing method thereof, a skirt folding method, and a heart valve. The stent device comprises a stent (1, 10) and a flexible skirt (2, 107), the skirt (2, 107) having an expanded state, in which the skirt is axially extended and surrounds the stent (1, 105) before release thereof, and a folded state, in which the skirt is driven by the deformation caused when the stent (1, 105) is released, collapses and folds axially along the released stent (1, 105) so as to form an annular peripheral leakage-blocking portion. The peripheral leakage prevention technology enables an interventional stent to fit to the inner wall of a vessel more snugly, such that the stent does not easily move and is more stable, thereby being suitable for more people, reducing additional risks of surgery and preventing complications such as peripheral leakage and thrombus.

Abstract: An electronic device such as a voice-controlled speaker device may have a housing. A speaker and other input-output components and control circuitry may be mounted within the housing. Light-emitting components may emit light that passes through a curved upper top cap portion or other housing structure. Some of the light-emitting components may be rotated to improve color balance. Optical structures such as a dual-shot injection molded light control plate may be disposed over the light-emitting components to promote light mixing, reduce hotspots, and improve contrast on the top cap. The light control plate may have an upper clear layer with bell-shaped cavity portions configured to help spread light in the lateral direction and may have a reflective lower layer with dish-shaped portions configured to reflect and diffuse light back towards the top cap. The surface of the dish-shaped portions may be provided with microtextured structures to help scatter light.

Abstract: An electronic device such as a voice-controlled speaker device may have a housing. A speaker and other input-output components and control circuitry may be mounted within the housing. Light-emitting components may emit light that passes through a curved upper top cap portion or other housing structure. The light-emitting components may be interconnected using a flex circuit on a curved substrate or may be mounted on a planar circuit board. A subset of the light-emitting components may be rotated to improve color balance. Optical structures such as light guides, lens, microlenses, and/or a diffuser layer may be disposed over the light-emitting components to promote light mixing, to reduce hotspots, and to improve contrast on the top cap. The diffuser layer may be suspended using a support structure having baffle members to constraint the angular spread of the emitted light. Illuminated or persistently visible glyphs may be displayed in or near the top cap portion.

Abstract: Disclosed are an improved leaflet of a cardiac valve, and a cardiac valve preform, a cardiac valve, and a processing method therefor. The improved leaflet of a cardiac valve comprises a leaflet body (1), wherein the leaflet body (1), in a height direction, is provided with a movable edge (12) on the top side and a fixed edge (11) on the bottom side, and the movable edge (12) and the fixed edge (11) extend in the width direction of the leaflet body (1) and are connected to connecting ears (10) on respective sides. Each of the connecting ears (10) comprises a pulling portion (2), the pulling portion (2) extending in the height direction and crossing the movable edge (12), wherein the movable edge (12) extends and intersects with the inner side of the pulling portion (2), and the fixed edge (11) extends and intersects with the outer side of the pulling portion (2).

Abstract: A pixel array may be illuminated with backlight illumination from a backlight. The backlight may include a two-dimensional array of light-emitting diodes, with each light-emitting diode being placed in a respective cell. Different light-emitting diodes may have unique brightness magnitudes based on the content of the given display frame. Driver integrated circuits may control one or more associated light-emitting diodes to have a desired brightness level. The driver integrated circuits may be formed in an active area of the backlight. The driver integrated circuits may be arranged in groups that are daisy chained together. A digital signal (that includes information such as addressing information) may be propagated through the group of driver integrated circuits. To manage thermal performance of the backlight, the backlight may include a thermally conductive layer and/or a heat sink structure. To increase the efficiency of the backlight, the backlight may include one or more reflective layers.

Abstract: A pixel array may be illuminated with backlight illumination from a backlight. The backlight may include a two-dimensional array of light-emitting diodes, with each light-emitting diode being placed in a respective cell. Different light-emitting diodes may have unique brightness magnitudes based on the content of the given display frame. Driver integrated circuits may control one or more associated light-emitting diodes to have a desired brightness level. The driver integrated circuits may be formed in an active area of the backlight. The driver integrated circuits may be arranged in groups that are daisy chained together. A digital signal (that includes information such as addressing information) may be propagated through the group of driver integrated circuits. To manage thermal performance of the backlight, the backlight may include a thermally conductive layer and/or a heat sink structure. To increase the efficiency of the backlight, the backlight may include one or more reflective layers.

Abstract: Disclosed is an interventional instrument that is convenient to position, comprising a support (1), wherein the support (1) is of a frame structure with a hollowed-out area (11) and is provided with an axis in space, and the support (1) has a loaded state, in which the support is radially compressed, and a released state, in which the support is radially expanded; a sealing film (2), connected to the support (1), and the position of which corresponds to at least part of the hollowed-out area, wherein in the loaded state, the peripheral face of the support (1) is enclosed to form a storage space, and the sealing film (2) is located in the storage space; and a friction increasing component (3) connected to the sealing film (2).

Abstract: The present invention provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: Disclosed are bispecific compounds (degraders) that target EP300/CBP for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: Provided herein are compounds of Formulae (I) and (II), and pharmaceutically acceptable salts, solvates, hydrates, polymorphs, co-crystals, tautomers, stereoisomers, isotopically labeled derivatives, prodrugs, and compositions thereof. The compounds described herein bind an E3 ubiquitin ligase (e.g., Cereblon) and induce degradation of a transcription factor (e.g., IKZF1, IKZF3). Also provided are pharmaceutical compositions comprising the compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases (e.g., cancers (e.g., carcinoma); leukemia, lung cancer, breast cancer, liver cancer, pancreatic cancer, gastric cancer, ovarian cancer, colon cancer, colorectal cancer, multiple myeloma, and acute myeloid leukemia (AML))). Further provided are methods of inducing the degradation of a transcription factor (e.g., IKZF1, IKZF3) by administering a compound or composition described herein to a subject and/or to a biological sample (e.g., cell or tissue).

Abstract: Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with HDAC3 activity.

Abstract: Textured cover assemblies for electronic devices are disclosed. The textured cover assemblies may be placed over a display and may provide anti-glare and anti-reflection properties to the electronic device.

Abstract: An electronic device may have input-output devices such as buttons formed from capacitive touch sensor electrodes. A transparent layer may be provided with opaque masking structures having a symbol-shaped opening aligned with a capacitive touch sensor electrode for a button or other input device. The symbol-shaped opening may be adjacent to the electrode and may be illuminated with light from a lighting system. The lighting system may include a light guide plate. The light guide plate may have edges that are oriented at non-zero angle with respect to each other. Light-emitting diodes of different colors may emit light into the edges. The light may be extracted from the light guide plate using bumps in a light extraction region. Light may be collimated using ribs formed on an opposing side of the light guide plate.

Abstract: An electronic device includes a housing, a speaker, control circuitry, a plurality of light-emitting components configured to emit light through an upper housing wall or other housing structure. A lens diffuser layer having lenses overlapping respective light-emitting components, a textured diffuser layer formed from textured coatings on a substrate, and a volume diffuser layer having light-scattering structures in a polymer layer might be included to project light from the light-emitting components. A light-guiding portion of the lens diffuser layer may guide light to a circular peripheral edge to form an illuminated ring visible through the upper housing wall.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a direct-lit backlight unit. The backlight unit may include an array of light-emitting diodes on a printed circuit board. The backlight unit may include first, second, and third light spreading layers formed over the array of light-emitting diodes. A color conversion layer may be formed over the first, second, and third light spreading layers. First and second brightness enhancement films may be formed over the color conversion layer.

Abstract: Disclosed in the present invention are a stent apparatus having a self-pleated skirt, a processing method therefor, a skirt pleating method, and a cardiac valve. The stent apparatus comprises a stent, and is further provided with a flexible skirt. The skirt comprises: an unfolded state, where the skirt extends axially and surrounds the periphery of the stent before release; and a stacked state, where the skirt is driven by deformation during release of the stent, and gathers and is stacked along an axial direction of the released stent to form an annular perivalvular leakage blocking part. The stent apparatus is further provided with a pull-wire which is merely threaded on the skirt, and the pull-wire may react to the radial deformation during the release of the stent to drive the skirt to enter the stacked state.

Abstract: The present invention provides bivalent inhibitors of BET bromodomains, such as compounds of Formulae (I), (II), (III), (IV), (V), and (VI). Some bromodomain-containing proteins (e.g., BRD4) have a tandem bromodomain primary structure comprising more than one bromodomain binding site (e.g., BRD4 comprises BD1 and BD2). Bivalent inhibitors of BET bromodomains provided herein can target bromodomains through advantageous multivalent interactions, and can therefore can be to treat diseases or conditions associated with bromodomain-containing proteins. The present also provides pharmaceutical compositions and kits comprising the inventive compounds, as well as methods of using the inventive compounds.

Abstract: The present invention provides compounds and pharmaceutically compositions thereof. The compounds and compositions are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: A method for structuring transmissible data of various types with universal applicability as between devices of various types includes a data content, a first data header, and a second data header. The first data header signifies numerical data or control/command data. The second data header is a description of a data group to which the collected data belongs. The data further can include a third data header configured to describe production process information of the data. The data further can include a fourth data header to describe a product type, an industrial field, a company name, and a company address.