Patents by Inventor Karl Guegler

Karl Guegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6852519
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 24, 2002
    Date of Patent: February 8, 2005
    Assignee: Applera Corporation
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady V. Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • Human cytoskeleton associated proteins
    Publication number: 20050003447
    Abstract: The invention provides human cytoskeleton associated proteins (CYSKP) and polynucleotides which identify and encode CYSKP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of CYSKP.
    Type: Application
    Filed: August 19, 2004
    Publication date: January 6, 2005
    Inventors: Preeti Lal, Y. Tang, Henry Yue, Jennifer Jackson, Olga Bandman, Neil Corley, Karl Guegler, Chandra Arvizu, Yalda Azimzai, Mariah Baughn
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20040266679
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: August 7, 2003
    Publication date: December 30, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Ishwar Chandramouliswaran, Karl Guegler, Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20040253698
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: July 8, 2004
    Publication date: December 16, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina DiFrancesco
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Publication number: 20040253705
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Application
    Filed: July 3, 2003
    Publication date: December 16, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Marion Webster, Chunhua Yan, Wei Shao, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20040247595
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: July 12, 2004
    Publication date: December 9, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20040229317
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: May 24, 2004
    Publication date: November 18, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Rhonda C. Brandon, Gennady V. Merkulov, Karen A. Ketchum, Valentina DiFrancesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20040229782
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: October 15, 2003
    Publication date: November 18, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Marion Webster, Chunhua Yan, Karen A. Ketchum, Ming-Hui Wei, Valentina De Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20040191829
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: April 30, 2004
    Publication date: September 30, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Gennady V. Merkulov, Karl Guegler, Ming-Hui Wei, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6780626
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 10, 2003
    Date of Patent: August 24, 2004
    Assignee: Applera Corporation
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Publication number: 20040152163
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Application
    Filed: March 12, 2004
    Publication date: August 5, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20040126861
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: January 7, 2004
    Publication date: July 1, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20040106775
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthlogs and paralogs or the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: July 2, 2003
    Publication date: June 3, 2004
    Inventors: Karl Guegler, Rhonda C Brandon, Valentina Di Francesco, Ellen M Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6730505
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: June 6, 2002
    Date of Patent: May 4, 2004
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Nucleic acid encoding a fusion protein comprising an EIF-4E domain and an EIF-4G domain joined by a linker domain
    Patent number: 6703239
    Abstract: Methods and compositions are provided for producing full-length cDNA libraries. In the subject methods, full length first strand cDNAs are isolated using a fusion protein of an eIF-4E domain and an eIF-4G domain separated by a flexible linker. Also provided is the novel fusion protein employed in the subject methods, as well as nucleic acids encoding, and host cells capable of expressing, the same. Finally, kits for use in practicing the subject methods are provided. The subject invention finds use in a variety of applications in which full-length cDNA libraries are employed.
    Type: Grant
    Filed: June 25, 2002
    Date of Patent: March 9, 2004
    Assignee: Incyte Corporation
    Inventors: Karl Guegler, Ruoying Tan, Michael J. Rose
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Publication number: 20040033526
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Application
    Filed: August 13, 2003
    Publication date: February 19, 2004
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human kinase proteins
    Patent number: 6689597
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: May 1, 2002
    Date of Patent: February 10, 2004
    Assignee: Applera Corporation
    Inventors: Ishwar Chandramouliswaran, Karl Guegler, Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phospholipase proteins, nucleic acid molecules encoding human phospholipase proteins, and uses thereof
    Patent number: 6689598
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phospholipase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phospholipase peptides, and methods of identifying modulators of the phospholipase peptides.
    Type: Grant
    Filed: March 14, 2002
    Date of Patent: February 10, 2004
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6630334
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 2, 2001
    Date of Patent: October 7, 2003
    Assignee: Applera Corporation
    Inventors: Karl Guegler, Marion Webster, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20030180786
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: April 30, 2003
    Publication date: September 25, 2003
    Applicant: APPLERA CORPORATION
    Inventors: Karl Guegler, Ellen M. Beasley, Valentina Di Francesco