Patents by Inventor Karl Guegler

Karl Guegler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20020137128
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: December 14, 2000
    Publication date: September 26, 2002
    Inventors: Ming-Hui Wei, Karl Guegler, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20020132324
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: February 1, 2002
    Publication date: September 19, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Jiayin Li, Karl Guegler, Ellen M. Beasley, Karen A. Ketchum, Valentina Di Francesco
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Publication number: 20020123120
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: May 1, 2002
    Publication date: September 5, 2002
    Applicant: PE CORPORATION (NY)
    Inventors: Ishwar Chandramouliswaran, Karl Guegler, Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Methods and compositions for producing full length cDNA libraries
    Publication number: 20020119477
    Abstract: Methods and compositions are provided for producing full-length CDNA libraries. In the subject methods, full length first strand cDNAs are isolated using a fusion protein of an eIF-4E domain and an eIF-4G domain separated by a flexible linker. Also provided is the novel fusion protein employed in the subject methods, as well as nucleic acids encoding, and host cells capable of expressing, the same. Finally, kits for use in practicing the subject methods are provided. The subject invention finds use in a variety of applications in which full-length cDNA libraries are employed.
    Type: Application
    Filed: November 1, 2001
    Publication date: August 29, 2002
    Inventors: Karl Guegler, Ruoying Tan, Michael J. Rose
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20020115166
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: December 13, 2000
    Publication date: August 22, 2002
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated nucleic acid molecules encoding human protease proteins, and uses thereof
    Patent number: 6436689
    Abstract: The present invention provides amino acid sequence of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identify orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Grant
    Filed: December 21, 2000
    Date of Patent: August 20, 2002
    Assignee: PE Corporation (NY)
    Inventors: Karl Guegler, Marion Webster, Chunhua Yan, Wei Shao, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Methods and compositions for producing full length cDNA libraries
    Patent number: 6436676
    Abstract: Methods and compositions are provided for producing full-length cDNA libraries. In the subject methods, full length first strand cDNAs are isolated using a fusion protein of an eIF-4E domain and an eIF-4G domain separated by a flexible linker. Also provided is the novel fusion protein employed in the subject methods, as well as nucleic acids encoding, and host cells capable of expressing, the same. Finally, kits for use in practicing the subject methods are provided. The subject invention finds use in a variety of applications in which full-length cDNA libraries are employed.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: August 20, 2002
    Assignee: Incyte Genomics, Inc.
    Inventors: Karl Guegler, Ruoying Tan, Michael J. Rose
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20020110852
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: May 22, 2001
    Publication date: August 15, 2002
    Inventors: Karl Guegler, Rhonda C. Brandon, Valentina Di Francesco, Ellen M. Beasley
  • ISOLATED HUMAN KINASE PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN KINASE PROTEINS, AND USES THEREOF
    Publication number: 20020110889
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: December 28, 2000
    Publication date: August 15, 2002
    Inventors: Ishwar Chandramouliswaran, Karl Guegler, Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20020103115
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: December 6, 2000
    Publication date: August 1, 2002
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6423521
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 28, 2000
    Date of Patent: July 23, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ishwar Chandramouliswaran, Karl Guegler, Marion Webster, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • ISOLATED HUMAN KINASE PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN KINASE PROTEINS, AND USES THEREOF
    Publication number: 20020094946
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: December 13, 2000
    Publication date: July 18, 2002
    Inventors: Karl Guegler, Karen Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof
    Patent number: 6420150
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: July 16, 2002
    Assignee: PE Corporation (NY)
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6416990
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: December 8, 2000
    Date of Patent: July 9, 2002
    Assignee: PE Corporation (NY)
    Inventors: Ming-Hui Wei, Karl Guegler, Karen A. Ketchum, Gennady V. Merkulov, Trevor Woodage, Valentina Di Francesco, Ellen M. Beasley
  • ISOLATED HUMAN DRUG-METABOLIZING PROTEINS, NUCLEIC ACID MOLECULES ENCODING HUMAN DRUG-METABOLIZING PROTEINS, AND USES THEREOF
    Publication number: 20020086381
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.
    Type: Application
    Filed: December 14, 2000
    Publication date: July 4, 2002
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human phosphodiesterase proteins, nucleic acid molecules encoding human phosphodiesterase proteins, and uses thereof
    Publication number: 20020086810
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the phosphodiesterase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the phosphodiesterase peptides, and methods of identifying modulators of the phosphodiesterase peptides.
    Type: Application
    Filed: December 20, 2000
    Publication date: July 4, 2002
    Inventors: Karl Guegler, Rhonda C. Brandon, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof
    Publication number: 20020086400
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the protease peptides, and methods of identifying modulators of the protease peptides.
    Type: Application
    Filed: December 21, 2000
    Publication date: July 4, 2002
    Inventors: Shiaoping Zhu, Karl Guegler, Marion Webster, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20020081649
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: December 21, 2000
    Publication date: June 27, 2002
    Inventors: Gennady V. Merkulov, Karl Guegler, Marion Webster, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • Isolated human transporter proteins, nucleic acid molecules encoding human transporter proteins, and uses thereof
    Publication number: 20020082191
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the transporter peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the transporter peptides, and methods of identifying modulators of the transporter peptides.
    Type: Application
    Filed: February 6, 2001
    Publication date: June 27, 2002
    Inventors: Karl Guegler, Rhonda C. Brandon, Gennady V. Merkulov, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley
  • ISOLATED HUMAN SERINE/THREONINE KINASE NUCLEIC ACID MOLECULES ENCODING HUMAN SERINE/THREONINE KINASE AND USES THEREOF
    Publication number: 20020082189
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Application
    Filed: December 7, 2000
    Publication date: June 27, 2002
    Inventors: Karl Guegler, Karen A. Ketchum, Valentina Di Francesco, Ellen M. Beasley