Abstract: An electronic device may have a display with a backlight. The backlight provides backlight illumination for an array of pixels that is displaying images. The backlight may include an array of cells. Each cell may contain a light source with one or more light-emitting diodes and a cavity reflector that reflects light from the light source outwardly through a diffuser for use in forming the backlight illumination. The light sources may be mounted to a printed circuit. Support posts on the printed circuit may be used to maintain the diffuser at a fixed distance from the printed circuit. Sensors on the printed circuit may be used to measure separation distances between the printed circuit and diffuser. Adjustments to pixel gain profiles can be made based on the measured separation distances.

Abstract: The present disclosure provides a silicone-modified dicyclopentadiene-derived hydroxy aromatic compound, which includes a structure represented by formula (I). Formula (I) is defined as in the specification. The present disclosure further provides a manufacturing method for a silicone-modified dicyclopentadiene-derived hydroxy aromatic compound and a curable product, wherein the curable product is obtained by mixing the silicone-modified dicyclopentadiene-derived hydroxy aromatic compound and a modified polyphenylene oxide resin, and then adding a peroxide to perform a curing reaction.

Abstract: A laser printing device for making high-precision 3D products includes a platform, a device supplying and spreading powder for transporting and spreading metal powder on the top surface of the platform, a first laser source for emitting continuous laser beam, a second laser source for emitting pulsed laser beam, an optical path switching device connected with the first laser source and the second laser source for controlling and selecting the first laser source and the second laser source to emit laser beam, a scanning galvanometer system for focusing the laser beam on the platform for making the continuous laser beam melt the metal powder and a layer of a product being formed after cooling, a mechanical processing device for polishing the final surface of the product. The pulsed laser beam cuts the edge of each newly-deposited layer with geometric accuracy. A laser printing method for 3D product is also provided.

Abstract: A light emitting diode (LED) display can calculate a common voltage charge of a line of pixels in the LED display, the common voltage charge comprising a difference between a first line of pixels and a second line of pixels. If the calculated common voltage charge exceeds a predetermined threshold, a toggle matrix can be generated for the line of pixels. The toggle matrix can include a matrix of charge values generated by calculating a difference in charge values for each subpixel a first line of subpixels with each subpixel a second line of subpixels. The LED display can identify one or more regions of subpixels exhibiting the predetermined toggle pattern in the toggle matrix. The LED display can generate a voltage correction charge to apply to affected regions of the display. Alternatively, the subpixels or pixels could be swapped with adjacent pixels to reduce toggling or settling error.

Abstract: Disclosed in the present invention are a stent apparatus having a self-pleated skirt, a processing method therefor, a skirt pleating method, and a cardiac valve. The stent apparatus comprises a stent, and is further provided with a flexible skirt. The skirt comprises: an unfolded state, where the skirt extends axially and surrounds the periphery of the stent before release; and a stacked state, where the skirt is driven by deformation during release of the stent, and gathers and is stacked along an axial direction of the released stent to form an annular perivalvular leakage blocking part. The stent apparatus is further provided with a pull-wire which is merely threaded on the skirt, and the pull-wire may react to the radial deformation during the release of the stent to drive the skirt to enter the stacked state.

Abstract: Provided herein are bifunctional compounds with a moiety or domain that is a binder of the ubiquitin receptor RPN13 and another moiety or domain that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided also are methods of inducing the degradation of DOT1L by administering a bifunctional compound or composition described herein, wherein one domain of the bifunctional compound is a binder of the ubiquitin receptor RPN13 and another domain of the compound is a binder of the target protein DOT1L in a subject.

Abstract: An electronic device such as a voice-controlled speaker device may have a housing. A speaker and other input-output components and control circuitry may be mounted within the housing. Light-emitting components may emit light that passes through a curved upper top cap portion or other housing structure. The light-emitting components may be interconnected using a flex circuit on a curved substrate or may be mounted on a planar circuit board. A subset of the light-emitting components may be rotated to improve color balance. Optical structures such as light guides, lens, microlenses, and/or a diffuser layer may be disposed over the light-emitting components to promote light mixing, to reduce hotspots, and to improve contrast on the top cap. The diffuser layer may be suspended using a support structure having baffle members to constraint the angular spread of the emitted light. Illuminated or persistently visible glyphs may be displayed in or near the top cap portion.

Abstract: The present disclosure provides compounds of any one of Formulae (I) and (II). The compounds described herein are inhibitors of histone methyltransferases (e.g., enhancer of zeste homolog 1 (EZH1) and enhancer of zeste homolog 2 (EZH2)) and are useful in treating and/or preventing a broad range of diseases (e.g., proliferative diseases). Also provided in the present disclosure are pharmaceutical compositions, kits, methods, and uses including or using a compound described herein. Further provided in the present disclosure are methods of identifying EZH1 and/or EZH2 inhibitors.

Abstract: Processes and systems for non-destructively storing, accessing, and editing information using nucleic acids are disclosed. Representative processes include a process for extracting a data file from a database, wherein the data file comprises information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for expanding a number of unique data files in a database that can be addressed with a predetermined number of oligonucleotide primers, wherein the unique data files each comprise information encoded into one or more polynucleotide strands and wherein the database comprises a plurality of polynucleotide strands; a process for differentially reading information encoded into one or more polynucleotide strands; a process for manipulating files while in storage; and a process for extracting a data file from a database, wherein the data file comprises information encoded into a polynucleotide strand.

Abstract: Systems and methods to compensate for color fringe visual artifacts due at least in part to subpixel locations on an electronic display are provided. An electronic device may include subpixel layout compensation circuitry (SLCC) and an electronic display. The SLCC may receive first image data and an indication of spatial positions of subpixels that make up pixels of an electronic display. The SLCC may generate second image data based at least in part on the first image data and the indication of the spatial positions of the subpixels. The second image data may reduce or eliminate a color fringe artifact that would otherwise occur without compensation.

Abstract: The present invention relates to methods, compositions and kits for treatment of ribosomal disorders and ribosomopathies, e.g. Diamond Blackfan anemia (DBA). In some embodiments, the invention relates to the use of novel classes of compounds, i.e. inhibitors of RSK (p90S6K); inhibitors of p70S6K; and inhibitors of rps6, to treat ribosomal disorders and ribosomopathies. In some embodiments, the invention relates to the use of specific Chk2 inhibitors and to the use of specific phenothiazine derivatives to treat ribosomal disorders and ribosomopathies, e.g. DBA.

Abstract: Disclosed are bifunctional compounds (degraders) that target HAT EP300 for degradation. Also disclosed are pharmaceutical compositions containing the degraders and methods of using the compounds to treat disease.

Abstract: A display may have a pixel array such as a liquid crystal pixel array. The pixel array may be illuminated with backlight illumination from a backlight unit. The backlight unit may include a printed circuit board, a plurality of light-emitting diodes mounted on the printed circuit board, at least one light spreading layer formed over the printed circuit board that spreads light received from the plurality of light-emitting diodes, a partially reflective layer formed over the at least one light spreading layer, a color conversion layer formed over the partially reflective layer, a collimating layer formed over the color conversion layer, a brightness enhancement film formed over the collimating layer, and a diffuser formed over the brightness enhancement film. The at least one light spreading layer may include two light spreading layers with elongated protrusions that are rotated relative to each other.

Abstract: Embodiments described herein generally take the form of an electronic device including a primary and secondary display; at least the secondary display is force-sensitive and further has its force-sensing circuitry in-plane with the display. The secondary display and force-sensing circuitry may be encapsulated between two glass layers that are bonded to one another by a frit. In some embodiments the force-sensing circuitry is formed from, or constitutes part of, the frit.

Abstract: An electronic device may include a display having a monolithic array of light-emitting diodes mounted to a surface of a substrate layer. The diodes may include contact pads. Driver circuitry may independently drive each of the diodes in the array using drive signals. The driver circuitry may be formed on a driver integrated circuit. Bond pads may be formed on a surface of the integrated circuit. Copper pillars may be grown on the bond pads. In another suitable arrangement, the driver circuitry may be formed on a driver printed circuit board coupled to an interposer by a flexible printed circuit. The interposer may include bond pads and copper pillars grown on the bond pads. The contact pads on each of the diodes may be simultaneously bonded to the copper pillars. A surface of the substrate layer may be patterned to form light redirecting elements if desired.

Abstract: The present invention provides compounds of Formula (I), and pharmaceutically compositions thereof. Compounds of Formula (I) are binders of bromodomains and/or bromodomain-containing proteins (e.g., bromo and extra terminal (BET) proteins). Also provided are methods, uses, and kits using the compounds and pharmaceutical compositions for inhibiting the activity (e.g., increased activity) of bromodomains and/or bromodomain-containing proteins and for treating and/or preventing in a subject diseases associated with bromodomains or bromodomain-containing proteins (e.g., proliferative diseases, cardiovascular diseases, viral infections, fibrotic diseases, metabolic diseases, endocrine diseases, and radiation poisoning). The compounds, pharmaceutical compositions, and kits are also useful for male contraception.

Abstract: A glass production apparatus producing continuously curved glass for covers and containers includes a crucible, a calender device, a cutting device, a molding device, and a crystallizing device. The crucible melts glass raw material and outputs a glass melt to calender device. The calender device rolls and presses the glass melt to prepare a glass belt with a preset temperature. The cutting device cuts the glass belt with the preset temperature into glass members. The molding device include at least one molding mold and a manipulator. Each of the at least one molding mold curves at least one portion of the glass member with the preset temperature to prepare a curved glass member. The manipulator transfers the curved glass member to the crystallizing device, the crystallizing device crystallizes the curved glass member to prepare a curved crystalline glass member. A method for manufacturing such glass is also provided.

Abstract: An electronic device may have a display. Inactive portions of the display such as peripheral portions of the display may be masked using an opaque masking layer. An opening may be provided in the opaque masking layer to allow light to pass. For example, a logo may be viewed through an opening in the opaque masking layer and a camera may receive light through an opening in the opaque masking layer. The display may include upper and lower polarizers, a color filter layer, and a thin-film transistor layer. The opaque masking layer may be formed on the upper polarizer, may be interposed between the upper polarizer and the color filter layer, or may be interposed between the color filter layer and the thin-film transistor layer. The upper polarizer may have unpolarized windows for cameras, logos, or other internal structures.

Abstract: A pixel array may be illuminated with backlight illumination from a backlight. The backlight may include a two-dimensional array of light-emitting diodes, with each light-emitting diode being placed in a respective cell. Different light-emitting diodes may have unique brightness magnitudes based on the content of the given display frame. Driver integrated circuits may control one or more associated light-emitting diodes to have a desired brightness level. The driver integrated circuits may be formed in an active area of the backlight. The driver integrated circuits may be arranged in groups that are daisy chained together. A digital signal (that includes information such as addressing information) may be propagated through the group of driver integrated circuits. To manage thermal performance of the backlight, the backlight may include a thermally conductive layer and/or a heat sink structure. To increase the efficiency of the backlight, the backlight may include one or more reflective layers.

Abstract: A pixel array may be illuminated with backlight illumination from a backlight. The backlight may include a two-dimensional array of light-emitting diodes, with each light-emitting diode being placed in a respective cell. Different light-emitting diodes may have unique brightness magnitudes based on the content of the given display frame. Driver integrated circuits may control one or more associated light-emitting diodes to have a desired brightness level. The driver integrated circuits may be formed in an active area of the backlight. The driver integrated circuits may be arranged in groups that are daisy chained together. A digital signal (that includes information such as addressing information) may be propagated through the group of driver integrated circuits. To manage thermal performance of the backlight, the backlight may include a thermally conductive layer and/or a heat sink structure. To increase the efficiency of the backlight, the backlight may include one or more reflective layers.